The relation between local and distal muscle fat infiltration in chronic whiplash using magnetic resonance imaging

Autoři: Anette Karlsson aff001;  Anneli Peolsson aff002;  James Elliott aff004;  Thobias Romu aff001;  Helena Ljunggren aff003;  Magnus Borga aff001;  Olof Dahlqvist Leinhard aff002
Působiště autorů: Department of Biomedical Engineering, Linköping University, Linköping, Sweden aff001;  Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden aff002;  Department of Medical and Health Sciences, Physiotherapy, Linköping University, Linköping, Sweden aff003;  Faculty of Health Sciences, The University of Sydney, Northern Sydney Local Health District, The Kolling Institute, St Leonards, NSW, Australia aff004;  Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America aff005;  Department of Medical and Health Sciences, Linkoping University, Linköping, Sweden aff006
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: 10.1371/journal.pone.0226037


The objective of this study was to investigate the relationship between fat infiltration in the cervical multifidi and fat infiltration measured in the lower extremities to move further into understanding the complex signs and symptoms arising from a whiplash trauma. Thirty-one individuals with chronic whiplash associated disorders, stratified into a mild/moderate group and a severe group, together with 31 age- and gender matched controls were enrolled in this study. Magnetic resonance imaging was used to acquire a 3D volume of the neck and of the whole-body. Cervical multifidi was used to represent muscles local to the whiplash trauma and all muscles below the hip joint, the lower extremities, were representing widespread muscles distal to the site of the trauma. The fat infiltration was determined by fat fraction in the segmented images. There was a linear correlation between local and distal muscle fat infiltration (p<0.001, r2 = 0.28). The correlation remained significant when adjusting for age and WAD group (p = 0.009) as well as when correcting for age, WAD group and BMI (p = 0.002). There was a correlation between local and distal muscle fat infiltration within the severe WAD group (p = 0.0016, r2 = 0.69) and in the healthy group (p = 0.022, r2 = 0.17) but not in the mild/moderate group (p = 0.29, r2 = 0.06). No significant differences (p = 0.11) in the lower extremities’ MFI between the different groups were found. The absence of differences between the groups in terms of lower extremities’ muscle fat infiltration indicates that, in this particular population, the whiplash trauma has a local effect on muscle fat infiltration rather than a generalized.

Klíčová slova:

Fats – Imaging techniques – Magnetic resonance imaging – Muscle analysis – Musculoskeletal injury – Myalgia – Spinal cord injury – Traumatic injury


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2019 Číslo 12