#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Syphilis among adult males with a history of male-to-male sexual contact living with diagnosed HIV in New York State (excluding New York City): The challenge of intersecting epidemics


Autoři: Rachel Hart-Malloy aff001;  Mark Rosenthal aff001;  Wendy Patterson aff001;  Salvatore Currenti aff001;  Travis O’Donnell aff001;  Jayleen KL Gunn aff001
Působiště autorů: Division of HIV/STD Epidemiology, Evaluation, and Partner Services, AIDS Institute, New York State Department of Health, Albany, New York, United States of America aff001;  Department of Epidemiology and Biostatistics, University at Albany, State University of New York, Rensselaer, New York, United States of America aff002;  United States Public Health Service, Atlanta, Georgia, United States of America aff003
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0226614

Souhrn

Since 2009, syphilis has been increasing in New York State (NYS) excluding New York City (NYC) among men with a history of male-to-male sexual contact (MSM). Because MSM make up a disproportionate number of new HIV infections, this study aims to: 1) establish yearly rates of early syphilis diagnosis, 2) assess factors associated with early syphilis diagnosis, and 3) describe missed opportunities for earlier diagnosis of syphilis among MSM living with diagnosed HIV(MSMLWDH) in NYS, excluding NYC. A cohort of adult MSMLWDH alive in 2013 were followed through 2016 to identify individuals with at least one early syphilis diagnosis between July 2014 and December 2016. Early syphilis diagnosis rates were calculated for 2015 and 2016. Crude relative risks and 95% confidence intervals were calculated to determine associations between available covariates and both syphilis diagnosis and missed opportunities. Missed opportunities were defined as reports of an HIV-related laboratory test within a given window corresponding to syphilis staging where syphilis testing was not performed at the same time. Of 7,512 MSMLWDH, 50.0% were non-Hispanic white, 85.4% aged ≥35, and 320(4.3%) had an early syphilis diagnosis. Yearly rates were: 1,838/100,000, and 1,681/100,000 in 2015 and 2016, respectively. Persons who were non-Hispanic black, living with diagnosed HIV for less than three years, aged <45, and were always virally suppressed or always in HIV care were significantly more likely to have a syphilis diagnosis. Over half of individuals had evidence of a missed opportunity for earlier syphilis diagnosis. Syphilis stage at diagnosis, older age, and syphilis diagnosis not concurrent with an HIV-related laboratory test were associated with a higher likelihood of having a missed opportunity. This study supports high interrelatedness of the syphilis and HIV epidemics among MSM. Since syphilis can impact HIV viral load suppression status, efforts to end the HIV epidemic need to be coupled with syphilis elimination efforts.

Klíčová slova:

HIV diagnosis and management – HIV epidemiology – HIV prevention – Laboratory tests – New York – Syphilis – Viral load


Zdroje

1. Centers for Disease Control and Prevention. HIV Surveillance Report, 2017. November 2018.

2. Hess KL, Hu X, Lansky A, Mermin J, Hall HI. Lifetime risk of a diagnosis of HIV infection in the United States. Annals of epidemiology. 2017;27(4):238–43. doi: 10.1016/j.annepidem.2017.02.003 28325538

3. Centers for Disease Control and Prevention. Estimated HIV incidence and prevalence in the United States, 2010–2015. 2018.

4. Bureau of HIV/AIDS Epidemiology AIDS Institute New York State Department of Health. New York State HIV/AIDS Annual Surveillance Report for Cases Diagnosed through December 2016. 2017.

5. Division of STD Prevention National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance 2017. 2018.

6. Patton ME, Su JR, Nelson R, Weinstock H, Centers for Disease C, Prevention. Primary and secondary syphilis—United States, 2005–2013. MMWR Morb Mortal Wkly Rep. 2014;63(18):402–6. 24807239; PubMed Central PMCID: PMC5779405.

7. de Voux A, Kidd S, Grey JA, Rosenberg ES, Gift TL, Weinstock H, et al. State-Specific Rates of Primary and Secondary Syphilis Among Men Who Have Sex with Men—United States, 2015. MMWR Morb Mortal Wkly Rep. 2017;66(13):349–54. doi: 10.15585/mmwr.mm6613a1 28384130; PubMed Central PMCID: PMC5657910.

8. Grey JA, Bernstein KT, Sullivan PS, Kidd SE, Gift TL, Hall EW, et al. Rates of Primary and Secondary Syphilis Among White and Black Non-Hispanic Men Who Have Sex With Men, United States, 2014. J Acquir Immune Defic Syndr. 2017;76(3):e65–e73. doi: 10.1097/QAI.0000000000001508 28749823; PubMed Central PMCID: PMC5634915.

9. New York State Department of Health. STI surveillance and partner services data (unpublished data) 2018.

10. Lucar J, Hart R, Rayeed N, Terzian A, Weintrob A, Siegel M, et al. Sexually Transmitted Infections Among HIV-Infected Individuals in the District of Columbia and Estimated HIV Transmission Risk: Data From the DC Cohort. Open Forum Infect Dis. 2018;5(2):ofy017. doi: 10.1093/ofid/ofy017 29479550; PubMed Central PMCID: PMC5804762.

11. Kalichman SC, Pellowski J, Turner C. Prevalence of sexually transmitted co-infections in people living with HIV/AIDS: systematic review with implications for using HIV treatments for prevention. Sex Transm Infect. 2011;87(3):183–90. doi: 10.1136/sti.2010.047514 21330572; PubMed Central PMCID: PMC4317792.

12. Solomon MM, Mayer KH, Glidden DV, Liu AY, McMahan VM, Guanira JV, et al. Syphilis predicts HIV incidence among men and transgender women who have sex with men in a preexposure prophylaxis trial. Clin Infect Dis. 2014;59(7):1020–6. doi: 10.1093/cid/ciu450 24928295; PubMed Central PMCID: PMC4166980.

13. Kaplan JE, Benson C, Holmes KK, Brooks JT, Pau A, Masur H, et al. Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association of the Infectious Diseases Society of America. MMWR Recomm Rep. 2009;58(RR-4):1–207; quiz CE1-4. 19357635.

14. Lynn WA, Lightman S. Syphilis and HIV: a dangerous combination. Lancet Infect Dis. 2004;4(7):456–66. doi: 10.1016/S1473-3099(04)01061-8 15219556.

15. de Voux A, Bernstein K, Bradley H, Kirkcaldy RD, Tie Y, Shouse RL, et al. Syphilis testing among sexually active men who have sex with men and who are receiving medical care for HIV in the United States-Medical Monitoring Project, 2013–2014. Clin Infect Dis. 2018. doi: 10.1093/cid/ciy571 29985985.

16. Mayer KH, Venkatesh KK. Interactions of HIV, other sexually transmitted diseases, and genital tract inflammation facilitating local pathogen transmission and acquisition. Am J Reprod Immunol. 2011;65(3):308–16. doi: 10.1111/j.1600-0897.2010.00942.x 21214660; PubMed Central PMCID: PMC3077541.

17. Ward H, Ronn M. Contribution of sexually transmitted infections to the sexual transmission of HIV. Curr Opin HIV AIDS. 2010;5(4):305–10. doi: 10.1097/COH.0b013e32833a8844 20543605; PubMed Central PMCID: PMC2923028.

18. An Q, Wejnert C, Bernstein K, Paz-Bailey G, Group NS. Syphilis Screening and Diagnosis Among Men Who Have Sex With Men, 2008–2014, 20 U.S. Cities. J Acquir Immune Defic Syndr. 2017;75 Suppl 3:S363–S9. doi: 10.1097/QAI.0000000000001412 28604440.

19. Pathela P, Braunstein SL, Blank S, Shepard C, Schillinger JA. The high risk of an HIV diagnosis following a diagnosis of syphilis: a population-level analysis of New York City men. Clin Infect Dis. 2015;61(2):281–7. doi: 10.1093/cid/civ289 25870333.

20. Grey J, Torrone, E., Kidd, S., Bernstein, K., Weinstock, H., editor Estimated Primary & Secondary Syphilis Rates in MSM by HIV Status—34 States, 2014. 25th Conference on Retroviruses and Opportunistic Infections; 2018; Boston, MA.

21. Shilaih M, Marzel A, Braun DL, Scherrer AU, Kovari H, Young J, et al. Factors associated with syphilis incidence in the HIV-infected in the era of highly active antiretrovirals. Medicine (Baltimore). 2017;96(2):e5849. doi: 10.1097/MD.0000000000005849 28079818; PubMed Central PMCID: PMC5266180 received unrestricted research and educational grants from Roche, Jansen, Gilead, and Merck Sharp and Dohme.

22. Braunstein S, Pathela, P., Kersanske, L., editor Incidence of Sexually Transmitted Diseases Among Persons With HIV New York City 2000–2010. Conference on Retroviruses and Opportunistic Infections; 2014; Boston, MA.

23. Lang R, Read R, Krentz HB, Ramazani S, Peng M, Gratrix J, et al. Increasing incidence of syphilis among patients engaged in HIV care in Alberta, Canada: a retrospective clinic-based cohort study. BMC Infect Dis. 2018;18(1):125. doi: 10.1186/s12879-018-3038-4 29534681; PubMed Central PMCID: PMC5851255.

24. Kofoed K, Gerstoft J, Mathiesen LR, Benfield T. Syphilis and human immunodeficiency virus (HIV)-1 coinfection: influence on CD4 T-cell count, HIV-1 viral load, and treatment response. Sex Transm Dis. 2006;33(3):143–8. doi: 10.1097/01.olq.0000187262.56820.c0 16505739.

25. Taylor MM, Newman DR, Schillinger JA, Lewis FM, Furness B, Braunstein S, et al. Viral Loads Among HIV-Infected Persons Diagnosed With Primary and Secondary Syphilis in 4 US Cities: New York City, Philadelphia, PA, Washington, DC, and Phoenix, AZ. J Acquir Immune Defic Syndr. 2015;70(2):179–85. doi: 10.1097/QAI.0000000000000730 26090756.

26. Jarzebowski W, Caumes E, Dupin N, Farhi D, Lascaux AS, Piketty C, et al. Effect of early syphilis infection on plasma viral load and CD4 cell count in human immunodeficiency virus-infected men: results from the FHDH-ANRS CO4 cohort. Arch Intern Med. 2012;172(16):1237–43. doi: 10.1001/archinternmed.2012.2706 22826097.

27. Buchacz K, Patel P, Taylor M, Kerndt PR, Byers RH, Holmberg SD, et al. Syphilis increases HIV viral load and decreases CD4 cell counts in HIV-infected patients with new syphilis infections. AIDS. 2004;18(15):2075–9. doi: 10.1097/00002030-200410210-00012 15577629.

28. New York State Department of Health Clinical Guidelines Program Sexually Transmitted Infections Guidelines Committee. Management of Syphilis in Patients with HIV 2018 [cited 2018]. Available from: https://www.hivguidelines.org/sti-care/syphilis/#tab_6.

29. Workowski KA, Bolan GA, Centers for Disease C, Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015;64(RR-03):1–137. 26042815; PubMed Central PMCID: PMC5885289.

30. Aberg JA, Gallant JE, Ghanem KG, Emmanuel P, Zingman BS, Horberg MA, et al. Primary care guidelines for the management of persons infected with HIV: 2013 update by the HIV medicine association of the Infectious Diseases Society of America. Clin Infect Dis. 2014;58(1):e1–34. doi: 10.1093/cid/cit665 24235263.

31. Cantor AG, Pappas M, Daeges M, Nelson HD. Screening for Syphilis: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA. 2016;315(21):2328–37. doi: 10.1001/jama.2016.4114 27272584.

32. Force USPST, Bibbins-Domingo K, Grossman DC, Curry SJ, Davidson KW, Epling JW Jr., et al. Screening for Syphilis Infection in Nonpregnant Adults and Adolescents: US Preventive Services Task Force Recommendation Statement. JAMA. 2016;315(21):2321–7. doi: 10.1001/jama.2016.5824 27272583.

33. Zetola NM, Engelman J, Jensen TP, Klausner JD. Syphilis in the United States: an update for clinicians with an emphasis on HIV coinfection. Mayo Clin Proc. 2007;82(9):1091–102. doi: 10.4065/82.9.1091 17803877.

34. New York State Department of Health. Medicaid screening for syphilis among adult males living with HIV by region (unpublished data); Internal NYSDOH collaboration. 2018.

35. Hart-Malloy R, Rosenthal, M., Patterson, W., Cukrovany, J., Currenti, S., Gunn, JLK, editor Syphilis diagnosis among men who have sex with men who are living with diagnosed HIV infection: Assessing morbidity in New York State (excluding New York City). STD Prevention Conference; 2018; Washington DC.

36. Centers for Disease Control and Prevention. Monitoring selected national HIV prevention and care objectives by using HIV surveillance data—United States and 6 dependent areas, 2015. HIV Surveillance Supplemental Report 2017.

37. HIV Reporting and Partner Notification Law Article 21 Title III. Sect. 2139 (1998).

38. New York State Codes, Rules, and Regulations; Volume A-1a (Title 10) SubChapter G- AIDS Testing, Communicable Diseases and Poisoning; Part 63- HIV/AIDS Testing, Reporting and Confidentiality of HIV-Related Information; Section 63.4: Filing of Reports, (05/17/2017, 2017).

39. Centers for Disease Control and Prevention. National Notifiable Diseases Surveillance System (NNDSS), Surveillance Case Definitions, Syphilis (Treponema pallidum) [cited 2018]. Available from: https://wwwn.cdc.gov/nndss/conditions/syphilis/.

40. United States Census Bureau. American Community Survey, 2017 American Community Survey 5-Year Estimate [5/14/2018]. Available from: http://factfinder.census.gov/.

41. Division of STD Prevention National Center for HIV/AIDS Viral Hepatitis STD and TB Prevention Centers for Disease Control and Prevention. Syphilis—CDC Fact Sheet (Detailed) 2017 [updated 11/30/2017; cited 2018]. Available from: https://www.cdc.gov/std/syphilis/stdfact-syphilis-detailed.htm.

42. Cherneskie T. An Update and Review of the Diagnosis and Management of Syphilis. Region II STD/HIV Prevention Training Center, New York City Department of Health and Mental Hygiene; New York, NY: 2006.

43. Callegari FM, Pinto-Neto LF, Medeiros CJ, Scopel CB, Page K, Miranda AE. Syphilis and HIV co-infection in patients who attend an AIDS outpatient clinic in Vitoria, Brazil. AIDS Behav. 2014;18 Suppl 1:S104–9. doi: 10.1007/s10461-013-0533-x 23732958; PubMed Central PMCID: PMC3818508.

44. Tesoriero JM, Johnson BL, Hart-Malloy R, Cukrovany JL, Moncur BL, Bogucki KM, et al. Improving Retention in HIV Care Through New York's Expanded Partner Services Data-to-Care Pilot. Journal of Public Health Management and Practice. 2017;23(3):255–63. doi: 10.1097/PHH.0000000000000483 00124784-201705000-00004. 27902561

45. Quinn TC, Wawer MJ, Sewankambo N, Serwadda D, Li C, Wabwire-Mangen F, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med. 2000;342(13):921–9. doi: 10.1056/NEJM200003303421303 10738050.

46. Marks G, Patel U, Stirratt MJ, Mugavero MJ, Mathews WC, Giordano TP, et al. Single Viral Load Measurements Overestimate Stable Viral Suppression Among HIV Patients in Care: Clinical and Public Health Implications. J Acquir Immune Defic Syndr. 2016;73(2):205–12. doi: 10.1097/QAI.0000000000001036 27105049; PubMed Central PMCID: PMC5964607.

47. Stirratt MJ, Marks G, O'Daniels C, Cachay ER, Sullivan M, Mugavero MJ, et al. Characterising HIV transmission risk among US patients with HIV in care: a cross-sectional study of sexual risk behaviour among individuals with viral load above 1500 copies/mL. Sex Transm Infect. 2018;94(3):206–11. doi: 10.1136/sextrans-2017-053178 29097417; PubMed Central PMCID: PMC5958893.

48. New York State Department of Health. Partner Services Data to Care Report, New York State (excluding New York City) 2015 [Agency Report]. 2017. Available from: https://www.health.ny.gov/diseases/aids/general/statistics/docs/partner_services.pdf.


Článek vyšel v časopise

PLOS One


2019 Číslo 12
Nejčtenější tento týden
Nejčtenější v tomto čísle
Kurzy

Zvyšte si kvalifikaci online z pohodlí domova

KOST
Koncepce osteologické péče pro gynekology a praktické lékaře
nový kurz
Autoři: MUDr. František Šenk

Sekvenční léčba schizofrenie
Autoři: MUDr. Jana Hořínková

Hypertenze a hypercholesterolémie – synergický efekt léčby
Autoři: prof. MUDr. Hana Rosolová, DrSc.

Svět praktické medicíny 5/2023 (znalostní test z časopisu)

Imunopatologie? … a co my s tím???
Autoři: doc. MUDr. Helena Lahoda Brodská, Ph.D.

Všechny kurzy
Kurzy Podcasty Doporučená témata Časopisy
Přihlášení
Zapomenuté heslo

Zadejte e-mailovou adresu, se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.

Přihlášení

Nemáte účet?  Registrujte se

#ADS_BOTTOM_SCRIPTS#