Long-term ambient hydrocarbons exposure and incidence of ischemic stroke

Autoři: Han-Wei Zhang aff001;  Victor C. Kok aff004;  Shu-Chun Chuang aff006;  Chun-Hung Tseng aff007;  Chin-Teng Lin aff008;  Tsai-Chung Li aff011;  Fung-Chang Sung aff013;  Chi Pang Wen aff014;  Chao A. Hsiung aff014;  Chung Y. Hsu aff015
Působiště autorů: Ph.D. Program for Aging, China Medical University, Taichung, Taiwan aff001;  Department of Electrical and Computer Engineering, Institute of Electrical Control Engineering, National Chiao Tung University, Hsinchu, Taiwan aff002;  Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan aff003;  Disease Informatics Research Group, Asia University Taiwan, Taichung, Taiwan aff004;  Department of Internal Medicine, Kuang Tien General Hospital, Taichung, Taiwan aff005;  Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan aff006;  Department of Neurology, China Medical University Hospital, and School of Medicine, China Medical University, Taichung, Taiwan aff007;  Brain Research Center, National Chiao Tung University, Hsinchu, Taiwan aff008;  Department of Electrical and Computer Engineering, Institute of Electrical Control Engineering, National Chiao Tung University, Hsinchu, Taiwan aff009;  Centre for Artificial Intelligence School of Software, Faculty of Engineering & IT, University of Technology Sydney Broadway 2007, Sydney, New South Wales, Australia aff010;  Graduate Institute of Biostatistics, College of Public Health, China Medical University, Taichung, Taiwan aff011;  Department of Healthcare Administration, College of Health Science, Asia University, Taichung, Taiwan aff012;  Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan aff013;  Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan aff014;  Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan aff015
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225363


Exposure to air pollutants is known to have adverse effects on human health; however, little is known about the association between hydrocarbons in air and an ischemic stroke (IS) event. We investigated whether long-term exposure to airborne hydrocarbons, including volatile organic compounds, increased IS risk. This retrospective cohort study included 283,666 people aged 40 years or older in Taiwan. Cox proportional hazards regression analysis was used to fit single- and multiple-pollutant models for two targeted pollutants, total hydrocarbons (THC) and nonmethane hydrocarbons (NMHC), and estimated the risk of IS. Before controlling for multiple pollutants, hazard ratios (HRs) of IS with 95% confidence intervals for the overall population were 2.69 (2.64–2.74) at 0.16-ppm increase in THC and 1.62 (1.59–1.66) at 0.11-ppm increase in NMHC. For the multiple-pollutant models controlling for PM2.5, the adjusted HR was 3.64 (3.56–3.72) for THC and 2.21 (2.16–2.26) for NMHC. Our findings suggest that long-term exposure to THC and NMHC may be a risk factor for IS development.

Klíčová slova:

Air pollution – Hydrocarbons – Inflammatory diseases – Insurance – Ischemic stroke – Particulates – Pollutants – stroke


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2019 Číslo 12