A single institution experience of the treatment of pancreatic ductal carcinoma: The demand and the role of radiation therapy

Autoři: Katsumaro Kubo aff001;  Koichi Wadasaki aff002;  Daisuke Komichi aff003;  Tamito Sasaki aff003;  Hiroyasu Yamada aff003;  Yasuhiro Matsugu aff004;  Toshiyuki Itamoto aff004;  Mihoko Doi aff005;  Katsunori Shinozaki aff005
Působiště autorů: Department of Radiation Oncology, Hiroshima High-Precision Radiotherapy Cancer Center, Hiroshima-shi, Hiroshima, Japan aff001;  Department of Radiation Oncology, Hiroshima Prefectural Hospital, Hiroshima-shi, Hiroshima, Japan aff002;  Department of Gastroenterology, Hiroshima Prefectural Hospital, Hiroshima-shi, Hiroshima, Japan aff003;  Department of Surgery, Hiroshima Prefectural Hospital, Hiroshima-shi, Hiroshima, Japan aff004;  Department of Clinical Oncology, Hiroshima Prefectural Hospital, Hiroshima-shi, Hiroshima, Japan aff005
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0227305


We aimed to demonstrate a single institution experience of treatment of pancreatic ductal carcinoma and to identify the role of radiation therapy. We assessed all patients who were diagnosed with pancreatic ductal carcinoma from January 2011 to December 2017. A total of 342 patients were enrolled. Thirteen, 131, 36, and 162 patients had stage I, II, III, and IV disease, respectively (UICC TNM, 7th edition). Among the patients with stages I–III disease, 94 underwent surgery, and the median overall survival (OS) was 33 months. Of patients with stages I–III disease who were not suitable for surgery, 58 patients received chemotherapy, and the median OS was 12 months. Among them, 17 patients received chemoradiotherapy added on chemotherapy and their OS was significantly better than that of patients who received chemotherapy alone. Of patients with stage IV disease, 111 received chemotherapy, and the median OS was 6 months. This study evaluated the demand, role, and outcome of each treatment modality and demonstrated a single institution experience of treatment of pancreatic ductal carcinoma. The demand and role of radiation therapy remained small; however, radiation therapy might have some importance as a local treatment.

Klíčová slova:

Cancer chemotherapy – Cancer treatment – Chemotherapy – Metastasis – Pancreatic cancer – Radiation therapy – Surgical and invasive medical procedures – Surgical oncology


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2019 Číslo 12
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