The microbiota composition of the offspring of patients with gestational diabetes mellitus (GDM)


Autoři: Valentina Ponzo aff001;  Ilario Ferrocino aff002;  Adriana Zarovska aff001;  Maria Bernadette Amenta aff003;  Filomena Leone aff003;  Clara Monzeglio aff004;  Rosalba Rosato aff005;  Marianna Pellegrini aff001;  Roberto Gambino aff001;  Maurizio Cassader aff001;  Ezio Ghigo aff001;  Luca Cocolin aff002;  Simona Bo aff001
Působiště autorů: Department of Medical Sciences, University of Turin, Turin, Italy aff001;  Department of Agricultural, Forestry, and Food Science, University of Turin, Turin, Italy aff002;  Clinical Nutrition Unit, S. Anna Hospital, Città della Salute e della Scienza, Turin, Italy aff003;  Gynecology and Obstetrics Unit, S. Anna Hospital, Città della Salute e della Scienza, Turin, Italy aff004;  Department of Psychology, University of Turin, Turin, Italy aff005
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: 10.1371/journal.pone.0226545

Souhrn

The microbiota composition of the offspring of women with gestational diabetes mellitus (GDM), a common pregnancy complication, is still little known. We investigated whether the GDM offspring gut microbiota composition is associated with the maternal nutritional habits, metabolic variables or pregnancy outcomes. Furthermore, we compared the GDM offspring microbiota to the microbiota of normoglycemic-mother offspring. Fecal samples of 29 GDM infants were collected during the first week of life and assessed by 16S amplicon-based sequencing. The offspring’s microbiota showed significantly lower α-diversity than the corresponding mothers. Earlier maternal nutritional habits were more strongly associated with the offspring microbiota (maternal oligosaccharide positively with infant Ruminococcus, maternal saturated fat intake inversely with infant Rikenellaceae and Ruminococcus) than last-trimester maternal habits. Principal coordinate analysis showed a separation of the infant microbiota according to the type of feeding (breastfeeding vs formula-feeding), displaying in breast-fed infants a higher abundance of Bifidobacterium. A few Bacteroides and Blautia oligotypes were shared by the GDM mothers and their offspring, suggesting a maternal microbial imprinting. Finally, GDM infants showed higher relative abundance of pro-inflammatory taxa than infants from healthy women. In conclusion, many maternal conditions impact on the microbiota composition of GDM offspring whose microbiota showed increased abundance of pro-inflammatory taxa.

Klíčová slova:

Bacteroides – Bifidobacterium – Escherichia – Gut bacteria – Infants – Microbiome – Pregnancy


Zdroje

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