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Sperm DNA integrity in adult survivors of paediatric leukemia and lymphoma: A pilot study on the impact of age and type of treatment


Autoři: Hermance Beaud aff001;  Océane Albert aff002;  Bernard Robaire aff002;  Marie Claude Rousseau aff001;  Peter T. K. Chan aff004;  Geraldine Delbes aff001
Působiště autorů: INRS-Centre Armand-Frappier Santé Biotechnologie, Laval, Quebec, Canada aff001;  Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec Canada aff002;  Department of Obstetrics & Gynecology, McGill University, Montreal, Quebec, Canada aff003;  Division of Urology, McGill University Health Center, Montreal, Quebec, Canada aff004
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0226262

Souhrn

Childhood cancer survivors (CCS) are more likely than siblings to report low sperm count and to use assisted reproductive technologies. Yet, it is still unclear if the sperm produced many years after remission of cancer display DNA and chromatin damage linked to male infertility and poor embryo development. As well, the importance of the age at diagnosis in relation to puberty is poorly understood. In this pilot study, we compared reproductive parameters and sperm damage from adult survivors of childhood leukemia and lymphoma, sub-divided into those diagnosed before or after puberty, to men with no history of cancer. Our data indicate that CCS, independently of the age of diagnosis, have a high risk of low sperm count and when sperm are present, chances of DNA and chromatin abnormalities appear similar to those seen in the general population. Exposure to alkylating agents is correlated with low sperm count whereas exposure to anthracyclines, and doxorubicin in particular, could have long-term consequences on sperm integrity. This study highlights the need for further research on fertility among male CCS and the importance of informing families about the potential long-term impact of chemotherapy on male fertility regardless of age at diagnosis.

Klíčová slova:

Acute lymphoblastic leukemia – Cancer detection and diagnosis – Cancer treatment – Chromatin – Pediatric oncology – Puberty – Semen – Sperm


Zdroje

1. Baade PD, Youlden DR, Valery PC, Hassall T, Ward L, Green AC, et al. Trends in incidence of childhood cancer in Australia, 1983–2006. British journal of cancer. 2010;102(3):620–6. doi: 10.1038/sj.bjc.6605503 20051948

2. Kaatsch P. Epidemiology of childhood cancer. Cancer treatment reviews. 2010;36(4):277–85. doi: 10.1016/j.ctrv.2010.02.003 20231056

3. Ries LAG, Melbert D, Krapcho M, Mariotto A, Miller BA, Feuer EJ, et al. SEER Cancer Statistics Review, 1975–2004, National Cancer Institute. http://seer.cancer.gov/csr/1975_2004/2007.

4. Steliarova-Foucher E, Colombet M, Ries LAG, Moreno F, Dolya A, Bray F, et al. International incidence of childhood cancer, 2001–10: a population-based registry study. The Lancet Oncology. 2017;18(6):719–31. doi: 10.1016/S1470-2045(17)30186-9 28410997

5. Green DM, Kawashima T, Stovall M, Leisenring W, Sklar CA, Mertens AC, et al. Fertility of male survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2010;28(2):332–9. doi: 10.1200/JCO.2009.24.9037 19949008

6. Prasad PK, Bowles T, Friedman DL. Is there a role for a specialized follow-up clinic for survivors of pediatric cancer? Cancer treatment reviews. 2010;36(4):372–6. doi: 10.1016/j.ctrv.2010.02.014 20189720

7. Reulen RC, Winter DL, Frobisher C, Lancashire ER, Stiller CA, Jenney ME, et al. Long-term cause-specific mortality among survivors of childhood cancer. JAMA: the journal of the American Medical Association. 2010;304(2):172–9. doi: 10.1001/jama.2010.923 20628130

8. Chow EJ, Stratton KL, Leisenring WM, Oeffinger KC, Sklar CA, Donaldson SS, et al. Pregnancy after chemotherapy in male and female survivors of childhood cancer treated between 1970 and 1999: a report from the Childhood Cancer Survivor Study cohort. The Lancet Oncology. 2016;17(5):567–76. doi: 10.1016/S1470-2045(16)00086-3 27020005

9. Green DM, Whitton JA, Stovall M, Mertens AC, Donaldson SS, Ruymann FB, et al. Pregnancy outcome of partners of male survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Journal of clinical oncology. 2003;21(4):716–21. doi: 10.1200/JCO.2003.04.085 12586811

10. Wasilewski-Masker K, Seidel KD, Leisenring W, Mertens AC, Shnorhavorian M, Ritenour CW, et al. Male infertility in long-term survivors of pediatric cancer: a report from the childhood cancer survivor study. Journal of cancer survivorship: research and practice. 2014;8(3):437–47. doi: 10.1007/s11764-014-0354-6 24711092

11. Chan D, Delbes G, Landry M, Robaire B, Trasler JM. Epigenetic alterations in sperm DNA associated with testicular cancer treatment. Toxicological sciences: an official journal of the Society of Toxicology. 2012;125(2):532–43. doi: 10.1093/toxsci/kfr307 22076425

12. Delbes G, Hales BF, Robaire B. Effects of the chemotherapy cocktail used to treat testicular cancer on sperm chromatin integrity. Journal of andrology. 2007;28(2):241–9; discussion 50–1. doi: 10.2164/jandrol.106.001487 17021337

13. O'Flaherty C, Hales BF, Chan P, Robaire B. Impact of chemotherapeutics and advanced testicular cancer or Hodgkin lymphoma on sperm deoxyribonucleic acid integrity. Fertility and sterility. 2010;94(4):1374–9. doi: 10.1016/j.fertnstert.2009.05.068 19591994

14. Tempest HG, Ko E, Chan P, Robaire B, Rademaker A, Martin RH. Sperm aneuploidy frequencies analysed before and after chemotherapy in testicular cancer and Hodgkin's lymphoma patients. Hum Reprod. 2008;23(2):251–8. doi: 10.1093/humrep/dem389 18083744

15. Bujan L, Walschaerts M, Brugnon F, Daudin M, Berthaut I, Auger J, et al. Impact of lymphoma treatments on spermatogenesis and sperm deoxyribonucleic acid: a multicenter prospective study from the CECOS network. Fertility and sterility. 2014;102(3):667–74 e3. doi: 10.1016/j.fertnstert.2014.06.008 25044088

16. Tremblay A, Beaud H, Delbès G. Effets transgénérationnels des chimiothérapies: l’exposition du père influence-t-elle la santé des générations futures? Gynécologie Obstétrique Fertilité & Sénologie 2017;45(11):609–18. https://doi.org/10.1016/j.gofs.2017.09.004.

17. Romerius P, Ståhl O, Moëll C, Relander T, Cavallin-Ståhl E, Gustafsson H, et al. Sperm DNA integrity in men treated for childhood cancer. Clinical Cancer Research. 2010;16(15):3843–50. doi: 10.1158/1078-0432.CCR-10-0140 20519359

18. Thomson AB, Campbell AJ, Irvine DS, Anderson RA, Kelnar CJH, Wallace WHB. Semen quality and spermatozoal DNA integrity in survivors of childhood cancer: A case-control study. Lancet. 2002;360(9330):361–7. doi: 10.1016/s0140-6736(02)09606-x 12241775

19. Revel A, Revel-Vilk S. Pediatric fertility preservation: is it time to offer testicular tissue cryopreservation? Molecular and cellular endocrinology. 2008;282(1–2):143–9. doi: 10.1016/j.mce.2007.11.003 18249486

20. Trama A, Botta L, Foschi R, Ferrari A, Stiller C, Desandes E, et al. Survival of European adolescents and young adults diagnosed with cancer in 2000–07: population-based data from EUROCARE-5. The Lancet Oncology. 2016;17(7):896–906. doi: 10.1016/S1470-2045(16)00162-5 27237614

21. Cooper TG, Noonan E, von Eckardstein S, Auger J, Baker HW, Behre HM, et al. World Health Organization reference values for human semen characteristics. Human reproduction update. 2010;16(3):231–45. doi: 10.1093/humupd/dmp048 19934213

22. Wallace WH, Shalet SM, Lendon M, Morris-Jones PH. Male fertility in long-term survivors of childhood acute lymphoblastic leukaemia. International journal of andrology. 1991;14(5):312–9. Epub 1991/10/01. doi: 10.1111/j.1365-2605.1991.tb01098.x 1794916

23. van Casteren NJ, van der Linden GH, Hakvoort-Cammel FG, Hahlen K, Dohle GR, van den Heuvel-Eibrink MM. Effect of childhood cancer treatment on fertility markers in adult male long-term survivors. Pediatric blood & cancer. 2009;52(1):108–12. doi: 10.1002/pbc.21780 18819129

24. Romerius P, Stahl O, Moell C, Relander T, Cavallin-Stahl E, Wiebe T, et al. High risk of azoospermia in men treated for childhood cancer. International journal of andrology. 2011;34(1):69–76. doi: 10.1111/j.1365-2605.2010.01058.x 20345878

25. Green DM, Liu W, Kutteh WH, Ke RW, Shelton KC, Sklar CA, et al. Cumulative alkylating agent exposure and semen parameters in adult survivors of childhood cancer: a report from the St Jude Lifetime Cohort Study. The Lancet Oncology. 2014;15(11):1215–23. doi: 10.1016/S1470-2045(14)70408-5 25239573

26. Evenson DP. Evaluation of sperm chromatin structure and DNA strand breaks is an important part of clinical male fertility assessment. Translational andrology and urology. 2017;6(Suppl 4):S495–S500. doi: 10.21037/tau.2017.07.20 29082168

27. Hohmann C, Borgmann-Staudt A, Rendtorff R, Reinmuth S, Holzhausen S, Willich SN, et al. Patient counselling on the risk of infertility and its impact on childhood cancer survivors: results from a national survey. J Psychosoc Oncol. 2011;29(3):274–85. doi: 10.1080/07347332.2011.563344 21590573

28. Vendramini V, Robaire B, Miraglia SM. Amifostine-doxorubicin association causes long-term prepubertal spermatogonia DNA damage and early developmental arrest. Hum Reprod. 2012;27(8):2457–66. doi: 10.1093/humrep/des159 22593430

29. Beaud H, van Pelt AM, Delbes G. Doxorubicin and vincristine affect undifferentiated rat spermatogonia. Reproduction. 2017. doi: 10.1530/REP-17-0005 28258155

30. Tremblay AR, Delbes G. In vitro study of doxorubicin-induced oxidative stress in spermatogonia and immature Sertoli cells. Toxicology and applied pharmacology. 2018;348:32–42. doi: 10.1016/j.taap.2018.04.014 29660436

31. Delbes G, Herrero MB, Troeung ET, Chan PT. The use of complimentary assays to evaluate the enrichment of human sperm quality in asthenoteratozoospermic and teratozoospermic samples processed with Annexin-V magnetic activated cell sorting. Andrology. 2013;1(5):698–706. doi: 10.1111/j.2047-2927.2013.00106.x 23843365

32. O'Flaherty C, Vaisheva F, Hales BF, Chan P, Robaire B. Characterization of sperm chromatin quality in testicular cancer and Hodgkin's lymphoma patients prior to chemotherapy. Hum Reprod. 2008;23(5):1044–52. doi: 10.1093/humrep/den081 18346994


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