#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Central sensitization in knee osteoarthritis and fibromyalgia: Beyond depression and anxiety


Autoři: Marina López-Ruiz aff001;  Josep Maria Losilla aff002;  Jordi Monfort aff003;  Mariona Portell aff002;  Teresa Gutiérrez aff004;  Violant Poca aff005;  Ferran Garcia-Fructuoso aff005;  Jone Llorente aff003;  Alba Garcia-Fontanals aff006;  Joan Deus aff001
Působiště autorů: Service of Psychiatry and Psychology, HM-Sant Jordi Clinic, Barcelona, Spain aff001;  Department of Methodology, Faculty of Psychology of Autonomous University of Barcelona, Cerdanyola del Vallés, Spain aff002;  Rheumatology Service, Hospital del Mar, Barcelona, Spain aff003;  Department of Clinical and Health Psychology, Faculty of Psychology of Autonomous University of Barcelona, Cerdanyola del Vallés, Spain aff004;  Rheumatology Service, Institute Ferran of Rheumatology (IFR), Barcelona, Spain aff005;  Benito Menni Complex Assistencial en Salut Mental, Sant Boi de Llobregat, Spain aff006
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0225836

Souhrn

Objectives

To determine the psychopathological profile of patients with central sensitization (CS) in a sample of knee osteoarthritis, with and without CS, and fibromyalgia, and to compare their psychopathological profiles.

Methods

The final sample consists of 19 patients with osteoarthritis and CS (mean 66.37 years ± 8.77), 41 osteoarthritis patients without CS (mean 66.8 ± 7.39 years), 47 fibromyalgia patients (mean 46.47 years ± 7.92) and 26 control subjects (mean 51.56 years ± 11.41). The psychopathological profile was evaluated with the Millon Multiaxial Clinical Inventory.

Results

The average score of MCMI-III reflect higher scores in the fibromyalgia and osteoarthritis-CS groups. Patients with osteoarthritis-CS are more likely to report larger scores in Borderline and Major Depression scales. Fibromyalgia patients are more likely to report more increased scores in Somatoform and Major Depression, versus osteoarthritis-CS group. Fibromyalgia patients versus osteoarthritis without CS are more likely to report higher scores in Schizoid, Depression, Histrionic, Sadistic, Borderline, Somatoform, Posttraumatic Stress Disorder and Major Depression scales.

Discussion

Patients with CS have less differences in their psychopathological profiles as well as in both osteoarthritis groups and greatest differences are obtained between the fibromyalgia and osteoarthritis without CS, so perhaps presence of CS is the key to differentiate those groups and not chronic pain. An exhaustive assessment brings more accurate psychopathological profiles, thus better psychological treatment could be applied.

Klíčová slova:

Depression – Emotions – Fibromyalgia – Osteoarthritis – Pain sensation – Personality – Personality disorders – Post-traumatic stress disorder


Zdroje

1. Peat G, McCarney R, Croft P. Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care. Ann Rheum Dis. 2001;60: 91–97. doi: 10.1136/ard.60.2.91 11156538

2. Queiroz LP. Worldwide epidemiology of fibromyalgia. Curr Pain Headache Rep. 2013;17: 356. doi: 10.1007/s11916-013-0356-5 23801009

3. Johnson VL, Hunter DJ. The epidemiology of osteoarthritis. Best Pract Res Clin Rheumatol. 2014;28: 5–15. doi: 10.1016/j.berh.2014.01.004 24792942

4. Axford J, Butt A, Heron C, Hammond J, Morgan J, Alavi A, et al. Prevalence of anxiety and depression in osteoarthritis: use of the Hospital Anxiety and Depression Scale as a screening tool. Clin Rheumatol. 2010;29: 1277–1283. doi: 10.1007/s10067-010-1547-7 20721594

5. Huang S-W, Wang W-T, Lin L-F, Liao C-D, Liou T-H, Lin H-W. Association between psychiatric disorders and osteoarthritis: a nationwide longitudinal population-based study. Medicine (Baltimore). 2016;95: e4016. doi: 10.1097/MD.0000000000004016 27368019

6. Kittelson AJ, George SZ, Maluf KS, Stevens-Lapsley JE. Future directions in painful knee osteoarthritis: harnessing complexity in a heterogeneous population. Phys Ther. 2014;94: 422–432. doi: 10.2522/ptj.20130256 24179141

7. Helminen E-E, Sinikallio SH, Valjakka AL, Väisänen-Rouvali RH, Arokoski JP. Determinants of pain and functioning in knee osteoarthritis: a one-year prospective study. Clin Rehabil. 2016;30: 890–900. doi: 10.1177/0269215515619660 27496698

8. Riddle DL, Kong X, Fitzgerald GK. Psychological Health Impact on Two-Year Changes in Pain and Function in Persons with Knee Pain: Data from the Osteoarthritis Initiative. Osteoarthr Cartil OARS Osteoarthr Res Soc. 2011;19: 1095–1101. doi: 10.1016/j.joca.2011.06.003 21723400

9. Stubbs B, Aluko Y, Myint PK, Smith TO. Prevalence of depressive symptoms and anxiety in osteoarthritis: a systematic review and meta-analysis. Age Ageing. 2016;45: 228–235. doi: 10.1093/ageing/afw001 26795974

10. Perrot S. Osteoarthritis pain. Best Pract Res Clin Rheumatol. 2015;29: 90–97. doi: 10.1016/j.berh.2015.04.017 26267003

11. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990;33: 160–172.

12. Wolfe F, Clauw DJ, Fitzcharles M-A, Goldenberg DL, Katz RS, Mease P, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res. 2010;62: 600–610. doi: 10.1002/acr.20140 20461783

13. Meeus M, Nijs J. Central sensitization: a biopsychosocial explanation for chronic widespread pain in patients with fibromyalgia and chronic fatigue syndrome. Clin Rheumatol. 2007;26: 465–473. doi: 10.1007/s10067-006-0433-9 17115100

14. Sluka KA, Clauw DJ. Neurobiology of fibromyalgia and chronic widespread pain. Neuroscience. 2016;338: 114–129. doi: 10.1016/j.neuroscience.2016.06.006 27291641

15. Huber A, Suman AL, Biasi G, Carli G. Predictors of psychological distress and well-being in women with chronic musculoskeletal pain: two sides of the same coin? J Psychosom Res. 2008;64: 169–175. doi: 10.1016/j.jpsychores.2007.09.005 18222130

16. Epstein SA, Kay G, Clauw D, Heaton R, Klein D, Krupp L, et al. Psychiatric disorders in patients with fibromyalgia. A multicenter investigation. Psychosomatics. 1999;40: 57–63. doi: 10.1016/S0033-3182(99)71272-7 9989122

17. Dobkin PL, Civita MD, Abrahamowicz M, Baron M, Bernatsky S. Predictors of health status in women with fibromyalgia: A prospective study. Int J Behav Med. 2006;13: 101–108. doi: 10.1207/s15327558ijbm1302_1 16712427

18. Fietta P, Fietta P, Manganelli P. Fibromyalgia and psychiatric disorders. Acta Bio-Medica Atenei Parm. 2007;78: 88–95.

19. Yunus MB. Fibromyalgia and overlapping disorders: the unifying concept of central sensitivity syndromes. Semin Arthritis Rheum. 2007;36: 339–356. doi: 10.1016/j.semarthrit.2006.12.009 17350675

20. Aaron LA, Bradley LA, Alarcón GS, Alexander RW, Triana-Alexander M, Martin MY, et al. Psychiatric diagnoses in patients with fibromyalgia are related to health care-seeking behavior rather than to illness. Arthritis Rheum. 1996;39: 436–445. doi: 10.1002/art.1780390311 8607892

21. Giesecke T, Williams DA, Harris RE, Cupps TR, Tian X, Tian TX, et al. Subgrouping of fibromyalgia patients on the basis of pressure-pain thresholds and psychological factors. Arthritis Rheum. 2003;48: 2916–2922. doi: 10.1002/art.11272 14558098

22. Jensen KB, Petzke F, Carville S, Fransson P, Marcus H, Williams SCR, et al. Anxiety and depressive symptoms in fibromyalgia are related to poor perception of health but not to pain sensitivity or cerebral processing of pain. Arthritis Rheum. 2010;62: 3488–95. doi: 10.1002/art.27649 20617526

23. de Souza JB, Potvin S, Goffaux P, Charest J, Marchand S. The deficit of pain inhibition in fibromyalgia is more pronounced in patients with comorbid depressive symptoms. Clin J Pain. 2009;25: 123–127. doi: 10.1097/AJP.0b013e318183cfa4 19333157

24. van Wilgen CP, Keizer D. The sensitization model to explain how chronic pain exists without tissue damage. Pain Manag Nurs Off J Am Soc Pain Manag Nurses. 2012;13: 60–65. doi: 10.1016/j.pmn.2010.03.001 22341140

25. Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011;152: S2–15. doi: 10.1016/j.pain.2010.09.030 20961685

26. Lluch E, Torres R, Nijs J, Van Oosterwijck J. Evidence for central sensitization in patients with osteoarthritis pain: A systematic literature review. Eur J Pain. 2014;18: 1367–1375. doi: 10.1002/j.1532-2149.2014.499.x 24700605

27. Lluch Girbés E, Dueñas L, Barbero M, Falla D, Baert IAC, Meeus M, et al. Expanded Distribution of Pain as a Sign of Central Sensitization in Individuals With Symptomatic Knee Osteoarthritis. Phys Ther. 2016;96: 1196–1207. doi: 10.2522/ptj.20150492 26939604

28. Wood LRJ, Peat G, Thomas E, Duncan R. Knee osteoarthritis in community-dwelling older adults: are there characteristic patterns of pain location? Osteoarthritis Cartilage. 2007;15: 615–623. doi: 10.1016/j.joca.2006.12.001 17276094

29. Finan PH, Buenaver LF, Bounds SC, Hussain S, Park RJ, Haque UJ, et al. Discordance between pain and radiographic severity in knee osteoarthritis: findings from quantitative sensory testing of central sensitization. Arthritis Rheum. 2013;65: 363–372. doi: 10.1002/art.34646 22961435

30. George S, Wittmer V, Fillingim R, Robinson M. Psychological influence on central sensitization of pain for patients with chronic low back pain. J Pain. 2005;6: S83. doi: 10.1016/j.jpain.2005.01.328

31. Imamura M, Imamura ST, Kaziyama HHS, Targino RA, Hsing WT, de Souza LPM, et al. Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: a controlled analysis. Arthritis Rheum. 2008;59: 1424–1431. doi: 10.1002/art.24120 18821657

32. Fleming KC, Volcheck MM. Central sensitization syndrome and the initial evaluation of a patient with fibromyalgia: a review. Rambam Maimonides Med J. 2015;6: e0020. doi: 10.5041/RMMJ.10204 25973272

33. Arendt-Nielsen L, Nie H, Laursen MB, Laursen BS, Madeleine P, Simonsen OH, et al. Sensitization in patients with painful knee osteoarthritis. Pain. 2010;149: 573–581. doi: 10.1016/j.pain.2010.04.003 20418016

34. Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986;29: 1039–1049. doi: 10.1002/art.1780290816 3741515

35. Millon T, Millon C, Davis R, Grossman S. MCMI-III: Millon Clinical Multiaxial Inventory. Pearson. 2009.

36. Burckhardt CS, Clark SR, Bennett RM. The fibromyalgia impact questionnaire: development and validation. J Rheumatol. 1991;18: 728–733. 1865419

37. Monterde S, Salvat I, Montull S, Fernández-Ballart J. Validación de la versión española del Fibromyalgia Impact Questionnaire. Rev Esp Reumatol. 2004;31: 507–513.

38. Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol. 1988;15: 1833–1840. 3068365

39. Escobar A, Quintana JM, Bilbao A, Azkárate J, Güenaga JI. Validation of the Spanish version of the WOMAC questionnaire for patients with hip or knee osteoarthritis. Western Ontario and McMaster Universities Osteoarthritis Index. Clin Rheumatol. 2002;21: 466–471. doi: 10.1007/s100670200117 12447629

40. Villanueva I, del Mar Guzman M, Javier Toyos F, Ariza-Ariza R, Navarro F. Relative efficiency and validity properties of a visual analogue vs a categorical scaled version of the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Index: Spanish versions. Osteoarthritis Cartilage. 2004;12: 225–231. doi: 10.1016/j.joca.2003.11.006 14972339

41. Garcia-Fontanals A, Portell M, García-Blanco S, Poca-Dias V, García-Fructuoso F, López-Ruiz M, et al. Vulnerability to Psychopathology and Dimensions of Personality in Patients With Fibromyalgia. Clin J Pain. 2017;33: 991–997. doi: 10.1097/AJP.0000000000000506 28448425

42. Uçar M, Sarp Ü, Karaaslan Ö, Gül AI, Tanik N, Arik HO. Health anxiety and depression in patients with fibromyalgia syndrome. J Int Med Res. 2015;43: 679–685. doi: 10.1177/0300060515587578 26249741

43. Häuser W, Fitzcharles M-A. Facts and myths pertaining to fibromyalgia. Dialogues Clin Neurosci. 2018;20: 53–62. 29946212

44. Adams LM, Turk DC. Psychosocial Factors and Central Sensitivity Syndromes. Curr Rheumatol Rev. 2015;11: 96–108. doi: 10.2174/1573397111666150619095330 26088211

45. Wise B, Niu J, Zhang Y, Wang N, Jordan J, Choy E, et al. Psychological factors and their relation to osteoarthritis pain. Osteoarthr Cartil OARS Osteoarthr Res Soc. 2010;18: 883–887. doi: 10.1016/j.joca.2009.11.016 20346403

46. Galvez-Sánchez CM, Duschek S, Reyes del Paso GA. Psychological impact of fibromyalgia: current perspectives. Psychol Res Behav Manag. 2019;12: 117–127. doi: 10.2147/PRBM.S178240 30858740


Článek vyšel v časopise

PLOS One


2019 Číslo 12
Nejčtenější tento týden
Nejčtenější v tomto čísle
Kurzy

Zvyšte si kvalifikaci online z pohodlí domova

KOST
Koncepce osteologické péče pro gynekology a praktické lékaře
nový kurz
Autoři: MUDr. František Šenk

Sekvenční léčba schizofrenie
Autoři: MUDr. Jana Hořínková

Hypertenze a hypercholesterolémie – synergický efekt léčby
Autoři: prof. MUDr. Hana Rosolová, DrSc.

Svět praktické medicíny 5/2023 (znalostní test z časopisu)

Imunopatologie? … a co my s tím???
Autoři: doc. MUDr. Helena Lahoda Brodská, Ph.D.

Všechny kurzy
Kurzy Podcasty Doporučená témata Časopisy
Přihlášení
Zapomenuté heslo

Zadejte e-mailovou adresu, se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.

Přihlášení

Nemáte účet?  Registrujte se

#ADS_BOTTOM_SCRIPTS#