Impact of mycoplasma pneumonia infection on urticaria: A nationwide, population-based retrospective cohort study in Taiwan

Autoři: Su-Boon Yong aff001;  Wei-Chu Yeh aff004;  Hsing-Ju Wu aff005;  Huang-Hsi Chen aff001;  Jing-Yang Huang aff007;  Tung-Ming Chang aff008;  James Cheng-Chung Wei aff001
Působiště autorů: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan aff001;  Division of Pediatric Allergy, Immunology and Rheumatology, Department of Pediatrics, Show Chwan Memorial Hospital, Changhua, Taiwan aff002;  Department of Nursing, Meiho University, Pingtung, Taiwan aff003;  Department of Emergency, Show Chwan Memorial Hospital, Changhua, Taiwan aff004;  Research Assistant Center, Show Chwan Memorial Hospital, Changhua, Taiwan aff005;  Department of Medical Research, Chang Bing Show Chwan Memorial Hospital, Lukang Town, Changhua County, Taiwan aff006;  Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan aff007;  Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan aff008;  Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan aff009;  Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan aff010
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article


Mycoplasma pneumonia (MP) infection might be pathogenically closely related to urticaria. This study is a nationwide population-based cohort study from 1997 to 2013, which investigated the association between MP infection and urticaria in Taiwan. A total of 1,175 patients were included for the study group, and 2,350 for the control group. Multivariate Cox regression analysis was performed to estimate the adjusted hazard ratio (aHR) for urticaria. Result showed that 254 patients with new-onset urticaria were involved in the study group and 465 incident cases in the control group. The incidence rates (per 100,000 person-months) of urticaria were 37.2 and 32.5 in the study and control groups, respectively. The relative risk is 1.1 (95% CI = 1.0–1.3) indicating no significant correlation between MP and urticaria. The multivariate analysis revealed that the risk of urticaria with MP infection (aHR = 1.1, P = 0.1058) had no statistically significance difference compared to the control group. However, the risk of urticaria in MP-infected patients aged between 20 and 59 years old was found to have increased (aHR = 1.6, 95% CI = 1.1–2.2) prior to a diagnosis.

Klíčová slova:

Diagnostic medicine – Pediatric infections – Respiratory infections – Streptococcal infections – Upper respiratory tract infections – Urticaria – Mycoplasma pneumonia – Mycoplasma pneumoniae


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2019 Číslo 12
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