Longitudinal changes in plasma hemopexin and alpha-1-microglobulin concentrations in women with and without clinical risk factors for pre-eclampsia

Autoři: Katja Murtoniemi aff001;  Grigorios Kalapotharakos aff003;  Tero Vahlberg aff004;  Katri Räikkonen aff005;  Eero Kajantie aff006;  Esa Hämäläinen aff010;  Bo Åkerström aff011;  Pia M. Villa aff012;  Stefan R. Hansson aff003;  Hannele Laivuori aff001
Působiště autorů: Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, University of Helsinki, Finland aff001;  Department of Obstetrics and Gynaecology, University of Turku and Turku University Hospital, Turku, Finland aff002;  Skåne University Hospital, Department of Clinical Sciences Lund, Department of Obstetrics and Gynecology, Lund University, Lund, Sweden aff003;  Department of Clinical Medicine, Biostatistics, University of Turku and Turku University Hospital, Turku, Finland aff004;  Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland aff005;  PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland aff006;  National Institute for Health and Welfare, Helsinki, Finland aff007;  Children`s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland aff008;  Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway aff009;  Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland aff010;  Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden aff011;  Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland aff012;  Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland aff013;  Department of Obstetrics and Gynecology, Tampere University Hospital and Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland aff014
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0226520


Recent studies have shown increased concentration of fetal hemoglobin (HbF) in pre-eclamptic women. Plasma hemopexin (Hpx) and alpha-1-microglobulin (A1M) are hemoglobin scavenger proteins that protect against toxic effects of free heme released in the hemoglobin degradation process. We used an enzyme-linked immunosorbent assay to analyze maternal plasma Hpx and A1M concentrations at 12–14, 18–20 and 26–28 weeks of gestation in three groups: 1) 51 women with a low risk for pre-eclampsia (LRW), 2) 49 women with a high risk for pre-eclampsia (PE) who did not develop PE (HRW) and 3) 42 women with a high risk for PE who developed PE (HRPE). The study had three aims: 1) to investigate whether longitudinal differences exist between study groups, 2) to examine if Hpx and A1M concentrations develop differently in pre-eclamptic women with small for gestational age (SGA) fetuses vs. pre-eclamptic women with appropriate for gestational age fetuses, and 3) to examine if longitudinal Hpx and A1M profiles differ by PE subtype (early-onset vs. late-onset and severe vs. non-severe PE). Repeated measures analysis of variance was used to analyze differences in Hpx and A1M concentrations between the groups. We found that the differences in longitudinal plasma Hpx and A1M concentrations in HRW compared to HRPE and to LRW may be associated with reduced risk of PE regardless of clinical risk factors. In women who developed PE, a high A1M concentration from midgestation to late second trimester was associated with SGA. There were no differences in longitudinal Hpx and A1M concentrations from first to late second trimester in high-risk women who developed early-onset or. late-onset PE or in women who developed severe or. non-severe PE.

Klíčová slova:

Body Mass Index – Hypertensive disorders in pregnancy – Management of high-risk pregnancies – Oxidative stress – Preeclampsia – Pregnancy


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