Focal inputs are a potential origin of local field potential (LFP) in the brain regions without laminar structure

Autoři: Takuma Tanaka aff001;  Kouichi C. Nakamura aff002
Působiště autorů: Graduate School of Data Science, Shiga University, Hikone, Shiga, Japan aff001;  MRC Brain Network Dynamics Unit, University of Oxford, Oxford, United Kingdom aff002
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article


Current sinks and sources spatially separated between the apical and basal dendrites have been believed to be essential in generating local field potentials (LFPs). According to this theory, LFPs would not be large enough to be observed in the regions without laminar structures, such as striatum and thalamus. However, LFPs are experimentally recorded in these regions. We hypothesized that focal excitatory input induces a concentric current sink and source generating LFPs in these regions. In this study, we tested this hypothesis by the numerical simulations of multicompartment neuron models and the analysis of simplified models. Both confirmed that focal excitatory input can generate LFPs on the order of 0.1 mV in a region without laminar structures. The present results suggest that LFPs in subcortical nuclei indicate localized excitatory input.

Klíčová slova:

Membrane potential – Neostriatum – Neuronal dendrites – Neurons – Radii – Simulation and modeling – Synapses – Dendritic structure


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2019 Číslo 12
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