Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM

Autoři: I-Weng Yen aff001;  Chien-Nan Lee aff002;  Ming-Wei Lin aff002;  Kang-Chih Fan aff001;  Jung-Nan Wei aff003;  Kuan-Yu Chen aff004;  Szu-Chi Chen aff005;  Yi-Yun Tai aff002;  Chun-Heng Kuo aff006;  Chia-Hung Lin aff001;  Chih-Yao Hsu aff001;  Lee-Ming Chuang aff007;  Shin-Yu Lin aff002;  Hung-Yuan Li aff007
Působiště autorů: Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu, Taiwan aff001;  Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan aff002;  Chia Nan University of Pharmacy and Science, Tainan, Taiwan aff003;  Ansn Clinic, Hsin-Chu, Taiwan aff004;  Department of Internal Medicine, Cardinal Tien Hospital, New Taipei City, Taiwan aff005;  Department of Internal Medicine, Fu Jen Catholic University Hospital, New Taipei City, Taiwan aff006;  Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan aff007
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0225978



Overweight and obesity are important risk factors of gestational diabetes mellitus (GDM). Clustering of metabolic risk factors in early pregnancy may be a potential pathogenesis between the link of overweight/obesity and GDM. Since it remains unexplored, we investigated if overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM in this cohort study.


Total 527 women who visited National Taiwan University Hospital for prenatal care in between November 2013 to April 2018 were enrolled. Risk factors of GDM in the first prenatal visit (FPV) were recorded. Overweight/obesity was defined if body mass index ≥24 kg/m2. GDM was diagnosed from the result of a 75g oral glucose tolerance test in 24–28 gestational weeks.


Overweight/obesity was associated with clustering of metabolic risk factors of GDM, including high fasting plasma glucose, high HbA1c, insulin resistance, high plasma triglyceride and elevated blood pressure in FPV (p<0.05). There was a positive relationship between the number of metabolic risk factors and the incidence of GDM (p <0.05). The odds ratios of HbA1c and diastolic blood pressure were higher in overweight/obese women, compared with those in normal-weight women.


Overweight/obesity is associated with clustering of metabolic risk factors in early pregnancy, which is correlated with higher risk of GDM. Our findings suggest that metabolic risk factors during early pregnancy should be evaluated in overweight/obese women.

Klíčová slova:

Blood plasma – Blood pressure – Medical risk factors – Obesity – Pregnancy


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2019 Číslo 12
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