ABO blood group and risk of newly diagnosed nonalcoholic fatty liver disease: A case-control study in Han Chinese population

Autoři: Guo-Chao Zhong aff001;  Shan Liu aff002;  Yi-Lin Wu aff003;  Mei Xia aff003;  Jin-Xian Zhu aff003;  Fa-Bao Hao aff004;  Lun Wan aff005
Působiště autorů: Graduate School, Chongqing Medical University, Chongqing, China aff001;  Department of Pediatrics, the People’s Hospital of Dazu District, Chongqing, China aff002;  Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China aff003;  Pediatric Surgery Center, Qingdao Women and Children’s Hospital, Qingdao University, Qingdao, Shandong, China aff004;  Department of Hepatobiliary Surgery, the People’s Hospital of Dazu District, Chongqing, China aff005
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0225792



ABO blood group has been associated with cardiovascular disease and cancer. However, whether ABO blood group is associated with nonalcoholic fatty liver disease (NAFLD) remains unknown. The present study aimed to clarify this issue.


A hospital-based case-control study was performed in southwestern China. A total of 583 newly ultrasound-diagnosed NAFLD cases and 2068 controls were included. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of developing NAFLD were calculated by multivariate logistic regression. A propensity score was developed for adjustment and matching.


The proportions of blood groups A, B, AB and O were 31%, 26%, 8% and 35%, respectively. Non-O blood groups were found to be significantly associated with an increased risk of NAFLD (the fully adjusted OR = 1.51, 95% CI: 1.19, 1.91); moreover, compared with blood group O, the fully adjusted ORs of developing NAFLD were 1.50 (95% CI: 1.13, 1.99) for blood group A, 1.59 (95% CI: 1.19, 2.14) for blood group B, and 1.37 (95% CI: 0.86, 2.18) for blood group AB. Similar results were obtained in both propensity-score-adjusted and propensity-score-matched analyses. No evidence of significant effect modification for the association of ABO blood group with the risk of NAFLD was found (all Pinteraction>0.05).


Non-O blood groups are significantly associated with an increased risk of NAFLD. Our findings provide some epidemiological evidence for a possible role of ABO glycosyltransferase in the pathogenesis of NAFLD. However, these findings need to be validated by future studies.

Klíčová slova:

Alcohol consumption – Blood groups – Coronary heart disease – Fatty liver – Hypertension – Cholesterol – Ultrasound imaging


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