Enhancement in dopamine reduces generous behaviour in women

Autoři: Sergio Oroz Artigas aff001;  Lu Liu aff001;  Sabrina Strang aff001;  Caroline Burrasch aff001;  Astrid Hermsteiner aff001;  Thomas F. Münte aff004;  Soyoung Q. Park aff001
Působiště autorů: Department of Psychology, University of Lübeck, Lübeck, Germany aff001;  Department of Decision Neuroscience & Nutrition, German Institute of Human Nutrition, Nuthetal, Germany aff002;  Deutsches Zentrum für Diabetes, Neuherberg, Germany aff003;  Department of Neurology, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany aff004;  Neuroscience Research Center, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany aff005
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0226893


Generosity is a human behavior common in social contexts. However, humans are not equally generous to everyone alike. Instead, generosity decreases as a function of social distance, an effect called social discounting. Studies show that such social discounting effect depends on diverse factors including personality traits, cultures, stress or hormonal levels. Recently, the importance of the neurotransmitter dopamine in regulating social interactions has been highlighted. However, it remains unclear how exactly dopamine agonist administration modulates generous behavior as a function of social discounting. Here, we investigate the causal effect of dopamine agonist administration on social discounting in a pharmacological intervention study. We employ a randomized, double-blind, within-subject design to investigate the impact of the D2/D3 receptor agonist pramipexole on social discounting by keeping gender constant. We apply hyperbolic social discount model to the data and provide evidence that women under pramipexole become less generous in general, especially towards close others. Our results highlight the crucial role of dopamine in social decision making.

Klíčová slova:

Behavior – Cognition – Decision making – Dopamine – Dopaminergics – Drug administration – Oxytocin – Prosocial behavior


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