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Bacteriologically-confirmed pulmonary tuberculosis in an Ethiopian prison: Prevalence from screening of entrant and resident prisoners


Autoři: Eliyas Tsegaye Sahle aff001;  Jill Blumenthal aff003;  Sonia Jain aff003;  Shelly Sun aff003;  Jason Young aff003;  Tsegahun Manyazewal aff001;  Habtamu Woldeamanuel aff001;  Lemma Teferra aff005;  Beniam Feleke aff006;  Olivier Vandenberg aff007;  Zilma Rey aff009;  Melissa Briggs-Hagen aff009;  Richard Haubrich aff010;  Wondwossen Amogne aff001;  John Allen McCutchan aff003
Působiště autorů: ADDIS-VP Project, Ethiopian Public Health Association, Addis Ababa, Ethiopia aff001;  École de Santé Publique, Université Libre de Bruxelles, Brussels, Belgium aff002;  University of California San Diego, San Diego, California, United States of America aff003;  Addis Ababa University, College of Health Sciences, Addis Ababa, Ethiopia aff004;  Ethiopian Federal Prison Administration, Addis Ababa, Ethiopia aff005;  Centers for Disease Control and Prevention, Addis Ababa, Ethiopia aff006;  Environmental and Occupational Health Research Centre (CRSET), School of Public Health, Université Libre de Bruxelles, Brussels, Belgium aff007;  Division of Infection & Immunity, University College London, London, United Kingdom aff008;  Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America aff009;  Gilead Sciences, Foster City, California, United States of America aff010
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0226160

Souhrn

Background

Pulmonary Tuberculosis (PTB) is a major health problem in prisons. Multiple studies of TB in regional Ethiopian prisons have assessed prevalence and risk factors but have not examined recently implemented screening programs for TB in prisons. This study compares bacteriologically-confirmed PTB (BC-PTB) prevalence in prison entrants versus residents and identifies risk factors for PTB in Kality prison, a large federal Ethiopian prison located in Addis Ababa, through a study of an enhanced TB screening program.

Methods

Participating prisoners (n = 13,803) consisted of 8,228 entrants screened continuously and 5,575 residents screened in two cross-sectional waves for PTB symptoms, demographics, TB risk factors, and medical history. Participants reporting at least one symptom of PTB were asked to produce sputum which was examined by microscopy for acid-fast bacilli, Xpert MTB/RIF assay and MGIT liquid culture. Prevalence of BC-PTB, defined as evidence of Mycobacterium tuberculosis (MTB) in sputum by the above methods, was compared in entrants and residents for the study. Descriptive analysis of prevalence was followed by bivariate and multivariate analyses of risk factors.

Results

Prisoners were mainly male (86%), young (median age 26 years) and literate (89%). Prevalence of TB symptoms by screening was 17% (2,334/13,803) with rates in residents >5-fold higher than entrants. Prevalence of BC-PTB detected by screening in participating prisoners was 0.16% (22/13,803). Prevalence in residents increased in the second resident screening compared to the first (R1 = 0.10% and R2 = 0.39%, p = 0.027), but remained higher than in entrants (4.3-fold higher during R1 and 3.1-fold higher during R2). Drug resistance (DR) was found in 38% (5/13) of culture-isolated MTB. Risk factors including being ever diagnosed with TB, history of TB contact and low Body Mass Index (BMI) (<18.5) were significantly associated with BC-PTB (p<0.05).

Conclusions

BC-PTB prevalence was strikingly lower than previously reported from other Ethiopian prisons. PTB appears to be transmitted within this prison based on its higher prevalence in residents than in entrants. Whether a sustained program of PTB screening of entrants and/or residents reduces prevalence of PTB in prisons is not clear from this study, but our findings suggest that resources should be prioritized to resident, rather than entrant, screening due to higher BC-PTB prevalence. Detection of multi- and mono-DR TB in both entrant and resident prisoners warrants regular screening for active TB and adoption of methods to detect drug resistance.

Klíčová slova:

Extensively drug-resistant tuberculosis – Medical risk factors – Prisoners – Prisons – Sputum – Tuberculosis – Tuberculosis diagnosis and management


Zdroje

1. World Health Organization (WHO). WHO report 2018: The top ten causes of death. Geneva: WHO. 2018. Available from: http://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death. Cited: 24 May 2018.

2. World Health Organization (WHO). Global tuberculosis report 2014. Geneva: WHO. 2014. Available from: http://www.who.int/tb/publications/global_report/gtbr14_executive_summary.pdf. Accessed on: 8 July 2016.

3. Harries A, Maher D, Raviglione M, Nunn P, Praag E Van. TB/HIV a clinical manual. 2004. 1–212.

4. Ministry of Health of Ethiopia (MOH) and Ethiopian Health and Nutrition Research Institute (EPHI). First Ethiopian national population based tuberculosis prevalence survey. EPHI. Addis Ababa, Ethiopia. 2012.

5. The Ethiopian Human Rights Commission. Human rights protection monitoring in Ethiopian prisons primary report. Addis Ababa, Ethiopia. 2012. Available from: http://www.ehrc.org.et/LinkClick.aspx?fileticket=1uE7TO6QzbQ%3D&tabid=117. Accessed on: 15 March 2014.

6. Baussano I, Williams BG, Nunn P, Beggiato M, Fedeli U, Scano F. Tuberculosis incidence in prisons: a systematic review. PLoS Med 2010; 7(12).

7. Habeenzu C, Mitarai S, Lubasi D, Mudenda V, Kantenga T, Mwansa J, et al. Tuberculosis and multidrug resistance in Zambian prisons, 2000–2001. Int J Tuberc Lung Dis. 2007; 11: 1216–20. 17958984

8. Noeske J, Ndi N, Mbondi S. Controlling tuberculosis in prisons against confinement conditions: a lost case? Experience from Cameroon. Int J Tuberc Lung Dis. 2011: 223–27. 21219685

9. Tuberculosis Coalition for Technical Assistance and International Committee of the Red Cross. Guidelines for control of tuberculosis in prisons. 2009. Available from: file:///C:/Users/GOD%20with%20us/Downloads/GuidelinesforControlofTBinPrisons.pdf. Accessed on: 17 September 2017.

10. United Nations Office on Drugs and Crime (UNODC). United nations office on drugs and crime HIV/AIDS prevention, care, treatment and support in prison settings: a framework for an effective national response. 2006. Available from: https://www.unodc.org/pdf/HIV-AIDS_prisons_July06.pdf. Accessed on: 28 March 2018.

11. Abebe DS, Bjune G, Ameni G, Biffa D, Abebe F. Prevalence of pulmonary tuberculosis and associated risk factors in eastern Ethiopian prisons. Int J Tuberc Lung Dis. 2011;15: 668–673. doi: 10.5588/ijtld.10.0363 21756520

12. Banda HT, Gausi F, Harries AD, Salaniponi FM, Prevalence of smear-positive pulmonary tuberculosis among prisoners in Malawi: a national survey. Int J Tuberc Lung Dis. 2009;13(12):1557–1559. 19919776

13. World Health Organization (WHO). Systematic screening for active tuberculosis: principles and recommendations. 2013. Available from: http://www.who.int/tb/publications/Final_TB_Screening_guidelines.pdf. Accessed on: 22 March 2016.

14. Ministry of Health of Ethiopia. Guidelines for clinical and programmatic management of TB, leprosy and TB/HIV in Ethiopia. 5th ed. Addis Ababa, Ethiopia. April 2012.

15. Zerihun Z, Girmay M, Adane W, Gobena A. Prevalence of pulmonary tuberculosis and associated risk factors in prisons of Gamo Goffa zone, south Ethiopia: a cross-sectional study. American Journal of Health Research. 2014; 2:291–97.

16. Ali S, Haileamlak A, Wieser A, Pritsch M, Heinrich N, Loscher T, et al. Prevalence of pulmonary tuberculosis among prison inmates in Ethiopia, a cross-sectional study. PLoS ONE. 2015;10.

17. Bayu B, Abera BM, Tegene L. Prevalence of pulmonary tuberculosis and associated factors among prisoners in Wolaita zone, southern Ethiopia: cross-sectional study. American Journal of Public Health Research. 2016;4:142–48.

18. Moges B, Amare B, Asfaw F, Tesfaye W, Tiruneh M, Belayhun Y, et al. Prevalence of smear positive pulmonary tuberculosis among prisoners in north Gondar zone prison, northwest Ethiopia. BMC Infectious Diseases. 2012;12:352. doi: 10.1186/1471-2334-12-352 23241368

19. Mauricio H, Paul B, Manuel N, Aguilera X. Modeling the spread of tuberculosis in semiclosed communities. Comput Math Methods Med. 2013;648291. doi: 10.1155/2013/648291 23762194

20. Fares A. Seasonality of Tuberculosis. Journal of Global Infectious Diseases. 2011;3(1):46–55. doi: 10.4103/0974-777X.77296 21572609

21. World Health Organization (WHO). Tuberculosis in prisons. Available from: http://www.who.int/tb/areas-of-work/population-groups/prisons-facts/en/. Accessed on: 30 December 2017.

22. World Health Organization (WHO). Global tuberculosis report 2017. Geneva. 2017. Available from: http://www.who.int/tb/publications/global_report/gtbr2017_main_text.pdf?ua=1. Accessed on: 12 April 2018.

23. Zeka Arzu N., Sezai Tasbakan, Cengiz Cavusoglu. Evaluation of the GeneXpert MTB/RIF Assay for Rapid Diagnosis of Tuberculosis and Detection of Rifampin Resistance in Pulmonary and Extrapulmonary Specimens. Journal of Clinical Microbiology, Dec. 2011, p. 4138–4141. Vol. 49, No. 12. A Available from: https://jcm.asm.org/content/jcm/49/12/4138.full.pdf. Accessed on: 6 October 2019. doi: 10.1128/JCM.05434-11 21956978

24. Grace Moraa Orina, Samson Adoka Ong'wen, Asito Stephen Amolo and Ondimu Thomas Orindi*Comparative Study of Smear Microscopy, Gene Xpert and Culture and Sensitivity Assays in Detection of Mycobacterium tuberculosis on Sputum Samples among Tuberculosis Suspected Cases in Nyamira County Referral Hospital. Mycobact Dis 2017, 7:3.

25. Shi Jin, Dong Wenzhu, Ma Yifeng, Liang Qian, Shang Yuanyuan, Wang Fen, et al. GeneXpert MTB/RIF Outperforms Mycobacterial Culture in Detecting Mycobacterium tuberculosis from Salivary Sputum. BioMed Research International, Volume 2018.

26. Havlir DV, Getahun H, Sanne I, Nunn, P Opportunities and challenges for HIV care in overlapping HIV and TB epidemics. JAMA. 2008;300(4):423–430. doi: 10.1001/jama.300.4.423 18647985

27. Candice KK, Joel DE. HIV and Tuberculosis: a Deadly Human Syndemic. Clinical Microbiology Reviews. Apr. 2011; 24(2).351–376. doi: 10.1128/CMR.00042-10 21482729

28. World Health Organization (WHO). Global tuberculosis report 2017. Geneva. 2017. Available from: http://www.who.int/tb/publications/global_report/gtbr2017_main_text.pdf?ua=1. Accessed on: 12 April 2018.

29. The World Bank. World bank HIV stastistics. The world bank group. 2018. Available from: https://data.worldbank.org/indicator/SH.HIV.ARTC.ZS. Accessed on: 28 April 2018.

30. Jee Sun Ha, Golub Jonathan E., Jo Jaeseong, Park Il Su, Ohrr Heechoul and Samet Jonathan M. Smoking and Risk of Tuberculosis Incidence, Mortality, and Recurrence in South Korean Men and Women. Am J Epidemiol. 2009 Dec 15; 170(12): 1478–1485. doi: 10.1093/aje/kwp308 19917554

31. Hassmiller KM. The association between smoking and tuberculosis. Salud Publica Mex. 2006; 48 Suppl 1:S201–16.


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