Central sensitization in knee osteoarthritis and fibromyalgia: Beyond depression and anxiety

Autoři: Marina López-Ruiz aff001;  Josep Maria Losilla aff002;  Jordi Monfort aff003;  Mariona Portell aff002;  Teresa Gutiérrez aff004;  Violant Poca aff005;  Ferran Garcia-Fructuoso aff005;  Jone Llorente aff003;  Alba Garcia-Fontanals aff006;  Joan Deus aff001
Působiště autorů: Service of Psychiatry and Psychology, HM-Sant Jordi Clinic, Barcelona, Spain aff001;  Department of Methodology, Faculty of Psychology of Autonomous University of Barcelona, Cerdanyola del Vallés, Spain aff002;  Rheumatology Service, Hospital del Mar, Barcelona, Spain aff003;  Department of Clinical and Health Psychology, Faculty of Psychology of Autonomous University of Barcelona, Cerdanyola del Vallés, Spain aff004;  Rheumatology Service, Institute Ferran of Rheumatology (IFR), Barcelona, Spain aff005;  Benito Menni Complex Assistencial en Salut Mental, Sant Boi de Llobregat, Spain aff006
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225836



To determine the psychopathological profile of patients with central sensitization (CS) in a sample of knee osteoarthritis, with and without CS, and fibromyalgia, and to compare their psychopathological profiles.


The final sample consists of 19 patients with osteoarthritis and CS (mean 66.37 years ± 8.77), 41 osteoarthritis patients without CS (mean 66.8 ± 7.39 years), 47 fibromyalgia patients (mean 46.47 years ± 7.92) and 26 control subjects (mean 51.56 years ± 11.41). The psychopathological profile was evaluated with the Millon Multiaxial Clinical Inventory.


The average score of MCMI-III reflect higher scores in the fibromyalgia and osteoarthritis-CS groups. Patients with osteoarthritis-CS are more likely to report larger scores in Borderline and Major Depression scales. Fibromyalgia patients are more likely to report more increased scores in Somatoform and Major Depression, versus osteoarthritis-CS group. Fibromyalgia patients versus osteoarthritis without CS are more likely to report higher scores in Schizoid, Depression, Histrionic, Sadistic, Borderline, Somatoform, Posttraumatic Stress Disorder and Major Depression scales.


Patients with CS have less differences in their psychopathological profiles as well as in both osteoarthritis groups and greatest differences are obtained between the fibromyalgia and osteoarthritis without CS, so perhaps presence of CS is the key to differentiate those groups and not chronic pain. An exhaustive assessment brings more accurate psychopathological profiles, thus better psychological treatment could be applied.

Klíčová slova:

Depression – Emotions – Fibromyalgia – Osteoarthritis – Pain sensation – Personality – Personality disorders – Post-traumatic stress disorder


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Článek vyšel v časopise


2019 Číslo 12