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ReklamaA cluster-randomized controlled trial of the effectiveness of the JUMP Math program of math instruction for improving elementary math achievement
Authors: Tracy Solomon aff001; Annie Dupuis aff002; Arland O’Hara aff001; Min-Na Hockenberry aff001; Jenny Lam aff001; Geraldine Goco aff001; Bruce Ferguson aff001; Rosemary Tannock aff006
Authors place of work: Department of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada aff001; Clinical Research Services, Hospital for Sick Children, Toronto, Ontario, Canada aff002; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada aff003; Department of Psychology, University of Toronto, Ontario, Canada aff004; Department of Psychiatry, University of Toronto, Ontario, Canada aff005; Neurosciences and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada aff006; Applied Psychology and Human Development, Ontario Institute for Studies in Education, University of Toronto, Toronto, Ontario, Canada aff007
Published in the journal: PLoS ONE 14(10)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0223049Summary
Students in many western countries struggle to achieve acceptable standards in numeracy despite its recognition as an important 21st century skill. As commercial math programs remain a staple of classroom instruction, investigations of their effectiveness are essential to inform decision-making regarding how to invest limited resources while maximizing student gains. We conducted a cluster randomized-controlled trial of the effectiveness of JUMP Math, a distinctive math program whose central tenets are empirically supported, for improving elementary math achievement (clinical trial.gov no. NCT02456181). The study involved 554 grade 2 (primary) and 592 grade 5 (junior) students and 193 teachers in 41 schools, in an urban-rural Canadian school board. Schools were randomly assigned to use either JUMP Math or their business-as-usual, problem-based approach to math instruction. We tracked student progress in math achievement on standardized and curriculum-based measures of computation and problem solving, for 2 consecutive school years. Junior students taught with JUMP Math made significantly greater progress in computation than their non-JUMP peers but the groups did not differ significantly in problem solving. Effects took hold relatively quickly, replicating the results from an earlier pilot study. Primary students in the non-JUMP group made significantly greater gains in problem solving and computation in year 1. But those taught with JUMP Math made significantly greater gains in problem solving and the groups did not differ in computation, in year 2. The positive effects of JUMP Math are noteworthy given that the JUMP Math teachers were likely still adjusting to the new program. That these positive findings were obtained in an effectiveness study (i.e. in real-world conditions), suggests that JUMP Math may be a valuable evidence-based addition to the teacher’s toolbox. Given the importance of numeracy for 21st century functioning, identifying and implementing effective math instruction programs could have far-reaching, positive implications.
Keywords:
Human learning – teachers – Schools – children – Spring – Working memory – Pilot studies – Problem solving
Introduction
Numeracy, the ability to understand and to utilize quantitative information, has been implicated in health management, criminality, financial welfare and employment, with greater numeracy skills related to better outcomes [1–4]. Indeed, employment in STEM fields (Science, Technology, Engineering and Mathematics), which rely heavily on mathematical skills, has been projected to increase three times as much as in non-STEM fields between 2005 and 2024 (33% versus 10%) and STEM graduates experience a higher employment rate and higher earnings than non-STEM graduates [5]. Yet in many western countries students’ mathematical skills remain far from adequate for eventual entry into a globally competitive, STEM-oriented workforce [6–8] (see S1 Text).
Efforts to improve mathematics achievement have focused increasingly on the early school years as early difficulties in mathematics have been linked to later academic and professional success. Individual differences in mathematical skill are already apparent upon Kindergarten entry and predict later academic achievement more strongly than early reading, attention, or socioemotional skills [9]. Persistent difficulty in mathematics is associated with lower rates of high school graduation and college entry and high school mathematics achievement predicts college graduation, career earnings and earnings growth [10, 11].
Much of the discussion has centered on the curriculum—what children should be taught, when and how they should be taught it (see for example, [12]). Curriculum expectations by grade are established by policy makers and typically delivered to students by way of commercial, textbook based programs. Indeed, a survey of almost 6000 math and science teachers indicated that 85% of elementary classrooms in the United States rely on at least one such program [13]. Yet studies investigating the effect of math programs on math achievement are a relatively recent phenomenon. Moreover, many studies lack scientific rigour and those that meet criteria for rigour often yield limited, and sometimes mixed, evidence regarding program impact (see [14–17]). Thus, we are only beginning to understand the extent to which math instruction programs influence math learning.
The limited evidence regarding the impact of math programs on math learning might lead Education stakeholders to focus on factors other than instruction to improve math achievement (e.g. class size, teacher preparation), while continuing to invest in programs whose impact remains unknown. Randomized-controlled trials (RCT’s) of math instruction programs are essential to determine their contribution to math achievement and to identify the programs that are most effective for improving it.
Program descriptions
We investigated the effectiveness of JUMP Math (JUMP), a distinctive approach to math instruction, developed by a Canadian mathematician based on a wealth of experience working with children with diverse math skills and challenges [18, 19]. The program is fully developed for K-8 and currently reaches more than 210, 000 students worldwide, with rapidly growing interest in Canada and the United States. It has been adapted to meet regional curriculum expectations (e.g. there is an American common core version), translated into multiple languages including French, Spanish and Bulgarian (translation into Inuktitut, a Canadian indigenous language, is also underway), and aims to be affordable (JUMP Math is a registered charity). Informal study in diverse settings suggested the potential for a positive impact on math learning [19]. JUMP instruction includes problem solving but the program is distinct from problem-based learning, the prevailing approach to math instruction in a number of countries, and its key ideas are empirically supported.
To elucidate the nature of JUMP instruction, it is instructive first to consider the central features of problem-based learning. Table 1 provides a summary of the key contrasts between the two curricula.
Tab. 1. Summary of key contrasts between problem-based math and JUMP math. Problem-based learning (see note [20]), [21–23] aims to develop the critical and creative mathematical reasoning children will eventually require in the modern workplace. A key feature is to make mathematics meaningful to children, to engage their attention and to promote a deep conceptual understanding of the material. Students are presented with real world problems and typically work collaboratively to determine, and then solve, the mathematics involved. Teachers facilitate learning, rather than instruct students directly. Children are encouraged to manipulate concrete materials (a wide variety of objects, pictures and so on) that are freely available, to discover target ideas. Calculators are permitted as early as Kindergarten to alleviate computational demands, thus leaving working memory resources free for the discovery process. Problem-based programs vary in their view of practice but typically eschew algorithms to encourage children to look beyond mathematical procedures and fact memorization and to focus on reasoning about the underlying concepts. Language plays a central role. With the emphasis on contextually rich problems and the inclusion of considerable explanatory material, mathematics texts tend to be linguistically dense and even very young students are required to communicate their thinking orally and in writing (using graphics, symbols and words). Indeed, explaining how they arrived at a problem solution is an essential part of problem-based lessons and considered a key indicator of children’s understanding of the material. For example, a grade 3 word problem retrieved from a well-known, online elementary teacher resource serving teachers in the region where the present research took place reads: “There are 30 legs in my backyard, but I'm counting dogs and kids. How many dogs and kids are in my backyard? Show different solutions to this problem”. Children are provided with manipulatives to help solve the problem and asked to show their solutions using “pictures, numbers and words”. [24] Assessment is both summative and cumulative, although supplementary diagnostic tools are increasingly called upon to help track progress.
In a typical problem-based lesson, the teacher presents a real-world word problem that is open-ended (has multiple possible solutions). Students then work collaboratively, in small groups, to solve the problem using a variety of materials and recording their work using graphics, symbols and text. Teachers circulate to check on progress, facilitate thinking and provide encouragement. The class then reconvenes and the teacher facilitates discussion as the groups share their problem-solving strategies and solutions.
In contrast, in the JUMP program concepts are reduced to increasingly smaller steps until students become proficient at executing that step, then built back up incrementally to meet the curriculum demands. A hallmark of the program is that lessons are finely scaffolded (guided) to help students arrive at target concepts–a process known as “guided discovery”. Moreover, the amount of scaffolding is tailored according to individual needs, allowing the whole class to work on the same concept simultaneously, while individual students vary widely in terms of where they are in the learning process. For example, in a lesson on perimeter in which irregular, right angled shapes are presented with some side lengths given and children must determine the length of the remaining sides, struggling students may work on relatively simple shapes with only one side length missing and lengths in the single digits, while more proficient students may receive problems with more complex shapes, multiple missing side lengths or lengths in the hundreds or thousands. The idea is for children at all levels of functioning to experience success at doing math and to associate this success with their efforts (see S1 Text).
A variety of models (concrete materials, diagrams, charts) are used purposefully in lessons explicitly linking the materials to mathematical ideas such as connecting 3 blocks to the magnitude “3”. However, the idea is to move students’ thinking from the concrete models towards abstract symbols (“3”, “x”) as soon as they have grasped the underlying concepts. For example, in an early algebra lesson in which blocks and a paper bag are used to represent quantities and a missing value, the blocks are gradually replaced with drawings of squares and then Arabic numbers, and the bag with empty squares, short underscores and then “x”, as the teacher works through the lesson. Paper and pencil work is favoured over calculators although students are taught and encouraged to use a unique finger counting method to aid mental computation. (see S1 Text). Moreover, substantial attention is directed to helping students acquire mathematical fact fluency.
JUMP aims to limit working memory and language demands. Much of the explanatory material is reserved for the teacher’s guides so that teachers can control the timing and the amount of information the children receive. In lieu of textbooks, students receive extensive practice working with the lesson ideas in practice and assessment books that contain worked examples and include real world problems pared down to the essential text. For example, at the end of a lesson on sums and differences younger children may be asked to solve problems such as “Midori had 35 pencil crayons. She lost 4. How many does she have left?” Problem complexity increases over time, as children are able to cope with greater mathematical and linguistic demands. Assessment at every step of the learning process is considered critical, to ensure understanding before moving on to new material. This may be as simple as asking “yes/no” questions, asking children to solve a specific problem or set of problems, to demonstrate their developing knowledge of the target concept. Clarifications are given as needed to help students understand why problem solutions work.
A typical JUMP lesson involves multiple iterations of relatively short periods of finely-scaffolded, direct instruction—explicit teaching of concepts and procedures, including the use of worked examples—given to the whole class, followed by plenty of individual practice (and occasional work with a partner) working with the lesson ideas (for a detailed description of a JUMP Math lesson see S1 Text). Teachers circulate to check on progress, provide feedback and encouragement. Example questions are taken up with the whole class with clarification as needed to share strategies, fill in knowledge gaps, and to verify comprehension before introducing new material.
Empirical support
The central tenets of JUMP math are well supported by the empirical evidence. Indeed, a meta-analysis comparing the effectiveness of unassisted discovery, explicit instruction and enhanced discovery found that explicit instruction was more effective than unassisted discovery, and that enhanced discovery incorporating scaffolding, worked examples, elicited explanations and feedback (all key features of JUMP) was the most beneficial for learning. [25] Another meta-analysis of five decades of research provides evidence for the positive effects of direct instruction on learning. [26]. Numerous studies have shown that children who attribute their success to their efforts are more likely to persevere in the face of challenges than children who attribute their success to inherent ability, ultimately leading to greater success. [27] Gradually fading out the concrete properties of manipulatives and moving towards abstract symbols has been shown to be more effective for learning than moving directly from concrete manipulatives to symbols [28, 29]. Indeed there is evidence that generic symbols (such as υ) may be more effective than concrete instantiations (such as detailed renderings of actual objects) for learning and transfer. [30]. There is also evidence of greater benefits from generating answers to calculation problems, compared to using a calculator, [31] and that finger counting can be an effective aid, especially for novice or struggling mathematicians. [32] Reducing problems to smaller, more manageable components is known to help alleviate working memory demands [33] and there is abundant evidence of the benefits of practice for skill acquisition. [34] The finding that children who have difficulty in math only fare better in math than children who struggle in both reading and math suggests that limiting the language demands of math materials may facilitate math processing. [35] Paring the student materials to only the essential information and allowing teachers to determine how much information to share, and when to share it with students thus takes children’s language and working memory limitations into account [36]. Finally, the development of professional tools to help track student progress (see e.g. [37]) as well as the emphasis on ongoing assessment in the current Response to Intervention model [38], attest to the importance of frequent assessment for effective instruction. Taken together, these findings suggest that the central principles of the JUMP program are well rooted in the scientific literature.
Present research
We first report a pilot study followed by a larger scale RCT investigating the impact of the JUMP program on elementary math achievement. In both studies, we were interested in the program’s effectiveness (impact in typical, real-world conditions), as opposed to its efficacy (potential impact in ideal conditions) for improving student math achievement. The pilot study aimed to determine if an RCT was feasible and warranted. Feasibility was important because there is no precedent for RCT’s in early Education in Canada. The pilot study focused on grade 5 (as the JUMP materials for grades 5/6 were the most refined at the time) and assessed the students’ progress over 5 months of instruction, largely in computation, given the program’s greater attention to mental math and practice. We reasoned that if JUMP was at all effective, we ought to see an impact here. The larger-scale RCT aimed to replicate and extend the pilot findings. The study involved teachers and students in grade 2 (7 year-olds) and grade 5 (10 year-olds) in a different school board. We evaluated teachers’ implementation fidelity and tracked student progress over two consecutive school years (through the end of grades 3 and 6) on a broad range of math outcomes that included students’ ability to apply their mathematical knowledge, widely regarded in contemporary education as a key indicator of math understanding. [21, 22]
In the scale-up RCT, we investigated the impact on math achievement in year 1, the summer, and year 2 of the study, to shed light on the trajectory of any effects of curricula. We included the summer period because math achievement is particularly vulnerable to so called “summer slide”, resulting in time spent at the beginning of the new school year reviewing the previous year’s work that could otherwise be directed towards learning new material [39]. Smaller summer losses would also indicate that more of the previous year’s material has been successfully transferred to long-term memory, which is an important indicator of learning [40]. Curricula that minimize summer losses could thus help students make greater advances during the school year. Given their extensive experience with problem solving, we expected that students who received their usual methods of math instruction would have an advantage on the problem solving measures, at least in the first year when both students and teachers in the JUMP group were adjusting to the new program. Given the greater attention given to mental math and practice in the JUMP program compared to problem-based learning, we anticipated that any positive effects of JUMP might first be discernible on the computational measures. At issue was the longer - term impact of the two curricula on the various math outcomes.
Pilot study
Overview
The pilot study involved grade 5 teachers and students in a rural school board (district; SB1) in Ontario, Canada. Participating schools were randomly assigned to use either JUMP Math (JUMP) or their business-as-usual approach to math instruction (SB1) for about 5 months, including mandatory school holiday breaks of about 3 weeks. We tracked student progress in math achievement, collected demographic data from the teachers and solicited feedback regarding their experience working with their assigned curricula (see S1 Text).
Ethics statement
The Research Ethics Boards (REB) at the Hospital for Sick Children, Toronto, Ontario, Canada and the participating school board approved the study procedures. Participation was voluntary. We obtained written, informed consent from parents and teachers prior to random assignment to curricula and assent from the children prior to testing. Other than the JUMP Math materials distributed to teachers in the JUMP group (at no cost), teachers did not receive any compensation for participating.
Materials and methods
Participants
Twenty-one principals consented to participate. Schools were randomly assigned to either the JUMP group (11 schools) or to the SB1 group (10 schools). However, 2 schools in the SB1 group declined after random assignment, which together with variation in the size of the participating schools, resulted in an imbalanced number of participating teachers and students in the two groups. The elementary student population in the participating school board was predominantly white, with middle to lower middle class backgrounds and low average, to average academic achievement (see Table 2 and S1 Text).
Tab. 2. Summary of student characteristics at baseline. Teachers were eligible to participate if they were accredited to teach in Ontario, in good standing, and did not plan to take a leave of absence during the study period. Eighteen JUMP and 11 SB1 teachers in the participating schools agreed to take part. As a group, the SB1 teachers had somewhat more teaching experience and somewhat stronger math backgrounds. (see S1 Text).
Students were eligible to participate if they had sufficient grasp of English and did not have developmental challenges serious enough to preclude full participation in the curriculum, as judged by their teacher. Eight to 10 students were randomly selected from each class for tracking, yielding a total of 270 students; 163 JUMP and 107 SB1. Boys and girls were roughly equally represented. Attrition was low; 7 additional students tested at baseline (about half in each group) moved to a non-study school prior to post data collection. The left side of Table 2 shows a summary of the pilot study student characteristics at baseline, which were highly similar in the two groups (see note [41]), [42–44].
Teacher professional development
Teachers in both groups received 2 full days (1 in the fall, 1 mid-year) of professional development (PD), according to their assigned curriculum (JUMP or SB1). The content and delivery of the PD was determined by the JUMP organization and by the participating school board, respectively. Members of our research team attended all of the PD sessions to ensure alignment with assigned curricula. We asked teachers to use only their assigned curriculum for the study duration.
The SB1-PD was in line with the business-as-usual, problem-based approach to math instruction and was delivered by members of the board pedagogical support team. The sessions comprised a review of regional expectations regarding the content and pedagogical approach for elementary math instruction, suggestions for implementation, and pedagogical demonstrations including small group work on problem solving. Teachers were given opportunities for questions and discussion. Their key resources following the PD included approved commercial textbooks, the accompanying teacher’s guides and student workbooks normally provided by the school board. As per usual practice, teachers were free to supplement with any other additional materials according to their student’s needs and continued to receive input from the board’s teaching support team, as needed.
Teachers in the JUMP group received the same PD that could be provided to any teacher adopting the program, which was delivered by a professional from the JUMP Math organization. The sessions consisted of numerous pedagogical demonstrations to introduce key program principles, guidance on how to use the teacher’s guides and student practice and assessment books, and suggestions for how to adapt the program for struggling and also for more advanced students. Teachers were given opportunities to ask questions and participate in discussion. Their key resources following the PD were grade specific teacher’s guides containing detailed, explicit lessons for the entire school year with suggestions for how to adapt the materials according to student’s math skills, and the student practice and assessment books containing a wealth of practice material (there are no student text books). Teachers were also encouraged to submit queries for input from the JUMP organization, as needed.
Measures and procedures
The math achievement outcome measures included the math fluency, calculation and quantitative concepts scales from the Woodcock-Johnson Achievement Battery (WJ-III [45]). We measured reading achievement with the letter word identification test also from the WJ-III, IQ with the Kaufman Brief Intelligence Test (KBIT; [46]), and verbal working memory with the backwards version of the non-word letter span test adapted from the Wechsler Intelligence Scale for Children (WISC-III [47]). We assessed math and reading achievement at baseline and post-intervention, and IQ and working memory at baseline only (see Table C in S1 Text).
Teachers completed a questionnaire probing their teaching experience, highest level of math education and the amount of math instruction time per week provided to their participating class. They also rated their math teaching experience during the study period on a 10-point scale from “very poor” (0) to “excellent” (10). Teachers in the JUMP group indicated if they would use their assigned curriculum again and if they would recommend it to other teachers.
Students were tested individually in a quiet area in their school by a local team of retired teachers who were familiar with the school board but blind to the study hypothesis and to random assignment to curricula. The study measures were administered in two sessions that took place on separate days. Breaks were given as needed.
Results
We used PROC MIXED in SAS 9.3 (copyright 2002–2012 SAS Institute Inc., Cary, NC, USA) to model the change in each outcome as a repeated measures hierarchical regression model. We entered baseline scores on the outcome variable, curriculum (JUMP, SB1), reading achievement at baseline, and gender. The results for the pilot study are shown in Fig 1. (see also Table D in S1 Text).
Fig. 1. Pilot study results. Results are based on standard scores and therefore indicate progress relative to same aged peers, which is represented by the 0 line. Vertical lines indicate 95% confidence limits around mean change scores. P-values and effect sizes (ES) are for the difference between the group means. Vertical lines that do not intersect the zero line indicate mean change that is significantly different from expected change, based on available norms. Note that effect sizes (ES) were derived from estimates from the repeated measures hierarchical regression models. We calculated standard deviation for the pre-post change by multiplying the standard error of the estimate of change for each curriculum by the square root of its degrees of freedom. Effect size is the change in the JUMP group minus the change in the SB1 group, divided by the pooled standard deviation. Hence, a positive value indicates better performance in the JUMP group, a negative value better performance in the SB2 group. An effect size of .25 is considered educationally meaningful [48]. A recent review of educational intervention research found that effect sizes are rarely as large as .30. Hence, values of .50 would be considered very large indeed [49].
As the figure shows, students who received JUMP instruction generally progressed more than their SB1 peers on all of the math achievement measures. The impact was strongest for math fluency, where the group difference was significant (mean change scores -.3 SB1, 2.3 JUMP, p = .001, ES = .7 math fluency; -2.5 SB1, -0.4 JUMP, p = .6, ES = .43 calculation; 2.1 SB1, 3.6 JUMP, p >.9, ES = .3 quantitative concepts). Moreover, comparing performance to expected change based on available norms we found that in the JUMP group, progress was significantly greater than expected on math fluency (p = 0.001) and quantitative concepts (p = .0003), and not significantly different from expected progress on calculation (p = .63). In the SB1 group, progress was not significantly different from expected on math fluency (p = .72) or quantitative concepts (p = .07), and significantly less than expected on calculation (p = .02). The difference between groups was not significant and relatively small for reading (mean change 0.6 SB1, 0.9 JUMP, p = .6, ES = .15) compared to the differences on the math measures, although only the JUMP group made significantly more than expected gains here, based on available norms (p = .27 SB1; p = .03 JUMP) (see S1 Text).
Teachers in the JUMP group rated their experience teaching math during the study period significantly more positively than teachers in the SB1 group (mean ratings 7.2 SB1, 8.2 JUMP, p = .03). All of the teachers who used JUMP indicated that they would use it again and that they would recommend it to other teachers.
Discussion
The pilot study results provided preliminary evidence of a positive impact of JUMP on grade 5 students’ math progress after just a few months of instruction. The impact was strongest on math fluency, but the JUMP group generally made more progress than their school board peers (compared to expected growth based on test norms). These findings are noteworthy given the relatively short study duration and our use of standardized measures, which can be insensitive to small but important changes especially in the short-term. JUMP instruction had relatively little impact on reading suggesting the program effect was specific to math progress, as opposed to more general pedagogical gains. Attrition was low and teacher feedback regarding working with the program was positive. As such, the pilot study results suggested that a scale-up RCT was both feasible and warranted.
Scale-up RCT
Overview
The scale up study was a registered cluster-randomized controlled trial—clinical trials.gov identifier NCT02456181 –conducted in a different Ontario school board (district; SB2) serving a small city and the surrounding rural counties. The student population was therefore an urban/rural mix. The study involved 41 schools, 193 teachers and 1146 students.
Table 3 provides an overview of the study design. Schools were randomly assigned to use either JUMP Math (JUMP) or the school board’s business-as-usual problem-solving approach (SB2) to teach math for two consecutive school years. The students were in grade 2 or grade 5 at the start of the study and we tracked their progress in math through the end of grades 3 and 6. Hence, the study included a primary division (grades 2/3) and a junior division (grades 5/6) elementary school cohort (in Canadian elementary schools the primary and junior divisions refer to grades K-3 and 4–6, respectively). The teachers who participated in year 1 were those who taught the study students in grades 2 or 5. The teachers who participated in year 2 were those who inherited and taught the study students in grades 3 or 6.
Tab. 3. Overview of the scale-Up RCT. Teachers received PD in their respective curricula, which we asked them to use for the duration of the school year. We assessed student’s math achievement at 4 time points—the fall and spring of each of the two school years (T1and T2 for year 1, and T3 and T4 for year 2). This allowed us to examine change in achievement in 3 time periods; year 1 (T1 to T2), the summer (T2 to T3) and year 2 (T3 to T4). We also assessed teachers’ fidelity of implementation of both types of instruction, around the middle of the each of two school years, by videotaping them as they taught math to their participating classes. As in the pilot study, we tracked student progress in reading as well as math to determine if any effects of JUMP were specific to math learning. To help characterize the groups at baseline we also assessed students’ IQ, working memory and processing speed. Finally, we collected demographic data from the teachers and solicited feedback regarding their experience working with their assigned curricula.
Ethics statement
The Research Ethics Board (REB) at the Hospital for Sick Children, Toronto, Ontario, Canada and the participating school board approved the study procedures. Participation was voluntary. We obtained written informed consent from teachers; in year 1, prior to randomization to curricula and in year 2, after the curricula were already in place. We obtained separate written, informed consent from teachers for the videotaping. We obtained written, informed consent from parents for both years of the study and assent from the students prior to participation.
JUMP Math resources were distributed to teachers in the JUMP group at no cost. To help equate the distribution of new math resources across groups, all of the teachers in the SB2 group received the equivalent of CDN$250 in gift cards to purchase math-related classroom materials of their choosing. Funds were offered after teachers had already consented to participate in the study.
Materials and methods
Participants
Elementary students attending the participating school board were predominantly white; 3% percent were born outside Canada, 5% had a non-English first language and 2% were English language learners (corresponding regional values 11%, 5%, 11%). Twenty-four percent were identified as requiring special education (regional value 19%, see note [50], [51]).
Members of our research team visited the 55 schools that were eligible to participate in the study (they had classes in the study grades and were not listed for potential closure or merger), presented an overview of the study to the school principals and addressed any concerns. Forty-one principals consented to participate. Too many prior commitments were the main reason for declining. Schools with consenting principals were assigned a numerical code and we used a random number table to randomly assign schools to curricula. One school dropped out after random assignment to the SB2 group, hence 40 schools participated (21 JUMP, 19 SB2). This, together with variation in the size of the participating schools, resulted in an imbalanced number of participating teachers and students in the two groups. The percentage of students in the participating schools who reached expectations on the regional math assessment in the year preceding the study was 52% JUMP, 60% SB2 for grade 3 (regional value 68%), and 39% JUMP, 56% SB2 for grade 6 (regional value 58%). [50] Thus, there was room for improvement in students’ math achievement. The average median household income was $68, 556 (range $46, 272 to $86, 181) for the JUMP schools and $68, 503 (range $42, 861 to $86, 791) for the SB2 schools (national median $69, 860). [52]
Teacher eligibility criteria were the same as for the pilot study; accredited to teach in Ontario, in good standing, and not planning to take a leave of absence during the study period. Members of our research team contacted eligible teachers either by email or in person and provided an overview of the study along with a detailed teacher consent form. Questions were encouraged and addressed immediately. In year 1, 115 teachers agreed to take part but 9 (2 JUMP, 7 SB2) declined following random assignment citing overwhelming schedules. Nine teachers who participated (5 JUMP, 4 SB2) left the study in year 1 due either to the end of a contract or for maternity leave and were replaced by new teachers. Thus, there were 106 teachers in year 1; 58 JUMP (31 grade 2, 27 grade 5) and 48 SB2 (26 grade 2, 22 grade 5). In year 2, 92 new teachers agreed to take part but 5 later declined (3 JUMP, 2 SB2) citing overwhelming schedules. However, 20 teachers who participated in year 1 also agreed to participate in year 2 (they taught grade 2 or 5 in year 1 and then inherited study students in grade 3 or 6 in year 2, in the same school). Ten teachers who participated (8 JUMP, 2 SB2) left the study in year 2 for the same reasons cited by teachers who left in year 1, and were replaced by new teachers. Thus, there were 107 teachers in year 2; 59 JUMP (34 grade 3, 25 grade 6) and 48 SB2 (27 grade 3, 21 grade 6). Replacement teachers were recruited to the study immediately and received a combination of the relevant PD and support implementing their assigned curriculum. As teacher changes tended to occur either relatively early or relatively late in the school year, student data were yoked to the predominant teacher and only the data from the predominant teacher were included in our analyses.
Table 4 shows a summary of demographic information for the final sample of teachers. Teachers in the primary division (grades 2 and 3) were mostly female, while in the junior division (grades 5 and 6) the percentage of females ranged from 52 to 65%. Teachers in the JUMP group had somewhat more teaching experience and most teachers in both groups had last studied math in high school (the rest had some university level math, see note [41], [42–44])
Tab. 4. Demographic information for final sample of teachers in Scale-Up RCT. Student eligibility criteria was the same as in the pilot study (sufficient grasp of English and no developmental challenges that would preclude full participation, as judged by their teacher) with the exception that both grade 2 and grade 5 students were eligible for the scale-up RCT. Teachers distributed detailed parental consent forms to eligible students in their classes. Fig 2 shows the CONSORT flow diagram of the student participants. Eleven hundred and seventy-three students who met the criteria for eligibility returned signed parental consent forms. Twenty-seven students were excluded from the study; 12 were not tested in error, 8 moved before T1 testing and 7 did not assent to participate. Thus at T1, there were 554 primary students (n = 350 JUMP, 204 SB2) and 592 junior students (n = 348 JUMP, 244 SB2) in the study (see “allocation” in Fig 2). Boys and girls were equally represented. We ran 1000 bootstrap samples of the math fluency data from the pilot study to estimate the power to replicate our findings with the sample size obtained for the scale up study, which was 78.3% and 77.9% for the primary and junior groups, respectively.
Fig. 2. CONSORT flow diagram of student participation in the Scale-Up RCT. Primary students are shown on the left and junior students on the right side of the Fig. See main text for reasons for being lost to follow-up. Young/old for grade denotes students whose date of birth indicated they had started school either a year earlier or a year later than usual. Students were excluded from the analysis for a given time period if they did not have data for either the beginning or the end of that time period, which was determined separately for each outcome measure. The number of students excluded due to missing data shown in the Fig is based on the broad math outcome measure (see measures) but this number varied slightly across the different outcome measures. Students were considered lost to follow-up after T1 testing if they moved during the study period (either to a school in the other group e.g. a JUMP student who moved to an SB2 school, or to a non-study school) or if the teacher who inherited them in year 2 did not consent to participate in the study (n = 11 teachers, roughly equally distributed across grade and curriculum). The latter group of students (n = 111, primary n = 40 JUMP, n = 15 SB2; junior n = 36 JUMP, n = 20 SB2) were assessed at T3 but not at T4, as parent consent was given for both years. Hence, the greater attrition in year 2 compared to year 1 or the summertime (see “follow-up” in the Fig).
Students whose date of birth indicated they had started school either a year earlier or a year later than usual (which is the year in which children turn 4 years of age, under current policy students cannot be held back or skip a grade once they start school), were considered “young/old for grade” and excluded from the analyses for all time periods (n = 14 students altogether, see Fig 2). Students were also excluded from the analysis for a given time period if they were missing data for either the beginning or the end of that period e.g. students who had data for T1 but not T2 were excluded from the analysis for year 1, of the outcome variable on which they were missing data. The number of students excluded for missing data shown in the Fig is based on the broad math outcome measure, but this number varied slightly across the different outcome measures (see measures and also “analysis” in Fig 2).
The right side of Table 2 shows a summary of the scale-up RCT student characteristics at baseline, which were generally comparable in the two groups (see note [41]), [42–44]. Test scores were in the average to low average range. The primary cohort performed somewhat better than the junior cohort on all of the measures except for working memory, which was more developed in the junior cohort (as expected). The relatively low PSP and CBC scores at baseline (the start of the school year) are to be expected for grade appropriate material.
Teacher professional development
Teacher PD in the scale up was the same as in the pilot (1 day in the fall, 1 day mid-year), with some modifications to the delivery of the SB1-PD. Following the fall PD, teachers in the SB2 group expressed concern at the possible bias of having JUMP PD delivered by a well-regarded, external expert in math pedagogy while the SB2-PD was delivered by the board support team. To address their concerns and to help maintain teacher motivation, SB2 teachers in year 1 received an additional ½ day PD in early December, delivered by a well-regarded, external expert in problem-based math instruction, who was nominated by the participating teachers. Accordingly, a different, well-regarded, external expert, also nominated by the teachers, delivered both PD days in year 2. Members of our research team attended all of the SB2-PD sessions, which were in line with problem-based math instruction, and included a review of regional guidelines, implementation guidance, pedagogical demonstrations and small group problem solving.
Note that in addition to the detailed teacher’s guides and student practice and assessment books, the JUMP group teachers also received grade specific JUMP Math smart board materials that were not available at the time of the pilot study.
Implementation fidelity
We measured fidelity of implementation of the two curricula in both years of the study by videotaping teachers as they taught their participating class for 1 full math period and then coding the videotapes according to the type of instruction used. Video recording was done around the middle of the school year (after the mid-year PD) in years 1 and 2, by members of the data collection team who were blind to the study hypotheses and to the teacher’s assignment to curricula.
The videotapes were coded by three accredited, occasional (substitute) teachers familiar with the problem-based approach to math instruction and who, apart from coding, were not otherwise involved with the study. They were blind to the study hypotheses and to teacher assignment to curricula. They watched videotapes of the JUMP PD, reviewed the materials provided at the SB2 PD sessions (SB2 trainers declined to be videotaped), received training on how to use the coding scheme and a detailed coding manual for reference. Videotapes were randomly assigned such that each coder coded 1/3 of the videotapes.
Coders watched the entire math class and captured their observations on 3 parallel timelines; teacher activity (what was the teacher doing?), student configuration (how were the students arranged?) and lesson content (what were the students engaged in?). For teacher activity and student configuration, they selected from a set of defined options and indicated start and stop times. The options for teacher activity were: review (of previously taught material), facilitation (asking questions, providing prompts to help students think through the problem), direct instruction (explicit teaching of concepts and procedures, including worked examples), organization (e.g. helping to form groups, find space to work in), circulation (to check on progress), available (attending to the class and addressing queries initiated by students), and distracted (occupied with something not related to the lesson). For student configuration the options were: whole class (students seated at their desks or on the carpet attending to the teacher), small group (working in pairs or small groups) and independent (working individually, usually at their desks). We tallied the total amount of time they observed the teacher in the various activities and the time the students spent in the different configurations, separately, and converted the results to a percentage of the class time, for each teacher. For lesson content, the coder noted the specific activity the students were engaged in (e.g. doing a fact fluency exercise, working on a problem), indicating start and stop times.
Coders then reviewed their observations and made 3 judgments: 1. They indicated the curriculum with which the lesson was most aligned selecting from: problem-based learning (SB2), guided discovery and scaffolding (JUMP), or neither, 2. They indicated the degree to which the observed lesson was aligned with their selected curriculum on a scale from 1-not at all to 7-very well aligned, and 3. They rated their confidence in their choice of curriculum from 1-not very confident to 5-very confident.
Twenty percent of each coder’s assignment was randomly selected and then randomly distributed to the 2 remaining coders for second coding. Cohen’s Kappa for overall inter-rater agreement was κ = .72, p < .0001. Kappa values of .61 -.80 indicate substantial agreement while values greater than .81 indicate almost perfect agreement [53, 54]. When they agreed about curriculum, their alignment ratings were identical or within 1-point 87% of the time and within 2 points 13% of the time. Disagreements regarding type of instruction were discussed as soon as possible after second coding but only the data from the original coder were used in our analyses. [see also S1 Text].
Table 5 summarizes the rate of participation in the observations/videotaping. One hundred and sixty four teachers consented to the videotaping, 16 of who participated and were videotaped in both years of the study (180 videotapes altogether, 85% of the participating classes). As the table shows, the rate of participation, though generally very good, was higher in year 1 than in year 2, especially for the junior teachers (see note [41]), [42–44].
Tab. 5. Summary of teacher participation in observations/videotaping. The large majority of observed teachers were coded as using their assigned curriculum, but a few teachers were coded as using the other curriculum (i.e. JUMP teachers using SB2 methods, or vice versa). These incongruent cases were roughly equally distributed across grade and condition (2–3 cases each or 7–14% of the observed classes) with the exception that for the SB2 group in grade 6, 5 of the observed classes (36%) were coded as JUMP lessons (by contrast only 12% of grade 6 JUMP classes were coded as SB2 lessons). When the assigned and observed curriculum were congruent, coder’s judgments of degree of alignment with type of instruction and their confidence in their ratings was generally good; for the majority of cases alignment was at least 5 out of 7 and confidence at least 4 out of 5. Teachers who met these three criteria—assigned/observed curriculum congruence, high alignment and high coder confidence—were considered high implementation fidelity teachers.
Of note, in the cases of curriculum congruence, degree of alignment and coder confidence did not differ significantly from year to year for either group of primary teachers or for the junior JUMP teachers (primary mean alignment JUMP 5.3 year 1 and 4.9 year 2, SB2 5.4 both years; primary mean confidence JUMP 4.2 both years, SB2 4.3 year 1, 4.1 year 2; junior mean alignment JUMP 5.1 year 1 and 4.8 year 2, mean confidence 4.3 year 1, 4.1 year 2). However, for the junior SB2 teachers, alignment was significantly higher in year 1 compared to year 2, but coder confidence did not differ from year to year (mean alignment 5.5 year 1 and 4.7 year 2, p = .04, mean confidence 4.1 in both years; all comparisons based on Wilcoxon rank sum tests).
Fig 3 shows the distribution of mean time spent in the different teacher roles and student configurations, for all of the observed classes (see also Table E in S1 Text). The results were generally consistent with what we would expect for the different curricula. For the primary classes (left side of Fig 3), the JUMP teachers spent substantially more time on direct instruction and relatively little time facilitating, while the pattern for the SB2 teachers was reversed, both groups spent a substantial amount of time circulating and some time on review. The JUMP students spent relatively more time working independently and less time working in small groups, while for the SB2 students this pattern was reversed. In both groups, the whole class was taught together at least half of the time, which reflects the time spent on direct instruction and discussion distributed throughout the JUMP lesson and the time spent on the problem-presentation at the outset and then reconvening at the end of the SB2 lesson.
Fig. 3. Distribution of time spent on teacher activities and in different student configurations in observed classes. The pattern we observed for the primary classes also held for the junior classes (right side of Fig 3), for both groups in grade 5 and for the JUMP group in grade 6. However, the SB2 lessons in grade 6 appeared more similar to, than distinct from, the JUMP lessons in that teachers spent relatively more time on direct instruction and less time facilitating and their students spent somewhat more time working individually and less time working in small groups. These findings, together with the relatively small number of SB2 teachers who participated in the observations in grade 6 (14) and the even smaller number with assigned/observed curriculum congruence (9 out of 14) raise concerns regarding fidelity of program delivery for the SB2 group in grade 6, and therefore suggest caution in interpreting the results for the junior student outcomes in year 2.
Measures and procedures
Math achievement
Our primary math achievement measures included the math fluency and calculation scales (two computational measures also used in the pilot study), as well as the applied problems scale from the WJ-III, which together yield a broad math cluster score. (see S1 Text). We supplemented these standardized tests with another problem solving and another computation measure. The supplementary measures comprise grade appropriate material only and give credit for appropriate steps taken toward the correct solution as well as the correct solution, providing additional opportunities for children to demonstrate the extent of their mathematical knowledge.
The problem-solving process measure (PSP), is a paper and pencil test based on items from a bank of word problems that have been used on the regional math assessment written annually at the end of grades 3 and 6. We developed different 5-problem tests for each of the study grades (2, 3, 5 and 6) with equivalent fall and spring forms of each test. Children were required to show their work as well as their final answer. PSP and Applied Problems from the WJ-III were significantly correlated at T1 (baseline), r = .61 and .52 for grade 2 and 5, respectively, and also at T4 (end of year 2), r = .59 and .64 for grade 3 and grade 6, respectively, all p’s < .0001. We also developed detailed scoring manuals for each grade based on publicly available guidelines. Children received a score between 0 and 40 for each of the 5 questions. Test scores represent the mean of the 5 question scores. (see S1 Text for further details regarding test development and scoring).
Curriculum-based computation (CBC) is a timed, paper and pencil test from the Monitoring Basic Skills Progress math kit [55] comprising 25 grade-specific computation questions. Children received a different but equivalent form of the test at the fall and spring testing. Scoring followed the developer’s instructions; 1 point was awarded for every digit in the correct position in the final answer. E.g. if the answer was 18, children received 2 points for 18, 1 point for 17 and 0 points for 81. Total scores for each test were converted to a percentage of the possible points on that test.
Additional measures
We measured reading achievement with the broad reading cluster from the WJ-III, which is based on performance on letter-word identification, reading fluency and passage comprehension.
We assessed IQ and working memory using the same measures used in the pilot study. Finally we assessed processing speed with the digit and letter versions of the Rapid Automatized Naming Test. [56] We assessed math and reading achievement at all four data collection time points but IQ, working memory and processing speed at baseline only. (see S1 Text)
Teachers completed a questionnaire probing their teaching experience, highest level of math education and the amount of math instruction time per week provided to their participating class. They also rated their math teaching experience during the study period on a 10-point scale from “very poor” (0) to “excellent” (10).
Procedures
Children were tested either individually or in small groups in a quiet area in their school. Testing was done by a local team of accredited, occasional (substitute) teachers who were familiar with the school board, but blind to the study hypotheses and to random assignment to curricula. The testers did not participate in the study and did not teach in the participating schools during the study period. The study measures were administered in 3 sessions that took place on separate days. Breaks were given as needed.
Analytic plan
As we were interested in comparing progress in math achievement between the two groups, within each of the three time periods: year 1 (T1 to T2); summer (T2 to T3); and year 2 (T3 to T4), growth in achievement was modeled using repeated measures hierarchical regression analysis, with repeated measures on students nested within classrooms, using PROC MIXED in SAS 9.4 (copyright 2002–2012 SAS Institute Inc., Cary, NC, USA). Classrooms nested in schools was not included in the models as the number of participating teachers was imbalanced across schools and there was often only one participating teacher in the study grades in a school. For PSP and CBC, we omitted the summer period as the test content was grade specific. We entered baseline performance on the outcome variable, broad reading (at baseline), sex, age on the first day of school, inter-test interval (days), curriculum (JUMP, SB2) and time period (year 1, summer, year 2), as well as 2-way interactions of inter-test interval by time period, baseline by time period, and curriculum by time period, to yield the following model:
Yijkt = μ + bi + αj + δt + (aδ)it + β1tX1tk + β2tX2k + β3X3k + β4X4k + β5X5k + eijkt
μ Denotes the intercept
bi Random deviation of the ith (classroom) teacher’s intercept from μ, bi ~ N(0,σb2)
αj Effect for condition j
δt Effect for time period t
(aδ)jt Condition × time period interaction
β1t Denotes the effect of the duration (days) of time period t, at time period t (all duration
× time period effects)
β2t Denotes the effect of baseline math score on the effect of time period t (all baseline
math score × time period effects)
β3 Denotes the effect of baseline reading score
β4 Denotes the effect of age on September 3 of year 1
β5 Denotes the effect of sex
X1tk Duration in days of time period t, child k
X2k Baseline math score for child k
X3k Baseline reading score for child k
X4k Age on September 3 of year 1, child k
X5k Indicator variable for sex, child k
eijkt Random error associated with child k at time t, in classroom i assigned to condition j
Var(eijkt) = σt2 and Cov[eijkt, eijkt’] = σkk’
To address our main research question regarding the impact of curriculum on math progress, we focus on the effect of curricula in each of the three time periods (see note [57]). Following similar previous research (see e.g. [58]), and to simplify the models, we analyzed the data for the two age groups (primary, grades 2/3; junior, grades 5/6) separately. Effect sizes were derived from estimates from the hierarchical repeated measures models, as in the pilot study.
We first report the results for the “per protocol” analysis (PP) i.e. based on all participating students, according to their randomly assigned curriculum. Note that we were unable to carry out intent-to-treat analysis i.e. including all participants randomly assigned to the two groups, regardless of whether they received the treatment or not—which is normally required for a clinical trial—as we did not recruit (or assess) any students at the 1 SB2 school that dropped out of the study after random assignment. As an important objective of the scale up RCT was to replicate and extend the findings from the pilot study, we report the results for the junior students first followed by the results for the primary students. Furthermore, for each age group, we report the results for the main outcomes–the WJ-III math achievement scales–followed by the results for the supplementary math outcomes. (see note [59]), [60]
Finally, based on our findings for implementation fidelity, including the finding that assigned and observed curriculum were sometimes incongruent, we also analyzed the data from only those students whose teachers were observed and met the criteria for high fidelity instruction (HiFi; see the results for implementation fidelity). For these analyses, year 1 and summer results are based on the data from students who had HiFi teachers in year 1, and year 2 results are based on data from students who had HiFi teachers in year 1 and year 2. The number of primary students who met these criteria was 256 JUMP and 117 SB2 for the analyses for year 1 and the summer, and 124 JUMP and 70 SB2 for the analyses for year 2. Note that these HiFi analyses were only carried out for the primary students. The more limited number of junior teachers who participated in the observations and even smaller number who met the criteria for high fidelity, especially in the SB2 group in year 2, precluded any meaningful analysis for the junior HiFi students.
Results
Per protocol (PP) analysis
Junior students: main outcomes
Fig 4 shows the results for the PP analysis for the junior students. In general, progress in math achievement for the junior students was fairly stable across the three time periods. Comparing progress between the groups we found that, for broad math, the two groups did not differ significantly in year 1 or the summer. However, the JUMP group made significantly greater gains than the SB2 group in year 2 (1.0 SB2, 1.2 JUMP, p = .7, ES = .04, year 1; -0.3 SB2, 0.6 JUMP, p = .2, ES = .14, summer; 0.2 SB2, 1.7 JUMP, p = .04, ES = .22, year 2). In contrast, for broad reading there were no significant differences between the two groups in any time period (3.6 SB2, 3.3 JUMP, p = .5, ES = -.06, year 1; 1.1 both groups, p > .9, ES = -.01, summer; 0.7 SB2, 1.3 JUMP, p = .3, ES = 0.11, year 2; see Fig 4, panel a).
Fig. 4. Results for the Junior Students. Broad Math (left side of panel a) is based on performance on applied problems, calculation and math fluency (shown separately in panel b). Vertical lines indicate 95% confidence limits around mean change scores. P-values and effect sizes (ES) in the Fig are for the difference between the group means. Results for the Woodcock-Johnson III measures are based on standard scores and therefore indicate progress relative to same aged peers, which is represented by the 0 line. Vertical lines that do not intersect the 0 line indicate mean change that is significantly different from expected change, based on test norms for the standardized measures (panels a and b) and 0 change for the supplementary measures (panel c). These findings were generally corroborated when we compared observed gains to expected gains based on test norms. Although only the JUMP group made significantly greater than expected progress on broad math in year 1 (p = .06 SB2, p = .01 JUMP), progress in both groups was not significantly different from expected in the summertime (p = .6 SB2, p = .2 JUMP). Furthermore, only the JUMP group continued to make significantly greater than expected progress in year 2 (p = .7 SB2, p = .001 JUMP). For broad reading, both groups made greater than expected progress in all time periods, except for the SB2 group in year 2 (p < .0001, p = .004 and p = .07 SB2; p < .0001, p = .001, and p < .0005 JUMP; for year 1, the summer, and year 2, respectively).
Analyses of the individual standardized tests (Fig 4 panel b) showed that the JUMP curriculum had a positive impact on math fluency, where significantly greater gains were already apparent in year 1 (0.1 SB2, 2.2 JUMP, p = .002, ES = .31). The group difference was not significant in year 2, (1.6 SB2, 3.0 JUMP, p = .07, ES = .15). The difference between groups was not significant in either year, for calculation (-0.2 SB2, -0.1 JUMP, p > 0.9, ES = .01 year 1; 0.2 SB2, 2.1 JUMP, p = .09, ES = .17 year 2) or for applied problems (2.1 SB2, 1.7 JUMP, p = .6, ES = -.05 year 1; -0.5 SB2, 0.6 JUMP, p = .1, ES = .14 year 2), and there were no significant differences between the two groups in gains on any of these measures in the summertime (0.4 SB2, 0.9 JUMP, p = .4, ES = .08 math fluency; 0.1 SB2, 0.3 JUMP, p = .9, ES = .02 calculation; -0.4 SB2, 0.7 JUMP, p = .1, ES = .15 applied problems).
Comparing observed to expected gains we found that the JUMP group made significantly greater than expected gains on math fluency in all time periods (p’s < .0001 years 1 and 2, p = .05 in the summer), while the SB2 group’s gains were only significantly greater than expected in year 2 (p = .9 year 1, p = .5 summer, p = .006 year 2). For calculation, gains in both groups were not significantly different from expected gains in year 1 or the summer (p = .8 SB2, p = .9 JUMP year 1; p = .9 SB2, p = .7 JUMP summer) and only the JUMP group made significantly greater than expected gains in year 2 (p = .8 SB2, p = .008 JUMP). For applied problems, both groups made significantly greater than expected gains in year 1 (p < .0001 SB2, p = .0002 JUMP) but their gains were not significantly different from expected gains in the summer or in year 2 (p = .5 SB2, p = .1 JUMP summer; p = .3 SB2, p = .2 JUMP year 2).
Junior students: supplementary outcomes
For PSP and CBC there were no significant group differences in either year (PSP 6.3 SB2, 5.4 JUMP, p = .3, ES = -.14 year 1; 3.4 SB2, 4.5 JUMP, p = .2, ES = .14 year 2; CBC 2.7 SB2, 4.3 JUMP, p = .2, ES = .17 year 1; 1.5 SB2, 2.1 JUMP, p = .7, ES = .06 year 2, see Fig 4 panel c). For PSP, both groups made significant gains (greater than 0) in both years (all p’s < .0001). However, for CBC, whereas both groups made significant gains (greater than 0) in year 1 (p = .009 SB2, p < .0001 JUMP), only the JUMP group made significant gains in year 2 (p = .2 SB2, p = .04 JUMP).
Primary students: main outcomes
Fig 5 shows the results for the PP analysis for the primary students. Progress in math achievement was generally less stable over the three time periods for the primary students compared to the junior students. As the Fig for broad math shows, the SB2 group made significantly greater progress in year 1 (4.4 SB2, 1.2 JUMP, p = .0004, ES = -.25) but there were no significant differences in progress in the two groups either in the summer or in year 2 (-4.7 SB2, -3.4 JUMP, p = .1, ES = .13 summer; -0.5 SB2, 0.7 JUMP, p = .2, ES = .10 year 2). For broad reading, there were no significant differences in progress between the groups either in year 1 or the summer (0.9 SB2, 1.2 JUMP, p = .5, ES = .06 year 1; -2.5 SB2, -2.9 JUMP, p = .3, ES = -.12 summer), but the JUMP group experienced significantly greater progress in year 2 (-1.0 SB2, 0.5 JUMP, p = .001, ES = .25; see Fig 5 panel a).
Fig. 5. Results for the primary students. Broad Math (left side of panel a) is based on performance on applied problems, calculation and math fluency (shown separately in panel b). Vertical lines indicate 95% confidence limits around mean change scores. P-values and effect sizes (ES) in the Fig are for the difference between the group means. Results for the Woodcock-Johnson III measures are based on standard scores and therefore indicate progress relative to same aged peers, which is represented by the 0 line. Vertical lines that do not intersect the 0 line indicate mean change that is significantly different from expect change, based on test norms for the standardized measures (panels a and b) and 0 change for the supplementary measures (panel c). These results were corroborated when we compared progress within each group to expected progress based on test norms. For broad math, both groups made significantly greater than expected gains in year 1 (p < .0001 SB2, p = .05 JUMP), lost significant ground in the summer (p’s < .0001), and their gains were not significantly different from expected gains in year 2 (p = .5 SB2, p = .2 JUMP). For broad reading, both groups also made significantly greater than expected gains in year 1 (p = .02 SB2, p = .0003 JUMP), and lost significant ground in the summer (p’s < .0001), but whereas the SB2 group also made significantly less than expected gains (p = .01), the JUMP group gains were not significantly different from expected gains, in year 2 (p = .1).
Analyses of the individual WJ-III math achievement tests (Fig 5 panel b) indicated that the pattern of results for broad math was largely due to performance on applied problems and calculation. For applied problems, the SB2 group gained significantly more than the JUMP group in year 1 (6.0 SB2, 4.0 JUMP, p = .03, ES = -.15) but progress in the two groups was not significantly different either in the summer or in year 2 (-2.6 SB2, -2.3 JUMP, p = .7, ES = .03 summer; -0.3 SB2, 1.2 JUMP, p = .09, ES = .12 year 2). In both groups, growth on calculation was generally more modest compared to applied problems, especially in year 1. The SB2 group made significantly greater progress in year 1 (-.4 SB2, -3.4 JUMP p = .01, ES = -.18), but lost significantly more ground in the summertime (-5.7 SB2, -3.0 JUMP, p = .02, ES = .17), compared to their JUMP peers. Progress in the two groups was not significantly different in year 2 (-.2 SB2, 0.0 JUMP, p = .9, ES = .01). For Math Fluency, there were no significant differences between the two groups in any time period (0.3 SB2, -0.1 JUMP, p = .6, ES = -.04 year 1; -3.8 SB2, -3.9 JUMP, p = .9, ES = -.01 summer; 1.2 SB2, 1.4 JUMP, p = .8, ES = .01 year 2).
Comparing performance within groups to expected growth based on test norms corroborated the between group findings. For applied problems, both groups gained significantly more than expected in year 1 (p’s < .0001) and significantly less than expected in the summertime (p’s < .0001). Neither group’s progress was significantly different from expected progress in year 2 (p = .6 SB2, p = .07 JUMP). For calculation, the SB2 group gains were not significantly different from expected, while the JUMP group gains were significantly less than expected in year 1 (p = .6 SB2, p = .0001 JUMP) and both groups gains were significantly less than expected in the summer (p < .0001 SB2; p = .0001 JUMP). Gains in both groups were not significantly different from expected gains in year 2 (p = .8 SB2, p > .9 JUMP). For math fluency, both groups progressed as much as expected in year 1 (p = .6 SB2, p = .8 JUMP) and significantly less than expected in the summer (p’s < .0001). Only the JUMP group progressed significantly more than expected in year 2 (p = .1 SB2, p = .03 JUMP).
Primary students: Supplementary outcomes
For PSP, the difference between groups was not significant in year 1 (5.4 SB2, 4.4 JUMP, p = .3, ES = -.13) but the JUMP group gained significantly more than the SB2 group in year 2 (3.3 SB2, 6.2 JUMP, p = .01, ES = .26). For CBC, there were no significant differences between groups in either year (8.4 SB2 8.4, 7.2 JUMP, p = .5, ES = -.10 year 1; 13.6 SB2, 11.7 JUMP, p = .3, ES = -.11 year 2, see Fig 5 panel c). All of the gains for PSP and CBC were significantly greater than zero (PSP both p ‘s < .0001 year 1; p = .0003 SB2, p < .0001 JUMP year 2; CBC all p’s < .0001).
High fidelity (HiFi) analysis
Primary students: Main outcomes
The results for the primary HiFi students are shown in Fig 6. As the Fig shows, the overall pattern of findings was in line with the results obtained for the PP primary sample, with the differences between groups generally becoming more pronounced. For broad math, there was a significant advantage to the SB2 group in year 1 (4.4 SB2, 0.9 JUMP, p = .003, ES = -.24), but the JUMP group progressed significantly more in year 2 (-2.5 SB2, 1.00 JUMP; p = .008, ES = .26). There was no significant difference in progress between the groups in the summertime (-4.6 SB2, -3.2 JUMP, p = .2, ES = .13). In contrast, for broad reading, there were no significant differences between the groups in year 1 (0.6 SB2, 0.8 JUMP, p = .8, ES = .03) or the summer (-2.8 SB2, -3.0 JUMP, p = .7, ES = -.05), but the JUMP group made significantly greater progress in year 2 (-1.0 SB2, 1.1 JUMP, p = .01, ES = .30; see Fig 6 panel a).
Fig. 6. Results for the high fidelity primary students. Results for students who received high fidelity instruction. Broad Math (left side of panel a) is based on performance on applied problems, calculation and math fluency (shown separately in panel b). Vertical lines indicate 95% confidence limits around mean change scores. P-values and effect sizes in the Fig are for the difference between the group means. Results for the Woodcock-Johnson III measures are based on standard scores and therefore indicate progress relative to same aged peers, which is represented by the 0 line. Vertical lines that do not intersect the 0 line indicate mean change that is significantly different from expected change, based on test norms for the standardized measures (panels a and b) and 0 change for the supplementary measures (panel c). As before, this pattern of findings was corroborated when we compared within group performance to expected progress based on test norms. For broad math, the SB2 group progressed significantly more than expected in year 1 (p < .0001) and less than expected in year 2 (p < .03), while the JUMP group progress was not significantly different from expected in either year (both p’s = .3). Both groups progressed significantly less than expected in the summer (p’s < .0001). For broad reading, neither group’s gains were significantly different from expected, in either year (p = .2 SB2, p = .07 JUMP for both years).
The results for broad math for the HiFi sample reflect the results for all three WJ-III math achievement measures. In year 1, the SB2 group made significantly more progress than the JUMP group on applied problems (5.8 SB2, 3.4 JUMP, p = .05, ES = -.16) and math fluency (2.7 SB2, 0.3 JUMP p = .04, ES = -.20) but not on calculation (-1.6 SB2, -3.2 JUMP, p = .3, ES = -.09). However, in year 2, the JUMP group made significantly greater gains on applied problems (-2.2 SB2, 1.3 JUMP, p = .02, ES = 0.24) and there were no significant differences between the groups on either math fluency (1.4 SB2, 1.6 JUMP, p = .9, ES = .01) or calculation (-2.1 SB2, 0.1 JUMP, p = .2, ES = .13; see Fig 6 panel b).
Comparing within group progress to expected growth we found that for applied problems, both groups improved significantly more than expected in year 1 (p < .0001 SB2, p = .0001 JUMP), significantly less than expected in the summer (p = .02 SB2 and p = .003 JUMP) and their progress was not significantly different from expected in year 2 (p = .09 SB2, p = .2 JUMP). For math fluency, the SB2 group advanced significantly more than expected in year 1 (p = .009) and as much as expected in year 2 (p = .3), while the JUMP group advanced as much as expected in both years (p = .7 year1, p = .2 year 2). Both groups advanced significantly less than expected in the summer (p’s < .0001). For calculation, progress in the SB2 group was not significantly different from expected in both years and significantly less than expected in the summer (p’s = .2 year 1 and year 2, p < .0001 summer). The JUMP group progressed significantly less than expected in year 1 and in the summer but grew as much as expected in year 2 (p = .003 year 1, p = .002 summer, p = .9 year 2).
Primary students: supplementary outcomes
The results for PSP and CBC for the HiFi primary sample were also in line with the results for the PP primary sample. For PSP, the groups did not differ significantly in year 1 (5.2 SB2, 4.2 JUMP, p = .4, ES = -.12) but the JUMP group grew significantly and substantially more than the SB2 group in year 2 (0.6 SB2, 7.6 JUMP, p = .0001, ES = .54). For CBC, progress in the two groups did not differ significantly in either year (7.9 SB2, 8.00 JUMP, p >.9, ES = .01 year 1; 16.9 SB2, 13.1 JUMP, p = .2, ES = -.16 year 2, see Fig 6 panel c). Finally, for PSP, both groups made significant gains in year 1 and only the JUMP group made significant gains in year 2 (significant p’s < .0001, p = .7 SB2 year 2), and for CBC both groups made significant gains in both years (all p’s < .0001).
Teachers
Teachers’ reports of their experience teaching math in the study year (s) were generally favourable in both groups and across study grades and none of the differences between groups were significant (based on Wilcoxon rank sum tests; M grade 2 : 7.8 SB2, 7.1 JUMP; grade 3 : 7.4 SB2, 7.5 JUMP; grade 5 : 7.7 SB2, 8.0 JUMP; grade 6 : 7.3 SB2, 6.6 JUMP).
Discussion
Junior students
Performance by the junior students was fairly stable across the three time periods. Even in the summer break when students usually experience losses [39], both groups’ progress was in keeping with that of same aged peers (based on available norms).
A key finding for the junior students was that we replicated the positive effect of JUMP instruction on math fluency that we found in the pilot study. These effects were already apparent in year 1 when the JUMP group made significantly greater gains than the SB2 group and only the JUMP group made significantly greater than expected gains based on available norms. It is possible that the advantage to the JUMP group on math fluency in year 1 facilitated their greater overall progress, as shown by significantly greater progress on broad math, in year 2.
Indeed, the JUMP group’s greater growth on broad math in year 2 is notable given our findings regarding implementation fidelity suggesting somewhat diluted program delivery in the SB2 group in year 2. Although the participation rate for the observations was comparable in the JUMP (68%) and SB2 groups (67%) in year 2, only 12% of the observed JUMP teachers were coded as using the SB2 group methods whereas 36% of the observed SB2 teachers who were coded as using JUMP instruction. Moreover, amongst those observed SB2 teachers who used their assigned method of instruction, almost half had relatively low alignment scores (less than 5 on a 7-point scale). As a group, the SB2 teachers spent relatively more time on direct instruction and less on facilitation, and their students spent more time working individually than in small groups, which is more similar to what we would expect to see in a JUMP class. These departures from SB2 instruction may have contributed to the finding that the SB2 students also progressed significantly more than expected on math fluency in year 2 (but not in year 1 or the summertime, based on test norms) and hence that the difference between the groups in year 2 was not significant.
We did not find a notable JUMP advantage on CBC, another computation measure, but this could be due to an apparent floor effect. Both groups made significant progress in year 1 and only the JUMP group made significant progress in year 2. But scores in both groups were very low at baseline and overall gains in both groups were limited. We vetted the CBC measure with non-study teachers prior to the scale-up study but it remains possible that the grade 5/6 Canadian curriculum is not optimally aligned with the content of the grade 5/6 CBC, which is an American measure.
A surprising finding was that the SB2 group did not fare significantly better than the JUMP group on either measure of problem solving, in any time period. Indeed, the SB2 group did not show any significant advantages even in year 1 when both teachers and students in JUMP classrooms were new to JUMP (which might have slowed progress temporarily), and in the face of high implementation fidelity. We observed all but 1 of the participating grade 5 teachers in year 1 and the large majority was using their randomly assigned curriculum with high alignment and coder confidence.
Finally, as in the pilot study, the finding that there were no group differences on broad reading in the scale up study (in any time period) suggests that, for the junior students, the significant effects of JUMP instruction were specific to math learning.
Primary students
A different pattern of results emerged for the primary students. In general, math progress was less stable for the primary students compared to their junior counterparts, with both groups losing substantial ground in the summertime when the students likely did not receive formal instruction. Furthermore, whereas the SB2 students made greater progress overall in year 1, the JUMP students experienced greater gains, on some measures, in year 2. This pattern of results became more pronounced when we restricted the analyses to only those students whose teachers were observed and who received high fidelity instruction.
The key finding for the primary students was an effect of curriculum on problem solving that varied from year to year. Although both groups made substantial gains, the SB2 group significantly outperformed their JUMP peers on applied problems in year 1 (a finding that obtained in both the PP and HiFi samples). However, the advantage to the SB2 group did not persist. Gains in the two groups did not differ significantly in the summertime for either the PP or the HiFi samples nor for the PP sample in year 2, and it is worth mentioning that we found significantly greater gains in the JUMP for the HiFi sample in year 2. The two groups made similar gains on PSP in year 1 but here as well the JUMP group made significantly greater gains than the SB2 group in year 2 (for both the PP and HiFi samples).
The change in direction of the group means from year to year along with our results for implementation fidelity suggest that, for primary students, the benefits of JUMP for problem solving may take time to manifest. In the first year, both the JUMP group teachers and their students were adapting to a new approach to math instruction while the SB2 group teachers and students continued to use their usual, problem based methods. However in the second year, only the teachers who inherited JUMP group students were new to JUMP, not the students. As implementation fidelity was consistently high from year to year (the large majority of teachers were coded as using their assigned curriculum with high alignment and coder confidence), the results suggest that students in the JUMP group may have experienced latent gains in year 1 that contributed to greater, discernible gains on problem solving in year 2.
All of the primary students initially struggled to make gains on calculation. With its steep item gradient and only a few items that are covered by the early elementary curriculum students would have to advance considerably for detectable effects within a single school year. This may have been especially challenging for the JUMP teachers and students in year 1 as they adapted to the new program. The SB2 group made significantly greater gains in year 1 (for the PP sample but not the HiFi sample) and whereas the SB2 group advanced as much as expected, the JUMP students lost significant ground in year 1 (PP and HiFi samples). But note that the SB2 group lost significantly more ground in the summertime (for the PP sample) and that performance was strongest overall in year 2 when both groups advanced as much as expected (PP and HiFi samples). Thus, an initial buffer against losses for the SB2 students on calculation in year 1 was no longer apparent by the summertime or in year 2.
In general, the two groups performed comparably on math fluency in all time periods. Indeed, the only group difference for math fluency was for the HiFi sample in year 1 when the students in the SB2 group made significantly greater gains than their JUMP peers. But as with calculation, this advantage was not apparent in year 2 (when only the JUMP group made greater than expected gains). For CBC, none of the between group differences were significant (both groups made significant gains in both years, with somewhat greater gains in year 2).
It is interesting that we also found a significant, positive effect of JUMP on broad reading in year 2 (for the PP and the HiFi samples). Given previous research linking affect (such as anxiety and mindset) with math achievement [27, 61, 62], it could be that latent positive effects on math achievement experienced in year 1 bolstered the primary JUMP group’s confidence in their learning, with spillover effects for academic progress more broadly in year 2. This interpretation is in line with Duncan et al’s meta-analysis investigating the contribution of pre-K math and reading skills to academic achievement at the end of elementary school that found that while pre-K math predicts later math achievement (.42) and pre-K reading predicts later reading achievement (.24), pre-K math also predicts later reading (.26) and more strongly than pre-K reading predicts later math (.10) [9]. In other words, early positive experiences with math learning may influence children’s academic self-efficacy more generally. Younger children may be more pliable compared to their older peers in this regard as they may have less entrenched beliefs about their academic abilities.
Finally, unlike the pilot study, the JUMP teachers in the scale-up study did not rate their math teaching experience in the study period more favourably than their comparison peers. But note that all of the groups’ ratings were generally positive.
General discussion
The present research investigated the effectiveness of JUMP Math, a distinctive approach to math instruction whose key ideas find support in the scientific literature, for improving elementary math achievement. Specifically, we asked if elementary students who received JUMP instruction experienced greater progress in math achievement compared to their same grade peers who received the extant, problem-based approach (the school board or SB students) over the study period. We first carried out a brief pilot study with a relatively small sample of grade 5 (junior) students and their teachers that yielded preliminary evidence of a positive effect of JUMP and suggested that an RCT was feasible. A subsequent, scale-up RCT conducted over two consecutive school years sought to replicate and extend the pilot study findings with a larger sample of junior and primary students and their teachers, and a broader range of outcomes that included measures of students’ ability to apply their mathematical knowledge.
The main findings for the junior students were early positive effects of JUMP instruction on math fluency that persisted over time, when the JUMP group also began to gain some traction on calculation. Their performance on problem solving was comparable to the comparison group in all time periods. That the positive impact of JUMP on computation obtained in two studies conducted with two different school boards strengthens their validity (we did not measure problem solving in the pilot study).
The positive impact on math fluency is an important finding because automatized math facts become stored in long-term memory thus freeing up limited working memory resources that can then be directed towards the conceptual aspects of the math to be learned (such as problem-solving). Previous developmental and neuroscience research has linked the tendency to rely on mathematical procedures (that tax working memory) with poorer math achievement and retrieving mathematical facts from long-term memory with better math achievement. (see e.g. [63–66]) As previously mentioned, significant gains in fluency in year 1 may have helped the JUMP group to make greater overall advances in math in year 2. While performance on standardized measures of math fluency is robustly, positively correlated with performance on applied problems [67], the beneficial impact of JUMP instruction on computation may take longer to manifest on measures of problem solving. Such benefits may have been obscured in the scale up study by the somewhat diluted program delivery in the comparison group teachers in year 2. Note as well, that individual differences in math fluency have been linked to individual differences in the precision of mental number representations and with mental number line linearity, with better fluency related to greater precision and linearity. [68, 69] Taken together, these findings suggest that the benefits of JUMP instruction for the junior students may extend beyond computational skill.
The lack of an SB2 group advantage on problem solving for the junior students is noteworthy because the students in the SB2 group had considerable experience with problem based math instruction coming into the study. The absence of an effect on PSP is particularly striking as the students are used to showing their work and to receiving feedback about the extent to which their answers meet curriculum expectations in their daily lessons. These results are important as they indicate that the positive impact of JUMP instruction on math fluency, can occur without concurrent detriment to progress in problem solving. As mentioned above, improved performance on computation may also confer benefits for problem solving that become discernible in time.
The pattern of results was different for the primary students. Notably, the SB2 group had a significant advantage on measures of problem solving and computation in year 1. This could be because the teachers and students in the SB2 group were using a familiar approach to math instruction while those in the JUMP group were adapting to a new program. The SB2 teachers also continued to receive pedagogical support (as per usual practice). Furthermore, as the SB2 group was using their business-as-usual approach, those teachers also had the benefit of the “community of practice” in their schools while the only teachers using JUMP in the JUMP schools were the grade 2 and grade 5 teachers participating in the study. The stronger performance by the SB2 students in year 1 may thus reflect potential gains with all of these supports in place. But note that the apparent advantages to the SB2 students in year 1 did not persist into year 2.
Indeed, a surprising and important finding was that the JUMP students significantly outperformed their SB2 peers on problem solving in year 2. The benefits to the JUMP group on PSP in particular, were considerable (effect size .26 PP sample, .54 HiFi sample). PSP items are based on problems that have been used in previous years on the regional assessment written annually at the end of grades 3 and 6. Problems are scored according to publicly available guidelines out of 40, with increments of 10 corresponding to a letter grade (e.g. a score between 30 to 40 is in the A range, between 20 and 30 the B range and so on). The observed gains in the JUMP group primary students in year 2 (PP Sample, JUMP 6.2 vs. SB2 3.3 points; HiFi sample, JUMP 7.6 vs. SB2 .6 points) thus correspond to a mean gain of more than half a letter grade, which is a substantial improvement in problem solving.
That the primary students in the JUMP group did not make significantly greater gains on the computational measures compared to their SB2 peers may be because the computational demands in grades 2 and 3 are still sufficiently low that children in the SB2 group could use alternative strategies (such as counting on) to arrive at solutions and perhaps a persistent focus by the students in both groups on problem solving, the approach to instruction the younger children had likely experienced from the start of formal schooling. After temporarily losing ground in progress on calculation by the JUMP group in year 1, the two groups of primary students made similar gains on the computation measures in year 2.
The finding that the primary students lost significant ground in the summertime is consistent with the results from a previous meta-analysis showing substantial summer losses in math. [39] Apart from significantly smaller losses on calculation by the JUMP group in the PP sample, neither group had an overall advantage here. It is not clear why both groups of junior students continued to keep pace with norms even in the summertime since the meta-analysis found that so called summer slide tended to increase with grade level. But note that the research reported predated the implementation of problem-based math instruction, which might have impacted the relation between summer slide in math and grade level.
In sum then, junior students who received JUMP instruction made greater progress on computation, with effects taking hold in the first year of the study, and both groups made similar, concurrent advances in problem solving. In contrast, primary students who received their usual, problem-based math instruction made greater progress on problem-solving and computational measures in the first year. The positive effect of JUMP instruction on primary students took time to manifest, appearing in the second year, and the main impact—on problem solving—occurred without lasting, detriment to progress in computation. The results for both divisions on problem solving are important as problem solving is widely believed to require a deep, conceptual understanding of math and developing good problem solving skills is arguably the goal of contemporary math education [22–23]. It is possible that the gains observed in the JUMP students in both divisions on some measures may have a positive influence on progress on the other measures once children, and also their teachers, have fully transitioned to JUMP pedagogy.
Strengths
Strengths of the present research include random assignment at the school level to curricula, the use of standardized and curriculum-based math outcomes, and the inclusion of computation as well as problem solving measures. Teachers in both groups were able to achieve good implementation fidelity, for those in the JUMP group with relatively little PD, indicating that teachers can take up and implement the JUMP Math program quickly. This, together with the availability of explicit teacher’s guides, smart board lessons and student materials and the teachers’ generally positive experience working with JUMP, suggests that the program that is implementation ready and teacher friendly.
Indeed, a particular strength of the present research was that in both studies we investigated the effectiveness (impact in typical, real-world conditions) as opposed to the efficacy (potential impact in ideal conditions) of the JUMP Math program. Teachers in both groups received PD that was in line with their respective curricula and we did not intervene with program delivery while the study was underway (e.g. to improve implementation fidelity). Children received the same amount and the same schedule of math instruction they normally received prior to study participation. Moreover, the large majority of students were taught by different teachers in the two consecutive school years of the scale-up study, which is typical of what would normally occur in most elementary schools. In addition to standardized measures, we also included math outcome measures that reflect the way that children are expected to approach their daily math work (in the scale up study); they are required to show and often to justify their work and are given credit for appropriate steps taken as well as for producing the correct solution. Moreover, all of the data were collected and coded by teachers with experience working with children who were blind to the study hypotheses and to random assignment to curricula, and who were not otherwise involved in the study. The results of the present research thus provide a good sense of the effects that could arise in the relatively short-term when adopting the JUMP program.
A further strength of the scale-up study was the generally high rate of participation in the teacher observations that provided implementation fidelity data critical to interpreting the student outcomes. That said, we acknowledge that a planned observation of one math class per teacher at mid-year may be limited in its representation of the type of instruction children experienced on a daily basis. We reasoned that more frequent observations might have lowered the participation rate and, more importantly, altered implementation fidelity and the classroom culture more generally, which could influence the study results and their generalizability. However, it remains possible that the teachers in both groups supplemented their assigned approach to math instruction and thus that there may have been some overlap in their math pedagogy.
That the observation participation rate was lower in year 2 compared to year 1 (67–82% year 2 vs. 88–100% year 1), might have been due to differences in teacher motivation. Year 1 teachers consented prior to random assignment to curricula while year 2 teachers joined the study after the randomly assigned curricula were already in place and thus did not share in any excitement that might have surrounded the outcome of random assignment and the launch of a new study. Year 1 teachers in the comparison group also received an additional half-day of math PD delivered by a widely recognized expert in math pedagogy of their choosing. Finally, year 2 teachers may have been somewhat stressed about participating in the study in a high-stakes testing year.
But note that these findings cannot explain the decline in performance in the primary comparison group students from year 1 to year 2 as any effect on teacher motivation in year 2 would have impacted both groups roughly equally. Moreover, the rate of teacher participation in the observations (88% grade 2, 78% grade 3), mean alignment (5.3 grade 2, 4.9 grade 3) and coder confidence (4.2 both years) scores were consistently high, and the incidence of assigned/observed curriculum incongruence (3 classes grade 2, 4 classes grade 3) was similarly low, in the primary division from year to year.
Limitations
One limitation is that the scale-up study involved schools from a single school board (district). However, the board was fairly large, included both urban and rural schools, and the board results from the most recent regional assessment of academic progress indicated a pattern of findings generally in line with the pattern for the region. The present findings are therefore likely to generalize to other comparable school boards. This notion is supported by the fact that we obtained similar results for the junior students for computation in the pilot and scale up studies that were conducted in different school boards.
Another limitation is that it is possible that the study design may have introduced some bias in the results for the SB2 group. Teachers in the SB2 group received two days of PD, to equate the PD time in the two groups, and year 1 teachers in the scale up study received the additional half day, which is more math focused PD than elementary teachers received prior to the study. Consequently, performance in the SB2 group might have over estimated the gains students would normally have achieved, especially in year 1.
A further limitation is that we were unable to carry out intent-to-treat analysis, which includes all participants randomly assigned to the two groups whether or not they received treatment or later withdrew from the study and is required for a clinical trial. As 2 schools in the pilot study and 1 school in the scale-up study (in the SB1 and SB2 groups, respectively) dropped out after random assignment, we were unable to proceed with recruitment or assessment of the eligible students in those schools. It is therefore not possible to know how data that might have been collected from those students could have influenced the study outcome. On the other hand, the overall completion rate for students over the two years of the study was fairly high.
Note as well that as the large majority of the participating students had different teachers in the two years of the scale-up study, the present study cannot speak to effects that might occur when both teachers and students are familiar with JUMP Math instruction (the number of teachers who participated in both years was too small for meaningful analysis). The possibility of latent gains in year 1 of the scale up study by the JUMP group primary students that became discernible in year 2 suggests that benefits might accrue with greater familiarity. Schools considering taking on the JUMP Math program would therefore do well to commit to a trial period that includes sufficient time when teachers and students have experience working with the program for a fair evaluation.
Finally, the present research also cannot speak to the active ingredients of either the JUMP or SB pedagogy that might have brought about the observed effects. Regarding the positive impact of JUMP, we hypothesize that tailored scaffolding of instruction allows children of all skill levels to experience success at math and that this experience promotes a sense of agency that motivates further efforts that ultimately lead to greater success.
Conclusions
Randomized controlled trials that evaluate the effectiveness of different approaches to math instruction are essential for helping educators to make informed decisions about how best to invest limited resources while maximizing student gains. In making sense of this research, it may be helpful to keep two considerations in mind. First, as instructional programs represent a constellation of features, that vary from program to program, different programs are likely to impact different outcomes, differentially. In other words, it is unlikely that this research will uncover a so-called silver bullet that brings about large, positive effects across the board, especially in the earliest years of adoption. Second, most evaluation research involves at least one experimental group that receives the novel program and a comparison group that continues to use the methods of instruction that are already in place (i.e. a business-as-usual group), and then comparing the groups’ growth on target outcomes. This means that the groups differ not only in type of instruction, but also in the students’ and teachers’ experience working with them. Effects of the intervention may take time to manifest and may be attenuated while teachers and students are still becoming familiar with it, especially so if the new program differs substantially from previous methods. A new approach to math instruction that yields positive effects on some key measures without concurrent slowing of progress on other key measures in the short-term, when this transition is still underway, may hold considerable promise for more wide-spread, longer term gains. Especially if math achievement scores appear intractable or are declining, the new approach to math instruction may well be a worthy investment.
The relative ease with which teachers were able to take up the JUMP Math program and its positive impact, even in the relatively short-term, on key measures of student math progress point to a viable alternative for math instruction that could be a valuable, evidence-based addition to the teacher’s toolbox. Math instruction programs can impact math learning. Given the role of numeracy in 21st century employability and overall well being, identifying and implementing effective approaches to early math instruction could have far-reaching, positive implications.
Supporting information
S1 Text [docx]
Supporting information.S1 Dataset [xlsx]
Pilot study data.S2 Dataset [xlsx]
Scale-Up study data.
Zdroje
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- Impact of group antenatal care (G-ANC) versus individual antenatal care (ANC) on quality of care, ANC attendance and facility-based delivery: A pragmatic cluster-randomized controlled trial in Kenya and Nigeria
- The relationship between management practices and the efficiency and quality of voluntary medical male circumcision services in four African countries
- Using AST-platelet ratio index and fibrosis 4 index for detecting chronic hepatitis C in a large-scale community screening
- Incidence and predictors of retreatment in chronic hepatitis B patients after discontinuation of entecavir or tenofovir treatment
- Elderly HIV-positive women: A gender-based analysis from the Multicenter Italian “GEPPO” Cohort
- Attitudes and perceptions towards hypoglycaemia in patients with diabetes mellitus: A multinational cross-sectional study
- Plasma mitochondrial DNA is elevated in obese type 2 diabetes mellitus patients and correlates positively with insulin resistance
- [Fam-] trastuzumab deruxtecan (DS-8201a)-induced antitumor immunity is facilitated by the anti–CTLA-4 antibody in a mouse model
- A global spatial analysis reveals where marine aquaculture can benefit nature and people
- Association between mitochondrial genetic variation and breast cancer risk: The Multiethnic Cohort
- Incorporating evaporative water loss into bioenergetic models of hibernation to test for relative influence of host and pathogen traits on white-nose syndrome
- Feasibility and effectiveness of electronic vs. paper partograph on improving birth outcomes: A prospective crossover study design
- Fisheries governance in the face of climate change: Assessment of policy reform implications for Mexican fisheries
- Modeling sediment oxygen demand in a highly productive lake under various trophic scenarios
- Spread of domestic animals across Neolithic western Anatolia: New stable isotope evidence from Uğurlu Höyük, the island of Gökçeada, Turkey
- Relationship of the lobular branch of the great auricular nerve to the tympanoparotid fascia: Spatial anatomy for salvage during face and neck lift
- Assessing precision and requirements of three methods to estimate roe deer density
- Systematic review and REMARK scoring of renal cell carcinoma prognostic circulating biomarker manuscripts
- Assessing the potential of plains zebra to maintain African horse sickness in the Western Cape Province, South Africa
- Biomechanical effects of rocker shoes on plantar aponeurosis strain in patients with plantar fasciitis and healthy controls
- Age, body weight and ovarian function affect oocyte size and morphology in non-PCOS patients undergoing intracytoplasmic sperm injection (ICSI)
- RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance
- Gut microbiome diversity is associated with sleep physiology in humans
- Geospatial analysis of the influence of family doctor on colorectal cancer screening adherence
- Can machine learning improve patient selection for cardiac resynchronization therapy?
- The rotating magnetocaloric effect as a potential mechanism for natural magnetic senses
- Nutrigenomic effect of conjugated linoleic acid on growth and meat quality indices of growing rabbit
- Restriction enzymes use a 24 dimensional coding space to recognize 6 base long DNA sequences
- Hypoxia induction in cultured pancreatic islets enhances endothelial cell morphology and survival while maintaining beta-cell function
- Assessment of community knowledge, practice, and determinants of malaria case households in the rural area of Raya Azebo district, Northern Ethiopia, 2017
- Leadership in informal stormwater governance networks
- Early diagnosis of Alzheimer’s disease using combined features from voxel-based morphometry and cortical, subcortical, and hippocampus regions of MRI T1 brain images
- Health related quality of life in sepsis survivors from the Prehospital Antibiotics Against Sepsis (PHANTASi) trial
- The dialogue between protozoa and bacteria in a microfluidic device
- Are dialects socially learned in marmoset monkeys? Evidence from translocation experiments
- A new carcharodontosaurian theropod (Dinosauria: Saurischia) from the Lower Cretaceous of Thailand
- Using remote sensing to detect whale strandings in remote areas: The case of sei whales mass mortality in Chilean Patagonia
- Americans preferred Syrian refugees who are female, English-speaking, and Christian on the eve of Donald Trump’s election
- Class III β-tubulin expression as a predictor of docetaxel-resistance in metastatic castration-resistant prostate cancer
- Quantitative assessment of acetabular bone defects: A study of 50 computed tomography data sets
- HaTSPiL: A modular pipeline for high-throughput sequencing data analysis
- The feasibility of using citizens to segment anatomy from medical images: Accuracy and motivation
- Bacterial diversity in Icelandic cold spring sources and in relation to the groundwater amphipod Crangonyx islandicus
- Pathogen surveillance in the informal settlement, Kibera, Kenya, using a metagenomics approach
- Movement and habitat selection of the western spadefoot (Spea hammondii) in southern California
- African-American and Caucasian participation in postmortem human brain donation for neuropsychiatric research
- Two-dimensional fruit quality factors and soil nutrients reveals more favorable topographic plantation of Xinjiang jujubes in China
- The burden of oral conditions among adolescents living with HIV at a clinic in Johannesburg, South Africa
- The impact of peer pressure on cigarette smoking among high school and university students in Ethiopia: A systemic review and meta-analysis
- Substitution of marijuana for opioids in a national survey of US adults
- Strategies for the hypothermic preservation of cell sheets of human adipose stem cells
- Active hepatocellular carcinoma is an independent risk factor of direct-acting antiviral treatment failure: A retrospective study with prospectively collected data
- Microliths in the South Asian rainforest ~45-4 ka: New insights from Fa-Hien Lena Cave, Sri Lanka
- Transgenic cotton and farmers’ health in Pakistan
- Social media as a data resource for #monkseal conservation
- A novel short-term high-lactose culture approach combined with a matrix-assisted laser desorption ionization-time of flight mass spectrometry assay for differentiating Escherichia coli and Shigella species using artificial neural networks
- Common pre-diagnostic features in individuals with different rare diseases represent a key for diagnostic support with computerized pattern recognition?
- Automated clear cell renal carcinoma grade classification with prognostic significance
- Comparative genomic analyses reveal diverse virulence factors and antimicrobial resistance mechanisms in clinical Elizabethkingia meningoseptica strains
- Reading-out task variables as a low-dimensional reconstruction of neural spike trains in single trials
- ‘Fat’s chances’: Loci for phenotypic dispersion in plasma leptin in mouse models of diabetes mellitus
- Economic sanctions and academia: Overlooked impact and long-term consequences
- Evaluation of soybean genotypes for reaction to natural field infection by Cercospora species causing purple seed stain
- Trajectories of prescription opioids filled over time
- Quandong stones: A specialised Australian nut-cracking tool
- Tripeptide Arg-Gly-Asp (RGD) modifies the molecular mechanical properties of the non-muscle myosin IIA in human bone marrow-derived myofibroblasts seeded in a collagen scaffold
- Functional models in genome-wide selection
- Average volume reference space for large scale registration of whole-body magnetic resonance images
- Model based estimation of population total in presence of non-ignorable non-response
- ESLI: Enhancing slope one recommendation through local information embedding
- Self-adaptive dual-strategy differential evolution algorithm
- Projected urban growth in the southeastern USA puts small streams at risk
- Adverse prognosis of glioblastoma contacting the subventricular zone: Biological correlates
- Widespread chytrid infection across frogs in the Peruvian Amazon suggests critical role for low elevation in pathogen spread and persistence
- Dysfunction of the blood-brain barrier in postoperative delirium patients, referring to the axonal damage biomarker phosphorylated neurofilament heavy subunit
- A low latency and low power indirect topology for on-chip communication
- Development and application of a framework to estimate health care costs in China: The cervical cancer example
- New oral anti-coagulants versus vitamin K antagonists in high thromboembolic risk patients
- Enriched taxa were found among the gut microbiota of centenarians in East China
- Model-based QTL detection is sensitive to slight modifications in model formulation
- Modeling the residential distribution of enrolled students to assess boundary-induced disparities in public school access
- A brief diet intervention can reduce symptoms of depression in young adults – A randomised controlled trial
- Associations of MGMT promoter hypermethylation with squamous intraepithelial lesion and cervical carcinoma: A meta-analysis
- Differences in energy and nutritional content of menu items served by popular UK chain restaurants with versus without voluntary menu labelling: A cross-sectional study
- The association between disordered eating and health-related quality of life among children and adolescents: A systematic review of population-based studies
- Prescribing patterns of polypharmacy in Korean pediatric patients
- Factors associated with directly observed treatment in tuberculosis/HIV coinfection cases in Porto Alegre, 2009-2013: A retrospective cohort
- Evaluation of date palm pollen (Phoenix dactylifera L.) encapsulation, impact on the nutritional and functional properties of fortified yoghurt
- Association between maternal fermented food consumption and infant sleep duration: The Japan Environment and Children's Study
- Discerning the functional networks behind processing of music and speech through human vocalizations
- Preference-based serial decisions are counterintuitively influenced by emotion regulation and conscientiousness
- Subgenotyping and genetic variability of hepatitis C virus in Palestine
- Supra-threshold perception and neural representation of tones presented in noise in conditions of masking release
- Measuring sustainability of seed-funded earth science informatics projects
- Contrast-enhanced spectral mammography with a compact synchrotron source
- Assessing the role of toll-like receptor in isolated, standard and enriched housing conditions
- Inequality in income change among cancer survivors five years after diagnosis: Evidence from a French national survey
- A novel fast-slow model of diabetes progression: Insights into mechanisms of response to the interventions in the Diabetes Prevention Program
- Integrated HIV surveillance finds recent adult hepatitis B virus (HBV) transmission and intermediate HBV prevalence among military in uncharacterized Caribbean country
- Declared impact of the US President’s statements and campaign statements on Latino populations’ perceptions of safety and emergency care access
- Two novel and correlated CF-causing insertions in the (TG)mTn tract of the CFTR gene
- Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis
- Practice and factors associated with active management of third stage of labor among obstetric care providers in Amhara region referral hospitals, North Ethiopia, 2018: A cross sectional study
- Animal-assisted therapy for patients in a minimally conscious state: A randomized two treatment multi-period crossover trial
- Macular thickness measurements of healthy, naïve cynomolgus monkeys assessed with spectral-domain optical coherence tomography (SD-OCT)
- Rice bran oil ameliorates inflammatory responses by enhancing mitochondrial respiration in murine macrophages
- Organ preservation solution containing dissolved hydrogen gas from a hydrogen-absorbing alloy canister improves function of transplanted ischemic kidneys in miniature pigs
- The effect of ‘Traffic-Light’ nutritional labelling in carbonated soft drink purchases in Ecuador
- Forma mentis networks quantify crucial differences in STEM perception between students and experts
- A population-based cohort study examining the association of documented bladder diverticulum and bladder cancer risk in urology patients
- Framework for rational donor selection in fecal microbiota transplant clinical trials
- HLA high-resolution typing by next-generation sequencing in Pandemrix-induced narcolepsy
- Health assessment of Conolophus subcristatus, Conolophus pallidus, and C. subcristatus X Amblyrhynchus cristatus hybrid (Galápagos land iguanas)
- Prognostic value of post-induction chemotherapy 18F-FDG PET-CT in stage II/III non-small cell lung cancer before (chemo-) radiation
- Risk factor-based subphenotyping of heart failure in the community
- An efficient and adaptive data-hiding scheme based on secure random matrix
- Endovascular treatment of different types of iliac occlusions—Results from an observational study
- Variation in pickleweed root-associated microbial communities at different locations of a saline solid waste management unit contaminated with petroleum hydrocarbons
- Consumption of rice, acceptability and sensory qualities of fortified rice amongst consumers of social safety net rice in Nepal
- Quantitative analysis of the bilateral coordination and gait asymmetry using inertial measurement unit-based gait analysis
- Application of metagenomic shotgun sequencing to detect vector-borne pathogens in clinical blood samples
- Higher underestimation of tumour size post-neoadjuvant chemotherapy with breast magnetic resonance imaging (MRI)—A concordance comparison cohort analysis
- Wealth accumulation in rotation forestry – Failure of the net present value optimization?
- Increased incidence of age-related macular degeneration in sensorineural hearing loss: A population-based cohort study
- Evaluating the foundations that help avert antimicrobial resistance: Performance of essential water sanitation and hygiene functions in hospitals and requirements for action in Kenya
- Effects of a hot ambient operating theatre on manual dexterity, psychological and physiological parameters in staff during a simulated burn surgery
- Introduction of quality management in a National Reference Laboratory in Germany
- Histopathological investigation of complex gill disease in sea farmed Atlantic salmon
- Common variants in glyoxalase I do not increase chronic pancreatitis risk
- Cognitive impairment in multiple sclerosis: An exploratory analysis of environmental and lifestyle risk factors
- Japanese nationwide survey of hypophosphatasia reveals prominent differences in genetic and dental findings between odonto and non-odonto types
- Interaction of detergents with biological membranes: Comparison of fluorescence assays with filtration protocols and implications for the rates of detergent association, dissociation and flip-flop
- Potential causes of early death among admitted newborns in a rural Tanzanian hospital
- Identification of glomerular and podocyte-specific genes and pathways activated by sera of patients with focal segmental glomerulosclerosis
- Prevalence and correlates of partner violence among adolescent girls and young women: Evidence from baseline data of a cluster randomised trial in Tanzania
- Development of an integrated fingerstick blood self-collection device for radiation countermeasures
- Concordance between gene expression in peripheral whole blood and colonic tissue in children with inflammatory bowel disease
- Effects of arthroscopic vs. mini-open rotator cuff repair on function, pain & range of motion. A systematic review and meta-analysis
- Broiler welfare trade-off: A semi-quantitative welfare assessment for optimised welfare improvement based on an expert survey
- Engagement in care among women and their infants lost to follow-up under Option B+ in eSwatini
- Hyperglycemia in the early stages of type 1 diabetes accelerates gastric emptying through increased networks of interstitial cells of Cajal
- Nanoaperture fabrication via colloidal lithography for single molecule fluorescence analysis
- A rapid, low pH, nutrient stress, assay to determine the bactericidal activity of compounds against non-replicating Mycobacterium tuberculosis
- Sialochemical analysis in polytraumatized patients in intensive care units
- The black sheep effect: The case of the deviant ingroup robot
- No relationship between fornix and cingulum degradation and within-network decreases in functional connectivity in prodromal Alzheimer’s disease
- Implementation of an international standardized set of outcome indicators in pregnancy and childbirth in Kenya: Utilizing mobile technology to collect patient-reported outcomes
- Breastfeeding support through wet nursing during nutritional emergency: A cross sectional study from Rohingya refugee camps in Bangladesh
- Does route matter? Impact of route of oxytocin administration on postpartum bleeding: A double-blind, randomized controlled trial
- Research on OpenCL optimization for FPGA deep learning application
- Drug therapy problems, medication adherence and treatment satisfaction among diabetic patients on follow-up care at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia
- Quality of life and symptom intensity over time in people with cancer receiving palliative care: Results from the international European Palliative Care Cancer Symptom study
- The dynamics of Early Celtic consumption practices: A case study of the pottery from the Heuneburg
- Safety and efficacy of artesunate-amodiaquine combined with either methylene blue or primaquine in children with falciparum malaria in Burkina Faso: A randomized controlled trial
- “Cementing” marriages through childbearing in subsequent unions: Insights into fertility differentials among first-time married and remarried women in Ghana
- Single session high definition transcranial direct current stimulation to the cerebellum does not impact higher cognitive function
- The contribution of age structure to the international homicide decline
- Genetic structure of Mexican lionfish populations in the southwest Gulf of Mexico and the Caribbean Sea
- A physiological dose of oral vitamin B-12 improves hematological, biochemical-metabolic indices and peripheral nerve function in B-12 deficient Indian adolescent women
- Nutritional status, cognitive achievement, and educational attainment of children aged 8-11 in rural South India
- Costs and cost-effectiveness analyses of mCARE strategies for promoting care seeking of maternal and newborn health services in rural Bangladesh
- Cause-specific mortality in the general population with transient dipstick-proteinuria
- Assessing hand dysfunction in cervical spondylotic myelopathy
- KETOS: Clinical decision support and machine learning as a service – A training and deployment platform based on Docker, OMOP-CDM, and FHIR Web Services
- Variation in activity rates may explain sex-specific dorsal color patterns in Habronattus jumping spiders
- Adjusting for spatial variation when assessing individual-level risk: A case-study in the epidemiology of snake-bite in Sri Lanka
- Acute sprint exercise transcriptome in human skeletal muscle
- Parenting and personality disorder: An overview and meta-synthesis of systematic reviews
- Female rats release a trapped cagemate following shaping of the door opening response: Opening latency when the restrainer was baited with food, was empty, or contained a cagemate
- Multiplex communities and the emergence of international conflict
- The impact of socioeconomic status on emergency department outcome in a low-income country setting: A registry-based analysis
- Effect of psycho-social support by teachers on improving mental health and hope of adolescents in an earthquake-affected district in Nepal: A cluster randomized controlled trial
- A cluster-randomized controlled trial of the effectiveness of the JUMP Math program of math instruction for improving elementary math achievement
- Transgenic mouse model for conditional expression of influenza hemagglutinin-tagged human SLC20A1/PIT1
- Use of rapid Model for End-Stage Liver Disease (MELD) increases for liver transplant registrant prioritization after MELD-Na and Share 35, an evaluation using data from the United Network for Organ Sharing
- Fishery Improvement Projects as a governance tool for fisheries sustainability: A global comparative analysis
- QRStree: A prefix tree-based model to fetal QRS complexes detection
- Fundraising and vote distribution: A non-equilibrium statistical approach
- Evaluation of PRRSv specific, maternally derived and induced immune response in Ingelvac PRRSFLEX EU vaccinated piglets in the presence of maternally transferred immunity
- Gene expression profiling of whole blood: A comparative assessment of RNA-stabilizing collection methods
- Alteration of adipose tissue immune cell milieu towards the suppression of inflammation in high fat diet fed mice by flaxseed oil supplementation
- Isoniazid preventive therapy: Uptake, incidence of tuberculosis and survival among people living with HIV in Bulawayo, Zimbabwe
- P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib
- Using long-term datasets to assess the impacts of dietary exposure to neonicotinoids on farmland bird populations in England
- Genetic mapping of distal femoral, stifle, and tibial radiographic morphology in dogs with cranial cruciate ligament disease
- Optimized bioluminescence analysis of adenosine triphosphate (ATP) released by platelets and its application in the high throughput screening of platelet inhibitors
- Consumer beliefs about healthy foods and diets
- An observational study on intracutaneous sodium storage in intensive care patients and controls
- Recovery when you are on your own: Slow population responses in an isolated marine reserve
- How does the method change what we measure? Comparing virtual reality and text-based surveys for the assessment of moral decisions in traffic dilemmas
- Is recent Afghanistan survey data suitable for fertility analysis? A regional investigation based on fertility inhibiting determinants
- Analytical validation of the Target Selector ctDNA platform featuring single copy detection sensitivity for clinically actionable EGFR, BRAF, and KRAS mutations
- Comparison of two swept-source optical coherence tomography biometers and a partial coherence interferometer
- Removal of anthracycline cytostatics from aquatic environment: Comparison of nanocrystalline titanium dioxide and decontamination agents
- A social media intervention to improve nutrition knowledge and behaviors of low income, pregnant adolescents and adult women
- Detection of vision and /or hearing loss using the interRAI Community Health Assessment aligns well with common behavioral vision/hearing measurements
- E-MOVIE - Experimental MOVies for Induction of Emotions in neuroscience: An innovative film database with normative data and sex differences
- Does self-reported pregnancy loss identify women at risk of an adverse cardiovascular phenotype in later life? Insights from UK Biobank
- An elevated glycemic gap predicts adverse outcomes in diabetic patients with necrotizing fasciitis
- 40-Hz auditory steady-state responses and the complex information processing: An exploratory study in healthy young males
- Highly diverse anaerobe-predominant vaginal microbiota among HIV-infected pregnant women in Zambia
- Decision-based models of the implementation of interventions in systems of healthcare: Implementation outcomes and intervention effectiveness in complex service environments
- Dual number-based variational data assimilation: Constructing exact tangent linear and adjoint code from nonlinear model evaluations
- Ultra-deep sequencing reveals pre-mRNA splicing as a sequence driven high-fidelity process
- Use of IoT sensing and occupant surveys for determining the resilience of buildings to forest fire generated PM2.5
- Classification of neurons in the adult mouse cochlear nucleus: Linear discriminant analysis
- Lek-associated movement of a putative Ebolavirus reservoir, the hammer-headed fruit bat (Hypsignathus monstrosus), in northern Republic of Congo
- Attenuation correction using 3D deep convolutional neural network for brain 18F-FDG PET/MR: Comparison with Atlas, ZTE and CT based attenuation correction
- Differences in macular capillary parameters between healthy black and white subjects with Optical Coherence Tomography Angiography (OCTA)
- Sealing agent reduces formation of single and dual-species biofilms of Candida albicans and Enterococcus faecalis on screw joints at the abutment/implant interface
- Chitotetraose activates the fungal-dependent endosymbiotic signaling pathway in actinorhizal plant species
- What is the optimum time for initiation of early mobilization in mechanically ventilated patients? A network meta-analysis
- Cognitive aptitude, peers, and trajectories of marijuana use from adolescence through young adulthood
- Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study
- Accuracy and interobserver-agreement of respiratory rate measurements by healthcare professionals, and its effect on the outcomes of clinical prediction/diagnostic rules
- Does task delegation to non-physician health professionals improve quality of diabetes care? Results of a scoping review
- The Univariate Flagging Algorithm (UFA): An interpretable approach for predictive modeling
- Profiles and trajectories of impaired social cognition in people with Prader-Willi syndrome
- Effect of pimobendan on physical fitness, lactate and echocardiographic parameters in dogs with preclinical mitral valve disease without cardiomegaly
- Sub-types of safety behaviours and their effects on social anxiety disorder
- Engaging in prosocial behavior explains how high self-control relates to more life satisfaction: Evidence from three Chinese samples
- Artificial fingerprints for cross-comparison of forensic DNA and protein recovery methods
- The organization of Golgi in Drosophila bristles requires microtubule motor protein function and a properly organized microtubule array
- Direct and moderating effects of environmental regulation intensity on enterprise technological innovation: The case of China
- Prevalence and associated factors of depression among Korean adolescents
- Transcriptome analysis of PK-15 cells in innate immune response to porcine deltacoronavirus infection
- Geographic variation in cardiometabolic risk distribution: A cross-sectional study of 256,525 adult residents in the Illawarra-Shoalhaven region of the NSW, Australia
- Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury
- Lipid profile changings after switching from rilpivirine/tenofovir disoproxil fumarate/emtricitabine to rilpivirine/tenofovir alafenamide/emtricitabine: Different effects in patients with or without baseline hypercholesterolemia
- A feature selection strategy for gene expression time series experiments with hidden Markov models
- Dissociating the sequential dependency of subjective temporal order from subjective simultaneity
- Early mobilization of critically ill patients in the intensive care unit: A systematic review and meta-analysis
- Population-based estimates of engagement in HIV care and mortality using double-sampling methods following home-based counseling and testing in western Kenya
- Vaginal temperature as indicative of thermoregulatory response in Nellore heifers under different microclimatic conditions
- Galectin-9 gene (LGALS9) polymorphisms are associated with rheumatoid arthritis in Brazilian patients
- The association of brightness with number/duration in human newborns
- Microslit on a chip: A simplified filter to capture circulating tumor cells enlarged with microbeads
- Integrating continuous differential evolution with discrete local search for meander line RFID antenna design
- The impact of the French soda tax on prices and purchases. An ex post evaluation
- Development and validation of monoclonal antibodies against N6-methyladenosine for the detection of RNA modifications
- Structural characterization of a novel polysaccharide from Sargassum thunbergii and its antioxidant and anti-inflammation effects
- Potential biomarker identification for Friedreich’s ataxia using overlapping gene expression patterns in patient cells and mouse dorsal root ganglion
- Major drug resistance mutations to HIV-1 protease inhibitors (PI) among patients exposed to PI class failing antiretroviral therapy in São Paulo State, Brazil
- Chile (Capsicum annuum) plants transformed with the RB gene from Solanum bulbocastanum are resistant to Phytophthora capsici
- Outcomes of acute coronary syndrome patients with concurrent extra-cardiac vascular disease in the era of transradial coronary intervention: A retrospective multicenter cohort study
- Analysis of gene co-expression networks of phosphate starvation and aluminium toxicity responses in Populus spp.
- Risk factors associated with IgA vasculitis with nephritis (Henoch–Schönlein purpura nephritis) progressing to unfavorable outcomes: A meta-analysis
- The prediction model of suicidal thoughts in Korean adults using Decision Tree Analysis: A nationwide cross-sectional study
- A multidimensional understanding of prosperity and well-being at country level: Data-driven explorations
- Factors associated with muscle mass in community-dwelling older people in Singapore: Findings from the SHIELD study
- The prevalence and risk of non-infectious comorbidities in HIV-infected and non-HIV infected men attending general practice in Australia
- Vibrio cholerae strains with inactivated cqsS gene overproduce autoinducer-2 which enhances resuscitation of dormant environmental V. cholerae
- Myocardial function in patients with anomalous left coronary artery from the pulmonary artery syndrome: A long-term speckle tracking echocardiographic study
- Enhanced anti-tumor effect of liposomal Fasudil on hepatocellular carcinoma in vitro and in vivo
- Joint distribution for number of crossings and longest run in independent Bernoulli observations. The R package crossrun
- Learning to play badminton altered resting-state activity and functional connectivity of the cerebellar sub-regions in adults
- Children’s dietary diversity and related factors in Rwanda and Burundi: A multilevel analysis using 2010 Demographic and Health Surveys
- Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson’s disease
- Precluding rare outcomes by predicting their absence
- Tidal inlet seafloor changes induced by recently built hard structures
- A further study on Franciscobasis Machado & Bedê, 2016 (Odonata: Coenagrionidae), a newly described genus from Minas Gerais, Brazil
- Associative responses to visual shape stimuli in the mouse auditory cortex
- Extracellular matrix turnover and inflammation in chemically-induced TMJ arthritis mouse models
- LRP receptors in chondrocytes are modulated by simulated microgravity and cyclic hydrostatic pressure
- Genetic associations with radiological damage in rheumatoid arthritis: Meta-analysis of seven genome-wide association studies of 2,775 cases
- Separating the effects of temperature and carbon allocation on the diel pattern of soil respiration in the different phenological stages in dry grasslands
- Unweaving tangled mortality and antibiotic consumption data to detect disease outbreaks – Peaks, growths, and foresight in swine production
- Factors associated with exclusive breast-feeding: A cross-sectional survey in Kaiyuan, Yunnan, Southwest China
- The Model of Mortality with Incident Cirrhosis (MoMIC) and the model of Long-term Outlook of Mortality in Cirrhosis (LOMiC)
- Burden of treatment-resistant depression in Medicare: A retrospective claims database analysis
- Genomic characterisation of perinatal Western Australian Streptococcus agalactiae isolates
- Sharing the filmic experience - The physiology of socio-emotional processes in the cinema
- A super-SILAC based proteomics analysis of diffuse large B-cell lymphoma-NOS patient samples to identify new proteins that discriminate GCB and non-GCB lymphomas
- Pneumoproteins are associated with pulmonary function in HIV-infected persons
- Tissue-specific expression of IgG receptors by human macrophages ex vivo
- Electrical impedance myography for the detection of muscle inflammation induced by λ-carrageenan
- Clustering of the structures by using “snakes-&-dragons” approach, or correlation matrix as a signal
- Asymmetric valuation of gains and losses in effort-based decision making
- Genomic and metabolic differences between Pseudomonas putida populations inhabiting sugarcane rhizosphere or bulk soil
- Method comparison for N-glycan profiling: Towards the standardization of glycoanalytical technologies for cell line analysis
- Gender linked fate explains lower legal abortion support among white married women
- L-3,3’,5-triiodothyronine and pregnenolone sulfate inhibit Torpedo nicotinic acetylcholine receptors
- eQTL mapping of rare variant associations using RNA-seq data: An evaluation of approaches
- Cell fishing: A similarity based approach and machine learning strategy for multiple cell lines-compound sensitivity prediction
- Macrogeographic genetic structure of Lutzomyia longipalpis complex populations using Next Generation Sequencing
- Dual-career through the elite university student-athletes’ lenses: The international FISU-EAS survey
- Machine learning prediction of emesis and gastrointestinal state in ferrets
- Impact of bitter tastant sub-qualities on retronasal coffee aroma perception
- Head orientation and electrode placement potentially influence fetal scalp ECG waveform
- Clinical outcomes associated with the use of the NexSite hemodialysis catheter with new exit barrier technology: Results from a prospective, observational multi-center registry study
- Geospatial correlates of early marriage and union formation in Ghana
- Disruption of white matter connectivity in chronic obstructive pulmonary disease
- Integrated evaluation of clinical, pathological and radiological prognostic factors in squamous cell carcinoma of the lung
- Saliva enhances infection of gingival fibroblasts by herpes simplex virus 1
- Pyk2-dependent phosphorylation of LSR enhances localization of LSR and tricellulin at tricellular tight junctions
- An alternative approach for estimating the number needed to treat for survival endpoints
- Bilirubin reduces visceral obesity and insulin resistance by suppression of inflammatory cytokines
- Can telemedicine initiative be an effective intervention strategy for improving treatment compliance for pediatric HIV patients: Evidences on costs and improvement in treatment compliance from Maharashtra, India
- Trial registration as a safeguard against outcome reporting bias and spin? A case study of randomized controlled trials of acupuncture
- Multi-disciplinary interventions for chronic pain involving education: A systematic review
- Impact of climate change on the integrity of the superstructure of deteriorated U.S. bridges
- Switching to bedaquiline for treatment of rifampicin-resistant tuberculosis in South Africa: A retrospective cohort analysis
- Efficacy of Lactobacillus-supplemented triple therapy for H. pylori eradication: A meta-analysis of randomized controlled trials
- Testing gene by community disadvantage moderation of sexual health outcomes among urban women
- The impact of leishmaniasis on mental health and psychosocial well-being: A systematic review
- Evaluation of a screening algorithm using the Strengths and Difficulties Questionnaire to identify children with mental health problems: A five-year register-based follow-up on school performance and healthcare use
- Optimized fast GPU implementation of robust artificial-neural-networks for k-space interpolation (RAKI) reconstruction
- The cost of illness and economic burden of endometriosis and chronic pelvic pain in Australia: A national online survey
- Refined distributed emotion vector representation for social media sentiment analysis
- Enhancing timeliness of drug overdose mortality surveillance: A machine learning approach
- A real-time gesture recognition system using near-infrared imagery
- Alcohol use and its association with sexual risk behaviors in the Armed Forces of the Republic of the Congo
- Improved survival rates in patients with H1N1 acute respiratory failure in Korea between 2009 and 2016
- Electroencephalographic features of discontinuous activity in anesthetized infants and children
- Tumor stromal type is associated with stromal PD-L1 expression and predicts outcomes in breast cancer
- Mutant prevention concentration of ozenoxacin for quinolone-susceptible or -resistant Staphylococcus aureus and Staphylococcus epidermidis
- The Echobot: An automated system for stimulus presentation in studies of human echolocation
- Evaluation of clinical manifestations, health risks, and quality of life among women with polycystic ovary syndrome
- Magnetic resonance imaging presentation of deep infiltrating endometriosis nodules before and after pregnancy: A case series
- Agrobacterium tumefaciens-mediated transformation of a hevein-like gene into asparagus leads to stem wilt resistance
- Effect of a Mentor Mother Programme on retention of mother-baby pairs in HIV care: A secondary analysis of programme data in Uganda
- Utilizing multiplex fluor LAMPs to illuminate multiple gene expressions in situ
- Genetic relationships between the RACK1 homolog cpc-2 and heterotrimeric G protein subunit genes in Neurospora crassa
- Is latent tuberculosis infection challenging in Iranian health care workers? A systematic review and meta-analysis
- A comparison of the risk of congestive heart failure-related hospitalizations in patients receiving hemodialysis and peritoneal dialysis - A retrospective propensity score-matched study
- A tailored approach to fusion transcript identification increases diagnosis of rare inherited disease
- Experiences, needs, and preferences for follow-up after stroke perceived by people with stroke and healthcare professionals: A focus group study
- Iodine supplementation of lactating women and assessment of infant visual information processing and maternal and infant thyroid function: A randomized trial
- The Nordic Maintenance Care Program: Does psychological profile modify the treatment effect of a preventive manual therapy intervention? A secondary analysis of a pragmatic randomized controlled trial
- Within-subject variability in human retinal nerve fiber bundle width
- Motivation for alcohol consumption or abstinence during pregnancy: A clinical-qualitative study in Brazil
- Comparison of conventional BLUP and single-step genomic BLUP evaluations for yearling weight and carcass traits in Hanwoo beef cattle using single trait and multi-trait models
- Do cognitive and non-cognitive abilities mediate the relationship between air pollution exposure and mental health?
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- Nitrogen nutrition is a key modulator of the sugar and organic acid content in citrus fruit
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- Correction: Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis
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- The effect of a hiding box on stress levels and body weight in Dutch shelter cats; a randomized controlled trial
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- Transforming growth factor beta 1 induces methylation changes in lung fibroblasts
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- Phosphorus-mediated alleviation of aluminum toxicity revealed by the iTRAQ technique in Citrus grandis roots
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- A cross sectional comparison of drug use indicators using WHO methodology in primary level hospitals participating in an Auditable Pharmaceutical Transactions and Services program versus non-APTS primary hospitals in Southern Ethiopia
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- Liquid biopsies for omics-based analysis in sentinel mussels
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- Trends in the characteristics of acute primary angle closure in Korea over the past 10-years
- Obesity-associated insulin resistance adversely affects skin function
- First-line treatments in EGFR-mutated advanced non-small cell lung cancer: A network meta-analysis
- In vivo human lower limb muscle architecture dataset obtained using diffusion tensor imaging
- Tobacco smoke exposure as a risk factor for human papillomavirus infections in women 18-26 years old in the United States
- The trigger-information-response model: Exploring health literacy during the first six months following a kidney transplantation
- Factors influencing the behaviour and perceptions of Australian veterinarians towards antibiotic use and antimicrobial resistance
- The development of an evidence-based street food vending model within a socioecological framework: A guide for African countries
- Sociodemographic changes and trends in the rates of new perinatal HIV diagnoses and transmission in Spain from 1997 to 2015
- Patient navigation services for cancer care in low-and middle-income countries: A scoping review
- Weather extremes and perinatal mortality – Seasonal and ethnic differences in northern Sweden, 1800-1895
- Cognitive, relational and task crafting: Spanish adaptation and analysis of psychometric properties of the Job Crafting Questionnaire
- Maternal and perinatal death surveillance and response in Ethiopia: Achievements, challenges and prospects
- Identification and characterisation of capidermicin, a novel bacteriocin produced by Staphylococcus capitis
- Joint emulation of Earth System Model temperature-precipitation realizations with internal variability and space-time and cross-variable correlation: fldgen v2.0 software description
- Extensive culturomics of 8 healthy samples enhances metagenomics efficiency
- Macroepidemiological aspects of porcine reproductive and respiratory syndrome virus detection by major United States veterinary diagnostic laboratories over time, age group, and specimen
- Correction: Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study
- Correction: Human indole(ethyl)amine-N-methyltransferase (hINMT) catalyzed methylation of tryptamine, dimethylsulfide and dimethylselenide is enhanced under reducing conditions - A comparison between 254C and 254F, two common hINMT variants
- Myofibrillar function differs markedly between denervated and dexamethasone-treated rat skeletal muscles: Role of mechanical load
- Quantitation of eumelanin and pheomelanin markers in diverse biological samples by HPLC-UV-MS following solid-phase extraction
- Kinetics of mean platelet volume predicts mortality in patients with septic shock
- An integrated epigenome and transcriptome analysis identifies PAX2 as a master regulator of drug resistance in high grade pancreatic ductal adenocarcinoma
- Combining CDK4/6 inhibitors ribociclib and palbociclib with cytotoxic agents does not enhance cytotoxicity
- Association of Medicaid expansion with health insurance coverage by marital status and sex
- Are current approaches for measuring access to clean water and sanitation inclusive of people with disabilities? Comparison of individual- and household-level access between people with and without disabilities in the Tanahun district of Nepal
- A proteomic clock for malignant gliomas: The role of the environment in tumorigenesis at the presymptomatic stage
- Monitoring Universal Health Coverage (UHC) in high Tuberculosis burden countries: Tuberculosis mortality an important tracer of UHC service coverage
- RCT evaluation of Skhokho: A holistic school intervention to prevent gender-based violence among South African Grade 8s
- On the use of Action Units and fuzzy explanatory models for facial expression recognition
- A systematic review of complementary and alternative medicine in oncology: Psychological and physical effects of manipulative and body-based practices
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- Determinants of temperature sensitivity of soil respiration with the decline of a foundation species
- Mindfulness meditation, time judgment and time experience: Importance of the time scale considered (seconds or minutes)
- Regional, institutional, and departmental factors associated with gender diversity among BS-level chemical and electrical engineering graduates
- Transepithelial transport of P-glycoprotein substrate by the Malpighian tubules of the desert locust
- Sex affects immunolabeling for histone 3 K27me3 in the trophectoderm of the bovine blastocyst but not labeling for histone 3 K18ac
- A survey of public attitudes toward uterus transplantation, surrogacy, and adoption in Japan
- Replacing plasma membrane outer leaflet lipids with exogenous lipid without damaging membrane integrity
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- Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study
- Antimicrobial efficacy of commercially available endodontic bioceramic root canal sealers: A systematic review
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- Synbiotic supplementation to decrease Salmonella colonization in the intestine and carcass contamination in broiler birds
- Bexarotene therapy ameliorates behavioral deficits and induces functional and molecular changes in very-old Triple Transgenic Mice model of Alzheimer´s disease
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- Identification of DNA methyltransferases and demethylases in Solanum melongena L., and their transcription dynamics during fruit development and after salt and drought stresses
- Environmental conditions for Jamestown Canyon virus correlated with population-level resource selection by white-tailed deer in a suburban landscape
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- Particularly neglected in countries with other challenges: High Toxoplasma gondii seroprevalence in pregnant women in Kabul, Afghanistan, while a low proportion know about the parasite
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- The causality of borrowing: Lexical loans in Eurasian languages
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- Deep architectures for long-term stock price prediction with a heuristic-based strategy for trading simulations
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- Organizational justice and illness reporting among Japanese employees with chronic diseases
- CavBench: A benchmark for protein cavity detection methods
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- Risk of pneumonia among residents living near goat and poultry farms during 2014-2016
- Lipid levels after childbirth and association with number of children: A population-based cohort study
- Birth outcomes in women who have taken adalimumab in pregnancy: A prospective cohort study
- ECMO with vasopressor use during early endotoxic shock: Can it improve circulatory support and regional microcirculatory blood flow?
- Effects of dietary intake and nutritional status on cerebral oxygenation in patients with chronic kidney disease not undergoing dialysis: A cross-sectional study
- Micro-RNA 150-5p predicts overt heart failure in patients with univentricular hearts
- Flexible learning spaces facilitate interaction, collaboration and behavioural engagement in secondary school
- Clinical significance and prognostic role of hypoxia-induced microRNA 382 in gastric adenocarcinoma
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- Prevalence of Trypanosoma cruzi infection in active military population of The Colombian National Army gathered in five departments
- An observational study comparing HPV prevalence and type distribution between HPV-vaccinated and -unvaccinated girls after introduction of school-based HPV vaccination in Norway
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- Attending to design when developing complex health interventions: A qualitative interview study with intervention developers and associated stakeholders
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- Characterization of sound scattering layers in the Bay of Biscay using broadband acoustics, nets and video
- Conducting human challenge studies in LMICs: A survey of researchers and ethics committee members in Thailand
- eNOS-NO-induced small blood vessel relaxation requires EHD2-dependent caveolae stabilization
- Clinical use of SAND battery to evaluate language in patients with Progressive Supranuclear Palsy
- The interplay of personality and attitudes toward own aging across two decades of later life
- Robust automated reading of the skin prick test via 3D imaging and parametric surface fitting
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- A psychoacoustic application for the adjustment of electrical hearing thresholds in cochlear implant patients
- Correction: Blue light-dependent human magnetoreception in geomagnetic food orientation
- Re-evaluation of a Tn5::gacA mutant of Pseudomonas syringae pv. tomato DC3000 uncovers roles for uvrC and anmK in promoting virulence
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- Illuminating biological pathways for drug targeting in head and neck squamous cell carcinoma
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- Adolescents living with HIV are at higher risk of death and loss to follow up from care: Analysis of cohort data from eight health facilities in Ethiopia
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- Comparative cost analysis of point-of-care versus laboratory-based testing to initiate and monitor HIV treatment in South Africa
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- A game theoretic setting of capitation versus fee-for-service payment systems
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- Establishing an infrastructure for collaboration in primate cognition research
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- Changes in real-life practice for hepatocellular carcinoma patients in the Republic of Korea over a 12-year period: A nationwide random sample study
- Correction: Homology analysis of malware based on ensemble learning and multifeatures
- Illness beliefs and emotional responses in mildly disabled stroke survivors: A qualitative study
- Extended-wavelength diffuse reflectance spectroscopy with a machine-learning method for in vivo tissue classification
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- Development of a recombinant replication-deficient rabies virus-based bivalent-vaccine against MERS-CoV and rabies virus and its humoral immunogenicity in mice
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- Elucidating optical field directed hierarchical self-assembly of homogenous versus heterogeneous nanoclusters with femtosecond optical tweezers
- Structure establishment of three-dimensional (3D) cell culture printing model for bladder cancer
- Elevated serum alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality
- Correction: Functional atlases for analysis of motor and neuropsychological outcomes after medial globus pallidus and subthalamic stimulation
- Correction: Estimating Body Composition in Adolescent Sprint Athletes: Comparison of Different Methods in a 3 Years Longitudinal Design
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- A comparison of sLASER and MEGA-sLASER using simultaneous interleaved acquisition for measuring GABA in the human brain at 7T
- Urinary Activin A is a novel biomarker reflecting renal inflammation and tubular damage in ANCA-associated vasculitis
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- Pollock avoided hydrodynamic instabilities to paint with his dripping technique
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- Photo-degradation dynamics of five neonicotinoids: Bamboo vinegar as a synergistic agent for improved functional duration
- Use of acoustic emission to identify novel candidate biomarkers for knee osteoarthritis (OA)
- Cetacean biodiversity, spatial and temporal trends based on stranding records (1920-2016), Victoria, Australia
- Neutrophil elastase inhibitor purification strategy from cowpea seeds
- Correction: Hafting of Middle Paleolithic tools in Latium (central Italy): New data from Fossellone and Sant’Agostino caves
- Coherent poly propagation materials with 3-dimensional photonic control over visible light
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- Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer
- Take one step backward to move forward: Assessment of genetic diversity and population structure of captive Asian woolly-necked storks (Ciconia episcopus)
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- Knowledge, attitudes and medical practice regarding hepatitis B prevention and management among healthcare workers in Northern Vietnam
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- Correction: Neural computational model GrowthEstimate: A model for studying living resources through digestive efficiency
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- Seventy-five mosses and liverworts found frozen with the late Neolithic Tyrolean Iceman: Origins, taphonomy and the Iceman’s last journey
- Hyaluronic acid and epidermal growth factor improved the bovine embryo quality by regulating the DNA methylation and expression patterns of the focal adhesion pathway
- Associations among knowledge, attitudes, and practices toward palliative care consultation service in healthcare staffs: A cross-sectional study
- A novel, wearable, electronic visual aid to assist those with reduced peripheral vision
- Genetic diversity and population structure of the Mediterranean sesame core collection with use of genome-wide SNPs developed by double digest RAD-Seq
- Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression
- Mobile health-based physical activity intervention for individuals with spinal cord injury in the community: A pilot study
- Factors influencing cultivated ginseng (Panax ginseng C. A. Meyer) bioactive compounds
- Estimation of soil pH with geochemical indices in forest soils
- Multiplexed editing of a begomovirus genome restricts escape mutant formation and disease development
- Correlates of longitudinal leukocyte telomere length in the Costa Rican Longevity Study of Healthy Aging (CRELES): On the importance of DNA collection and storage procedures
- Collaboration and followership: A stochastic model for activities in social networks
- Evaluating access to oral anti-diabetic medicines: A cross-sectional survey of prices, availability and affordability in Shaanxi Province, Western China
- Comparison of corneal elevation and pachymetry measurements made by two state of the art corneal tomographers with different measurement principles
- Use of a pressure-sensing walkway system for biometric assessment of gait characteristics in goats
- Current status and direct medical cost of amyotrophic lateral sclerosis in the region of Catalonia: A population-based analysis
- Engineering a single-chain antibody against Trypanosoma cruzi metacyclic trypomastigotes to block cell invasion
- Can work climate foster pro-environmental behavior inside and outside of the workplace?
- Gene editing of PKLR gene in human hematopoietic progenitors through 5’ and 3’ UTR modified TALEN mRNA
- Pelvic alignment changes during the perinatal period
- Interatrial blocks prevalence and risk factors for human immunodeficiency virus-infected persons
- Life-course trajectories of body mass index and subsequent cardiovascular risk among Chinese population
- Inhibitory interaction networks among coevolved Streptomyces populations from prairie soils
- Exploiting contextual information to improve call prediction
- Visual inputs decrease brain activity in frontal areas during silent lipreading
- The synergistic effects of TaAGP.L-B1 and TaSSIVb-D mutations in wheat lead to alterations of gene expression patterns and starch content in grain development
- Live-attenuated H1N1 influenza vaccine candidate displays potent efficacy in mice and ferrets
- Robust, real-time generic detector based on a multi-feature probabilistic method
- Maize leaves drought-responsive genes revealed by comparative transcriptome of two cultivars during the filling stage
- Xenon lamps used for fruit surface sterilization can increase the content of total flavonols in leaves of Lactuca sativa L. without any negative effect on net photosynthesis
- An alternative procedure to obtain the mortality rate with non-linear functions: Application to the case of the Spanish population
- Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis
- Longitudinal assessment of post-surgical physical activity in endometrial and ovarian cancer patients
- THINGS: A database of 1,854 object concepts and more than 26,000 naturalistic object images
- Evaluation of ranibizumab and aflibercept for the treatment of diabetic macular edema in daily clinical practice
- Proteomic analysis of Escherichia coli detergent-resistant membranes (DRM)
- Correction: Effect of curcuminoids and curcumin derivate products on thioredoxin-glutathione reductase from Taenia crassiceps cysticerci. Evidence suggesting a curcumin oxidation product as a suitable inhibitor
- Correction: Predicting childhood obesity using electronic health records and publicly available data
- Correction: Estimating the value of tropical coastal wetland habitats to fisheries: Caveats and assumptions
- Correction: The effects of sympathetic activity induced by ice water on blood flow and brachial artery flow-mediated dilatation response in healthy volunteers
- Determinants of frailty development and progression using a multidimensional frailty index: Evidence from the English Longitudinal Study of Ageing
- Supporting informed clinical trial decisions: Results from a randomized controlled trial evaluating a digital decision support tool for those with intellectual disability
- BMAL1 associates with chromosome ends to control rhythms in TERRA and telomeric heterochromatin
- Antimicrobial resistance genotypes and phenotypes of Campylobacter jejuni isolated in Italy from humans, birds from wild and urban habitats, and poultry
- Hepatopulmonary syndrome has low prevalence of pulmonary vascular abnormalities on chest computed tomography
- Early and long-term outcomes of coronary artery bypass surgery with and without use of heart-lung machine and with special respect to renal function - A retrospective study
- Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15
- The FTO genetic variants are associated with dietary intake and body mass index amongst Emirati population
- Expression of Concern: The Coordination of Cell Growth during Fission Yeast Mating Requires Ras1-GTP Hydrolysis
- Correction: Lentivirus-Mediated Knockdown of Astrocyte Elevated Gene-1 Inhibits Growth and Induces Apoptosis through MAPK Pathways in Human Retinoblastoma Cells
- Relationship between self-disclosure to first acquaintances and subjective well-being in people with schizophrenia spectrum disorders living in the community
- Remarkable cell recovery from cerebral ischemia in rats using an adaptive escalator-based rehabilitation mechanism
- Integrating environmental and neighborhood factors in MaxEnt modeling to predict species distributions: A case study of Aedes albopictus in southeastern Pennsylvania
- Post-overdose interventions triggered by calling 911: Centering the perspectives of people who use drugs (PWUDs)
- The prevalence of intimate partner violence among couples signing up for universally offered parent preparation
- Analysis of gear surface morphology based on gray level co-occurrence matrix and fractal dimension
- Abiotic, present-day and historical effects on species, functional and phylogenetic diversity in dry grasslands of different age
- Clonality analysis of pulmonary tumors by genome-wide copy number profiling
- A relictual troglomorphic harvestman discovered in a volcanic cave of western Argentina: Otilioleptes marcelae, new genus, new species, and Otilioleptidae, new family (Arachnida, Opiliones, Gonyleptoidea)
- HIV drug resistance in persons who inject drugs enrolled in an HIV prevention trial in Indonesia, Ukraine, and Vietnam: HPTN 074
- Dietary acid load significantly predicts 10-years survival in patients underwent coronary artery bypass grafting (CABG) surgery
- Regulation of nitrogen availability results in changes in grain protein content and grain storage subproteomes in barley (Hordeum vulgare L.)
- Diagnostic test evaluation methodology: A systematic review of methods employed to evaluate diagnostic tests in the absence of gold standard – An update
- Longitudinal trends of and factors associated with inappropriate antibiotic prescribing for non-bacterial acute respiratory tract infection in Japan: A retrospective claims database study, 2012–2017
- Revealing users’ experience and social interaction outcomes following a web-based smoking prevention intervention for adolescents: A qualitative study
- Coordination of human movements resulting in motor strategies exploited by skilled players during a throwing task
- Impact of pericardiectomy on exercise capacity and sleep of patients with chronic constrictive pericarditis
- Blue-violet light decreases VEGFa production in an in vitro model of AMD
- Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach
- Speed of processing training and depression in assisted and independent living: A randomized controlled trial
- Induced cardiomyocyte maturation: Cardiac transcription factors are necessary but not sufficient
- What happens in the brain of meditators when perception changes but not the stimulus?
- Comparison of HIV-1 Vif and Vpu accessory proteins for delivery of polyepitope constructs harboring Nef, Gp160 and P24 using various cell penetrating peptides
- Are degree of urbanisation and travel times to healthcare services associated with the processes of care and outcomes of heart failure? A retrospective cohort study based on administrative data
- A PDGFRβ-PI3K signaling axis mediates periosteal cell activation during fracture healing
- Influence of transcutaneous vagus nerve stimulation on cardiac vagal activity: Not different from sham stimulation and no effect of stimulation intensity
- Co-prescription network reveals social dynamics of opioid doctor shopping
- Contractile properties of superficial skeletal muscle affect postural control in healthy young adults: A test of the rambling and trembling hypothesis
- Does intrauterine crowding affect the force generating capacity and muscle composition of the piglet front limb?
- Correction: Measuring compassionate healthcare with the 12-item Schwartz Center Compassionate Care Scale
- Facilitators and barriers to traditional medicine use among cancer patients in Malawi
- Expression of CMV protein pp65 in cutaneous malignant melanoma
- The evolution of mental health outcomes across a combat deployment cycle: A longitudinal study of a Guam-based National Guard unit
- Caesarean section delivery and childhood obesity in a British longitudinal cohort study
- Incidence, characteristics, and mortality of infective endocarditis in France in 2011
- Pfcyp51 exclusively determines reduced sensitivity to 14α-demethylase inhibitor fungicides in the banana black Sigatoka pathogen Pseudocercospora fijiensis
- Evaluation of the bacterial ocular surface microbiome in clinically normal cats before and after treatment with topical erythromycin
- Histological and developmental insights into the herbivorous dentition of tapinocephalid therapsids
- Differential immunomodulation of T-cells by immunoglobulin replacement therapy in primary and secondary antibody deficiency
- A longitudinal study on perceived health in cardiovascular patients: The role of conscientiousness, subjective wellbeing and cardiac self-efficacy
- The effectiveness of interferon beta versus glatiramer acetate and natalizumab versus fingolimod in a Polish real-world population
- Interactions of Streptococcus suis serotype 9 with host cells and role of the capsular polysaccharide: Comparison with serotypes 2 and 14
- Honey bee and native solitary bee foraging behavior in a crop with dimorphic parental lines
- A flexible formula for incorporating distributive concerns into cost-effectiveness analyses: Priority weights
- Correction: Lack of association between hypothyroxinemia of prematurity and transient thyroid abnormalities with adverse long term neurodevelopmental outcome in very low birth weight infants
- A reconnaissance survey of farmers’ awareness of hypomagnesaemic tetany in UK cattle and sheep farms
- Health workers’ perception of malaria rapid diagnostic test and factors influencing compliance with test results in Ebonyi state, Nigeria
- Conformational flexibility of fork-remodeling helicase Rad5 shown by full-ensemble hybrid methods
- The increasing importance of fellowships and career development awards in the careers of early-stage biomedical academic researchers
- Occurrence and stability of hetero-hexamer associations formed by β-carboxysome CcmK shell components
- Auxin driven indoleamine biosynthesis and the role of tryptophan as an inductive signal in Hypericum perforatum (L.)
- Dynamic activation of Wnt, Fgf, and Hh signaling during soft palate development
- Distance to large rivers affects fish diversity patterns in highly dynamic streams of Central Amazonia
- Real vs. immersive-virtual emotional experience: Analysis of psycho-physiological patterns in a free exploration of an art museum
- Modulation of brain tumor risk by genetic SNPs in PARP1gene: Hospital based case control study
- Processed meat intake and chronic disease morbidity and mortality: An overview of systematic reviews and meta-analyses
- Modeling ENSO impact on rice production in the Mekong River Delta
- The feasibility of a behavioral group intervention after weight-loss surgery: A randomized pilot trial
- EMR-integrated minimal core dataset for routine health care and multiple research settings: A case study for neuroinflammatory demyelinating diseases
- A review of a 13-month period of FilmArray Meningitis/Encephalitis panel implementation as a first-line diagnosis tool at a university hospital
- Increased BMI has a linear association with late-onset preeclampsia: A population-based study
- Autoantibody production significantly decreased with APRIL/BLyS blockade in murine chronic rejection kidney transplant model
- Vancomycin-resistance gene cluster, vanC, in the gut microbiome of acute leukemia patients undergoing intensive chemotherapy
- Telomere length in COPD: Relationships with physical activity, exercise capacity, and acute exacerbations
- Mutual role of ecto-5'-nucleotidase/CD73 and concentrative nucleoside transporter 3 in the intestinal uptake of dAMP
- Impact of faecal calprotectin measurement on clinical decision-making in patients with Crohn’s disease and ulcerative colitis
- Additive effects of a small molecular PCNA inhibitor PCNA-I1S and DNA damaging agents on growth inhibition and DNA damage in prostate and lung cancer cells
- Autophagy is important to the acidogenic metabolism of Aspergillus niger
- Continuous ratings of movie watching reveal idiosyncratic dynamics of aesthetic enjoyment
- Sensitivity and specificity of serum soluble interleukin-2 receptor for diagnosing sarcoidosis in a population of patients suspected of sarcoidosis
- Enhancing genomic selection by fitting large-effect SNPs as fixed effects and a genotype-by-environment effect using a maize BC1F3:4 population
- Quantitation and modeling of post-translational modifications in a therapeutic monoclonal antibody from single- and multiple-dose monkey pharmacokinetic studies using mass spectrometry
- Microbial induced solidification and stabilization of municipal solid waste incineration fly ash with high alkalinity and heavy metal toxicity
- Extracellular vesicles in human semen modulate antigen-presenting cell function and decrease downstream antiviral T cell responses
- A fault-tolerant aware scheduling method for fog-cloud environments
- Correction: BCG vaccination and tuberculosis prevention: A forty years cohort study, Monastir, Tunisia
- Correction: Perceptions among transgender women of factors associated with the access to HIV/AIDS-related health services in Yogyakarta, Indonesia
- Assessing the convergent validity between the automated emotion recognition software Noldus FaceReader 7 and Facial Action Coding System Scoring
- Deep learning based banana plant detection and counting using high-resolution red-green-blue (RGB) images collected from unmanned aerial vehicle (UAV)
- Comparison of cardiorespiratory fitness between preschool children with normal and excess body adipose ~ An observational study
- Intraregional differences in renal function in the Northern Netherlands: The Lifelines Cohort Study
- Effects of MCHM on yeast metabolism
- Signaling impacts of GMO labeling on fruit and vegetable demand
- Dietary specialization depending on ecological context and sexual differences in Asiatic black bears
- Electronic device use and beverage related sugar and caffeine intake in US adolescents
- Isolation and characterization of five novel probiotic strains from Korean infant and children faeces
- Correction: Silymarin in non-cirrhotics with non-alcoholic steatohepatitis: A randomized, double-blind, placebo controlled trial
- Correction: Anatomical analysis of antebrachial cutaneous nerve distribution pattern and its clinical implications for sensory reconstruction
- Endothelial nitric oxide synthase limits host immunity to control disseminated Candida albicans infections in mice
- Lack of detection of Candida nivariensis and Candida bracarensis among 440 clinical Candida glabrata sensu lato isolates in Kuwait
- Nonlinear dynamics captures brain states at different levels of consciousness in patients anesthetized with propofol
- Visual encounters on line transect surveys under-detect carnivore species: Implications for assessing distribution and conservation status
- Menstrual health communication among Indian adolescents: A mixed-methods study
- Fast fluorescence in situ hybridisation for the enhanced detection of MET in non-small cell lung cancer
- The influence of personality on the effect of iTBS after being stressed on cortisol secretion
- Parental and peer support and modelling in relation to domain-specific physical activity participation in boys and girls from Germany
- Oral delivery of water-soluble compounds to the phytoseiid mite Neoseiulus californicus (Acari: Phytoseiidae)
- Force perceptual bias caused by muscle activity in unimanual steering
- Correction: Comparison of risk models for mortality and cardiovascular events between machine learning and conventional logistic regression analysis
- Correction: Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium
- Providencia entomophila sp. nov., a new bacterial species associated with major olive pests in Tunisia
- Safety of intravitreal ziv-aflibercept in choroido-retinal vascular diseases: A randomised double-blind intervention study
- A novel framework for evaluating the impact of individual decision-making on public health outcomes and its potential application to study antiviral treatment collection during an influenza pandemic
- Reduction of the rocuronium-induced withdrawal reflex by MR13A10A, a generic rocuronium with a novel solution: A randomized, controlled study
- Emotionally expressed voices are retained in memory following a single exposure
- Megabenthic communities of the Ligurian deep continental shelf and shelf break (NW Mediterranean Sea)
- Election forensics: Using machine learning and synthetic data for possible election anomaly detection
- A randomized crossover trial comparing the Nifty cup to a medicine cup in preterm infants who have difficulty breastfeeding at Komfo Anokye Teaching Hospital (KATH) in Kumasi, Ghana
- The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease
- Genomic impact of severe population decline in a nomadic songbird
- Evolution of high-sensitivity troponin-T and echocardiography parameters in patients undergoing high efficiency on-line hemodiafiltration versus conventional low-flux hemodialysis
- Full genome characterization of 12 citrus tatter leaf virus isolates for the development of a detection assay
- Intake of myo-inositol hexaphosphate and urinary excretion of inositol phosphates in Wistar rats: Gavage vs. oral administration with sugar
- Enhancing financial security of female sex workers through a community-led intervention in India: Evidence from a longitudinal survey
- In-silico prediction of novel genes responsive to drought and salinity stress tolerance in bread wheat (Triticum aestivum)
- Genetic diversification of Panstrongylus geniculatus (Reduviidae: Triatominae) in northern South America
- Partitioning the risk of tuberculosis transmission in household contact studies
- Recommendation system in social networks with topical attention and probabilistic matrix factorization
- Using satellite-measured relative humidity for prediction of Metisa plana’s population in oil palm plantations: A comparative assessment of regression and artificial neural network models
- A drug interaction study investigating the effect of Rifabutin on the pharmacokinetics of Maraviroc in healthy subjects
- Emotional and behavioral problems, social competence and risk factors in 6–16-year-old students in Beijing, China
- Clinicopathologic and prognostic significance of tumor-associated macrophages in patients with hepatocellular carcinoma: A meta-analysis
- Involution of retinopathy of prematurity and neurodevelopmental outcomes after intravitreal bevacizumab treatment
- Travel demand and distance analysis for free-floating car sharing based on deep learning method
- Genome-wide identification, characterization, expression and enzyme activity analysis of coniferyl alcohol acetyltransferase genes involved in eugenol biosynthesis in Prunus mume
- Population analysis of D6-like plasmid prophage variants associated with specific IncC plasmid types in the emerging Salmonella Typhimurium ST213 genotype
- The high resource impact of reformatting requirements for scientific papers
- Egg yolk-free cryopreservation of bull semen
- Fine epitope mapping of glycoprotein Gn in Guertu virus
- Are hospital nurse staffing practices associated with postoperative cardiac events and death? A systematic review
- Dysregulation of macrophage development and phenotype in diabetic human macrophages can be rescued by Hoxa3 protein transduction
- Aging and the wandering brain: Age-related differences in the neural correlates of stimulus-independent thoughts
- Elucidating stygofaunal trophic web interactions via isotopic ecology
- Experimental characterization of two archaeal inosine 5'-monophosphate cyclohydrolases
- Scientist and data architect collaborate to curate and archive an inner ear electrophysiology data collection
- No effect of triple-pulse TMS medial to intraparietal sulcus on online correction for target perturbations during goal-directed hand and foot reaches
- Correction: Controlling Social Stress in Virtual Reality Environments
- TNF-α is responsible for the contribution of stromal cells to osteoclast and odontoclast formation during orthodontic tooth movement
- Viral respiratory infections and the oropharyngeal bacterial microbiota in acutely wheezing children
- Alteration of humoral, cellular and cytokine immune response to inactivated influenza vaccine in patients with Sickle Cell Disease
- To tweet or not to tweet, that is the question: A randomized trial of Twitter effects in medical education
- Visualizing a field of research: A methodology of systematic scientometric reviews
- True Colors: Commercially-acquired morphological genotypes reveal hidden allele variation among dog breeds, informing both trait ancestry and breed potential
- Impact of the detection of ζ-globin chains and hemoglobin Bart’s using immunochromatographic strip tests for α0-thalassemia (--SEA) differential diagnosis
- Cognitive impairment and medication adherence post-stroke: A five-year follow-up of the ASPIRE-S cohort
- Correction: Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism
- Correction: Lower prevalence of Blastocystis sp. infections in HIV positive compared to HIV negative adults in Ghana
- Correction: Precision public health: Mapping socioeconomic disparities in opioid dispensations at Swedish pharmacies by Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (MAIHDA)
- Epidemiological, clinical and laboratory characteristics of the measles resurgence in the Republic of Serbia in 2014-2015
- Macro-charcoal accumulation in floodplain wetlands: Problems and prospects for reconstruction of fire regimes and environmental conditions
- Stage at diagnosis and stage-specific survival of breast cancer in Latin America and the Caribbean: A systematic review and meta-analysis
- Correction: Retraction: Stiffening-Induced High Pulsatility Flow Activates Endothelial Inflammation via a TLR2/NF-κB Pathway
- TEM8/ANTXR1-specific CAR T cells mediate toxicity in vivo
- Clinical impact of intraoperative hyperlactatemia during craniotomy
- Intubation with channeled versus non-channeled video laryngoscopes in simulated difficult airway by junior doctors in an out-of-hospital setting: A crossover manikin study
- Age and growth of stocked juvenile Shoal Bass in a tailwater: Environmental variation and accuracy of daily age estimates
- Sex-specific differences in risk factors of lymph node metastasis in patients with early gastric cancer
- The impact of electroconvulsive therapy on the spatial QRS-T angle and cardiac troponin T concentration in psychiatric patients
- BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss
- Investigation on the hereditary basis of colorectal cancers in an African population with frequent early onset cases
- Comparison of cancer prevalence between patients with glomerulonephritis and the general population at the time of kidney biopsy
- Predictors of time to unfavorable treatment outcomes among patients with multidrug resistant tuberculosis in Oromia region, Ethiopia
- Experimentally validated simulation of coronary stents considering different dogboning ratios and asymmetric stent positioning
- The membrane effects of melittin on gastric and colorectal cancer
- Exclusive breastfeeding policy, practice and influences in South Africa, 1980 to 2018: A mixed-methods systematic review
- Hippocampal subfield volumes and pre-clinical Alzheimer’s disease in 408 cognitively normal adults born in 1946
- Uncorrected low hyperopia in young subjects induces postural instability even in those with clear visual acuity
- Membrane associated proteins of two Trichomonas gallinae clones vary with the virulence
- Awareness, current use of electronic cigarettes and associated smoking factors in Zhejiang Chinese adolescents
- Associations between pre-pregnancy BMI, gestational weight gain, and prenatal diet quality in a national sample
- Effects of continuous ketamine infusion on hemodynamics and mortality in critically ill children
- Optofluidic laser speckle image decorrelation analysis for the assessment of red blood cell storage
- Complete chloroplast genome sequence and phylogenetic analysis of Spathiphyllum 'Parrish'
- Strategic science communication as planned behavior: Understanding scientists’ willingness to choose specific tactics
- Understanding spatial patterns of soils for sustainable agriculture in northern Ethiopia’s tropical mountains
- Does Japan’s national nutrient-based dietary guideline improve lifestyle-related disease outcomes? A retrospective observational cross-sectional study
- Agitation near the end of life with dementia: An ethnographic study of care
- Tick-borne encephalitis virus infections in Germany. Seasonality and in-year patterns. A retrospective analysis from 2001-2018
- Encouraging perspective taking: Using narrative writing to induce empathy for others engaging in negative health behaviors
- Considerations of target surface area and the risk of radiosurgical toxicity
- Correction: A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells
- Effect of using immobilization device in fluoroscopic study in pediatric patient: Focused on radiation dose reduction in voiding cystourethrogram
- Temporal trends in breast cancer survival by race and ethnicity: A population-based cohort study
- Contamination of hospital surfaces with respiratory pathogens in Bangladesh
- The impact on the bioenergetic status and oxidative-mediated tissue injury of a combined protocol of hypothermic and normothermic machine perfusion using an acellular haemoglobin-based oxygen carrier: The cold-to-warm machine perfusion of the liver
- Association between hospital interval and survival in patients with oral cancer: A waiting time paradox
- Translating a stress management intervention for rural Latina breast cancer survivors: The Nuevo Amanecer-II
- Comprehensive management of obstructive sleep apnea by telemedicine: Clinical improvement and cost-effectiveness of a Virtual Sleep Unit. A randomized controlled trial
- Proteomic characterisation of the Chlamydia abortus outer membrane complex (COMC) using combined rapid monolithic column liquid chromatography and fast MS/MS scanning
- Harnessing therapeutic viruses as a delivery vehicle for RNA-based therapy
- Korean soybean core collection: Genotypic and phenotypic diversity population structure and genome-wide association study
- Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study
- Measurement of structural integrity of the spinal cord in patients with amyotrophic lateral sclerosis using diffusion tensor magnetic resonance imaging
- Typological analysis of public-private partnerships in the veterinary domain
- Improved clinical outcome after medial open-wedge osteotomy despite cartilage lesions in the lateral compartment
- Rapid and structure-specific cellular uptake of selected steroids
- Avoiding gambling harm: An evidence-based set of safe gambling practices for consumers
- Epidemiology of chronic pain in Ukraine: Findings from the World Mental Health Survey
- PIAS1 is not suitable as a urothelial carcinoma biomarker protein and pharmacological target
- Double triage to identify poorly annotated genes in maize: The missing link in community curation
- N-acetyl cysteine restores the fertility of vitrified–warmed mouse oocytes derived through ultrasuperovulation
- Architecture of population-differentiated polymorphisms in the human genome
- Linguistic neutrosophic power Muirhead mean operators for safety evaluation of mines
- Extracellular vesicles nanoarray technology: Immobilization of individual extracellular vesicles on nanopatterned polyethylene glycol-lipid conjugate brushes
- Exercise intensity-dependent effects of arm and leg-cycling on cognitive performance
- How information about perpetrators’ nature and nurture influences assessments of their character, mental states, and deserved punishment
- Stringent response governs the oxidative stress resistance and virulence of Francisella tularensis
- In silico assessment of human Calprotectin subunits (S100A8/A9) in presence of sodium and calcium ions using Molecular Dynamics simulation approach
- Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging
- Measurable residual disease monitoring for patients with acute myeloid leukemia following hematopoietic cell transplantation using error corrected hybrid capture next generation sequencing
- Characteristics of complementary medicine therapists in Switzerland: A cross-sectional study
- Lack of generalization between explicit and implicit visuomotor learning
- Diet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population
- Effects of temperature and salinity on respiratory losses and the ratio of photosynthesis to respiration in representative Antarctic phytoplankton species
- Self-reported non-receipt of HIV test results: A silent barrier to HIV epidemic control in Mozambique
- Plasma midkine concentrations in healthy children, children with increased and decreased adiposity, and children with short stature
- Echocardiography overestimates LV mass in the elderly as compared to cardiac CT
- Efficacy of cotrimoxazole (Sulfamethoxazole-Trimethoprim) as a salvage therapy for the treatment of bone and joint infections (BJIs)
- Molecular mechanism of antimicrobial activity of chlorhexidine against carbapenem-resistant Acinetobacter baumannii
- First identification of the benzimidazole resistance-associated F200Y SNP in the beta-tubulin gene in Ascaris lumbricoides
- Green synthesis of silver nanoparticles using Solanum mammosum L. (Solanaceae) fruit extract and their larvicidal activity against Aedes aegypti L. (Diptera: Culicidae)
- Enterovirus 71 seroepidemiology in Taiwan in 2017 and comparison of those rates in 1997, 1999 and 2007
- Effect of statin on life prognosis in Japanese patients undergoing hemodialysis
- 13C and 15N NMR identification of product compound classes from aqueous and solid phase photodegradation of 2,4,6-trinitrotoluene
- Off-target effects of CRISPRa on interleukin-6 expression
- Exploring the antimicrobial properties of dark-operating ceramic-based nanocomposite materials for the disinfection of indoor air
- Experienced males recognise and avoid mating with non-virgin females in the western flower thrips
- Liver transplantation in patients with a history of migration—A German single center comparative analysis
- Retraction: The Different Role of Notch1 and Notch2 in Astrocytic Gliomas
- Correction: Understanding climate change from a global analysis of city analogues
- Comparison of 4D Flow MRI to 2D Flow MRI in the pulmonary arteries in healthy volunteers and patients with pulmonary hypertension
- The relationship between sleep quality, inappropriate medication use and frailty among older adults in aged care homes in Malaysia
- Clonal diversity and spatial genetic structure in the long-lived herb, Prairie trillium
- Medication histories documentation at the community pharmacy setting: A study from Jordan
- Population dynamics of an invasive bird parasite, Philornis downsi (Diptera: Muscidae), in the Galapagos Islands
- Because you had a bad day: General and daily relations between reactive temperament, emotion regulation, and depressive symptoms in youth
- Socioeconomic status and alcohol use disorders across the lifespan: A co-relative control study
- Generation of deletions and precise point mutations in Dictyostelium discoideum using the CRISPR nickase
- Polymorphisms in vasoactive eicosanoid genes of kidney donors affect biopsy scores and clinical outcomes in renal transplantation
- Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma: A preclinical F98 glioblastoma rat model study
- Validation and perception of a key feature problem examination in neurology
- Gender affirmative HIV care framework: Decisions on feminizing hormone therapy (FHT) and antiretroviral therapy (ART) among transgender women
- Quantifying international human mobility patterns using Facebook Network data
- Localization and characterization of thyroid microcalcifications: A histopathological study
- Young children are the main victims of fast food induced obesity in Brazil
- Understanding self-reported importance of religion/spirituality in a North American sample of individuals at risk for familial depression: A principal component analysis
- Standing balance of professional ballet dancers and non-dancers under different conditions
- 30-day unplanned readmission rate in otolaryngology patients: A population-based study in Thuringia, Germany
- Physical exercise stimulates salivary secretion of cystatins
- Vintage electronics for trusted radiation measurements and verified dismantlement of nuclear weapons
- Keepin’ it real: Linguistic models of authenticity judgments for artificially generated rap lyrics
- Carbon emission reduction and profit distribution mechanism of construction supply chain with fairness concern and cap-and-trade
- Modulations of microbehaviour by associative memory strength in Drosophila larvae
- Changes in peak expiratory flow rates using two head-tilt/chin-lift maneuver angles in young healthy conscious volunteers
- 3D image analysis reveals differences of CD30 positive cells and network formation in reactive and malignant human lymphoid tissue (classical Hodgkin Lymphoma)
- Change in larval fish assemblage in a USA east coast estuary estimated from twenty-six years of fixed weekly sampling
- 2-methylquinazoline derivative F7 as a potent and selective HDAC6 inhibitor protected against rhabdomyolysis-induced acute kidney injury
- Correction: Reducing growth and developmental problems in children: Development of an innovative postnatal risk assessment
- Comparative analysis of the vertebral pneumatization in pterosaurs (Reptilia: Pterosauria) and extant birds (Avialae: Neornithes)
- Associations between cognitive performance and sigma power during sleep in children with attention-deficit/hyperactivity disorder, healthy children, and healthy adults
- Retraction: MiR-375 Is Epigenetically Downregulated by HPV-16 E6 Mediated DNMT1 Upregulation and Modulates EMT of Cervical Cancer Cells by Suppressing lncRNA MALAT1
- Comparing growth patterns of three species: Similarities and differences
- Iron is increased in the brains of ageing mice lacking the neurofilament light gene
- Economic evaluation of community acquired pneumonia management strategies: A systematic review of literature
- A participatory community case study of periurban coastal flood vulnerability in southern Ecuador
- Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL
- Mitochondrial dysfunctions in leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL)
- MRI-based visualization of rTMS-induced cortical plasticity in the primary motor cortex
- Knowledge, attitudes, and practices related to anthrax and animal care: A case-control study in Georgia
- Information diffusion in signed networks
- Nurses’ perspectives on their communication with patients in busy oncology wards: A qualitative study
- Inflammation in acute coronary syndrome: Expression of TLR2 mRNA is increased in platelets of patients with ACS
- ART is key to clearing oncogenic HPV genotypes (HR-HPV) in anal mucosa of HIV-positive MSM
- Retraction: Fluid–Structure Interaction-Based Biomechanical Perception Model for Tactile Sensing
- Correction: Role of Caveolin-1 in Atrial Fibrillation as an Anti-Fibrotic Signaling Molecule in Human Atrial Fibroblasts
- The French adaptation and validation of the Partners in Health (PIH) scale among patients with chronic conditions seen in primary care
- Depth inversion with a 3D structure influences brightness perception
- Analysis of group evolution prediction in complex networks
- Effect of aridity and dune type on rhizosphere soil bacterial communities of Caragana microphylla in desert regions of northern China
- Knowledge, attitudes, and practices related to TB among the general population of Ethiopia: Findings from a national cross-sectional survey
- Correction: Personality traits in companion dogs—Results from the VIDOPET
- MANET 3.0: Hierarchy and modularity in evolving metabolic networks
- Agreement study on gait assessment using a video-assisted rating method in patients with idiopathic normal-pressure hydrocephalus
- Single fixed low-dose rituximab as induction therapy suppresses de novo donor-specific anti-HLA antibody production in ABO compatible living kidney transplant recipients
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- Video lecturing in Clicker-assisted English flipped class
- Significant changes of the choroid in patients with ocular ischemic syndrome and symptomatic carotid artery stenosis
- Skewed T cell responses to Epstein-Barr virus in long-term asymptomatic kidney transplant recipients
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- Host plants influence the composition of the gut bacteria in Henosepilachna vigintioctopunctata
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- The association between flavor capsule cigarette use and sociodemographic variables: Evidence from Chile
- Relations between gross motor skills and executive functions, controlling for the role of information processing and lapses of attention in 8-10 year old children
- Linalool acts as a fast and reversible anesthetic in Hydra
- Double burden of maternal and child malnutrition and socioeconomic status in urban Sri Lanka
- Using isotemporal substitution to predict the effects of changing physical behaviour on older adults’ cardio-metabolic profiles
- Adherence to general medical checkup and cancer screening guidelines according to self-reported smoking status: Korea National Health and Nutrition Examination Survey (KNHANES) 2010–2012
- Do older English adults exhibit day-to-day compensation in sedentary time and in prolonged sedentary bouts? An EPIC-Norfolk cohort analysis
- Linoleic acid supplementation of cell culture media influences the phospholipid and lipid profiles of human reconstructed adipose tissue
- Correction: Factors associated with hospitalization and death among TB/HIV co-infected persons in Porto Alegre, Brazil
- An ex vivo tissue model of cartilage degradation suggests that cartilage state can be determined from secreted key protein patterns
- Reporting adverse events related to medical devices: A single center experience from a tertiary academic hospital
- Enterohemorrhagic Escherichia coli infection inhibits colonic thiamin pyrophosphate uptake via transcriptional mechanism
- Estimating biodiversity changes in the Camargue wetlands: An expert knowledge approach
- Decreased risk of Parkinson’s disease in diabetic patients with thiazolidinediones therapy: An exploratory meta-analysis
- Retraction: Carboxyamidotriazole-Orotate Inhibits the Growth of Imatinib-Resistant Chronic Myeloid Leukaemia Cells and Modulates Exosomes-Stimulated Angiogenesis
- Lipoarabinomannan from Mycobacterium indicus pranii shows immunostimulatory activity and induces autophagy in macrophages
- A measure of inconsistencies in intertemporal choice
- A novel radiopaque tissue marker for soft tissue localization and in vivo length and area measurements
- Anatomical, histological and computed tomography comparisons of the eye and adnexa of crab-eating fox (Cerdocyon thous) to domestic dogs
- Subpopulation augmentation among habitat patches as a tool to manage an endangered Mojave Desert wetlands-dependent rodent during anthropogenic restricted water climate regimes
- Characteristics of CD5-positive diffuse large B-cell lymphoma among Koreans: High incidence of BCL2 and MYC double-expressors
- Fossil tabulate corals reveal outcrops of Paleozoic sandstones in the Atlantic Coastal Plain Province, Southeastern USA
- Coming and going – Historical distributions of the European oyster Ostrea edulis Linnaeus, 1758 and the introduced slipper limpet Crepidula fornicata Linnaeus, 1758 in the North Sea
- Behavioral predictors of subsequent respiratory illness signs in dogs admitted to an animal shelter
- Novel chemotherapeutic agent, FND-4b, activates AMPK and inhibits colorectal cancer cell proliferation
- Can emotional intelligence be improved? A randomized experimental study of a business-oriented EI training program for senior managers
- Genetic variability in landraces populations and the risk to lose genetic variation. The example of landrace ‘Kyperounda’ and its implications for ex situ conservation
- Sleep problems are a strong predictor of stress-related metabolic changes in police officers. A prospective study
- Age, sex and primary care setting differences in patients’ perception of community healthcare seeking behaviour towards health services
- Kinematic analyses including finite helical axes of drop jump landings demonstrate decreased knee control long after anterior cruciate ligament injury
- Effects of model inaccuracies on reaching movements with intermittent control
- C-reactive protein to albumin ratio predicts the outcome in renal cell carcinoma: A meta-analysis
- A new synthetic lure for management of the invasive giant African snail, Lissachatina fulica
- Bridging solvent molecules mediate RNase A – Ligand binding
- Variation in methods, results and reporting in electronic health record-based studies evaluating routine care in gout: A systematic review
- The use of prophylactic intra-aortic balloon pump in high-risk patients undergoing coronary artery bypass grafting
- Compliance with clinical guidelines for breast cancer management: A population-based study of quality-of-care indicators in France
- Dysregulated T helper type 1 (Th1) and Th17 responses in elderly hospitalised patients with infection and sepsis
- Acute effects of differential learning on football kicking performance and in countermovement jump
- Escherichia coli and Salmonella spp. isolated from Australian meat chickens remain susceptible to critically important antimicrobial agents
- Play like me: Similarity in playfulness promotes social play
- Awareness of family health history in a predominantly young adult population
- Care pathways during a child’s final illness in rural South Africa: Findings from a social autopsy study
- Intranasal lidocaine for acute migraine: A meta-analysis of randomized controlled trials
- Evaluating case management as a complex intervention: Lessons for the future
- Allele-specific enhancer interaction at the Peg3 imprinted domain
- Has the “M” word been framed? Marijuana, cannabis, and public opinion
- Is spontaneous normalization of systolic blood pressure within 24 hours after ischemic stroke onset related with favorable outcomes?
- Mixotrophic cultivation of Spirulina platensis in dairy wastewater: Effects on the production of biomass, biochemical composition and antioxidant capacity
- Constitutive expression of an A-5 subgroup member in the DREB transcription factor subfamily from Ammopiptanthus mongolicus enhanced abiotic stress tolerance and anthocyanin accumulation in transgenic Arabidopsis
- Stable carbon isotope diagnostics of mammalian metabolism, a high-resolution isotomics approach using amino acid carboxyl groups
- Factors associated with depressive symptoms in patients with ankylosing spondylitis in Northern Taiwan
- A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period
- Retraction: Reversal Effect of ST6GAL 1 on Multidrug Resistance in Human Leukemia by Regulating the PI3K/Akt Pathway and the Expression of P-gp and MRP1
- Potential role for microRNA-16 (miR-16) and microRNA-93 (miR-93) in diagnosis and prediction of disease progression in mycosis fungoides in Egyptian patients
- Rapid visual categorization is not guided by early salience-based selection
- Relative contribution of climate and non-climate drivers in determining dynamic rates of boreal birds at the edge of their range
- A simple-to-use nomogram to predict long term survival of patients undergoing coronary artery bypass grafting (CABG) using bilateral internal thoracic artery grafting technique
- Effects of sonication parameters on transcranial focused ultrasound brain stimulation in an ovine model
- Antenatal and intrapartum interventions for reducing caesarean section, promoting vaginal birth, and reducing fear of childbirth: An overview of systematic reviews
- Relative species abundance successfully predicts nestedness and interaction frequency of monthly pollination networks in an alpine meadow
- Correction: RCER: Reliable Cluster-based Energy-aware Routing protocol for heterogeneous Wireless Sensor Networks
- Amphibians on the hotspot: Molecular biology and conservation in the South American Atlantic Rainforest
- Role of psychosocial status in predicting health-related quality of life at 1-year follow-up among newly diagnosed people living with HIV
- Application of national pollutant inventories for monitoring trends on dioxin emissions from stationary industrial sources in Australia, Canada and European Union
- The association between vaccination confidence, vaccination behavior, and willingness to recommend vaccines among Finnish healthcare workers
- Retraction: Interleukin-1β-Induced Autophagy-Related Gene 5 Regulates Proliferation of Embryonic Stem Cell-Derived Odontoblastic Cells
- A localized sanitation status index as a proxy for fecal contamination in urban Maputo, Mozambique
- E2 protein is the major determinant of specificity at the human papillomavirus origin of replication
- “You’re kind of at war with yourself as a nurse”: Perspectives of inpatient nurses on treating people who present with a comorbid opioid use disorder
- A refinement approach in a mouse model of rehabilitation research. Analgesia strategy, reduction approach and infrared thermography in spinal cord injury
- Circulating cell-free DNA from plasma undergoes less fragmentation during bisulfite treatment than genomic DNA due to low molecular weight
- Understanding fatigue in adults with visual impairment: A path analysis study of sociodemographic, psychological and health-related factors
- Retraction: Mouse-Induced Pluripotent Stem Cells Differentiate into Odontoblast-Like Cells with Induction of Altered Adhesive and Migratory Phenotype of Integrin
- A novel analytical method to assess the effect of imipenem/cilastatin on liver function laboratory indexes in Chinese underage inpatients: Probability distribution curve
- The cause of anorexia and proportion of its recovery in older adults without underlying disease: Results of a retrospective study
- Referral and admission to intensive care: A qualitative study of doctors’ practices in a Tanzanian university hospital
- Agreement between clinical and non-clinical digital manometer for assessing maximal respiratory pressures in healthy subjects
- Heads or tails? Differential translational regulation in cercarial heads and tails of schistosome worms
- Horizontal seed dispersal by dung beetles reduced seed and seedling clumping, but did not increase short-term seedling establishment
- The coupling of the M2 muscarinic receptor to its G protein is voltage dependent
- Subsidy strategy of pharmaceutical e-commerce platform based on two-sided market theory
- Shoulder girdle injuries involving the medial clavicle differ from lateral clavicle injuries with a focus on concomitant injuries and management strategies: A retrospective study based on nationwide routine data
- Unraveling middle childhood attachment-related behavior sequences using a micro-coding approach
- Divergence history and hydrothermal vent adaptation of decapod crustaceans: A mitogenomic perspective
- Duration of solid fuel cookstove use is associated with increased risk of acute lower respiratory infection among children under six months in rural central India
- Evolving flocking in embodied agents based on local and global application of Reynolds’ rules
- Non-invasive contrast enhanced ultrasound molecular imaging of inflammation in autoimmune myocarditis for prediction of left ventricular fibrosis and remodeling
- Care coordination for chronic and complex health conditions: An experienced based co-design study engaging consumer and clinician groups for service improvement
- Association between socioeconomic status and diet quality in Mexican men and women: A cross-sectional study
- Surveillance of panicle positions by unmanned aerial vehicle to reveal morphological features of rice
- Is Betula carpatica genetically distinctive? A morphometric, cytometric and molecular study of birches in the Bohemian Massif with a focus on Carpathian birch
- Correction: Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance
- The genome of the migratory nematode, Radopholus similis, reveals signatures of close association to the sedentary cyst nematodes
- Factors associated with pneumococcal carriage and density in infants and young children in Laos PDR
- Overlap between telangiectasia and photoreceptor loss increases with progression of macular telangiectasia type 2
- The role of hope for health professionals in rehabilitation: A qualitative study on unfavorable prognosis communication
- Expression of miR-34a-5p is up-regulated in human colorectal cancer and correlates with survival and clock gene PER2 expression
- Molecular characterization and In Vitro synthesis of infectious RNA of a Turnip vein-clearing virus isolated from Alliaria petiolata in Hungary
- Assessment of client satisfaction with pharmacist services at outpatient pharmacy of Tikur Anbessa Specialized Hospital
- Thermogravimetric analysis of the co-combustion of coal and polyvinyl chloride
- Roles of leptin in the recovery of muscle and bone by reloading after mechanical unloading in high fat diet-fed obese mice
- Unexpected high seroprevalence of hepatitis E virus in patients with alcohol-related cirrhosis
- APOL1-G0 protects podocytes in a mouse model of HIV-associated nephropathy
- Integrating a gait analysis test in hospital rehabilitation: A service design approach
- Correction: Bioactivity-guided isolation of rosmarinic acid as the principle bioactive compound from the butanol extract of Isodon rugosus against the pea aphid, Acyrthosiphon pisum
- Soil-borne fungi influence seed germination and mortality, with implications for coexistence of desert winter annual plants
- Applying Corrigan’s progressive model of self-stigma to people with depression
- Do psychosocial factors modify the negative association between disability and life satisfaction in old age?
- Public perception of coastal habitat loss and habitat creation using artificial floating islands in the UK
- Transcriptional foliar profile of the C3-CAM bromeliad Guzmania monostachia
- Application of tuned liquid column ball damper (TLCBD) for improved vibration control performance of multi-storey structure
- Do protection gradients explain patterns in herbivore densities? An example with ungulates in Zambia’s Luangwa Valley
- Consequences of chronic bacterial infection in Drosophila melanogaster
- The effects of environmental parameters on the microbial activity in peat-bog lakes
- Differences in protein structural regions that impact functional specificity in GT2 family β-glucan synthases
- Correction: Identification of lysine methylation in the core GTPase domain by GoMADScan
- Changes of absorbed dose rate in air in metropolitan Tokyo relating to radiocesium released from the Fukushima Daiichi Nuclear Power Plant accident: Results of a five-year study
- Histological chorioamnionitis, antenatal steroids, and neonatal outcomes in very low birth weight infants: A nationwide study
- A machine learning approach for the prediction of pulmonary hypertension
- Altered microbiota, fecal lactate, and fecal bile acids in dogs with gastrointestinal disease
- Impaired processing of threat in psychopathy: A systematic review and meta-analysis of factorial data in male offender populations
- Dimethyl disulfide (DMDS) as an effective soil fumigant against nematodes in China
- Risk factors for hepatitis C infection among adult patients in Kedah state, Malaysia: A case–control study
- Factoring a 2 x 2 contingency table
- The development of connectives in three to five-year-old monolingual Spanish-speaking children
- Foliar plasticity related to gradients of heat and drought stress across crown orientations in three Mediterranean Quercus species
- The evolution of haploid chromosome numbers in Meliponini
- Bloodstream infections caused by Escherichia coli in onco-haematological patients: Risk factors and mortality in an Italian prospective survey
- Facial features and unethical behavior – Doped athletes show higher facial width-to-height ratios than non-doping sanctioned athletes
- Non-resolution of non-alcoholic fatty liver disease (NAFLD) among urban, adult Sri Lankans in the general population: A prospective, cohort follow-up study
- Left ventricular simulation of cardiac compression: Hemodynamics and regional mechanics
- Are we ready for scaling up restoration actions? An insight from Mediterranean macroalgal canopies
- Age-related changes in size, bone microarchitecture and volumetric bone mineral density of the mandible in the harbor seal (Phoca vitulina)
- Parasitism modifies the direct effects of warming on a hemiparasite and its host
- Analytic performance of PANArray HPV and HPV 9G DNA chip tests for genotyping of high-risk human papillomavirus in cervical ThinPrep PreservCyt samples
- Transcript profile of skeletal muscle lipid metabolism genes affected by diet in a piglet model of low birth weight
- Differential impact of smoking on cardiac or non-cardiac death according to age
- Influence of injectate volume on paravertebral spread in erector spinae plane block: An endoscopic and anatomical evaluation
- Correction: Nitrogen starvation induces distinct photosynthetic responses and recovery dynamics in diatoms and prasinophytes
- Healthcare needs and programmatic gaps in transition from pediatric to adult care of vertically transmitted HIV infected adolescents in India
- Retraction: Neuronal Differentiation Dictates Estrogen-Dependent Survival and ERK1/2 Kinetic by Means of Caveolin-1
- Correction: Disability and its association with sociodemographic factors among elderly persons residing in an urban resettlement colony, New Delhi, India
- Antibacterial activity of varying UMF-graded Manuka honeys
- Correction: Synthesis of IL-6 by Hepatocytes Is a Normal Response to Common Hepatic Stimuli
- Detection and genetic characterization of Echinococcus granulosus mitochondrial DNA in serum and formalin-fixed paraffin embedded cyst tissue samples of cystic echinococcosis patients
- Deep-learning-based risk stratification for mortality of patients with acute myocardial infarction
- Links between meaning in life and physical quality of life after rehabilitation: Mediating effects of positive experiences with physical exercises and mobility
- The estrogen effect; clinical and histopathological evidence of dichotomous influences in dogs with spontaneous mammary carcinomas
- The association between socioeconomic status, psychopathological symptom burden in mothers, and early childhood caries of their children
- Increased rate of FEV1 decline in HIV patients despite effective treatment with HAART
- Parallels between stream and coastal water quality associated with groundwater discharge
- Determinants of anemia among pregnant women attending antenatal care in Horo Guduru Wollega Zone, West Ethiopia: Unmatched case-control study
- Depression and anxiety among pregnant women living with HIV in Kilimanjaro region, Tanzania
- Shift in trophic niches of soil microarthropods with conversion of tropical rainforest into plantations as indicated by stable isotopes (15N, 13C)
- On the development of sleep states in the first weeks of life
- CCR5 receptor antagonism inhibits hepatitis C virus (HCV) replication in vitro
- Investigation into pathophysiology of naturally occurring palatal instability and intermittent dorsal displacement of the soft palate (DDSP) in racehorses: Thyro-hyoid muscles fatigue during exercise
- Correction: Reducing phenolic off-flavors through CRISPR-based gene editing of the FDC1 gene in Saccharomyces cerevisiae x Saccharomyces eubayanus hybrid lager beer yeasts
- MitoToxy assay: A novel cell-based method for the assessment of metabolic toxicity in a multiwell plate format using a lactate FRET nanosensor, Laconic
- Correction: Evidence for plant-derived xenomiRs based on a large-scale analysis of public small RNA sequencing data from human samples
- Correction: Prognostic impact of systolic blood pressure variability in people with diabetes
- Retraction: Sialoglycosylation of RBC in Visceral Leishmaniasis Leads to Enhanced Oxidative Stress, Calpain-Induced Fragmentation of Spectrin and Hemolysis
- Too much? Mortality and health service utilisation among Danish children 1999-2016: A register-based study
- Effects of sodium-glucose cotransporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors on diabetic retinopathy and its progression: A real-world Korean study
- Shipworm bioerosion of lithic substrates in a freshwater setting, Abatan River, Philippines: Ichnologic, paleoenvironmental and biogeomorphical implications
- Genetic codes optimized as a traveling salesman problem
- Effect of antenatal detection of small-for-gestational-age newborns in a risk stratified retrospective cohort
- Using family network data in child protection services
- Transcriptome sequencing reveals the effect of biochar improvement on the development of tobacco plants before and after topping
- Volatile anesthetics versus total intravenous anesthesia in patients undergoing coronary artery bypass grafting: An updated meta-analysis and trial sequential analysis of randomized controlled trials
- Cumulative fluid balance predicts mortality and increases time on mechanical ventilation in ARDS patients: An observational cohort study
- Stated-preference research in HIV: A scoping review
- Correction: Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database
- Antinociceptive compounds and LC-DAD-ESIMSn profile from Dictyoloma vandellianum leaves
- Time series experimental design under one-shot sampling: The importance of condition diversity
- Evaluation of protocols for rRNA depletion-based RNA sequencing of nanogram inputs of mammalian total RNA
- Prevalence and predictors of primary postpartum hemorrhage: An implication for designing effective intervention at selected hospitals, Southern Ethiopia
- Correction: Stillbirths in urban Guinea-Bissau: A hospital- and community-based study
- Correction: Method for spike detection from microelectrode array recordings contaminated by artifacts of simultaneous two-photon imaging
- Correction: Peripheral blood mononuclear cells extracts VEGF protein levels and VEGF mRNA: Associations with inflammatory molecules in a healthy population
- Correction: Novel site-specific PEGylated L-asparaginase
- Effect of caffeine ingestion on competitive rifle shooting performance
- Correction: Color adaptation induced from linguistic description of color
- MEK inhibition suppresses B regulatory cells and augments anti-tumor immunity
- Correction: A biface production older than 600 ka ago at Notarchirico (Southern Italy) contribution to understanding early Acheulean cognition and skills in Europe
- Correction: A urinary extracellular vesicle microRNA biomarker discovery pipeline; from automated extracellular vesicle enrichment by acoustic trapping to microRNA sequencing
- Measurement of horizontal ocular deviation on magnetic resonance imaging in various disease with acute vertigo
- Clinical outcomes of early gastric cancer with non-curative resection after pathological evaluation based on the expanded criteria
- Detection of quantitative trait loci associated with drought tolerance in St. Augustinegrass
- An examination of the Kuleshov effect using still photographs
- Correction: Relationship between non-communicable diseases and background characteristics among homeless people in Nagoya City, Japan
- An exploration of automated narrative analysis via machine learning
- Correction: Frozen by stress: Stress increases scope insensitivity
- The pragmatic role of trust in young children’s interpretation of unfamiliar signals
- Measuring egocentric distance perception in virtual reality: Influence of methodologies, locomotion and translation gains
- Mathematical modeling of cardiac function to evaluate clinical cases in adults and children
- Correction: Forecasting the impact of population ageing on tuberculosis incidence
- “The car is my extra legs” – Experiences of outdoor mobility amongst immigrants in Sweden with late effects of polio
- Correction: Multilevel analyses of on-demand medication data, with an application to the treatment of Female Sexual Interest/Arousal Disorder
- Correction: The world’s user-generated road map is more than 80% complete
- Correction: Predictors of opioid efficacy in patients with chronic pain: A prospective multicenter observational cohort study
- Correction: Comparative prognostic accuracy of sepsis scores for hospital mortality in adults with suspected infection in non-ICU and ICU at an academic public hospital
- Correction: Biosynthesis of the oxygenated diterpene nezukol in the medicinal plant Isodon rubescens is catalyzed by a pair of diterpene synthases
- Correction: Effect of early measles vaccine on pneumococcal colonization: A randomized trial from Guinea-Bissau
- Correction: Tuberculosis patients in an Indian mega-city: Where do they live and where are they diagnosed?
- Correction: Priority Queue Based Reactive Buffer Management Policy for Delay Tolerant Network under City Based Environments
- Correction: Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma
- Correction: A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas
- Correction: Evolution and study of a copycat effect in intimate partner homicides: A lesson from Spanish femicides
- Correction: Transforming growth factor beta 1 induces methylation changes in lung fibroblasts
- Correction: Congenital Zika Syndrome in a Brazil-Paraguay-Bolivia border region: Clinical features of cases diagnosed between 2015 and 2018
- Correction: Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression
- Correction: Factors influencing the behaviour and perceptions of Australian veterinarians towards antibiotic use and antimicrobial resistance
- Correction: Nonalcoholic fatty liver disease is a risk factor for large-for-gestational-age birthweight
- Retraction: Butyrate Attenuates Lipopolysaccharide-Induced Inflammation in Intestinal Cells and Crohn's Mucosa through Modulation of Antioxidant Defense Machinery
- Retraction: Tetrandrine Suppresses Lipopolysaccharide-Induced Microglial Activation by Inhibiting NF-κB and ERK Signaling Pathways in BV2 Cells
- Correction: Isolation of five Enterobacteriaceae species harbouring blaNDM-1 and mcr-1 plasmids from a single paediatric patient
- Correction: Generation and selection of pluripotent stem cells for robust differentiation to insulin-secreting cells capable of reversing diabetes in rodents
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