The effect of prioritization over cognitive-motor interference in people with relapsing-remitting multiple sclerosis and healthy controls


Autoři: Barbara Postigo-Alonso aff001;  Alejandro Galvao-Carmona aff001;  Cristina Conde-Gavilán aff003;  Ana Jover aff003;  Silvia Molina aff003;  María A. Peña-Toledo aff003;  Roberto Valverde-Moyano aff003;  Eduardo Agüera aff003
Působiště autorů: Department of Psychology, Universidad Loyola Andalucía. Seville, Spain aff001;  Human Neuroscience Lab (HNL), Universidad Loyola Andalucía, Seville, Spain aff002;  Neurology Service, Reina Sofía University Hospital, Cordoba, Spain aff003;  Maimonides Institute for Research in Biomedicine of Cordoba, (IMIBIC), Cordoba, Spain aff004
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: 10.1371/journal.pone.0226775

Souhrn

The cognitive-motor interference (CMI) produced by simultaneous performance of a cognitive and a motor task has been proposed as a marker of real-life impairment of people with Multiple Sclerosis (pwMS), yet there is no consensus on the dual task (DT) procedure. This study aimed to compare DT performance of pwMS and healthy controls (HC) under different instructions and to examine its association with neuropsychological and clinical variables. PwMS (N = 23; relapsing-remitting course) and HC (N = 24) completed the cognitive (Verbal Fluency) and motor (walking) tasks under three conditions: independently or as single task (ST), both tasks simultaneously at best capacity or double prioritization (DT-DP), and only the cognitive task at best capacity while walking at preferred speed or cognitive prioritization (DT-CP). Compared to HC, pwMS walked significantly slower and produced less correct words under all conditions. The distance walked by pwMS and HC significantly differed between conditions (DT-CP< DT-DP< ST). PwMS produced more words during ST respective to DT-DP and DT-CP, with no difference between both DT conditions. HC showed no differences in cognitive performance between conditions. Motor and cognitive dual-task costs (DTC) were similar between groups. Only in pwMS, the cognitive DTC of DT-DP was different from zero. CMI measures correlated with neuropsychological, symptomatic, physiological (cognitive event-related potentials) and clinical variables. These results suggest that cognitive performance while walking is impaired in pwMS, but not in HC. CMI over cognitive performance might be a potential early marker of cognitive decline in pwMS, which may be enhanced by the instruction to prioritize both tasks in DT.

Klíčová slova:

Cognition – Cognitive impairment – Cognitive psychology – Memory recall – Multiple sclerosis – Neuropsychological testing – Neuropsychology – Walking


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2019 Číslo 12