A world map of evidence-based medicine: Density equalizing mapping of the Cochrane database of systematic reviews

Autoři: David A. Groneberg aff001;  Stefan Rolle aff001;  Michael H. K. Bendels aff001;  Doris Klingelhöfer aff001;  Norman Schöffel aff001;  Jan Bauer aff001;  Dörthe Brüggmann aff001
Působiště autorů: The Institute of Occupational, Social and Environmental Medicine, Goethe University Frankfurt, Frankfurt, Germany aff001
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0226305


Systematic reviews represent the core and backbone of evidence-based medicine (EBM) strategies in all fields of medicine. In order to depict a first global sketch of the international efforts in the Cochrane database systematic reviews (CDSR), we analyzed the systematic reviews of the Cochrane database. Our global maps of systematic reviewing offer intriguing structural insights into the world of EBM strategies. They demonstrate that for the CDSR, the UK and Commonwealth countries take the lead position. Since patients, care providers and health systems all over the world benefit from systematic reviewing, institutions in other countries should increase their commitment.

Klíčová slova:

Australia – Canada – Citation analysis – Economic analysis – Medicine and health sciences – Systematic reviews – United States – Evidence based medicine


1. Starr M, Chalmers I, Clarke M, Oxman AD. The origins, evolution, and future of The Cochrane Database of Systematic Reviews. International journal of technology assessment in health care. 2009;25 Suppl 1:182–95. Epub 2009/06/19. doi: 10.1017/s026646230909062x 19534840.

2. Chevret S, Ferguson ND, Bellomo R. Are systematic reviews and meta-analyses still useful research? No. Intensive Care Med. 2018;44(4):515–7. Epub 2018/04/18. doi: 10.1007/s00134-018-5066-3 29663047.

3. Groneberg-Kloft B, Fischer TC, Quarcoo D, Scutaru C. New quality and quantity indices in science (NewQIS): the study protocol of an international project. J Occup Med Toxicol. 2009;4:16. Epub 2009/06/27. doi: 10.1186/1745-6673-4-16 19555514; PubMed Central PMCID: PMC2708171.

4. Groneberg-Kloft B, Quarcoo D, Scutaru C. Quality and quantity indices in science: use of visualization tools. EMBO reports. 2009;10(8):800–3. Epub 2009/08/04. doi: 10.1038/embor.2009.162 19648952; PubMed Central PMCID: PMC2726685.

5. Quarcoo D, Bruggmann D, Klingelhofer D, Groneberg DA. Ebola and Its Global Research Architecture—Need for an Improvement. PLoS neglected tropical diseases. 2015;9(9):e0004083. Epub 2015/09/26. doi: 10.1371/journal.pntd.0004083 26406894; PubMed Central PMCID: PMC4583251.

6. Bruggmann D, Pulch K, Klingelhofer D, Pearce CL, Groneberg DA. Ovarian cancer: density equalizing mapping of the global research architecture. International journal of health geographics. 2017;16(1):3. Epub 2017/01/15. doi: 10.1186/s12942-016-0076-2 28086974; PubMed Central PMCID: PMC5237222.

7. Schreiber M, Klingelhofer D, Groneberg DA, Bruggmann D. Patient safety: the landscape of the global research output and gender distribution. BMJ open. 2016;6(2):e008322. Epub 2016/02/14. doi: 10.1136/bmjopen-2015-008322 26873042; PubMed Central PMCID: PMC4762108.

8. Gastner MT, Newman ME. Diffusion-based method for producing density-equalizing maps. Proceedings of the National Academy of Sciences of the United States of America. 2004;101(20):7499–504. Epub 2004/05/12. doi: 10.1073/pnas.0400280101 15136719; PubMed Central PMCID: PMC419634.

9. Groneberg-Kloft B, Scutaru C, Kreiter C, Kolzow S, Fischer A, Quarcoo D. Institutional operating figures in basic and applied sciences: scientometric analysis of quantitative output benchmarking. Health research policy and systems. 2008;6:6. Epub 2008/06/17. doi: 10.1186/1478-4505-6-6 18554379; PubMed Central PMCID: PMC2459159.

10. CIA. The World Factbook, URL: https://www.cia.gov/library/publications/the-world-factbook/ (accessed Jan 2019). 2017.

11. UIS.stat. Science, technology and innovation, URL: http://data.uis.unesco.org (accessed Aug 2019). 2013–18.

12. Glynn RW, Scutaru C, Kerin MJ, Sweeney KJ. Breast cancer research output, 1945–2008: a bibliometric and density-equalizing analysis. Breast cancer research: BCR. 2010;12(6):R108. Epub 2010/12/24. doi: 10.1186/bcr2795 21176219; PubMed Central PMCID: PMC3046453.

13. Schoffel N, Krempel M, Bundschuh M, Bendels MH, Bruggmann D, Groneberg DA. Pancreatic Cancer-Critical Examination of the Global Research Architecture and Recent Scientific Developments. Pancreas. 2016;45(10):1378–85. Epub 2016/10/18. doi: 10.1097/MPA.0000000000000693 27518470.

14. Glynn RW, Lowery AJ, Scutaru C, O'Dwyer T, Keogh I. Laryngeal cancer: quantitative and qualitative assessment of research output, 1945–2010. The Laryngoscope. 2012;122(9):1967–73. Epub 2012/06/01. doi: 10.1002/lary.23401 22648552.

15. Phillips N. A close look at China's rise. Nature. 2017;545(7655):S39. Epub 2017/05/26. doi: 10.1038/545S39a 28538710.

16. Phillips N. Nature Index 2016 Japan. Nature. 2016;531(7594):S97. Epub 2016/03/18. doi: 10.1038/531S97a 26982025.

17. Djulbegovic B, Guyatt GH. Progress in evidence-based medicine: a quarter century on. Lancet. 2017;390(10092):415–23. doi: 10.1016/S0140-6736(16)31592-6 WOS:000405911300030. 28215660

18. Bruggmann D, Lohlein LK, Louwen F, Quarcoo D, Jaque J, Klingelhofer D, et al. Caesarean Section—A Density-Equalizing Mapping Study to Depict Its Global Research Architecture. International journal of environmental research and public health. 2015;12(11):14690–708. Epub 2015/11/26. doi: 10.3390/ijerph121114690 26593932; PubMed Central PMCID: PMC4661674.

19. Dickersin K, Manheimer E. The Cochrane Collaboration: evaluation of health care and services using systematic reviews of the results of randomized controlled trials. Clinical obstetrics and gynecology. 1998;41(2):315–31. Epub 1998/07/01. doi: 10.1097/00003081-199806000-00012 9646964.

20. Bendels MH, Bruggmann D, Schoffel N, Groneberg DA. Gendermetrics.NET: a novel software for analyzing the gender representation in scientific authoring. J Occup Med Toxicol. 2016;11:43. Epub 2016/09/22. doi: 10.1186/s12995-016-0133-6 27651823; PubMed Central PMCID: PMC5024497.

21. Bendels MHK, Wanke E, Schoffel N, Bauer J, Quarcoo D, Groneberg DA. Gender equality in academic research on epilepsy-a study on scientific authorships. Epilepsia. 2017;58(10):1794–802. Epub 2017/09/01. doi: 10.1111/epi.13873 28857143.

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2019 Číslo 12
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