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ReklamaElevation, an emotion for prosocial contagion, is experienced more strongly by those with greater expectations of the cooperativeness of others
Authors: Adam Maxwell Sparks aff001; Daniel M. T. Fessler aff001; Colin Holbrook aff001
Authors place of work: Department of Anthropology, University of California Los Angeles, Los Angeles, California, United States of America aff001; Center for Behavior, Evolution and Culture, University of California Los Angeles, Los Angeles, California, United States of America aff002; Bedari Kindness Institute, University of California Los Angeles, Los Angeles, California, United States of America aff003; Department of Cognitive and Information Sciences, University of California Merced, Merced, California, United States of America aff004
Published in the journal: PLoS ONE 14(12)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0226071Summary
A unique emotion, elevation, is thought to underlie prosocial contagion, a process whereby witnessing a prosocial act leads to acting prosocially. Individuals differ in their propensity to experience elevation, and thus their proneness to prosocial contagion, but little is known about the causes of such variation. We introduce an adaptationist model wherein elevation marks immediate circumstances in which generalized prosociality is advantageous, with this evaluation of circumstances hinging in part on prior expectations of others’ prosociality. In 15 studies, we add to evidence that elevation can reliably be elicited and mediates prosocial contagion. Importantly, we confirm a novel prediction–generated by our adaptationist account–that an idealistic attitude, which indexes others’ expected degree of prosociality, moderates the relationship between exposure to prosocial cues and experiencing elevation. We discuss how our findings inform both basic theorizing in the affective sciences and translational efforts to engineer a more harmonious world, and we offer future research directions to further test and extend our model.
Keywords:
Learning – Human learning – Employment – Behavior – emotions – Motivation – Prosocial behavior – Gratitude
Introduction
Increasing the basic scientific understanding of psychological mechanisms underlying prosocial behavior is of theoretical importance across the social sciences, and has applied significance for engineering cooperative institutions [1]. Many emotions appear to play a role in prosocial behavior [2–6], among them elevation, the uplifting affect experienced upon witnessing others’ morally praiseworthy actions [7].
Here we present a novel adaptationist model wherein elevation functions to upregulate prosocial behavior in situations that are especially favorable for cooperative investments. The psychological mechanisms that regulate elevation must do so by interpreting when ambiguous social cues suggest that the present situation is ripe for investing in prosociality, where such interpretation is informed by prior social expectations. This leads to a novel empirical prediction, that individual differences in elevation response to similar social cues should be a function of differences in baseline expectations about the cooperativeness of others.
We then report 15 original empirical studies (total N = 8,118), the results of which replicate and extend several previously-reported elevation findings, and, importantly, also strongly support our novel prediction. Our open data set thus both adds confidence regarding previous findings that informed our theoretical model and offers novel evidence for a crucial feature of our model.
A brief review of scholarship on elevation
Drawing heavily on prior work, especially two recent review papers in the field of positive psychology [8,9], but interpreting the empirical record through the lens of our model, we characterize elevation using four key features useful for differentiating among emotions [10,11]: (1) clusters of culturally-embedded folk affect terms used to describe the experience, (2) experienced physiological responses, (3) motivational/behavioral patterns, and (4) eliciting conditions.
Lay English speakers have no precise term for elevation, but “lifted up,” “inspired,” “moved,” “respect,” and “awe” are folk affect terms often used to describe the experience. Somatic symptoms of elevation include warmth in the chest, chills or goosebumps, a lump in the throat, and tears in the eyes. Elevation involves motivations to help others and be a better person, motives that appear to cause actual cooperative behavior [12–15]. The cooperative motives associated with elevation appear to be generalized, rather than directed at a specific target, as is the case with gratitude [16]. Self-report measures of elevation vary in their details, but typically involve Likert scale measures based on some or all of these first three characteristics of elevation: folk terms, somatic sensations, and prosocial motives. These three features are the basis of three corresponding subscales in the elevation measures we describe below. (We will argue that a fourth category of items commonly used in elevation scales, statements which capture general views of humanity, are better treated as measuring an attitude rather than part of the emotion itself.)
Our interpretation is that elevation is elicited by exceptional prosocial behavior. Prosocial behavior refers to one or more persons conferring a benefit on one or more other persons, at some immediate cost to the actor(s), i.e., cooperation. “Exceptional” implies that the witnessed prosociality is rare, extreme, spectacular, or in some other way violates the expectations of the witness, i.e., the set of stimuli that elicit elevation is some region within a continuum of prosocial behaviors from mundane to remarkable. Our perspective is somewhat different from that of other researchers. Both of the recent review papers define “witnessing moral beauty” as the eliciting condition of elevation, language that stems from Haidt’s [7] formal introduction of the construct of elevation to the modern scientific community as being an emotion elicited by “acts of human moral beauty or virtue,” a sketch which itself followed from Thomas Jefferson’s [17] musings about strong emotional responses to reading fictional “acts of charity or gratitude” that “deeply impress with beauty,” such as great acts of “fidelity” or “generosity.” Haidt elaborated that elicitors of elevation include “unexpected acts of human goodness, kindness, and compassion,” and especially charitable behavior. Clearly there is a great deal of overlap between the behavior sets marked by “exceptional cooperation” and “moral beauty,” and the same may be said for the notion of “moral heroism” [18]. Our interpretation of elevation’s elicitor set differs from the prevailing interpretation in the field of positive psychology by emphasizing the flow of costs and benefits between interacting parties rather than relying on moral and/or aesthetic judgments of these interactions. It is not our present goal to attempt a full analysis of the (in)compatibilities of these two models. Rather, we report and interpret supportive evidence for a prediction about individual differences in elevation that was facilitated by our theoretical linkage of elevation to theories regarding the evolution and maintenance of cooperative behavior, as we elaborate below.
Elevation as part of an adaptive affective system for prosocial contagion
We can use the above sketch of the form of the elevation to infer its function; in the language of evolutionary biology, we can use information about the structure of the proximate mechanism to generate models of ultimate explanations for its existence. In turn, ultimate models can be used to generate hypotheses used to guide further empirical investigation of mechanisms [19,20]. Our general approach to modeling emotions as evolved biological mechanisms builds from Gervais and Fessler’s [11] Attitude-Scenario-Emotion framework, which we tailor to the current topic based on a functional analysis of the cooperative inputs and outputs of elevation. The resulting model generates hypotheses about the attitudes that are likely to regulate this emotion, yielding the testable prediction, investigated in the empirical portion of this paper, that individual differences in elevation experiences stem from individual’s prior expectations regarding the cooperativeness of other people.
General adaptationist model of affective systems
The Attitude-Scenario-Emotion model [11] is a novel synthetic framework, developed with a focus on emotions that regulate dyadic social relationships. To our knowledge, the work reported here is the first extensive use of this framework in empirical investigation of a specific emotion, and, as we later elaborate, the first extension of the model beyond dyads.
Building on much prior work, Gervais and Fessler [11] distinguish between emotions and attitudes (and also sentiments, which we address in the General Discussion). Emotions are fast-acting and short-lived responses to events that reorganize psychological and physiological systems to quickly respond to a scenario, the challenges or opportunities indexed by particular sets of stimuli. Social scenarios require subjective interpretation in light of one’s specific circumstances. The appropriate emotional responses depend on (among other things) the people involved, and, more specifically, their expected behaviors and the value of those behaviors for the would-be responder. Such expectations are encoded as attitudes, and thus, in the Attitude-Scenario-Emotion framework, differences in attitudes can cause differences in interpretation of scenarios, which in turn cause differences in emotion and behavior. We will use this hypothesized general structure to predict and explain individual variation specific to elevation experiences.
Functional theories of prosocial behavior
The critical outputs of the elevation mechanism are prosocial motivation and subsequent behavior. Accordingly, our functionalist approach to explaining a mechanism that causes cooperation draws on extensive literature addressing ultimate explanations of how individuals can enhance biological fitness through cooperation. Such explanations variously invoke the functional logic of kinship, reciprocity, mutualism, vested interest, and costly signaling, all in the context of competition for social partners within biological markets [21,22].
Critically, with the exception of kin-based altruism, all known individually-adaptive explanations of cooperation require that an actor’s investment in costly prosocial behavior leads to a subsequent payoff via benefits received from others. The fitness-profitability of prosociality is thus contingent on others’ actions; correspondingly, humans appear capable of behavior that is situationally contingent on expectations of others’ prosociality. In experimental paradigms in which participants face real-stakes cooperative dilemmas, individual cooperativeness is influenced by the apparent cooperativeness of other players [23–34]. Even experimental exposure to information about the apparent cooperativeness of distant others has similar effects [35–37]. Expanding further, field studies suggest that a variety of cues about prevailing levels of local prosociality contagiously inform a host of social behaviors [38–42].
Our model of elevation and idealism
Against this backdrop, we posit that elevation is a mechanism that motivates adaptive upregulation of prosocial behavior following the interpretation of social cues as indicating that the current situation is ripe for cooperative investment, i.e., this emotion is a mechanism for adaptive prosocial contagion. (It is not our claim that elevation is the only such emotion; in the General Discussion we compare elevation to other putative prosocial emotions.)
Consider the case of witnessing an exceptionally prosocial exemplar, a common experimental method for eliciting elevation. We essentially agree with Algoe & Haidt’s [16] interpretation that, in such situations, “other-praising emotions” like elevation have prestige-biased learning functions [43], and we specifically connect this to the functional logic of cooperation as follows: The exceptionally prosocial exemplar provides a cue that the present environment is one in which prosociality may be especially rewarding, not only because the exemplar herself may be a good candidate to reciprocate [7], but also because her current prosociality implies that her past prosociality has been rewarded rather than exploited by third parties, indirectly suggesting that the local environment includes other cooperators and/or prosocial punishers who guard against antisocial behavior [24,44–46]. Thus, the individual who witnesses a prosocial exemplar may infer that she would likely benefit from behaving cooperatively too, and such benefits might derive from many people or pathways, explaining the diffuse (rather than targeted) prosocial motives noted by Algoe & Haidt [16]. (Note that the inferences we are describing are at a functional level; this need not imply that individuals are consciously aware of such inferences. Just as disgust might motivate someone to recoil from feces without conscious concern for pathogen-inflicted costs, elevation might motivate prosocial contagion without any conscious concern for cooperatively-delivered benefits.)
One pragmatic difficulty confronting a mechanism for adaptive prosocial contagion is that the social cues to be interpreted are inherently ambiguous, such that executing the above adaptive logic necessarily requires preliminary interpretive processing that produces such functional inferences as:
The behavior I just witnessed was prosocial.
The cooperative individual(s) are likely to benefit from their actions.
I would benefit from similar acts.
Here we approach variation in the experience of elevation as being derived from individual differences that should make such inferences (whether implicit or explicit) more likely. When making such inferences, Type I errors are possible; the detection of an apparently benevolent actor is an imperfect cue to the future profitability of prosociality for the observer, especially for an observer new to the context. For example, a seeming act of kindness could, in fact, be bait in a trap for later exploitation. Given imperfect information, how then do observers determine how to condition current behavior on the informational value of the cue? In a Bayesian sense, the estimated likelihood that a given hypothesis is true (e.g., that this is a good time/place to behave prosocially) depends both on the immediate evidence and the prior estimate that the hypothesis is true. Thus, one’s prior expectations about how people tend to respond to prosocial behavior should regulate one’s interpretation of—and thus emotional and behavioral reactions to—an observed act of apparent extreme prosociality. (In the empirical work presented here, we measured participants’ prior expectations and their emotional and behavior responses, but did not measure their interpretations of the actions that they had witnessed, a decision reflecting the lack of a priori theoretical reasons for expecting that such functional inferences will necessarily be available to conscious mechanisms.)
In our model, these prior expectations regarding others’ prosociality are encoded in attitudes. In the dyadic framework introduced by Gervais and Fessler, an attitude towards an individual summarizes the attitude-holder’s expectations and valuations of that person, based on previous experiences. Attitudes can be characterized along a dimension we label “idealism-cynicism.” A more idealistic attitude towards someone indexes the expectation that the person tends to treat people prosocially; a more cynical (i.e., less idealistic) attitude towards someone corresponds to the expectation of more selfish behavior. An individual who has more idealistic prior attitudes towards the people involved in a social scenario should be more likely to interpret the witnessed behavior of the apparently prosocial exemplar as genuinely prosocial; more likely to expect cooperative responses to that behavior by others; and more likely to expect similar treatment herself in response to her own prosocial behavior. Conversely, a more cynical attitude towards the same individuals makes it less likely that the exemplar’s actions are interpreted as genuinely prosocial; less likely that other actors are expected to respond cooperatively to the original action; and less likely that the witness will assume that her own prosocial behavior would be rewarded. Accordingly, a witness’s idealism-cynicism towards the actors in a scenario (for simplicity, hereafter idealism) should moderate elevation and subsequent behavior in response to that scenario.
One key empirical implication of theoretically distinguishing between elevation and idealism
In Gervais and Fessler’s Attitude-Scenario-Emotion framework, the relationship between attitudes and emotions is bidirectional. Attitudes summarize past experience to adaptively shape emotional responses to immediate circumstances, where such experience is both accrued by the individual and framed by predispositions that may have been formulated over deep evolutionary time (for example, a sex difference in the propensity to construe social relationships as, respectively, competitive or cooperative [47]); in turn, emotions provide input that updates the attitude in light of present experience. Because attitudes aggregate across many occurrences, with the exception of extraordinary events, a given emotional experience will make only an incremental contribution to the corresponding enduring attitude. Nevertheless, we can expect that information in attitudinal format will be part of the output of an emotion, as this is the medium through which Bayesian updating of attitudes occurs.
Given this framework, tentative support can be found in existing literature for our novel model of the relationship between idealistic attitudes and elevation. Elevation researchers commonly suggest that elevation results in feeling close to others, and self-report scales intended to measure the experience of elevation frequently include items such as “I feel optimistic about humanity.” In our perspective, feelings and cognitive assessments about others are attitudinal, rather than emotional. Thus, research to date appears to have merged the emotion of elevation, the underlying attitudinal dimension of idealism (directed towards “humanity” rather than a specific individual), and the feedback between the former and the latter.
Building on others’ extensive prior work, below we document our efforts to design and implement experimental methods that create elevation-mediated prosocial contagion, and to test the unique proposal that individual differences in the propensity to experience elevation, and subsequently upregulate prosocial motivations and behavior, importantly stem from variation in baseline expectations of others’ prosociality–that is, from individual differences in prior idealistic attitudes. Thus, the present empirical effort attempts to both replicate key effects that informed our novel model of elevation and test a novel prediction generated by this model.
Fig 1 summarizes how the ASE model is applied to case of elevation, and how several of the model’s key concepts are operationalized in our methods.
Fig. 1. Structure of the elevation-idealism system. Methods
We have conducted multiple pre-registered, large-sample studies aimed at testing various aspects of our model. Our primary results here are meta-analyses of open data from all available studies that allow us to estimate the relationships between idealism, elevation, and behavior across varying types of scenarios (K = 15).
In all studies, participants completed a self-report scale intended to measure generalized idealism, then watched one or two videos and self-reported their elevation response to each. These data allow us to (1) assess how distributions of self-report emotional response outcomes differ by eliciting scenario (i.e., video type) and (2) test whether baseline idealism explains individual variation in elevation. In most studies, this was followed by one or more measures of real or hypothetical prosocial behavior, allowing an assessment of the relationship between emotion and behavior. As described and discussed below, and detailed in S1 Appendix, we refined our methods, measures, and stimuli across this series of studies and in several pilot efforts.
Table 1 summarizes the methods.
Tab. 1. Sample information. Participants and recruitment
Participants in field studies (k = 4) were recruited in public places in Los Angeles (mostly, but not exclusively, on or near the UCLA campus) and participated on the spot using tablet computers. Participants in all other studies (k = 11) were recruited via Amazon.com’s Mechanical Turk internet crowdsourcing platform (hereafter MTurk) to complete the study online. Online and field participants were recruited for “an [academic survey / research study] about feelings and memory”. Repeat participation across online studies was automatically precluded based on MTurk worker ID in most cases. Recruitment in field studies also attempted to exclude repeat participants; additionally, these studies generally targeted people who were alone in public, rather than with a group, although these were not strict requirements (we also conducted field studies, not reported here, in which pairs of individuals were specifically targeted for recruitment); all individual participants in field studies described here were removed from close proximity with other people at the time of participation. In our online studies, participants were randomly assigned to experimental condition; in field studies, conditions alternated across successive participants.
Research ethics statement
All studies complied with ethical regulations and were approved by the UCLA Office of the Human Research Protection Program under protocol #14–001681. Informed consent was obtained from all participants.
Video stimuli
Most of our studies involved an experimental contrast between the emotional and behavioral effects of exposure to, respectively, a prosocial video and an athletic video. In several online studies, participants watched a neutral video and recorded their elevation response prior to the aforementioned experimental intervention. In some studies, some or all participants saw only one of these three types of videos–such designs obviously do not allow direct experimental comparisons, but are included here in meta analyses estimating effects specific to a relevant video.
Prosocial video
Our prosocial video consisted of a lightly edited version of Unsung Hero, a Thai television commercial. This 3-minute video, employed by other emotion researchers as well [48], depicts a young man engaging in a variety of helpful acts (e.g., giving money to a beggar, feeding a stray dog, helping a street vendor lift her cart); as the story progresses viewers witness positive consequences for those the protagonist helps, and recipients’ displays of gratitude and positive orientation toward him. Thus, this video contains numerous cues indicative of both the presence of a prosocial primary actor, and eventual rewards for his prosociality provided by others in that actor’s community.
Athletic video
In most studies, we used the prosocial video in an experimental condition, contrasting it to a control Athletic video, chosen to be similarly enjoyable and entertaining but to contain far fewer cues of prosociality. Like Unsung Hero, this video features high production quality, a focal young man performing exceptional acts in an urban environment, and evocative music. Instead of a series of charitable and helpful actions, the protagonist performs parkour, a type of street acrobatics. Other elevation researchers have similarly contrasted prosocial stimuli with athletic or artistic displays as positively-valenced control conditions [12,49]; we chose parkour because viewers can readily recognize the skills required to, for example, run up a wall and perform a back flip, and thus do not require any understanding of a specific artistic or competitive context to appreciate the extraordinary nature of the performance. (In the General Discussion we consider implications of minor ambiguous cues to prosociality in this video: the impressive physical performance seems intended to entertain viewers, and the fact of the video being made and watched suggests that the performer has achieved some social status or rewards derived from diligent training efforts.)
Neutral video
In several studies, we implemented methods wherein, after completing the baseline idealism scale, participants watched a neutral video and then completed an elevation scale. This was done in order to: (1) attempt to reduce any variation in participants’ baseline emotion state (due to experiences just prior to participation, etc.); (2) familiarize participants with the elevation scale; and (3) facilitate within-subject comparisons of elevation measures prior to and after the primary experimental manipulation.
The Neutral video features 30 seconds of footage filmed in a commuter train occupied by a few unremarkable passengers who exhibit no overt exceptional behavior. It thus lacks the entertaining and mildly prosocial features of our Athletic video. Thus, should any minor variation in elevation response to the Neutral video be observed, this would more likely be to be due to methods issues (imperfect scale items, inattentive participants, etc.) rather than meaningful individual differences indexed by idealistic attitudes.
Attitude measure: Idealism-cynicism scale(s)
We conceptualize idealistic attitudes as baseline internal regulatory variables that are consulted when processing potentially elevating social scenarios, variables that are updated based on experience in a somewhat Bayesian process. In light of theorizing that attitudes can be updated by emotional experiences [11], we always measured idealism before participants were exposed to video stimuli; in some studies, we also measured idealism after said exposure.
We attempted to measure idealism with respect to people in general, rather than as an attitude towards specific individuals as in Gervais and Fessler’s model (more on this in the General Discussion). While the details of the idealism measure were refined over the course of the studies reported here, all versions of the scale show good internal reliability (alphas between .82 and .93 in our online studies, and between .73 and .86 in our field studies) and can be straightforwardly interpreted as measuring the extent to which generic others are expected to behave prosocially versus exploitatively toward each other and/or towards the self, e.g., “people [in general] try to be fair,”“I prefer to keep a distance from most people in my broader community”. S1 Appendix includes full details of the various scale versions used here, plus a description of an informal scale development effort based on data from pilot studies (also openly available).
Emotion measure: Elevation scale(s)
Our elevation scale, largely derived from scales used in prior work in this area [12,13,15,16,50,51], was refined over the course of our initial studies. Despite varying somewhat in their details, all versions of the scale have high internal reliability (full scale alphas > 0.95, subscale alphas > 0.80) and all versions include the same three conceptual subscales as reviewed above: terms describing somatic responses (e.g., “tears in the eyes”), folk terms for related affects (e.g., “moved”), and statements describing prosocial motivations (e.g., “want to help”). See S1 Appendix for all items.
Along with elevation items, we included several items measuring general positive affect (e.g., “entertained”, “happy”), an emotion variable which serves as a contrast in several analyses.
Initially following methods of other investigators, our earliest studies presented elevation items as “right now I feel [item],” while subsequent studies framed the items as “the video made me feel [item].” We prefer the latter framing as a way to focus participants’ reports on the emotion induced by the video specifically; our concern with the former framing is that it might suggest that participants should reflect upon the entire experience of participating in the research study (see S1 Appendix). Similarly, our initial efforts included a “view of humanity” subscale which was later removed because our primary focus here is to assess the impact of baseline attitudes on elevation, rather than to explore updates to attitudes resulting from the experience of elevation.
Behavior measures
Shortly after completing the elevation scale, in many studies participants’ prosocial behavior was gauged using a variety of measures, as follows:
Real charitable donation
In field studies, wherein passers-by participated in research in exchange for cash payment, participants had the opportunity to donate any or all of their payment to the UCLA Children’s Hospital via an anonymous donation procedure. Participants recorded their intended donation amount, if any, on the last item in the anonymous survey administered via tablet computer; participants then received their cash payment and, while the researcher turned away, placed any donation into a padded envelope and sealed it. The researcher then marked the outside of the envelope with a code that could be matched to the questionnaire responses; a different researcher later logged the contents of the envelopes, thus ensuring that donation decisions were truly anonymous. Although care was exercised in processing donated funds, the procedure of matching coded envelopes to electronic data left room for human error; thus, the amount pledged by the participant is arguably a more infallible data point than is the amount donated. However, the former is an imperfect approximation of the actual donation, as participants were free to donate any amount regardless of their pledge, and some openly claimed to have donated a different amount from that pledged (a few even gave more than their participation fee, which was not an available pledge option). We analyzed both pledges and recorded actual donations, finding that they are highly correlated and produce similar results. In the main text we report analyses based on actual donations; see S2 Appendix for analyses of pledges.
Hypothetical charitable donation
Our online studies used the MTurk employment platform, hence, instead of being compensated volunteers, participants were paid workers. Even the implied suggestion that MTurk workers donate a portion of their wages could be considered inconsistent with the nature of their engagement. Accordingly, rather than asking whether they wished to donate real money to a charitable cause, we instead asked how likely they would be to choose the charitable option in a hypothetical scenario wherein a new employer offered to automatically deduct and distribute charitable donations from employee salaries.
Written messages
Because Internet users frequently provide feedback or express opinions without compensation, we felt that it would not violate expectations associated with MTurk employment to present MTurk participants with an optional opportunity to provide free-response feedback, expressing their thoughts about specific topics. Since these responses were not directly compensated, providing them was costly behavior by participants in response to a request for help. These responses were coded to produce quantitative variables, as follows: feedback provided (yes/no), task performance, and apparent friendliness. The latter two variables were subjectively coded by research assistants who were partially blind to experimental condition (the content of some responses revealed the condition) but were not blind to the hypothesis at issue.
Task performance was a subjective evaluation of how well the participant answered the question posed, akin to a grade on a short-essay exam. Criteria included apparent effort, thoroughness, and thoughtfulness, but not language skills, rater’s feelings about or intellectual evaluation of the content, or the friendliness of the content. Friendliness was a subjective evaluation of whether the tone and content of the message suggested that the participant sought to initiate or preserve a positive relationship with the researchers. Criteria included politeness, compliments/enthusiasm about the study or researchers, and demonstrations of own prosociality, but not task performance.
The specific free response prompts varied between and/or within studies. Four to six research assistants coded every response. We evaluated interrater reliability based on one-way intraclass correlations (ICCs) [52] calculated in R; when topic of the response varied within studies, the data were evaluated separately. ICC values can be interpreted as roughly similar to correlation coefficients. As detailed in Table 2, ICCs for Performance were between .60 and .75, which can be subjectively characterized as moderate or good consistency, whereas Friendliness ratings showed poor consistency. Results based on friendliness scores should thus be interpreted with caution.
Tab. 2. Intraclass correlations for ratings of Performance and Friendliness. Hypotheses and analysis
Because all studies used very similar methods, simply pooling all data for most analyses is a reasonable option. Alternatively, analyses can be conducted separately on data from each study and then the effects meta-analyzed. We conducted analyses based on both approaches in R [53], using the metafor package [54], yielding the same qualitative conclusions. In the main text we present visuals based on pooled data (for study-level versions of these figures, see S2 Appendix) and describe meta-analytically derived effect size estimates.
Elevation as mediator of prosocial contagion
Previous research suggests that elevation mediates the effect of exposure to prosocial scenarios on prosocial behavior. To evaluate whether our studies replicate this finding, we used the R mediation package [55] to conduct mediation analyses with elevation (as a function of experimental condition: Prosocial or Athletic) as the mediator, and behaviors (as a function of condition and elevation) as the outcomes. We report the total effects (tau), which contrast behavior in the two conditions such that positive effects show prosocial contagion, and the proportion of these effects mediated by the emotion. We conduct alternate versions of these analyses using each of the elevation subscales rather than the full elevation scale, and contrast those results with models using general positive affect instead of elevation measures.
Idealism as a moderator of the relationship between condition and elevation
Our novel perspective predicts that differences in elevation response to the same prosocial stimulus should be driven in part by differences in baseline idealism, such that people who expect others to behave more cooperatively will be more elevated. Thus, among people exposed to a video that contains strong candidate cues of prosociality (Prosocial video), there should be a significant correlation between idealism and elevation. For exposure to videos with little (Athletic video) or no (Neutral video) prosocial content, the elevation system should not be activated, such that any variation in self-report measures of elevation should reflect methodological imprecision (e.g., noise) and not the influence of idealism. We can estimate the relationship between baseline idealism and measures of elevation following all three video stimuli, and then compare these effect sizes. While the methods of the studies generating these effect size estimates are not perfectly uniform, we are not aware of any methodological asymmetries that would undermine the validity of such comparison. Alternative analyses can be done at the study level: in studies experimentally contrasting our Prosocial and Athletic conditions, this predicts an interaction between condition and idealism on elevation such that idealism is a stronger predictor of elevation in the Prosocial condition than the Athletic condition.
Results
Before presenting analyses related to our novel hypothesis concerning the relationship between idealistic attitudes and elevation, we first report results that establish that these methods replicate previous findings about the relationships between exposure to prosocial stimuli, self-reports of elevation, and subsequent prosocial behavior. We also show that elevation is distinguishable from mere positive affect.
Replication of previous elevation findings
Responses to elevation scale and its subscales vary as a function of eliciting stimuli, and are distinguishable from positive affect
Our data set includes k = 29 effect estimates of elevation response following exposure to one of our three video stimuli. Among these, type of stimuli is a significant moderator of the effect of video exposure on elevation level (QM = 2,020.92, p < .001), an effect clearly visible in Fig 2. The Neutral stimulus (k = 7) results in near-zero elevation (on 0–3 scale, raw estimate = 0.20 [0.13–0.27]); the Athletic control video (k = 11) causes slightly higher elevation (0.57 [0.55–0.59]); and the Prosocial video (k = 11) causes much stronger elevation (2.01 [1.93–2.09]). This pattern of elevation differs from that of general positive affect, which also differs by stimuli (QM = 990.72, p < .001); is also very low in response to the Neutral video 0.28 [0.22–0.35]); and is also high in response to the Prosocial video (1.99 [1.91–2.07]). Positive affect (1.56 [1.48–1.63]) is fairly high following the Athletic video, indicating that this stimulus serves its intended purpose as a positively-valenced control condition.
Fig. 2. Emotion as a function of idealism and condition. Emotion measures include general positive affect, elevation, and three elevation subscales. Data pooled from 13 relevant studies (total observations: Neutral = 5040, Athletic = 2454, Prosocial = 2619). As intended, there are consistent, dramatic differences wherein elevation scores are markedly higher in the Prosocial condition than in the Athletic condition. That said, elevation scores in the latter are not zero. Examining scores on the subscales of the elevation measure reveals that the (low) levels of elevation reported in the Athletic condition stem largely from the emotion terms. This is understandable given that folk affect labels such as “inspired” and “moved” have broad referents (see General Discussion), underscoring the importance of using multiple methods of reporting subjective experiences. That said, it is worth noting that participants’ scores on the emotion terms subscale are often at ceiling in the Prosocial condition, suggesting that, despite its incomplete specificity, this subscale has high sensitivity.
Behavior varies by condition, consistent with prosocial contagion
Our data set includes k = 7 studies contrasting the effects of the Athletic and Prosocial videos on the hypothetical charity outcome variable. Visualizing pooled data from these studies reveals a shift towards greater charitability in the Prosocial condition (Fig 3, top panel); the same patterns are present in each study (S2 Appendix). Making the simplifying assumption that numeric Likert scale values can be treated as quantitative, the meta-analytic estimate of the standardized mean difference between conditions on the charity likelihood scale is 0.47 [0.38–0.55]. The corresponding scale mean estimates are 2.78 [2.68–2.88] in the Athletic condition and 3.39 [3.28–3.49] in the Prosocial condition.
Fig. 3. Prosocial contagion: Exposure to a prosocial video is associated with more charitable behavior and intent than exposure to a similarly entertaining control video. Figure pools data from all studies contrasting similar conditions (K = 11). For the real charity outcome variable, k = 4 studies are available. The shift towards generosity in the Prosocial condition is again visible (Fig 3, bottom panel), and again present in each study and for the charity pledges recorded minutes before the actual charity donation (Supplement); the standardized mean difference in real charitable donation betweens conditions is 0.31 [0.21–0.41]. The corresponding mean donation estimates (in U.S.$) are 2.60 [2.40–2.80] in the Athletic condition and 3.25 [3.10–3.40] in the Prosocial condition.
Elevation mediates prosocial contagion
For all of the three behavioral outcomes where prosocial contagion was observed, mediation models suggest that elevation fully mediates the total effect of video condition (Athletic vs. Prosocial) on behavior (Table 3). This is true for analysis of data pooled from all studies and for all study-level charity outcomes (S2 Appendix). The study-level mediation effects of elevation for the friendliness outcomes are all positive, albeit typically with wide confidence intervals (S2 Appendix). Similar results obtain when any of the elevation subscales are used as the mediator variable (S2 Appendix). Of particular importance, not only do self-reported prosocial motives (e.g., “I want to help”) predict actual prosocial behavior (indicating that such self-reports are not merely cheap talk in the service of impression management), but so too do self-reports of both somatic sensations (e.g. “I feel a lump in my throat”) and folk affect terms (e.g., “I feel touched”), suggesting that self-reported motives indeed reflect the motivational facet of an integrated emotion. In marked contrast, positive affect is a far weaker mediator of prosocial contagion.
Tab. 3. Prosocial contagion and mediation thereof. Idealism explains variation in elevation response, specific to prosocial cues
Having established that our methods reliably induce an emotion state that mediates behavior, we now turn towards our novel question of interest, explaining individual differences in the experience of that emotion.
Fig 2 illustrates that elevation has differing associations with idealistic attitudes across the three types of stimuli. Our data set includes 24 estimates of the correlation coefficient between these variables; meta-analysis reveals stimulus type to be a significant moderator of the effect (QM = 50.20, p< .001). Elevation is robustly predicted by idealistic attitudes in the Prosocial condition (k = 9, 0.22 [0.18–0.26]), whereas the effect is minimal in the Athletic condition (k = 9, 0.08 [0.02–0.15]) and absent following the Neutral video (k = 6, -0.02 [-0.05–0.02]). The weak positive relationship between idealistic attitudes and elevation scale scores in the Athletic condition is driven largely by the subscale employing folk affect terms (k = 9, 0.10 [0.04–0.17]).
In contrast to the idealism-elevation relationship, there was no significant difference in the correlations between idealism and positive affect between the Prosocial (k = 8, 0.20 [0.16–0.25]) and Athletic conditions (k = 8, 0.15 [0.10–0.21]). In both conditions, idealism predicts positive affect. Speculatively, this may be because appreciating a performance may constitute a form of cooperation, be it with the performer himself, the creator of the video of the performance, or the experimenters who show that video to the participant (see General Discussion).
General discussion
Building on previous researchers’ work, in a series of 15 studies we experimentally assessed the role of elevation in prosocial contagion. We consistently replicate—and extend—the finding that self-report measures of elevation in response to prosocial stimuli statistically mediate corresponding variation in behavioral responses and motivations; to our knowledge, our field studies are the first to demonstrate this relationship outside of a laboratory or online setting. These findings add convergent validity to a growing body of similar results [8,9].
Further extending these findings, and addressing our key novel hypothesis, results confirm that stronger elevation response is associated with more idealistic attitudes, i.e., greater estimates of the prosociality of other people. Moreover, this attitude-emotion relationship is moderated by context, being evident only in response to our prosocial stimulus–exactly as is to be expected if, rather than simply being a manifestation of an optimistic disposition, idealism is part of a mechanism designed by natural selection to adjust prosocial motivation as a function of the profitability of prosociality in a given situation.
The utility of the Attitude-Scenario-Emotion model of affective systems
We applied a key principle of Gervais and Fessler’s [11] Attitude-Scenario-Emotion model: the mechanisms governing the deployment of an emotion should be adaptively sensitive to the context-specific costs and benefits of the behaviors motivated by that emotion. In their model, attitudes are the mechanisms that encode various expectations and valuations to allow such emotional calibration. Deductive research on affective systems can therefore distinguish between the emotion and the baseline attitudes that should moderate the deployment of that emotion.
The conceptual distinction between emotion and attitude proved useful for understanding elevation. Previous investigators’ research, which often employs measurement instruments that combine emotional and attitudinal information, can be reinterpreted as indicating that the somatic and motivational symptoms of elevation are associated with feelings and cognitions consistent with idealistic attitudes. Our work clarifies this association. Methodologically, our studies cleave the two constructs, measuring them separately and at different times. Our data show that these variables are associated only in contexts relevant to contagious prosociality. These results are consistent with a mechanistic model whereby idealistic attitudes regulate the deployment of elevation. More work is required to refine and more extensively test the model, and the present methods could be readily adapted to test other implications of our model, or to directly contrast our model with rival models. Future work could investigate the cue processing aspect of our model (Fig 1), which was not directly tested here. For example, idealism could be associated with stronger endorsement of inferences such as “the actor I witnessed was behaving cooperatively,” and “I would benefit from behaving similarly.” It is possible that this functional logic is consciously accessible, although keeping such information out of consciousness might help avoid the negative consequences of appearing Machiavellian [3,6].
Functional perspectives on elevation
In light of the positive valence of elevation, researchers have often noted elevation’s fit with Fredrickson’s broaden-and-build theory [8,56,57], a high-level functional theory, focusing largely on the valence and motivational outputs of emotion systems. This theory holds that, unlike negatively-valenced emotions, positive emotions tend to broaden the individual’s set of available behavioral options, which functions to build the individual’s personal resources. Gervais and Fessler’s Attitude-Scenario-Emotion model is potentially compatible with broaden-and-build, as the former does not address characteristics of superordinate positive/negative categories of emotions, instead emphasizing form/function fits between the outputs of specific emotion systems and specific adaptive challenges or opportunities implied by the informational inputs to the system. Thus we anchor our model of elevation—an emotion widely agreed to cause cooperative behavior—against functional-level theories of how cooperative behavior can enhance biological fitness, and apply the Attitude-Scenario-Emotion model to understand the adaptive fit between affective mechanisms and the selection pressures implied by the cues that elicit the emotion. Selection favors strategic cooperators over indiscriminate cooperators, so mechanisms that cause cooperative behavior—including elevation–should do so when cues suggest that cooperation is especially likely to be profitable (in the currency of biological inclusive fitness). This interpretation finds common ground with broaden-and-build in that adaptive use of prosociality builds personal resources (or otherwise contributes to fitness-relevant goals), but our theory adds functional specificity regarding the nature of prosociality calibration in response to relevant information, and the process by which this occurs.
Algoe and Haidt [16] suggest that elevation responds to “moral excellence that does not benefit the self” (p 3). (“The self” refers to the witness of the behavior. This distinguishes elevation from gratitude, which is associated with benefits to the self–more on this below.) They argue that elevation motivates the witness to engage in relationship-building with the prestigious virtuous actor, and these relationships facilitate learning by imitation such that the learner eventually gains prestige similarly to the exemplar. While Algoe and Haidt do not explicitly present this verbal model in evolutionary-functional terms, and while our model does not explicitly invoke the concepts of prestige-biased learning or “moral excellence,” the two models are in general agreement on at least three important points, discussed below.
First, despite our largely bypassing the issue of morality, our model is generally consistent with Algoe and Haidt’s framing of the emotion and/or its elictors in moral terms. Indeed, many investigators conceptualize elevation as related to moral judgment. Haidt [7] positions elevation as the opposite of moral disgust; Diessner and colleagues [58] claim that moral beauty elicits elevation. We suggest that the kinds of behavior that elicit elevation can be regarded as on the extreme end of a continuum from mundane to spectacular cooperation; given the centrality of cooperation in most systems of morality [59,60], such actions are likely to be judged as virtuous under a variety of moral schemas. Thus, elevation can be understood as constituting an extreme end of corresponding continua of emotional and cognitive responses to such behavior, along with morally-valenced admiration (more on this below) or, antithetically, condemnation [18]. Beyond this, our framework does not directly engage with moral considerations and theories; instead we focus on a functional analysis of behavioral inputs and outputs that include prosociality. Evolutionary theories of moral judgments [61] often build from the same body of theory about the functions of cooperation on which we base our elevation model, suggesting avenues for further theoretical unification.
Second, we have emphasized that the inputs and outputs of elevation both involve cooperative behavior, a phenomenon we call prosocial contagion. This could also be described as “imitation” of a prosocial strategy. Third, such contagion or imitation is expected to lead to the imitator reaping social benefits similarly to the exemplar.
One notable difference between Algoe and Haidt’s approach and our model is that ours does not require any future relationship between the elevated witness and the exceptionally cooperative actor(s), though our model accommodates such scenarios among various possible avenues of future cooperation. In our model, the information gained by witnessing the actor is sufficient to recalibrate the system to the likely benefits of a cooperative strategy; a strategic response need not include the exemplar as an ongoing social partner in exchange of information or resources. We are open to the possibility that elevation might be associated with a desire to learn more from the exemplar or otherwise invest in that relationship, but are not aware of any systematic investigation of this issue.
Further, we note two difficulties with Algoe and Haidt’s prestige-biased learning account. One, our methods and those of many other investigators establish that elevation can be induced in situations where the virtuous exemplar is distant or fictional (more on fictional elicitors below), and thus not available as an ongoing social partner. Two, elevation is more strongly associated with diffuse prosocial motives (e.g., “I want to be a better person”) and helpful behaviors directed at various third parties, rather than motivation that more narrowly targets cooperatives efforts towards an exemplar. Whether these two patterns reveal a true structure of elevation–one that is inconsistent with the prestige-biased learning account–or are simply artifacts of research methods deserves further investigation.
Comparing elevation to other constructs
Although it is increasingly possible to differentiate discrete emotional states using brain imaging [62], such methods are costly and cumbersome, limiting their utility for much basic research on emotions. Correspondingly, many investigations of emotion rely at least in part on participants’ reports of their current (or imagined) emotional state in response to a witnessed (or hypothetical) event [63–66]. In asking subjects to identify or describe qualia (e.g., “How does X make you feel?” etc.), investigators either rely on participants to generate lexical labels for feeling-states, or else employ scales using previously generated labels. While valuable, such methods suffer the limitation that emic emotion terms do not directly correspond with the psychological mechanisms, or even the outputs thereof, at issue. Work in psychological anthropology, cultural psychology, and related fields explores how cultural schemas differentially frame, emphasize, or ignore facets of emotions, and how this shapes not only how participants talk about their emotions, but, moreover, both their experience of emotions and the manner in which emotions impact their behavior [10,67,68]. As such, folk affect terms cannot be expected to carve nature at its joints, but instead embody the complex interaction of biologically-evolved psychological mechanisms and culturally-evolved models of persons, experiences, and social relations. This poses methodological problems for the investigator exploring postulated universal features of affective architecture [10,63], importantly including the pitfall that lexical labels and folk categories often blur the lines among emotions and associated cognitions [10,11].
Likely reflecting phylogenetic and/or ontogenetic processes of serial homology, there are family resemblances within classes of emotions. As a consequence, compounding the problem of cultural models noted above, lexical labels often address features shared by related emotions, such that self-report alone will frequently fail to adequately differentiate discrete underlying mechanisms–a particularly acute problem when, as in the case of English speakers addressing elevation, the given language lacks a distinctive term for the emotion at issue. Identifying discrete underlying mechanisms thus requires triangulation using the combination of eliciting conditions, qualia, and behavioral tendencies/motives [10].
With the above considerations in mind, we turn now to the issue of elevation’s place among other emotions, focusing on comparisons within the family of emotions putatively associated with prosocial behavior: gratitude, admiration, kama muta, and awe.
Gratitude
As mentioned above, gratitude and elevation both involve cooperative behavior as input and output, but can be distinguished empirically, with corresponding functional distinctions. Simplifying slightly, gratitude is experienced when benefits are received from another party; prosocial motives are then directed towards the benefactor. This mechanistic structure fits well with the functional logic of direct reciprocity [4,16]. In contrast, elevation does not fit neatly into this direct-reciprocity logic: at the input level, elevation is typically elicited not by being on the receiving end of benefits, but rather by observing someone else being aided in this manner; at the output level, elevation is associated with prosocial motives directed broadly at other people—or even at society at large—rather than at the benefactor whom one has observed as a third party. Nevertheless, while the distinction between gratitude and elevation is clear, our account of elevation does not inherently constrain elevation elicitation to the observation of acts that do not benefit the self. An exceptionally generous act benefiting the self could present a cue that initiates both gratitude and elevation, driven by the implied functional inferences that both prosociality directed at the benefactor and a more diffuse prosociality are likely to be good investments.
Admiration
Algoe and Haidt classify elevation, gratitude, and admiration as “other-praising emotions,” where admiration is a response to “extraordinary displays of skill, talent, or achievement,” and elevation is similarly defined, but restricted to extraordinary moral virtue (which, as noted above, we translate roughly as extraordinary cooperative behavior). Linking admiration to the functional logic of prestige-biased learning [43], they suggest avenues by which admiration might lead to prosocial behavior. For example, cooperative behavior directed towards those possessing highly valued skills can be profitable if it facilitates learning from the skillful exemplar, such as in an apprenticeship, where low-skilled help buys access to expertise. Praising an exceptionally skilled exemplar, including moral praise, similarly invests one’s own social capital in increasing the prestige of the exemplar [18], which could be considered a prosocial consequence of admiration.
While admiration thus plays a role in pathways leading to prosocial behavior, we caution against concluding that directing material or social rewards towards the exemplar (or any future direct relationship with the exemplar) should always be the expected response to witnessing extraordinary skill. First, some exemplars dispense their wisdom freely through specific channels but are difficult to access otherwise; in such situations admiration should motivate information-seeking focused on the exemplars but not necessarily direct cooperation with them. Second, some skills may be admired but acquiring them judged to be beyond the observer’s ability or interests. In such cases, admiration might affectively mark that individual’s skills as an important feature of the individual, but further investment in the relationship may not be useful. Third, the information present in an extraordinary display of skill can be exploited without any further cooperative or informational relationship with the exemplar. Just as an extraordinarily prosocial exemplar implies that prosocial behavior can be rewarded in the present social environment, any extraordinary performance of other skills can imply that developing such skills is possible and can be rewarded. In such situations, admiration could motivate independent learning or seeking other exemplars.
In sum, we think that admiration is likely to be a part of the elevation experience because it is a response to extraordinary praiseworthy behavior more generally (indeed, it is an item on our scales), but we do not expect all admiration experiences to motivate prosocial behavior.
Kama muta
Fiske and colleagues [10,48,69–71] have recently inductively explored an emotion that they label kama muta, which is isomorphic with elevation in several ways, including folk terminology (e.g., “moved”), somatic symptoms (e.g., “moist eyes”), and many of the eliciting stimuli (including, among others, the same video from which our prosocial stimulus was created). Like our adaptationist account of elevation, these authors also propose that kama muta functions to regulate cooperative behavior. However, kama muta researchers specify communal sharing as the type of cooperation that is both the input cue and the output motivation, whereas our proposal regarding the function of elevation does not privilege a specific mode of cooperation either as input or as output, and instead focuses on the adaptive fit between eliciting cues and the expected biological fitness value of behavioral outputs. Importantly, these investigators have yet to map the functional logic whereby witnessing communal sharing should favor motivation to engage in communal sharing.
We do note that at least one type of plausibly prosocial behavior measured in our studies–providing optional free response answers in online studies–did not show any evidence of prosocial contagion, so we are open to theoretical refinements that specify certain types of cooperative outputs of the system(s) under investigation. Are elevation and kama muta different labels for the same emotion? Is one a variant, or particular manifestation, of the other? The parallel bodies of work on elevation and kama muta raise important questions for future work.
Awe
“Awe” is commonly used as part of lay descriptions of the elevation experience. Piff et al. [72] present results that they and others interpret as indicating that awe itself causes prosocial behavior [73]. Prior investigators have usefully characterized awe as a response to an exceptional stimulus beyond the observer’s previous experience or frames of reference, resulting in a need to refine existing mental representations to accommodate the new information [74,75]. It is not clear that such an information-based recalibration process would necessarily favor prosocial output, raising the question of the mechanisms responsible for the results that Piff et al. report. Paralleling our argument regarding admiration, we propose that, rather than being a direct driver of prosocial behavior, in those cases where awe is linked to prosociality, this occurs via indirect causal pathways.
If elevation is elicited by exceptional prosociality (as noted above, this is a characterization unique to our model, but consistent with the moral-virtue account offered by prior investigators), this straightforwardly implicates awe as likely to be a component of the experience. In this view, awe functions as a general-purpose learning mechanism that informs other downstream systems given the presence of important new information, and elevation is one such downstream system. In this sense, awe could be said to cause prosociality, albeit indirectly.
Awe experienced in the context of elevation is positively-valenced and a response to specifically prosocial stimuli, but awe can also be experienced as negative and fear-linked, and is often—if not prototypically–experienced in response to non-social stimuli [74,76]. The informational recalibration construal of awe suggests links to social emotions and behavior in some of these situations. If asocial novel stimuli that induce awe also present challenges that are best solved through cooperative means (e.g., working with neighbors to cope with a powerful natural threat, etc.) or present opportunities to deliver perceived benefits to social partners (e.g., sharing an amazing scenic view with a partner), cooperative behavior is likely to follow. Complementing this functional perspective, Nelson-Coffey et al. (2019) note that previous research on awe’s effects has not adequately accounted for other mechanisms, especially a family of social emotions that the authors show are commonly experienced alongside awe, such as gratitude, compassion, and feelings of social connectedness. This provides a framework for reinterpreting Piff et al.’s results. For example, participants taken to view tall trees reported more awe and behaved more helpfully than participants taken to view tall buildings. Rather than interpret this as evidence that awe causes prosociality, we suggest that prosocial emotions related to the enjoyable awe-inducing experience are the cause here. Participants may have felt gratitude to the experimenter, or elevation because the local community is maintaining a spectacular natural public resource.
Piff et al. [72] also suggest that awe influences prosocial behavior via the feeling that one is small. This could be reconciled with our reinterpretation, to the extent that such feelings are an indirect expression of prosocial attitudes and emotions. Mental representations of size have been shown to index traits relevant to social standing, including prestige [77], so feeling small could be associated with high valuation of others. Although feeling “small” can thus be linked to prosocial behavior, it is not clear that, in general, feeling small is a good fit with approach-oriented prosocial motives. For example, shame is similarly associated with the subjective sense of feeling small [63,78], yet, rather than leading individuals to approach others and interact with them prosocially, it instead motivates withdrawal from social interactions–particularly withdrawal from those who elicited the shame [63,78]; likewise, the shame experience is associated with anger and aggression, the antithesis of prosociality [79].
In sum, we think that awe is likely to be a part of the elevation experience because it is a mechanism that responds to noteworthy or exceptional new information, but we do not expect all awe experiences to motivate prosocial behavior.
Which prosocial cues induce elevation?
The studies reported here rely exclusively on a single elevating video and two control videos, providing analytical precision, but doing so at the expense of generalizability. Unsung Hero, the source of our Prosocial video, is crafted to evoke a strong emotional reaction, and thus offers a useful starting point given our research goals. Nonetheless, in light of our reliance on a single stimulus, generalizing from our results requires caution. Testing the elevating effects of various stimuli can help address questions about the boundaries of the phenomenon, a topic we are exploring in other work [80]. In the next sections, we discuss two critical dimensions of stimulus variety.
Fictional vs real scenarios
The modern study of elevation was inspired by Thomas Jefferson’s musings about emotional responses to fictional great deeds [16,17]. Continuing this Jeffersonian thinking, we induced elevation using a story about a fictional prosocial hero. The use of fictional stimuli is common in psychological research, including most work on elevation to date, a method based on the assumption that responses to fiction reflect psychology that evolved for responding to real events. Humans have been carefully examining the distinction between emotional responses to fiction and to reality for thousands of years–Hindu sages long ago described rasa, an experience of “tasting” emotion induced by dramatic illusion [68].
Considering this issue in the context of our model of elevation as a response to informative cues about the social environment, we note that there are informational differences between fictional stimuli and real events. Presenting someone with an evocative narrative is in itself a social act to which the recipient may respond separately or in combination with the response to the stimulus itself. This general “outer frame” issue has been previously raised as a concern in regard to the interpretation of experimental economic games as models for cooperative dilemmas more generally [81–83]. As is true of all such research, the experimental control afforded by presenting stimuli precisely determined by the investigator comes at the cost of reduced ecological validity, underscoring the importance of more naturalistic approaches in future research. We note, however, that, per the observations noted above, sharing stories is an ancient social tradition [84], and that being presented with a story about prosocial behavior might imply that there are real prosocial opportunities (e.g., with the story-teller, whose choice of narrative might reveal her likely cooperativeness, or with other audience members, whose attention to the narrative might reveal their likely cooperativeness), such that the logic of contagious prosociality applies equally well to information from the outer frame. Future work may attempt to disambiguate the extent to which elevation and related prosocial behavior are best understood as a response to the story itself (e.g., because, at least to some extent, we automatically respond to fictional social scenarios as if they were real, akin to salivation in response to pictures of food or sexual arousal in response to pornography) and/or to the social act of sharing a story that includes prosocial content.
The type(s) of prosociality cues in the eliciting stimuli
We have thus far emphasized the information value of the presence of an extreme cooperator, but, importantly, multiple cues are likely informative. Our Prosocial video also contains cues about how people respond to the exemplar, cues that are also congruent with elevation elicitation, in that beneficiaries of the protagonists’ actions eventually respond positively. Future work can more carefully consider the dynamic integration of multiple–and possibly incongruent–social cues presented over various time courses with respect to outcomes including emotional response, behavior, and attitude updating. For example, in recent work, we explored how elevation experiences differ as a function of the social actions responding to an initial act by an exceptionally kind actor. We found that elevation is diminished when other people respond to the exemplar in antisocial ways compared to neutral-response scenarios; intriguingly, at least within the constraints of the methods that we employed, elevation is not enhanced when others respond prosocially to the exemplar [80].
Our control Athletic video was intended to be neutral with respect to prosociality, but it is possible that minor, indirect cues of prosociality may be detectable. While acrobatic behavior itself is not inherently prosocial, many types of skilled performances are appreciated and rewarded by audiences, such that (quasi)cooperative relationships can emerge from common interest in non-prosocial activities such as sports or arts [18], or, as suggested above, enjoying awe-inducing scenic views. For example, the production of a video of the performance implies that the athlete has been rewarded for doing something that people enjoy. Relatedly, due to the entertaining nature of the video, the experiment itself might be regarded as unexpectedly pleasant–a minor kindness to the participant performed by the researcher; our Athletic condition could thus have induced a modest degree of elevation relative to the neutral condition via the outer frame.
Alternately, modest increases in elevation scores in the Athletic condition relative to baseline may owe to overlap between emotions (or merely between the relevant folk affect terms, e.g., “inspired”) attending, on the one hand, a positive feeling toward a skilled performer such as admiration, as discussed above (indeed “admiration” is an item on this subscale) and, on the other hand, the more cooperation-specific mechanisms of elevation. Consistent with this explanation, it is the folk affect term subscale of our elevation measure that is primarily responsible for the non-floor elevation scores in the Athletic condition, and for idealism’s slight value as a predictor of elevation response to this video. Participants report being “inspired” by the athlete, and feeling “admiration” for him, but they do not get tears in their eyes, nor are they more motivated to behave prosocially. Potentially compatible with a prestige-biased learning account, feelings of admiration and so on are more likely among idealistic participants. If feeling “inspired” is linked to entertaining the possibility that one might learn from a skilled performer, then believing that others are generally prosocial may be one prerequisite for such feelings, as prosocial actors provide access to learners seeking to emulate them.
Regardless of the causes of the minor effects of the Athletic video on elevation, this stimulus nonetheless performs its methodological function as a positively-valenced control condition, since general positive affect is similar between this and the experimental condition.
What behaviors does elevation govern?
Like much research on prosociality, we used both real, pledged, and hypothetical financial generosity as dependent measures, producing our strongest evidence of behavioral contagion. In real-world systems, prosociality obviously takes many non-financial forms. In consideration of this, we reported evidence based on subjective evaluation of the content of free-response messages written by participants. Although the results are suggestive that behavioral contagion can take the form of a friendly interaction style, interpersonal friendliness is subject to considerable interpretation, hence our findings should be viewed with caution. We encourage experimenters to employ multiple measures of prosocial behavior; such diversity of methods will be especially useful in resolving theoretical questions regarding specific types of output behaviors.
Study populations
The current research utilized two different methods of convenience sampling, and found qualitatively similar results both among samples composed of people on the street of a large, cosmopolitan American city and in multiple large national samples of MTurk workers. The extent to which our findings would generalize to underrepresented segments of the U.S. population or to other cultures is an open question. Fiske et al [69] argue that the emotion which they label kama muta occurs across cultures and throughout history; if elevation and kama muta are indeed closely related, or even isomorphic (see discussion above), the current findings may generalize quite broadly. In a separate report [85], we present data from elevation studies we conducted in non-Western countries. The type of diversity most relevant to our theoretical model is along the dimension of idealistic attitudes. In the samples reported here, the distribution of this trait is largely in the more idealistic half of the range of the scale (Fig 2, top panel), as should be expected since the outer frame was a cooperative interaction between researcher and participant. If and when highly cynical people are susceptible to prosocial contagion is an interesting and challenging topic for future study. Lastly, our open data set includes various standard demographic variables available for secondary analysis; e.g., we present an exploratory investigation of sex differences in S2 Appendix.
Measurement
Recent reviews of elevation research have suggested that standardized measurement scales could be useful [8,9]. We sought to create a reasonably short scale to use in both online and field studies. Despite its brevity, our scale arguably offers improvements over many existing measures, as we designed subscales to allow for analytic parsing of the elevation experience, and excluded attitudinal items that might confound results. Further development of a richer elevation scale with additional subscale items, allowing for more detailed assessments of which aspects of elevation are unique to this emotion and which are shared with other affective experiences, could be valuable. Relatedly, as is true of much research on emotions employing self-report scales, the types of prompts sometimes used in studying elevation (e.g., “right now I feel”) suffer the limitation that participants’ responses appear to blend reactions to the stimulus with reactions to the experimenters (or, at the least, with reactions to the experience of being in the experiment), i.e., this prompt blurs what we term the inner frame and the outer frame. Although participants are unlikely to be fully cognizant of the various inputs determining their current emotional state, nonetheless, explicitly directing participants to think about the stimulus (e.g., “the video made me feel”), as we have done in many of our studies, plausibly reduces the contribution of the outer frame to self-reports.
We measured participants’ idealism towards an extremely general set of people (either “my broader community” or “people in general”). In large-scale societies in which individuals frequently interact with others about whom they know little, such generic attitudes may be useful. However, because adaptive calibration of responses is facilitated by attitudinal accuracy, whenever past experience, socially transmitted information, or both afford discrete attitudes focused on particular classes of others, individuals should possess attitudes with various levels of specificity. Future research may explain more variance in emotion by measuring the relevant idealisms with greater precision (e.g., with regard to in-group members versus others, or, even more precisely, towards specific individuals involved in a scenario, etc.). More broadly, ethnocentric attitudes are obvious candidates for study, and may plausibly be associated with greater elevation in response to in-group prosociality than to similar behavior by out-group members; stereotypes are likewise relevant.
Comparing idealism to other constructs
We have introduced the novel construct of idealistic attitudes, and have shown that this variable explains variation in elevation, as predicted. Idealistic attitudes likely connect to such phenomena as trust, secure attachment, and agreeableness, among many others. Our approach offers a coherent conceptual foundation for the exploration of such connections. For example, an influential framing of trust defines it as “the willingness of a party to be vulnerable to the actions of another party based on the expectation that the other will perform a particular action important to the trustor, irrespective of the ability to monitor or control that other party” [86]. As we have discussed, prosocial actions both have the potential to enhance the individual’s welfare via direct or indirect reciprocity, and, simultaneously, place the individual at risk of exploitation. Hence, trust in others is central to prosociality as an adaptive strategy, and can be viewed as a key component of the cognitive representation of others that we term idealism. Likewise, the ontogenetic process of attachment and its resulting impact on adult social orientation can be understood as the calibration over developmental experience of the propensity to trust others [87]. Lastly, the personality trait agreeableness can be understood as patterned behavior resulting from a high level of trust in others, a correspondingly high level of idealism, and a resulting propensity toward prosociality [88]. While the present project does not explore the multiplex connections between our own and other models and constructs, as we hope the above discussion makes clear, there is great potential for integration among them.
Future direction: Other emotions regulated by idealism?
The Attitude-Scenario-Emotion model posits that a given attitude can potentiate or inhibit various emotions in relevant scenarios; this entire network of attitude, scenarios, and links to multiple emotions is labeled a sentiment. Besides elevation, what other social emotions may be embedded in the sentiment anchored by idealistic attitudes? Are high-idealists more outraged (or disappointed) by exploitative actors? More sympathetic to victims? More grateful towards benefactors? More ashamed of their own mistakes? More delighted by (or proud of) their friends’ successes? Answering such questions will leverage the substantial potential of the Attitude-Scenario-Emotion approach to illuminating individual differences in emotion and social behavior.
Harnessing elevation to engineer cooperation
A growing literature provides an empirical basis for the conclusion that elevation is a potentially important factor in the spread of prosocial behavior within groups. This corpus offers an invaluable foundation for research into elevation. However, being largely inductively derived, previous pioneering work in this area appears to have conflated two conceptually distinct phenomena. From a functionalist perspective, willingness to engage in prosocial action should hinge on the profitability of such action in the current social context. The results reported here document that prior expectations of others’ prosociality predict the extent to which exposure to a depiction of a highly prosocial actor elicits elevation, which in turn shapes the observer’s own prosocial behavior. Individuals thus differ in their susceptibility to elevation as a pathway of contagious prosociality. In principle, the effects of experience and socially transmitted information on idealism are such that virtuous cycles can occur (or be created) within groups, resulting in communities that are increasingly prosocial and increasingly emotionally rewarding. Understanding more fully the possibility that individuals harbor multiple idealisms, each directed toward different social categories or geographical locales, will thus likely be important in illuminating cultural and regional differences in prevailing levels of prosocial behavior. Looking forward, a fuller portrait of the relationship between experience, expectations, and emotions may prove critical in our comprehension of the factors leading to the origins and stability of communities in which individuals benefit, rather than exploit, one another.
Supporting information
S1 Appendix [pdf]
Supplementary procedure.S2 Appendix [pdf]
Supplementary results.
Zdroje
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- Lower IQ and poorer cognitive profiles in treated perinatally HIV-infected children is irrespective of having a background of international adoption
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- Dissociations of oral foci of infections with infectious complications and survival after haematopoietic stem cell transplantation
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- Investigating gene expression profiles of whole blood and peripheral blood mononuclear cells using multiple collection and processing methods
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- “My mother in-law forced my husband to divorce me”: Experiences of women with infertility in Zamfara State of Nigeria
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- The Black identity, hair product use, and breast cancer scale
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- Reversed metabolic reprogramming as a measure of cancer treatment efficacy in rat C6 glioma model
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- Associations between adverse childhood family environments and blood pressure differ between men and women
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- Assessing service and treatment needs and barriers of youth who use illicit and non-medical prescription drugs in Northern Ontario, Canada
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- The opportunities and risks of mobile phones for refugees’ experience: A scoping review
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- Frequency and determinants of health care utilization for symptomatic reproductive tract infections in rural Indian women: A cross-sectional study
- BPRF: Blockchain-based privacy-preserving reputation framework for participatory sensing systems
- Gang confrontation: The case of Medellin (Colombia)
- Adaptive smartphone-based sensor fusion for estimating competitive rowing kinematic metrics
- Prevalence of Cryptococcal Antigenemia and associated factors among HIV/AIDS patients on second-line antiretroviral therapy at two hospitals in Western Oromia, Ethiopia
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- A leader-follower model for discrete competitive facility location problem under the partially proportional rule with a threshold
- Process elements contributing to community mobilization for HIV risk reduction and gender equality in rural South Africa
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- Multiscale analysis for patterns of Zika virus genotype emergence, spread, and consequence
- Incidences of community onset severe sepsis, Sepsis-3 sepsis, and bacteremia in Sweden – A prospective population-based study
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- Towards text mining therapeutic change: A systematic review of text-based methods for Therapeutic Change Process Research
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- Anemia and associated factors among type-2 diabetes mellitus patients attending public hospitals in Harari Region, Eastern Ethiopia
- The KLDpT activation loop motif is critical for MARK kinase activity
- Pro-renin receptor suppresses mitochondrial biogenesis and function via AMPK/SIRT-1/ PGC-1α pathway in diabetic kidney
- Evaluation of upconverting nanoparticles towards heart theranostics
- Severe childhood anemia and emergency blood transfusion in Gadarif Hospital, eastern Sudan
- Gender differences in the effect of self-rated health (SRH) on all-cause mortality and specific causes of mortality among individuals aged 50 years and older
- PyLandStats: An open-source Pythonic library to compute landscape metrics
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- Association between attitudes of stigma toward mental illness and attitudes toward adoption of evidence-based practice within health care providers in Bahrain
- The efficacy of conditioned medium released by tonsil-derived mesenchymal stem cells in a chronic murine colitis model
- Generation of targeted homozygosity in the genome of human induced pluripotent stem cells
- Pathways to care and outcomes among hospitalised HIV-seropositive persons with cryptococcal meningitis in South Africa
- Fungicides, herbicides and bees: A systematic review of existing research and methods
- The risk of active tuberculosis among individuals living in tuberculosis-affected households in the Republic of Korea, 2015
- Intraoperative ketorolac in high-risk breast cancer patients. A prospective, randomized, placebo-controlled clinical trial
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- Comparative study of the composition of cultivated, naturally grown Cordyceps sinensis, and stiff worms across different sampling years
- Factors affecting the spread of multiple information in social networks
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- Network dynamics of Broca’s area during word selection
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- An expanded rating curve model to estimate river discharge during tidal influences across the progressive-mixed-standing wave systems
- Neuroimaging modality fusion in Alzheimer’s classification using convolutional neural networks
- Ginkgo biloba extract increases neurite outgrowth and activates the Akt/mTOR pathway
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- Men and women differ in their perception of gender bias in research institutions
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- Serum procalcitonin as an independent diagnostic markers of bacteremia in febrile patients with hematologic malignancies
- New physiological bench test reproducing nocturnal breathing pattern of patients with sleep disordered breathing
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- Non-spherical particles in optical tweezers: A numerical solution
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- Single nucleotide polymorphisms associated with susceptibility for development of colorectal cancer: Case-control study in a Basque population
- Fragment-based design of small molecule PCSK9 inhibitors using simulated annealing of chemical potential simulations
- Development and validation of the Scale of Motives for Using Social Networking Sites (SMU-SNS) for adolescents and youths
- Formation of a structurally-stable conformation by the intrinsically disordered MYC:TRRAP complex
- Generation of swine movement network and analysis of efficient mitigation strategies for African swine fever virus
- Transient effect of melatonin treatment after neonatal hypoxic-ischemic brain injury in rats
- The Determinants of Household Food Waste Generation and its Associated Caloric and Nutrient Losses: The Case of Lebanon
- Housekeeping gene validation for RT-qPCR studies on synovial fibroblasts derived from healthy and osteoarthritic patients with focus on mechanical loading
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- ABO blood group and risk of newly diagnosed nonalcoholic fatty liver disease: A case-control study in Han Chinese population
- Circulation of influenza virus from 2009 to 2018 in Cameroon: 10 years of surveillance data
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- Evaluating the impact of setting delineators in tunnels based on drivers’ visual characteristics
- Quinolone nonsusceptibility among enteric pathogens isolated from international travelers – Foodborne Diseases Active Surveillance Network (FoodNet) and National Antimicrobial Monitoring System (NARMS), 10 United States sites, 2004 – 2014
- Influence of Debaryomyces hansenii on bacterial lactase gene diversity in intestinal mucosa of mice with antibiotic-associated diarrhea
- Food from faeces: Evaluating the efficacy of scat DNA metabarcoding in dietary analyses
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- Effects of nutrient level and planting density on population relationship in soybean and wheat intercropping populations
- Prediction model for dengue fever based on interactive effects between multiple meteorological factors in Guangdong, China (2008–2016)
- Antihypertensive treatment and risk of cardiovascular mortality in patients with chronic kidney disease diagnosed based on the presence of proteinuria and renal function: A large longitudinal study in Japan
- Circadian misalignment alters insulin sensitivity during the light phase and shifts glucose tolerance rhythms in female mice
- Commonly missed nursing cares in the obstetrics and gynecologic wards of Tigray general hospitals; Northern Ethiopia
- Description and phylogeny of a new species of Liolaemus (Iguania: Liolaemidae) endemic to the south of the Plurinational State of Bolivia
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- Sequence analyses at mitochondrial and nuclear loci reveal a novel Theileria sp. and aid in the phylogenetic resolution of piroplasms from Australian marsupials and ticks
- Use of three points to determine the accuracy of guided implantation
- Citric-acid dialysate improves the calcification propensity of hemodialysis patients: A multicenter prospective randomized cross-over trial
- Plasmacytoid dendritic cell and myeloid dendritic cell function in ageing: A comparison between elderly and young adult women
- Predicting the replicability of social science lab experiments
- Lomax exponential distribution with an application to real-life data
- Territoriality and the organization of technology during the Last Glacial Maximum in southwestern Europe
- Global longitudinal strain can predict heart failure exacerbation in stable outpatients with ischemic left ventricular systolic dysfunction
- Barriers to chronic Hepatitis B treatment and care in Ghana: A qualitative study with people with Hepatitis B and healthcare providers
- Exploring the workplace climate and culture in relation to food environment-related factors in Norwegian kindergartens: The BRA-study
- The evaluation of the Woman’s Condom marketing approach: What value did peer-led interpersonal communication add to the promotion of a new female condom in urban Lusaka?
- Composition and structure of the culturable gut bacterial communities in Anopheles albimanus from Colombia
- Discovery of genomic variations by whole-genome resequencing of the North American Araucana chicken
- A siRNA mediated hepatic dpp4 knockdown affects lipid, but not glucose metabolism in diabetic mice
- Central sensitization in knee osteoarthritis and fibromyalgia: Beyond depression and anxiety
- A Bayesian Monte Carlo approach for predicting the spread of infectious diseases
- Clinical and epidemiological characteristics of imported dengue fever among inbound passengers: Infrared thermometer–based active surveillance at an international airport
- Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots
- Impact of oral probiotic Lactobacillus acidophilus vaccine strains on the immune response and gut microbiome of mice
- An investigation of the equine epidermal growth factor system during hyperinsulinemic laminitis
- Ranking hospitals when performance and risk factors are correlated: A simulation-based comparison of risk adjustment approaches for binary outcomes
- The effect of carbohydrate sources: Sucrose, invert sugar and components of mānuka honey, on core bacteria in the digestive tract of adult honey bees (Apis mellifera)
- Runs of Homozygosity and NetView analyses provide new insight into the genome-wide diversity and admixture of three German cattle breeds
- Backward compatibility of whole genome sequencing data with MLVA typing using a new MLVAtype shiny application for Vibrio cholerae
- Total sleep deprivation increases pain sensitivity, impairs conditioned pain modulation and facilitates temporal summation of pain in healthy participants
- The effects of urbanization on bee communities depends on floral resource availability and bee functional traits
- Dynamics of essential interaction between firms on financial reports
- Drug overdose among women in intimate relationships: The role of partner violence, adversity and relationship dependencies
- Robust effect of metabolic syndrome on major metabolic pathways in the myocardium
- California condor microbiomes: Bacterial variety and functional properties in captive-bred individuals
- Using baited remote underwater videos (BRUVs) to characterize chondrichthyan communities in a global biodiversity hotspot
- Evaluation of the potential of a new ribavirin analog impairing the dissemination of ovarian cancer cells
- Grazing offsets the stimulating effects of nitrogen addition on soil CH4 emissions in a meadow steppe in Northeast China
- Molecular characterization of fowl adenovirus isolate of Malaysia attenuated in chicken embryo liver cells and its pathogenicity and immunogenicity in chickens
- Prolonged fasting followed by refeeding modifies proteome profile and parvalbumin expression in the fast-twitch muscle of pacu (Piaractus mesopotamicus)
- Agriculture development and CO2 emissions nexus in Saudi Arabia
- Influence of a neck compression collar on cerebrovascular and autonomic function in men and women
- Visceral leishmaniasis in Northeast Brazil: What is the impact of HIV on this protozoan infection?
- βC1, pathogenicity determinant encoded by Cotton leaf curl Multan betasatellite, interacts with calmodulin-like protein 11 (Gh-CML11) in Gossypium hirsutum
- Expanded eligibility for HIV testing increases HIV diagnoses—A cross-sectional study in seven health facilities in western Kenya
- Clinically useful limited sampling strategy to estimate area under the concentration-time curve of once-daily tacrolimus in adult Japanese kidney transplant recipients
- Re-introduction of dengue virus serotype 2 in the state of Rio de Janeiro after almost a decade of epidemiological silence
- The salivary gland proteome of root-galling grape phylloxera (Daktulosphaira vitifoliae Fitch) feeding on Vitis spp.
- Efficacy of antimalarial drugs for treatment of uncomplicated falciparum malaria in Asian region: A network meta-analysis
- A study of the impact of data sharing on article citations using journal policies as a natural experiment
- The higher they go the harder they could fall: The impact of risk-glorifying commercials on risk behavior
- Optimization of TripleTOF spectral simulation and library searching for confident localization of phosphorylation sites
- Evidence for pre-climacteric activation of AOX transcription during cold-induced conditioning to ripen in European pear (Pyrus communis L.)
- Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance
- Examining psychosocial correlates of physical activity and sedentary behavior in youth with and without HIV
- Modeling record scores in the snatch and its variations in the long-term training of young weightlifters
- Women with metabolic syndrome show similar health benefits from high-intensity interval training than men
- Long-term tracking demonstrates effectiveness of a partnership-led training program to advance the careers of biomedical researchers from underrepresented groups
- Serological evidence of arboviruses and coccidia infecting horses in the Amazonian region of Brazil
- Life-cycle mediated effects of urbanization on parasite communities in the estuarine fish, Fundulus heteroclitus
- Rapid serial blinks: An index of temporally increased cognitive load
- Do cancer stem cells exist? A pilot study combining a systematic review with the hierarchy-of-hypotheses approach
- Diversity of a cytokinin dehydrogenase gene in wild and cultivated barley
- PyRates—A Python framework for rate-based neural simulations
- Interdependence of balance mechanisms during bipedal locomotion
- Ecological interdependencies and resource competition: The role of information and communication in promoting effective collaboration in complex management situations
- Quaking-induced conversion of prion protein on a thermal mixer accelerates detection in brains infected with transmissible spongiform encephalopathy agents
- A new finite element based parameter to predict bone fracture
- Clinical, imaging features and outcome in internal carotid artery versus middle cerebral artery disease
- The association of weight status and weight perception with number of confidants in adolescents
- Smoking trajectories and risk of stroke until age of 50 years – The Northern Finland Birth Cohort 1966
- Discoidin domain Receptor 2: A determinant of metabolic syndrome-associated arterial fibrosis in non-human primates
- L-lysine protects C2C12 myotubes and 3T3-L1 adipocytes against high glucose damages and stresses
- IGF-1-enhanced miR-513a-5p signaling desensitizes glioma cells to temozolomide by targeting the NEDD4L-inhibited Wnt/β-catenin pathway
- Performance, complexity and dynamics of force maintenance and modulation in young and older adults
- Selection of appropriate reference genes for quantitative real-time reverse transcription PCR in Betula platyphylla under salt and osmotic stress conditions
- A method for complete plant taxon and site inventories in large forest areas with the help of orienteering maps, as exemplified by target forests in Switzerland
- Bilateral Parkinson’s disease model rats exhibit hyperalgesia to subcutaneous formalin administration into the vibrissa pad
- Microbial diversity and mineral composition of weathered serpentine rock of the Khalilovsky massif
- Interaction strength in plant-pollinator networks: Are we using the right measure?
- Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo
- Psychometric properties of the PERMA Profiler for measuring wellbeing in Australian adults
- Host-mediated microbiome engineering (HMME) of drought tolerance in the wheat rhizosphere
- Trust development as an expectancy-learning process: Testing contingency effects
- Mutation analysis of annual sediment discharge at Wu Long station in Wu Jiang River Basin from 1960 to 2016
- Improving distribution models of riparian vegetation with mobile laser scanning and hydraulic modelling
- Skeletal muscle alterations in tachycardia-induced heart failure are linked to deficient natriuretic peptide signalling and are attenuated by RAS-/NEP-inhibition
- Comprehensive value assessment of drugs using a multi-criteria decision analysis: An example of targeted therapies for metastatic colorectal cancer treatment
- Leisure-time physical activity and sports in the Brazilian population: A social disparity analysis
- Robot-assisted unicompartmental knee arthroplasty can reduce radiologic outliers compared to conventional techniques
- Causes of inferior relative survival after testicular germ cell tumor diagnosed 1953–2015: A population-based prospective cohort study
- Autosomal-dominant hypotrichosis with woolly hair: Novel gene locus on chromosome 4q35.1-q35.2
- Mystery or method? Evaluating claims of increased energy expenditure during a ketogenic diet
- Commentary on: Abundance and distribution of microplastics within surface sediments of a key shellfish growing region of Canada
- The genetic and environmental effects on school grades in late childhood and adolescence
- Metabolic power in hurling with respect to position and halves of match-play
- Local, nonlinear effects of cGMP and Ca2+ reduce single photon response variability in retinal rods
- Personality traits and risky behavior among motorcyclists: An exploratory study
- The long-term arterial assist intermittent pneumatic compression generating venous flow obstruction is responsible for improvement of arterial flow in ischemic legs
- Human-nature relationships in context. Experiential, psychological, and contextual dimensions that shape children’s desire to protect nature
- The spatio-temporal patterns of the topsoil organic carbon density and its influencing factors based on different estimation models in the grassland of Qinghai-Tibet Plateau
- INT reduction is a valid proxy for eukaryotic plankton respiration despite the inherent toxicity of INT and differences in cell wall structure
- Gestational diabetes mellitus diagnosed at 24 to 28 weeks of gestation in older and obese Women: Is it too late?
- Hermetia illucens in diets for zebrafish (Danio rerio): A study of bacterial diversity by using PCR-DGGE and metagenomic sequencing
- Thermotolerant Campylobacter spp. in chicken and bovine meat in Italy: Prevalence, level of contamination and molecular characterization of isolates
- Prognostic value of maximum standard uptake value, metabolic tumor volume, and total lesion glycolysis of positron emission tomography/computed tomography in patients with breast cancer: A systematic review and meta-analysis
- Understanding the variability of handheld spectral-domain optical coherence tomography measurements in supine infants
- Helicobacter pylori antibody and pepsinogen testing for predicting gastric microbiome abundance
- Outcome of bimodality definitive chemoradiation does not differ from that of trimodality upfront neck dissection followed by adjuvant treatment for >6 cm lymph node (N3) head and neck cancer
- Belief in conspiracy theories: The predictive role of schizotypy, Machiavellianism, and primary psychopathy
- Does seed size mediate sex-specific reproduction costs in the Callosobruchus maculatus bean beetle?
- Characters matter: How narratives shape affective responses to risk communication
- First-4-week erythrocyte sedimentation rate variability predicts erythrocyte sedimentation rate trajectories and clinical course among patients with pyogenic vertebral osteomyelitis
- Walking with head-mounted virtual and augmented reality devices: Effects on position control and gait biomechanics
- Cohort Profile: The Dutch Perined-Lifelines birth cohort
- Accelerated development of rice stripe virus-resistant, near-isogenic rice lines through marker-assisted backcrossing
- Physical determinants of vault performance and their age-related differences across male junior and elite top-level gymnasts
- The transcriptome analysis of the Arabidopsis thaliana in response to the Vibrio vulnificus by RNA-sequencing
- Stable depletion of RUNX1-ETO in Kasumi-1 cells induces expression and enhanced proteolytic activity of Cathepsin G and Neutrophil Elastase
- Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM
- Genome-wide association mapping of total antioxidant capacity, phenols, tannins, and flavonoids in a panel of Sorghum bicolor and S. bicolor × S. halepense populations using multi-locus models
- Choosing important health outcomes for comparative effectiveness research: 5th annual update to a systematic review of core outcome sets for research
- Balancing fire risk and human thermal comfort in fire-prone urban landscapes
- Low-rank graph optimization for multi-view dimensionality reduction
- Time optimal entrainment control for circadian rhythm
- Why do football clubs fail financially? A financial distress prediction model for European professional football industry
- Reconstruction error based deep neural networks for coronary heart disease risk prediction
- Exploring the geography of serious mental illness and type 2 diabetes comorbidity in Illawarra—Shoalhaven, Australia (2010 -2017)
- To be or not to be an inclusive teacher: Are empathy and social dominance relevant factors to positive attitudes towards inclusive education?
- Seasonality of deaths with respect to age and cause in Chitral District Pakistan
- Myalgic encephalomyelitis/chronic fatigue Syndrome (ME/CFS): Investigating care practices pointed out to disparities in diagnosis and treatment across European Union
- Poor nutrition for under-five children from poor households in Ethiopia: Evidence from 2016 Demographic and Health Survey
- The effect of a curriculum-based physical activity intervention on accelerometer-assessed physical activity in schoolchildren: A non-randomised mixed methods controlled before-and-after study
- Safety and immune cell kinetics after donor natural killer cell infusion following haploidentical stem cell transplantation in children with recurrent neuroblastoma
- On-site blood culture incubation shortens the time to knowledge of positivity and microbiological results in septic patients
- In vivo ultrasound thermal ablation control using echo decorrelation imaging in rabbit liver and VX2 tumor
- Genome wide identification and characterization of microsatellite markers in black pepper (Piper nigrum): A valuable resource for boosting genomics applications
- Child behaviour and subsequent changes in body weight, composition and shape
- RBM3 and CIRP expressions in targeted temperature management treated cardiac arrest patients—A prospective single center study
- Segmentation of distal airways using structural analysis
- A single intra-articular injection of 2.0% non-chemically modified sodium hyaluronate vs 0.8% hylan G-F 20 in the treatment of symptomatic knee osteoarthritis: A 6-month, multicenter, randomized, controlled non-inferiority trial
- What effort is required in retrieving self-defining memories? Specific autonomic responses for integrative and non-integrative memories
- Influence of pre-pregnancy body mass index (p-BMI) and gestational weight gain (GWG) on DNA methylation and protein expression of obesogenic genes in umbilical vein
- Early recovery after endoscopic totally extraperitoneal (TEP) hernia repair in athletes with inguinal disruption: A prospective cohort study
- Extending the information content of the MALDI analysis of biological fluids via multi-million shot analysis
- Effects of the performance parameters of a wheelchair on the changes in the position of the centre of gravity of the human body in dynamic condition
- An analysis of atmospheric water vapor variations over a complex agricultural region using airborne imaging spectrometry
- Factors influencing harmonized health data collection, sharing and linkage in Denmark and Switzerland: A systematic review
- Intracerebroventricular administration of the thyroid hormone analog TRIAC increases its brain content in the absence of MCT8
- Gaze direction reveals implicit item and source memory in older adults
- Social influences on smoking cessation in mid-life: Prospective cohort of UK women
- Cord compression defined by MRI is the driving factor behind the decision to operate in Degenerative Cervical Myelopathy despite poor correlation with disease severity
- Characterization of testis-specific serine/threonine kinase 1-like (TSSK1-like) gene and expression patterns in diploid and triploid Pacific abalone (Haliotis discus hannai; Gastropoda; Mollusca) males
- Eavesdropping on dolphins: Investigating the habits of bottlenose dolphins (Tursiops truncatus) through fixed acoustic stations
- Modeling narrative structure and dynamics with networks, sentiment analysis, and topic modeling
- Screening colonoscopy and flexible sigmoidoscopy for reduction of colorectal cancer incidence: A case-control study
- Focal inputs are a potential origin of local field potential (LFP) in the brain regions without laminar structure
- Emergency Department visits due to intoxications in a Dutch university hospital: Occurrence, characteristics and health care costs
- The effects of isobaric and hyperbaric bupivacaine on maternal hemodynamic changes post spinal anesthesia for elective cesarean delivery: A prospective cohort study
- Child protection, domestic violence, and ethnic minorities: Narrative results from a mixed methods study in Australia
- Prediction of early C-reactive protein levels after non-cardiac surgery under general anesthesia
- Long-term outcome in patients after treatment for Cushing’s disease in childhood
- The effects of diurnal intermittent fasting on proinflammatory cytokine levels while controlling for sleep/wake pattern, meal composition and energy expenditure
- Snord94 expression level alters methylation at C62 in snRNA U6
- Gender differences in the interaction effect of cumulative risk and problem-focused coping on depression among adult employees
- The relation between local and distal muscle fat infiltration in chronic whiplash using magnetic resonance imaging
- Prevalence of hypothermia on admission to recovery room remains high despite a large use of forced-air warming devices: Findings of a non-randomized observational multicenter and pragmatic study on perioperative hypothermia prevalence in France
- De novo transcriptome analysis and identification of genes associated with immunity, detoxification and energy metabolism from the fat body of the tephritid gall fly, Procecidochares utilis
- Linking surveillance and clinical data for evaluating trends in bloodstream infection rates in neonatal units in England
- Women’s decision-making power and undernutrition in their children under age five in the Democratic Republic of the Congo: A cross-sectional study
- Ocular surface and tear film changes in workers exposed to organic solvents used in the dry-cleaning industry
- The interferon-gamma pathway is selectively up-regulated in the liver of patients with secondary hemophagocytic lymphohistiocytosis
- Serotonin modulates behavior-related neural activity of RID interneuron in Caenorhabditis elegans
- Risk factors of post-discharge under-five mortality among Danish children 1997-2016: A register-based study
- Apologies as signals for change? Implicit theories of personality and reactions to apologies during the #MeToo movement
- Correction: Modeling the natural history of fatty liver using lifestyle–related risk factors: Effects of body mass index (BMI) on the life–course of fatty liver
- Knee joint biomechanics in transtibial amputees in gait, cycling, and elliptical training
- The polarity protein Dlg5 regulates collective cell migration during Drosophila oogenesis
- Resolving fluorescent species by their brightness and diffusion using correlated photon-counting histograms
- Rapid loss of flight in the Aldabra white-throated rail
- Effects of acupuncture at Pericardium-6 and Stomach-36 on nausea, sedation and gastrointestinal motility in healthy dogs administered intravenous lidocaine infusions
- Classification of flavors in cigarillos and little cigars and their variable cellular and acellular oxidative and cytotoxic responses
- Image denoising via a non-local patch graph total variation
- Chemogenomic profiling to understand the antifungal action of a bioactive aurone compound
- Short-term treatment with a peroxisome proliferator-activated receptor α agonist influences plasma one-carbon metabolites and B-vitamin status in rats
- Elevation, an emotion for prosocial contagion, is experienced more strongly by those with greater expectations of the cooperativeness of others
- Efficient delipidation of a recombinant lung surfactant lipopeptide analogue by liquid-gel chromatography
- Isobaric mass tagging and triple quadrupole mass spectrometry to determine lipid biomarker candidates for Alzheimer's disease
- Awareness of polycystic ovary syndrome among obstetrician-gynecologists and endocrinologists in Northern Europe
- Maternal death review and surveillance: The case of Central Hospital, Benin City, Nigeria
- Assessing insomnia management in community pharmacy setting in Jordan: A simulated patient approach
- Mapping the EORTC QLQ-C30 and QLQ-H&N35 to the EQ-5D for head and neck cancer: Can disease-specific utilities be obtained?
- Increasing sika deer population density may change resource use by larval dung beetles
- The fertile grounds of reproductive activism in The Gambia: A qualitative study of local key stakeholders’ understandings and heterogeneous actions related to infertility
- Subtle changes in striatal muscarinic M1 and M4 receptor expression in the DYT1 knock-in mouse model of dystonia
- Using evidence when planning for trial recruitment: An international perspective from time-poor trialists
- Molecular identification of Ehrlichia, Anaplasma, Babesia and Theileria in African elephants and their ticks
- Does educational level predict hearing aid self-efficacy in experienced older adult hearing aid users from Latin America? Validation process of the Spanish version of the MARS-HA questionnaire
- Psychometric properties of the Portuguese version of the National Eye Institute Visual Function Questionnaire-25
- Chlamydiaceae in wild, feral and domestic pigeons in Switzerland and insight into population dynamics by Chlamydia psittaci multilocus sequence typing
- Longitudinal Doppler references for monochorionic twins and comparison with singletons
- Survey on Chlamydiaceae in cloacal swabs from Swiss turkeys demonstrates absence of Chlamydia psittaci and low occurrence of Chlamydia gallinacean
- Computational singular perturbation analysis of brain lactate metabolism
- Reproductive life-history strategies in a species-rich assemblage of Amazonian electric fishes
- Analyzing and interpreting spatial and temporal variability of the United States county population distributions using Taylor's law
- Direct comparison of retinal structure and function in retinitis pigmentosa by co-registering microperimetry and optical coherence tomography
- Cattle intestinal microbiota shifts following Escherichia coli O157:H7 vaccination and colonizationtravel
- The genetic diversity and population structure of Sophora alopecuroides (Faboideae) as determined by microsatellite markers developed from transcriptome
- Significant reduction of vancomycin resistant E. faecium in the Norwegian broiler population coincided with measures taken by the broiler industry to reduce antimicrobial resistant bacteria
- Dual-hemispheric transcranial direct current stimulation (tDCS) over primary motor cortex does not affect movement selection
- Pharmacological or genetic targeting of Transient Receptor Potential (TRP) channels can disrupt the planarian escape response
- Establishment and characterization of transformed goat primary cells by expression of simian virus 40 large T antigen for orf virus propagations
- Flax rust infection transcriptomics reveals a transcriptional profile that may be indicative for rust Avr genes
- Optimizing sgRNA length to improve target specificity and efficiency for the GGTA1 gene using the CRISPR/Cas9 gene editing system
- Diversity of A(H5N1) clade 2.3.2.1c avian influenza viruses with evidence of reassortment in Cambodia, 2014-2016
- The effects of kinesiology taping on experimentally-induced thermal and mechanical pain in otherwise pain-free healthy humans: A randomised controlled repeated-measures laboratory study
- Tobacco and E-cigarette use among cancer survivors in the United States
- Sharing of gut microbial strains between selected individual sets of twins cohabitating for decades
- Loading… loading… The influence of download time on information search
- Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide
- Echolocation while drinking: Pulse-timing strategies by high- and low-frequency FM bats
- A novel one-class classification approach to accurately predict disease-gene association in acute myeloid leukemia cancer
- Characterization and quantitative trait locus mapping of late-flowering from a Thai soybean cultivar introduced into a photoperiod-insensitive genetic background
- Plasmodium falciparum infection dysregulates placental autophagy
- Intraocular pressure elevation after subtenon triamcinolone acetonide injection; Multicentre retrospective cohort study in Japan
- Generalized nonlinear Schrödinger equations describing the Second Harmonic Generation of femtosecond pulse, containing a few cycles, and their integrals of motion
- Community perception of abortion, women who abort and abortifacients in Kisumu and Nairobi counties, Kenya
- Expression of Concern: Synthesized multiple antigenic polypeptide vaccine based on B-cell epitopes of human heparanase could elicit a potent antimetastatic effect on human hepatocellular carcinoma in vivo
- Correction: Effective methods for the inactivation of Francisella tularensis
- The Salmonella type III effector SpvC triggers the reverse transmigration of infected cells into the bloodstream
- Spatial patterns of tuberculosis and HIV co-infection in Ethiopia
- Serum PCSK6 and corin levels are not associated with cardiovascular outcomes in patients undergoing coronary angiography
- On a remarkable sexual dimorphic trait in the Characiformes related to the olfactory organ and description of a new miniature species of Tyttobrycon Géry (Characiformes: Characidae)
- Effect of integrating a video intervention on parenting practices and related parental self-efficacy regarding health behaviours within the Feel4Diabetes-study in Belgian primary schoolchildren from vulnerable families: A cluster randomized trial
- Type 2 diabetes care: Improvement by standardization at a diabetes rehabilitation clinic. An observational report
- Regulating pharmacists as contraception providers: A qualitative study from Coastal Kenya on injectable contraception provision to youth
- The impact of familial risk and early life adversity on emotion and reward processing networks in youth at-risk for bipolar disorder
- Melanism evolution in the cat family is influenced by intraspecific communication under low visibility
- Gene expression profiles classifying clinical stages of tuberculosis and monitoring treatment responses in Ethiopian HIV-negative and HIV-positive cohorts
- Selection of valid reference genes for quantitative real-time PCR in Cotesia chilonis (Hymenoptera: Braconidae) exposed to different temperatures
- Magnitude of surgical site infection and its associated factors among patients who underwent a surgical procedure at Wolaita Sodo University Teaching and Referral Hospital, South Ethiopia
- Kyasanur Forest Disease vaccination coverage and its perceived barriers in Goa, India—A mixed methods operational research
- Maternal psychosocial risk factors and lower respiratory tract infection (LRTI) during infancy in a South African birth cohort
- Ameliorating effects of Gö6976, a pharmacological agent that inhibits protein kinase D, on collagen-induced arthritis
- Regional hypothermia improves gastric microcirculatory oxygenation during hemorrhage in dogs
- Dynamical comparison between Drosha and Dicer reveals functional motion similarities and dissimilarities
- Retraction: Circulating FoxP3+ regulatory T and interleukin17-producing Th17 cells actively influence HBV clearance in de novo Hepatitis B virus infected patients after orthotopic liver transplantation
- Correction: Data in question: A survey of European biobank professionals on ethical, legal and societal challenges of biobank research
- Expression of HIF-1α is related to a poor prognosis and tamoxifen resistance in contralateral breast cancer
- Metabolic responses of wheat seedlings to osmotic stress induced by various osmolytes under iso-osmotic conditions
- A δ2H Isoscape of blackberry as an example application for determining the geographic origins of plant materials in New Zealand
- Fiber visualization for preoperative glioma assessment: Tractography versus local connectivity mapping
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- A scalable culturing system for the marine annelid Platynereis dumerilii
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- Bacteriologically-confirmed pulmonary tuberculosis in an Ethiopian prison: Prevalence from screening of entrant and resident prisoners
- Multi-objective AGV scheduling in an automatic sorting system of an unmanned (intelligent) warehouse by using two adaptive genetic algorithms and a multi-adaptive genetic algorithm
- Identification of novel non-myelin biomarkers in multiple sclerosis using an improved phage-display approach
- PTH1-34 improves bone healing by promoting angiogenesis and facilitating MSCs migration and differentiation in a stabilized fracture mouse model
- Micro-RNA signatures in monozygotic twins discordant for congenital heart defects
- Aspirin enhances sensitization to the egg-white allergen ovalbumin in rats
- HCV incidence is associated with injecting partner age and HCV serostatus mixing in young adults who inject drugs in San Francisco
- Adherence is associated with a favorable outcome after lung transplantation
- Selection and validation of reference genes desirable for gene expression analysis by qRT-PCR in MeJA-treated ginseng hairy roots
- Availability, prices and affordability of essential medicines for treatment of diabetes and hypertension in private pharmacies in Zambia
- Retraction: Is insulin resistance the cause of fibromyalgia? A preliminary report
- Amnestic mild cognitive impairment in Parkinson’s disease: White matter structural changes and mechanisms
- Menagerie: A text-mining tool to support animal-human translation in neurodegeneration research
- Profusion of G-quadruplexes on both subunits of metazoan ribosomes
- Analysis of genome-wide DNA arrays reveals the genomic population structure and diversity in autochthonous Greek goat breeds
- Impact of human-derived hemoglobin based oxygen vesicles as a machine perfusion solution for liver donation after cardiac death in a pig model
- Microbial diversity within the digestive tract contents of Dezhou donkeys
- Nexrutine and exercise similarly prevent high grade prostate tumors in transgenic mouse model
- Shannon entropy approach reveals relevant genes in Alzheimer’s disease
- Experimental hut evaluation of DawaPlus 3.0 LN and DawaPlus 4.0 LN treated with deltamethrin and PBO against free-flying populations of Anopheles gambiae s.l. in Vallée du Kou, Burkina Faso
- Induction of miR 21 impairs the anti-Leishmania response through inhibition of IL-12 in canine splenic leukocytes
- Ultra-deep massively parallel sequencing with unique molecular identifier tagging achieves comparable performance to droplet digital PCR for detection and quantification of circulating tumor DNA from lung cancer patients
- Correction: Synanthropic Mammals as Potential Hosts of Tick-Borne Pathogens in Panama
- Pupillometry evaluation of melanopsin retinal ganglion cell function and sleep-wake activity in pre-symptomatic Alzheimer’s disease
- Sickness absence and disability pension before and after first childbirth and in nulliparous women by numerical gender segregation of occupations: A Swedish population-based longitudinal cohort study
- New insights into intranuclear inclusions in thyroid carcinoma: Association with autophagy and with BRAFV600E mutation
- Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study
- The impact of mental health recovery narratives on recipients experiencing mental health problems: Qualitative analysis and change model
- Not so unique to Primates: The independent adaptive evolution of TRIM5 in Lagomorpha lineage
- Distributed forecasting and ant colony optimization for the bike-sharing rebalancing problem with unserved demands
- Chronic dietary supplementation with kynurenic acid, a neuroactive metabolite of tryptophan, decreased body weight without negative influence on densitometry and mandibular bone biomechanical endurance in young rats
- Higher neuron densities in the cerebral cortex and larger cerebellums may limit dive times of delphinids compared to deep-diving toothed whales
- Individual variation in migratory movements of chinstrap penguins leads to widespread occupancy of ice-free winter habitats over the continental shelf and deep ocean basins of the Southern Ocean
- Correction: Anabolic steroids among resistance training practitioners
- Correction: Incidence of sexually transmitted infections in men who have sex with men and who are at substantial risk of HIV infection – A meta-analysis of data from trials and observational studies of HIV pre-exposure prophylaxis
- Retraction: Multidrug-Resistance Related Long Non-Coding RNA Expression Profile Analysis of Gastric Cancer
- The effect of emotional information from eyes on empathy for pain: A subliminal ERP study
- NKL homeobox gene activities in normal and malignant myeloid cells
- Personal distress as a mediator between self-esteem, self-efficacy, loneliness and problematic video gaming in female and male emerging adult gamers
- Correction: Quantitative CT analysis of honeycombing area predicts mortality in idiopathic pulmonary fibrosis with definite usual interstitial pneumonia pattern: A retrospective cohort study
- Prevalence of vitamin D deficiency in women from southern Brazil and association with vitamin D-binding protein levels and GC-DBP gene polymorphisms
- Balance control mechanisms do not benefit from successive stimulation of different sensory systems
- Measuring individual differences in cognitive abilities in the lab and on the web
- Correction: Improving the impact of HIV pre-exposure prophylaxis implementation in small urban centers among men who have sex with men: An agent-based modelling study
- Objective sleep assessment in >80,000 UK mid-life adults: Associations with sociodemographic characteristics, physical activity and caffeine
- Self-reported traffic-related air pollution and respiratory symptoms among adults in an area with modest levels of traffic
- A hierarchical loss and its problems when classifying non-hierarchically
- Cross-cultural examination of the Big Five Personality Trait Short Questionnaire: Measurement invariance testing and associations with mental health
- A geographically weighted random forest approach for evaluate forest change drivers in the Northern Ecuadorian Amazon
- Spatial genetic structure and diversity of natural populations of Aesculus hippocastanum L. in Greece
- Anemia in patients with diabetic foot ulcer and its impact on disease outcome among Nigerians: Results from the MEDFUN study
- The effectiveness of physiotherapy interventions on pain and quality of life in adults with persistent post-surgical pain compared to usual care: A systematic review
- Association between anxiety and non-coding genetic variants of the galanin neuropeptide
- Evaluating the effectiveness of HOCl application on odor reduction and earthworm population growth during vermicomposting of food waste employing Eisenia fetida
- What is known about the quality of out-of-hospital emergency medical services in the Arabian Gulf States? A systematic review
- Impact of dietary patterns, individual and workplace characteristics on blood pressure status among civil servants in Bida and Wushishi communities of Niger State, Nigeria
- Robust detection of event-related potentials in a user-voluntary short-term imagery task
- Microbiota composition of the dorsal patch of reproductive male Leptonycteris yerbabuenae
- Characteristics of the gut microbiota in professional martial arts athletes: A comparison between different competition levels
- Interpreting social determinants: Emergent properties and adolescent risk behaviour
- Tulathromycin treatment does not affect bacterial dissemination or clearance of Brucella melitensis 16M following experimental infection of goats
- Hydrogenotrophic methanogens of the mammalian gut: Functionally similar, thermodynamically different—A modelling approach
- Gene delivery of a modified antibody to Aβ reduces progression of murine Alzheimer’s disease
- Flock sensitivity and specificity of pooled fecal qPCR and pooled serum ELISA for screening ovine paratuberculosis
- Disrupted resting-state brain functional network in methamphetamine abusers: A brain source space study by EEG
- Steady expression of high oleic acid in peanut bred by marker-assisted backcrossing for fatty acid desaturase mutant alleles and its effect on seed germination along with other seedling traits
- DNA metabarcoding-based diet survey for the Eurasian otter (Lutra lutra): Development of a Eurasian otter-specific blocking oligonucleotide for 12S rRNA gene sequencing for vertebrates
- Dynamics of photosynthetic responses in 10 rubber tree (Hevea brasiliensis) clones in Colombian Amazon: Implications for breeding strategies
- Inferring disease severity in rheumatoid arthritis using predictive modeling in administrative claims databases
- An evaluation of different classification algorithms for protein sequence-based reverse vaccinology prediction
- Detecting false intentions using unanticipated questions
- In vitro activity and In vivo efficacy of Isoliquiritigenin against Staphylococcus xylosus ATCC 700404 by IGPD target
- When risk becomes illness: The personal and social consequences of cervical intraepithelial neoplasia medical surveillance
- Sperm DNA integrity in adult survivors of paediatric leukemia and lymphoma: A pilot study on the impact of age and type of treatment
- Swaying slower reduces the destabilizing effects of a compliant surface on voluntary sway dynamics
- Dye diffusion during laparoscopic tubal patency tests may suggest a lymphatic contribution to dissemination in endometriosis: A prospective, observational study
- Intra-individual correlations between quantitative THK-5351 PET and MRI-derived cortical volume in Alzheimer’s disease differ according to disease severity and amyloid positivity
- Assessment of the role of Trichomonas tenax in the etiopathogenesis of human periodontitis: A systematic review
- Root and alveolar bone changes in first premolars adjacent to the traction of buccal versus palatal maxillary impacted canines
- Investigating multisite pain as a predictor of self-reported falls and falls requiring health care use in an older population: A prospective cohort study
- The socio-economic status gradient in median lifespan by birth cohorts: Evidence from Dutch Olympic athletes born between 1852 and 1947
- Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening
- Brief group-delivered motivational interviewing is equally effective as brief group-delivered cognitive-behavioral therapy at reducing alcohol use in risky college drinkers
- Predicting the occurrence of surgical site infections using text mining and machine learning
- Organic carbon sequestration in sediments of subtropical Florida lakes
- Reliability of isokinetic knee strength measurements in children: A systematic review and meta-analysis
- Plasma concentration of neurofilament light chain protein decreases after switching from tenofovir disoproxil fumarate to tenofovir alafenamide fumarate
- Revealing the assembly of filamentous proteins with scanning transmission electron microscopy
- Effects of treated wastewater on the ecotoxicity of small streams – Unravelling the contribution of chemicals causing effects
- Air quality and obesity at older ages in China: The role of duration, severity and pollutants
- Breeding French bulldogs so that they breathe well—A long way to go
- A network-centric approach for estimating trust between open source software developers
- A novel scoring system to predict the requirement for surgical intervention in victims of motor vehicle crashes: Development and validation using independent cohorts
- Prediction of overt hepatic encephalopathy by the continuous reaction time method and the portosystemic encephalopathy syndrome test in clinically mentally unimpaired patients with cirrhosis
- Attentional capture by Pavlovian reward-signalling distractors in visual search persists when rewards are removed
- Validation of risk factors for recurrence of renal cell carcinoma: Results from a large single-institution series
- Real world, big data cost of pharmaceutical treatment for rheumatoid arthritis in Greece
- Does training with amplitude modulated tones affect tone-vocoded speech perception?
- Accuracy of the Cosmed K5 portable calorimeter
- Non-invasive diagnostic criteria of hepatocellular carcinoma: Comparison of diagnostic accuracy of updated LI-RADS with clinical practice guidelines of OPTN-UNOS, AASLD, NCCN, EASL-EORTC, and KLSCG-NCC
- Omentin-1 in diabetes mellitus: A systematic review and meta-analysis
- Immunological recovery, failure and factors associated with CD-4 T-cells progression over time, among adolescents and adults living with HIV on Antiretroviral Therapy in Northern Ethiopia: A retrospective cross sectional study
- Correction: Examining the relationship between socio-economic status, WASH practices and wasting
- Prediction of poor outcome after hypoxic-ischemic brain injury by diffusion-weighted imaging: A systematic review and meta-analysis
- Correction: Change in left inferior frontal connectivity with less unexpected harmonic cadence by musical expertise
- Absence of posture-dependent and posture-congruent memory effects on the recall of action sentences
- Identifiability and numerical algebraic geometry
- Co-infection of cattle with Fasciola hepatica or F. gigantica and Mycobacterium bovis: A systematic review
- High maternal self-efficacy is associated with meeting Institute of Medicine gestational weight gain recommendations
- Isolation of endothelial cells, pericytes and astrocytes from mouse brain
- Effects of metformin administration on endocrine-metabolic parameters, visceral adiposity and cardiovascular risk factors in children with obesity and risk markers for metabolic syndrome: A pilot study
- Physiological impact of nanoporous acupuncture needles: Laser Doppler perfusion imaging in healthy volunteers
- A world map of evidence-based medicine: Density equalizing mapping of the Cochrane database of systematic reviews
- Common trust and personal safety issues: A systematic review on the acceptability of health and social interventions for persons with lived experience of homelessness
- Implications of monocular vision for racing drivers
- Effect of arteriovenous access closure and timing on kidney function in kidney transplant recipients
- Expression of Concern: Activation of Notch Signaling Is Required for Cholangiocarcinoma Progression and Is Enhanced by Inactivation of p53 In Vivo
- Correction: Calorie information and dieting status modulate reward and control activation during the evaluation of food images
- Immune responses to a HSV-2 polynucleotide immunotherapy COR-1 in HSV-2 positive subjects: A randomized double blinded phase I/IIa trial
- What Twitter teaches us about patient-provider communication on pain
- Development of a computer-aided design software for the quantitative evaluation of aesthetic damage
- Microtubules are necessary for proper Reticulon localization during mitosis
- Human perception and biosignal-based identification of posed and spontaneous smiles
- State of household need for caregivers and determinants of psychological burden among caregivers of older people in Thailand: An analysis from national surveys on older persons
- Dietary habits of the black-necked swan Cygnus melancoryphus (Birds: Anatidae) and variability of the aquatic macrophyte cover in the Río Cruces wetland, southern Chile
- Improving emotional health and self-esteem of Malaysian adolescents living in orphanages through Life Skills Education program: A multi-centre randomized control trial
- Radiocarbon, Bayesian chronological modeling and early European metal circulation in the sixteenth-century AD Mohawk River Valley, USA
- Economic evaluation of HPV DNA test as primary screening method for cervical cancer: A health policy discussion in Greece
- Clonality testing in the lymph nodes from dogs with lymphadenomegaly due to Leishmania infantum infection
- Transcriptome landscape of Rafflesia cantleyi floral buds reveals insights into the roles of transcription factors and phytohormones in flower development
- Comparison of 6-week PMTCT outcomes for HIV-exposed and HIV-unexposed infants in the era of lifelong ART: Results from an observational prospective cohort study
- Sex differences in physical performance by age, educational level, ethnic groups and birth cohort: The Longitudinal Aging Study Amsterdam
- HIV-1 proteins gp120 and tat induce the epithelial–mesenchymal transition in oral and genital mucosal epithelial cells
- Correction: Intraperitoneal administration of follistatin promotes adipocyte browning in high-fat diet-induced obese mice
- Inflammatory mediators and lung abnormalities in HIV: A systematic review
- An investigation of machine learning methods in delta-radiomics feature analysis
- Differences in receipt of opioid agonist treatment and time to enter treatment for opioid use disorder among specialty addiction programs in the United States, 2014-17
- Intensity-modulated ventricular irradiation for intracranial germ-cell tumors: Survival analysis and impact of salvage re-irradiation
- Personalized breast cancer screening strategies: A systematic review and quality assessment
- The shifting epidemiology and serotype distribution of invasive pneumococcal disease in Ontario, Canada, 2007-2017
- Backwashing performance of self-cleaning screen filters in drip irrigation systems
- Hierarchical cluster analysis to identify the homogeneous desertification management units
- MicroRNA-710 regulates multiple pathways of carcinogenesis in murine metastatic breast cancer
- MicroRNA profiling in canine multicentric lymphoma
- Early impact of agropastoral activities and climate on the littoral landscape of Corsica since mid-Holocene
- Barriers and facilitators for caregiver involvement in the home care of people with pressure injuries: A qualitative study
- Evaluating mob stocking for beef cattle in a temperate grassland
- Suicide among physicians and health-care workers: A systematic review and meta-analysis
- Survival kinetics of Listeria monocytogenes on chickpeas, sesame seeds, pine nuts, and black pepper as affected by relative humidity storage conditions
- Free thiol groups on poly(aspartamide) based hydrogels facilitate tooth-derived progenitor cell proliferation and differentiation
- Acute and chronic traumatic diaphragmatic hernia: 10 years’ experience
- Application of DArT seq derived SNP tags for comparative genome analysis in fishes; An alternative pipeline using sequence data from a non-traditional model species, Macquaria ambigua
- Dipole-wind interactions under gap wind jet conditions in the Gulf of Tehuantepec, Mexico: A surface drifter and satellite database analysis
- PfmPif97-like regulated by Pfm-miR-9b-5p participates in shell formation in Pinctada fucata martensii
- Synapsin 1 promotes Aβ generation via BACE1 modulation
- Predictive utility of the C-reactive protein to albumin ratio in early allograft dysfunction in living donor liver transplantation: A retrospective observational cohort study
- Effects of SCUBA bubbles on counts of roving piscivores in a large remote marine protected area
- Examining practice effects in repeated measurements of vibration perception thresholds on finger pulps of healthy individuals – Is it possible to improve your results over a clinically relevant test interval?
- Analysis of gut microbiota of obese individuals with type 2 diabetes and healthy individuals
- The evaluation of AMSR-E soil moisture data in atmospheric modeling using a suitable time series iteration to derive land surface fluxes over the Tibetan Plateau
- Comparison of plasma fatty acid binding protein 4 concentration in venous and capillary blood
- Nonalcoholic fatty liver disease and hepatic fibrosis among perinatally HIV-monoinfected Asian adolescents receiving antiretroviral therapy
- Environmental enrichment effects after early stress on behavior and functional brain networks in adult rats
- Correction: Heart rate recovery and morbidity after noncardiac surgery: Planned secondary analysis of two prospective, multi-centre, blinded observational studies
- Developmental expression of human tau in Drosophila melanogaster glial cells induces motor deficits and disrupts maintenance of PNS axonal integrity, without affecting synapse formation
- TRPC3 determines osmosensitive [Ca2+]i signaling in the collecting duct and contributes to urinary concentration
- Correction: May the change of platelet to lymphocyte ratio be a prognostic factor for T3-T4 laryngeal squamous cell carcinoma: A retrospective study
- Awareness, willingness to use, and history of HIV PrEP use among gay, bisexual, and other men who have sex with men in Nigeria
- Odor quality profile is partially influenced by verbal cues
- A novel assessment for Readiness Evaluation during Simulated Dismounted Operations: A reliability study
- Cognitive bias modification for energy drink cues
- Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation
- Correction: Assessment of lung function in successfully treated tuberculosis reveals high burden of ventilatory defects and COPD
- Verification of mesenchymal stem cell injection therapy for interstitial cystitis in a rat model
- Vertical transmission of HIV among pregnant women who initially had false–negative rapid HIV tests in four South African antenatal clinics
- Tapped out or barely tapped? Recommendations for how to harness the vast and largely unused potential of the Mechanical Turk participant pool
- Are lizards sensitive to anomalous seasonal temperatures? Long-term thermobiological variability in a subtropical species
- Mutation spectrums of TSC1 and TSC2 in Chinese women with lymphangioleiomyomatosis (LAM)
- “That’s all Fake”: Health professionals stigma and physical healthcare of people living with Serious Mental Illness
- On the interpretation of the atmospheric mechanism transporting the environmental trigger of Kawasaki Disease
- Comparison of the Panther Fusion and Allplex assays for the detection of respiratory viruses in clinical samples
- Acute kidney injury in Ugandan children with severe malaria is associated with long-term behavioral problems
- Rho-associated kinase and zipper-interacting protein kinase, but not myosin light chain kinase, are involved in the regulation of myosin phosphorylation in serum-stimulated human arterial smooth muscle cells
- Use of detailed family history data to improve risk prediction,with application to breast cancer screening
- The promise of open survey questions—The validation of text-based job satisfaction measures
- Measuring within-day cognitive performance using the experience sampling method: A pilot study in a healthy population
- Shifts in trait-based and taxonomic macrofauna community structure along a 27-year time-series in the south-eastern North Sea
- Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients
- Factors associated with repeat rectal Neisseria gonorrhoeae and Chlamydia trachomatis screening following inconclusive nucleic acid amplification testing: A potential missed opportunity for screening
- Beyond Buddhism and animism: A psychometric test of the structure of Burmese Theravada Buddhism
- Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases
- Assessment of the perceived safety culture in the petrochemical industry in Japan: A cross-sectional study
- The Intersection of Human Disturbance and Diel Activity, with Potential Consequences on Trophic Interactions
- Levels of caspase-3 and histidine-rich glycoprotein in the embryo secretome as biomarkers of good-quality day-2 embryos and high-quality blastocysts
- Improving accuracy for finite element modeling of endovascular coiling of intracranial aneurysm
- Drought stress and re-watering affect the abundance of TIP aquaporin transcripts in barley
- Intra- and inter-task reliability of spatial attention measures in healthy older adults
- Genome-wide comparisons of gene expression in adult versus elderly burn patients
- Challenges to generating political prioritization for adolescent sexual and reproductive health in Kenya: A qualitative study
- Chronic atrophic gastritis and intestinal metaplasia surrounding diffuse-type gastric cancer: Are they just bystanders in the process of carcinogenesis?
- GLAMbox: A Python toolbox for investigating the association between gaze allocation and decision behaviour
- Correction: Rapid visual categorization is not guided by early salience-based selection
- Oxygen inhalation improves postoperative survival in ketamine-xylazine anaesthetised rats: An observational study
- An inter-island comparison of Darwin’s finches reveals the impact of habitat, host phylogeny, and island on the gut microbiome
- The use of opioids in low acuity pediatric trauma patients
- The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem cell based granulocyte differentiation model
- Primary Epstein-Barr virus infection with and without infectious mononucleosis
- “Disruptive behavior” in the operating room: A prospective observational study of triggers and effects of tense communication episodes in surgical teams
- Measuring affect-related cognitive bias: Do mice in opposite affective states react differently to negative and positive stimuli?
- Impaired cardiac performance, protein synthesis, and mitochondrial function in tumor-bearing mice
- Determinants of speeding among new generations of car drivers from the Arabian Peninsula. An investigation based among Omani drivers using the theory of planned behaviour
- Modulation of protective reflex cough by acute immune driven inflammation of lower airways in anesthetized rabbits
- KRAS and NRAS mutational gene profile of metastatic colorectal cancer patients in Jordan
- Successional, spatial, and seasonal changes in seed rain in the Atlantic forest of southern Bahia, Brazil
- Ultrasound microbubble potentiated enhancement of hyperthermia-effect in tumours
- Introgression of a cry1Ab transgene into open pollinated maize and its effect on Cry protein concentration and target pest survival
- Benefits of VISION Max automated cross-matching in comparison with manual cross-matching: A multidimensional analysis
- An explorative study identifies miRNA signatures for the diagnosis of non-celiac wheat sensitivity
- Effects of long-term statin-treatment on coronary atherosclerosis in patients with inflammatory joint diseases
- Connectivity differences between Gulf War Illness (GWI) phenotypes during a test of attention
- Native speakers like affixes, L2 speakers like letters? An overt visual priming study investigating the role of orthography in L2 morphological processing
- A partial genome assembly of the miniature parasitoid wasp, Megaphragma amalphitanum
- Can we learn from the ecology of the Bohemian gentian and save another closely related species of Gentianella?
- Are we prepared? The development of performance indicators for public health emergency preparedness using a modified Delphi approach
- Racial discrimination in medical care settings and opioid pain reliever misuse in a U.S. cohort: 1992 to 2015
- Applying circuit theory and landscape linkage maps to reintroduction planning for California Condors
- An improved understanding of ungulate population dynamics using count data: Insights from western Montana
- Pediatric trainees systematically under-report duty hour violations compared to electronic health record defined shifts
- An exclusive human milk diet for very low birth weight newborns—A cost-effectiveness and EVPI study for Germany
- Investigating unexplained genetic variation and its expression in the arbuscular mycorrhizal fungus Rhizophagus irregularis: A comparison of whole genome and RAD sequencing data
- Disease activity and damage in patients with primary Sjogren’s syndrome: Prognostic value of salivary gland ultrasonography
- A low-loss and compact single-layer butler matrix for a 5G base station antenna
- Response of rhizosphere bacterial community of Taxus chinensis var. mairei to temperature changes
- Choosing and enjoying violence in narratives
- Phylogeography, genetic diversity, and population structure of Nile crocodile populations at the fringes of the southern African distribution
- Association between workplace bullying and burnout, professional quality of life, and turnover intention among clinical nurses
- Factors predictive of the success of tuberculosis treatment: A systematic review with meta-analysis
- Area extraction and spatiotemporal characteristics of winter wheat–summer maize in Shandong Province using NDVI time series
- Caring for the elderly: A person-centered segmentation approach for exploring the association between health care needs, mental health care use, and costs in Germany
- Potentially inappropriate medication in older participants of the Berlin Aging Study II (BASE-II) – Sex differences and associations with morbidity and medication use
- Previously implanted mitral surgical prosthesis in patients undergoing transcatheter aortic valve implantation: Procedural outcome and morphologic assessment using multidetector computed tomography
- Towards elimination of measles and rubella in Italy: Progress and challenges
- Molecular characterization of pulmonary defenses against bacterial invasion in allergic asthma: The role of Foxa2 in regulation of β-defensin 1
- A validation of machine learning-based risk scores in the prehospital setting
- Early life starvation has stronger intra-generational than transgenerational effects on key life-history traits and consumption measures in a sawfly
- Longitudinal changes in plasma hemopexin and alpha-1-microglobulin concentrations in women with and without clinical risk factors for pre-eclampsia
- Feasibility of thin-slice abdominal CT in overweight patients using a vendor neutral image-based denoising algorithm: Assessment of image noise, contrast, and quality
- Women's abortion seeking behavior under restrictive abortion laws in Mexico
- Understanding the combining ability for physiological traits in soybean
- Second language learning induces grey matter volume increase in people with multiple sclerosis
- Increased performance of DNA metabarcoding of macroinvertebrates by taxonomic sorting
- Hybrid denture acrylic composites with nanozirconia and electrospun polystyrene fibers
- Predictive sampling effort and species-area relationship models for estimating richness in fragmented landscapes
- The mixture toxicity of heavy metals on Photobacterium phosphoreum and its modeling by ion characteristics-based QSAR
- Exogenous melatonin reduces the inhibitory effect of osmotic stress on photosynthesis in soybean
- Comparative analysis of ascorbate peroxidases (APXs) from selected plants with a special focus on Oryza sativa employing public databases
- The microbiota composition of the offspring of patients with gestational diabetes mellitus (GDM)
- Analysis of 13,312 benthic invertebrate samples from German streams reveals minor deviations in ecological status class between abundance and presence/absence data
- Extending the use of the World Health Organisations’ water sanitation and hygiene assessment tool for surveys in hospitals – from WASH-FIT to WASH-FAST
- Measuring subjective social status in children of diverse societies
- The effect of gut passage by waterbirds on the seed coat and pericarp of diaspores lacking “external flesh”: Evidence for widespread adaptation to endozoochory in angiosperms
- Cost effectiveness of therapeutic drug monitoring for imatinib administration in chronic myeloid leukemia
- Tissue ACE phenotyping in lung cancer
- Risk factors in the illness-death model: Simulation study and the partial differential equation about incidence and prevalence
- Association of cord blood methylation with neonatal leptin: An epigenome wide association study
- Clonality, spatial structure, and pathogenic variation in Fusarium fujikuroi from rain-fed rice in southern Laos
- Effect of Iodine treatments on Ocimum basilicum L.: Biofortification, phenolics production and essential oil composition
- In Vitro detection of Chronic Wasting Disease (CWD) prions in semen and reproductive tissues of white tailed deer bucks (Odocoileus virginianus)
- Thermodilution vs estimated Fick cardiac output measurement in an elderly cohort of patients: A single-centre experience
- Association between depressive symptoms and poor sleep quality among Han and Manchu ethnicities in a large, rural, Chinese population
- Application of pharmacogenomics and bioinformatics to exemplify the utility of human ex vivo organoculture models in the field of precision medicine
- Adherence to dietary guidelines for the Spanish population and risk of overweight/obesity in the SUN cohort
- Impact on mortality of being seropositive for hepatitis C virus antibodies among blood donors in Brazil: A twenty-year study
- Dietary intake as a predictor for all-cause mortality in hemodialysis subjects (NUGE-HD study)
- Rats’ (Rattus norvegicus) tool manipulation ability exceeds simple patterned behavior
- Luminescent and fluorescent triple reporter plasmid constructs for Wnt, Hedgehog and Notch pathway
- A lab-on-a-chip for rapid miRNA extraction
- Ghost hunting in the nonlinear dynamic machine
- Dysregulation of sterol regulatory element-binding protein 2 gene in HIV treatment-experienced individuals
- Evaluation of bacteriophage as an adjunct therapy for treatment of peri-prosthetic joint infection caused by Staphylococcus aureus
- Neuronal and glial DNA methylation and gene expression changes in early epileptogenesis
- Kinetics of the thermal inactivation and the refolding of bacterial luciferases in Bacillus subtilis and in Escherichia coli differ
- The use of back propagation neural networks and 18F-Florbetapir PET for early detection of Alzheimer’s disease using Alzheimer’s Disease Neuroimaging Initiative database
- Refinement of metabolite detection in cystic fibrosis sputum reveals heme correlates with lung function decline
- Labeling surface proteins with high specificity: Intrinsic limitations of phosphopantetheinyl transferase systems
- Irradiation dose response under hypoxia for the application of the sterile insect technique in Drosophila suzukii
- Neutrophils remain detrimentally active in hydroxyurea-treated patients with sickle cell disease
- Correction: Enhancing genomic selection by fitting large-effect SNPs as fixed effects and a genotype-by-environment effect using a maize BC1F3:4population
- Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates
- DUSTBot: A duplex and stealthy P2P-based botnet in the Bitcoin network
- Force-stabilizing synergies can be retained by coordinating sensory-blocked and sensory-intact digits
- Temperature time series analysis at Yucatan using natural and horizontal visibility algorithms
- Genome-wide identification and expression profile of the MADS-box gene family in Erigeron breviscapus
- Evaluating the international standards gap for the use of acupuncture needles by physiotherapists and chiropractors: A policy analysis
- Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip
- The protein architecture in Bacteria and Archaea identifies a set of promiscuous and ancient domains
- Utility of preoperative electrophysiological testing of the facial nerve in patients with vestibular schwannoma
- Dynamics of plasma micronutrient concentrations and their correlation with serum proteins and thyroid hormones in patients with paracoccidioidomycosis
- Equity in aid allocation and distribution: A qualitative study of key stakeholders in Northern Uganda
- Health-related quality of life and intensity-specific physical activity in high-risk adults attending a behavior change service within primary care
- Syphilis among adult males with a history of male-to-male sexual contact living with diagnosed HIV in New York State (excluding New York City): The challenge of intersecting epidemics
- Entropy of human leukocyte antigen and killer-cell immunoglobulin-like receptor systems in immune-mediated disorders: A pilot study on multiple sclerosis
- Insights into fungal diversity of a shallow-water hydrothermal vent field at Kueishan Island, Taiwan by culture-based and metabarcoding analyses
- Predicting Abundances of Aedes mcintoshi, a primary Rift Valley fever virus mosquito vector
- Self-association of human beta-galactocerebrosidase: Dependence on pH, salt, and surfactant
- Lowbush blueberry fruit yield and growth response to inorganic and organic N-fertilization when competing with two common weed species
- Copy number-based quantification assay for non-invasive detection of PVT1-derived transcripts
- Association between religiosity and depression varies with age and sex among adults in South America: Evidence from the CESCAS I study
- Recall accuracy of weekly automated surveys of health care utilization and infectious disease symptoms among infants over the first year of life
- Physiological response of North China red elder container seedlings to inoculation with plant growth-promoting rhizobacteria under drought stress
- Acute kidney injury – A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction
- Neurotherapeutic effects of Ginkgo biloba extract and its terpene trilactone, ginkgolide B, on sciatic crush injury model: A new evidence
- Clinical utility of mono-exponential model diffusion weighted imaging using two b-values compared to the bi- or stretched exponential model for the diagnosis of biliary atresia in infant liver MRI
- Optical coherence tomography angiography reveals progressive worsening of retinal vascular geometry in diabetic retinopathy and improved geometry after panretinal photocoagulation
- Comparison of standard and alternative methods for chest compressions in a single rescuer infant CPR: A prospective simulation study
- Characterization of the physical properties of electron-beam-irradiated white rice and starch during short-term storage
- Colonic bacterial composition is sex-specific in aged CD-1 mice fed diets varying in fat quality
- The nature of the ligand’s side chain interacting with the S1'-subsite of metallocarboxypeptidase T (from Thermoactinomyces vulgaris) determines the geometry of the tetrahedral transition complex
- Clarithromycin use and the risk of mortality and cardiovascular events: A systematic review and meta-analysis
- Droplet digital PCR assays for the quantification of brown trout (Salmo trutta) and Arctic char (Salvelinus alpinus) from environmental DNA collected in the water of mountain lakes
- Vitamin E TPGS based transferosomes augmented TAT as a promising delivery system for improved transdermal delivery of raloxifene
- Estimation of membrane bending modulus of stiffness tuned human red blood cells from micropore filtration studies
- Retrospective analysis of central venous catheters in elective intracranial surgery - Is there any benefit?
- Clinical impact of visceral-to-subcutaneous fat ratio in patients with acute aortic dissection
- Correction: Are viral-infections associated with Ménière’s Disease? A systematic review and meta-analysis of molecular-markers of viral-infection in case-controlled observational studies of MD
- Epidemiology of cardiovascular diseases related admissions in a referral hospital in the South West region of Cameroon: A cross-sectional study in sub-Saharan Africa
- Tankyrase inhibition sensitizes cells to CDK4 blockade
- Spelling performance on the web and in the lab
- Heteroxanthin as a pigment biomarker for Gonyostomum semen (Raphidophyceae)
- Sexually transmitted founder HIV-1 viruses are relatively resistant to Langerhans cell-mediated restriction
- High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans
- Correction: Safety and efficacy of tacrolimus-coated silicone plates as an alternative to mitomycin C in a rabbit model of conjunctival fibrosis
- Correction: Uncertainty analysis of species distribution models
- Correction: Testosterone deficiency reduces the effects of late cardiac remodeling after acute myocardial infarction in rats
- Correction: Trends and predictors of mother-to-child transmission of HIV in an era of protocol changes: Findings from two large health facilities in North East Nigeria
- Habitat quality, configuration and context effects on roe deer fecundity across a forested landscape mosaic
- Recording behaviour of indoor-housed farm animals automatically using machine vision technology: A systematic review
- Correction: Influence of three artificial light sources on oviposition and half-life of the Black Soldier Fly, Hermetia illucens (Diptera: Stratiomyidae): Improving small-scale indoor rearing
- Lead-I ECG for detecting atrial fibrillation in patients attending primary care with an irregular pulse using single-time point testing: A systematic review and economic evaluation
- External validation of clinical prediction rules for complications and mortality following Clostridioides difficile infection
- Vitamin D deficiency at the time of delivery – Prevalence and risk of postpartum infections
- Changing perioperative prophylaxis during antibiotic therapy and iterative debridement for orthopedic infections?
- Tyrphostin AG490 reduces inflammation and fibrosis in neonatal obstructive nephropathy
- Evaluation of antibiotic susceptibility patterns of pathogens isolated from routine laboratory specimens at Ndola Teaching Hospital: A retrospective study
- Age-period-cohort analysis with a constant-relative-variation constraint for an apportionment of period and cohort slopes
- Early neonatal outcomes of very-low-birth-weight infants in Turkey: A prospective multicenter study of the Turkish Neonatal Society
- Improving graphs of cycles approach to structural similarity of molecules
- Heterotrimeric G-alpha subunits Gpa11 and Gpa12 define a transduction pathway that control spore size and virulence in Mucor circinelloides
- Clinical outcome of admitted HIV/AIDS patients in Ethiopian tertiary care settings: A prospective cohort study
- How the size of the to-be-learned material influences the encoding and later retrieval of associative memories: A pupillometric assessment
- "Tremendous financial burden": Crowdfunding for organ transplantation costs in Canada
- Stochastically modeling multiscale stationary biological processes
- Distribution of aerophilous diatom communities associated with terrestrial green macroalgae in the South Shetland Islands, Maritime Antarctica
- An eye-tracking approach to Autonomous sensory meridian response (ASMR): The physiology and nature of tingles in relation to the pupil
- Structural diversity in the atomic resolution 3D fingerprint of the titin M-band segment
- AlleleProfileR: A versatile tool to identify and profile sequence variants in edited genomes
- Spike culture derived wheat (Triticum aestivum L.) variants exhibit improved resistance to multiple chemotypes of Fusarium graminearum
- N-acetyl cysteine attenuates oxidative stress and glutathione-dependent redox imbalance caused by high glucose/high palmitic acid treatment in pancreatic Rin-5F cells
- Neurofilaments in blood is a new promising preclinical biomarker for the screening of natural scrapie in sheep
- Comparative transcriptome reveals the potential modulation mechanisms of estradiol affecting ovarian development of female Portunus trituberculatus
- Determinants of Group B streptococcal virulence potential amongst vaginal clinical isolates from pregnant women
- Identification of QTLs for resistance to maize rough dwarf disease using two connected RIL populations in maize
- Retraction: Ramentaceone, a Naphthoquinone Derived from Drosera sp., Induces Apoptosis by Suppressing PI3K/Akt Signaling in Breast Cancer Cells
- Correction: Differences in energy and nutritional content of menu items served by popular UK chain restaurants with versus without voluntary menu labelling: A cross-sectional study
- Correction: Cross-presentation of a spread-defective MCMV is sufficient to prime the majority of virus-specific CD8+ T cells
- Correction: An observational study comparing HPV prevalence and type distribution between HPV-vaccinated and -unvaccinated girls after introduction of school-based HPV vaccination in Norway
- Aortic pressure and forward and backward wave components in children, adolescents and young-adults: Agreement between brachial oscillometry, radial and carotid tonometry data and analysis of factors associated with their differences
- Clinical ethics consultation among Italian ethics committee: A mixed method study
- Epidemiology of tick-borne encephalitis in China, 2007- 2018
- Narrative warmth and quantitative competence: Message type affects impressions of a speaker
- Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains
- Comparison of quality control methods for automated diffusion tensor imaging analysis pipelines
- Self-efficacy, procrastination, and burnout in post-secondary faculty: An international longitudinal analysis
- Should social disconnectedness be included in primary-care screening for cardiometabolic disease? A systematic review of the relationship between everyday stress, social connectedness, and allostatic load
- Fast and accurate quantification of insertion-site specific transgene levels from raw seed samples using solid-state nanopore technology
- Maternal employment and child nutritional status in Uganda
- Correction: Saiga horn user characteristics, motivations, and purchasing behaviour in Singapore
- Disparities in survival by stage after surgery between pancreatic head and body/tail in patients with nonmetastatic pancreatic cancer
- Acknowledgements are not just thank you notes: A qualitative analysis of acknowledgements content in scientific articles and reviews published in 2015
- Interocular asymmetry of the superonasal retinal nerve fibre layer thickness and blood vessel diameter in healthy subjects
- Does it still fit? – Adapting affordance judgments to altered body properties in young and older adults
- Health-related quality of life in patients with atrial fibrillation: The role of symptoms, comorbidities, and the type of atrial fibrillation
- A systems approach identifies Enhancer of Zeste Homolog 2 (EZH2) as a protective factor in epilepsy
- Statistical learning and the uncertainty of melody and bass line in music
- The association between childhood maltreatment and empathic perspective taking is moderated by the 5-HTT linked polymorphic region: Another example of “differential susceptibility”
- Household air pollution and arthritis in low-and middle-income countries: Cross-sectional evidence from the World Health Organization’s study on Global Ageing and Adult Health
- Firefighters’ occupational stress and its correlations with cardiorespiratory fitness, arterial stiffness, heart rate variability, and sleep quality
- Diagnostic utility of CT for small bowel obstruction: Systematic review and meta-analysis
- Clinical nurses’ beliefs, knowledge, organizational readiness and level of implementation of evidence-based practice: The first step to creating an evidence-based practice culture
- Attitude and behaviour of Dutch Otorhinolaryngologists to Evidence Based Medicine
- Electronic cigarettes and insulin resistance in animals and humans: Results of a controlled animal study and the National Health and Nutrition Examination Survey (NHANES 2013-2016)
- Cytogenetics of the small-sized fish, Copeina guttata (Characiformes, Lebiasinidae): Novel insights into the karyotype differentiation of the family
- Infant rhesus macaque (Macaca mulatta) personality and subjective well-being
- Potential effects of ursodeoxycholic acid on accelerating cutaneous wound healing
- Healthcare utilization and costs of cardiopulmonary complications following cardiac surgery in the United States
- Prediction of train wheel diameter based on Gaussian process regression optimized using a fast simulated annealing algorithm
- Comparative de novo transcriptomics and untargeted metabolomic analyses elucidate complicated mechanisms regulating celery (Apium graveolens L.) responses to selenium stimuli
- Cognitive dysfunction in mice lacking proper glucocorticoid receptor dimerization
- Prevalence, awareness, treatment and control of hypertension and sodium intake in Zhejiang Province, China: A cross-sectional survey in 2017
- Autofluorescence spectroscopy in redox monitoring across cell confluencies
- Impact of mycoplasma pneumonia infection on urticaria: A nationwide, population-based retrospective cohort study in Taiwan
- Correction: Dual pathway for metabolic engineering of Escherichia coli to produce the highly valuable hydroxytyrosol
- Rapid label-free analysis of Opisthorchis viverrini eggs in fecal specimens using confocal Raman spectroscopy
- Associations of systemic, serum lipid and lipoprotein metabolic pathway gene variations with polypoidal choroidal vasculopathy in China
- MRI-guided, transrectal, intraprostatic steam application as potential focal therapeutic modality for prostatic diseases in a large animal translational model: A feasibility follow-up study
- Predicting breast cancer risk using personal health data and machine learning models
- External validation of the relative fat mass (RFM) index in adults from north-west Mexico using different reference methods
- A study on separation of the protein structural types in amino acid sequence feature spaces
- α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway
- A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans
- The effect of prioritization over cognitive-motor interference in people with relapsing-remitting multiple sclerosis and healthy controls
- Ionomic and transcriptomic analyses of two cotton cultivars (Gossypium hirsutum L.) provide insights into the ion balance mechanism of cotton under salt stress
- Soluble lytic transglycosylase SLT of Francisella novicida is involved in intracellular growth and immune suppression
- Glucocorticoid and dietary effects on mucosal microbiota in canine inflammatory bowel disease
- Zoonotic Babesia: A scoping review of the global evidence
- Utility of citizen science data: A case study in land-based shark fishing
- Response of cassava cultivars to African cassava mosaic virus infection across a range of inoculum doses and plant ages
- Correction: Risk factors for tooth loss in adults: A population-based prospective cohort study
- Dynamic deformation of femur during medial compartment knee osteoarthritis
- A novel ε-sensitive correlation indistinguishable scheme for publishing location data
- Interaction between BDNF val66met polymorphism and personality on long-term cardiac outcomes in patients with acute coronary syndrome
- What factors do make quality improvement work in primary health care? Experiences of maternal health quality improvement teams in three Puskesmas in Indonesia
- Social anxiety changes the way we move—A social approach-avoidance task in a virtual reality CAVE system
- Evaluation of a savings-led family-based economic empowerment intervention for AIDS-affected adolescents in Uganda: A four-year follow-up on efficacy and cost-effectiveness
- From sea monsters to charismatic megafauna: Changes in perception and use of large marine animals
- Association between IQ and FMR1 protein (FMRP) across the spectrum of CGG repeat expansions
- Impact of sports activity on Polish adults: Self-reported health, social capital & attitudes
- Hold your breath – Differential behavioral and sensory acuity of mosquitoes to acetone and carbon dioxide
- Comparative analysis of eight DNA extraction methods for molecular research in mealybugs
- Age-dependent survival rate of the colonial Little Tern (Sternula albifrons)
- The metabotropic glutamate receptor subtype 1 regulates development and maintenance of lemniscal synaptic connectivity in the somatosensory thalamus
- Impact of HFE variants and sex in lung cancer
- Study of congenital Morgagnian cataracts in Holstein calves
- Decreasing prevalence of contamination with extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in retail chicken meat in the Netherlands
- Screening of differentially expressed immune-related genes from spleen of broilers fed with probiotic Bacillus cereus PAS38 based on suppression subtractive hybridization
- Factors governing the performance of Auxiliary Nurse Midwives in India: A study in Pune district
- Writing in the air: Facilitative effects of finger writing in older adults
- Enzymatic production of bioactive peptides from scotta, an exhausted by-product of ricotta cheese processing
- Effect of endometriosis on the fecal bacteriota composition of mice during the acute phase of lesion formation
- Experimental infection of lambs with tick-borne encephalitis virus and co-infection with Anaplasma phagocytophilum
- Leishmania amazonensis resistance in murine macrophages: Analysis of possible mechanisms
- Comparison between the induced membrane technique and distraction osteogenesis in treating segmental bone defects: An experimental study in a rat model
- A dengue fever predicting model based on Baidu search index data and climate data in South China
- Revierparks as an integrated green network in Germany: An option for Amman?
- Detection and analysis of pulse waves during sleep via wrist-worn actigraphy
- From dangerous branches to urban banyan: Facilitating aerial root growth of Ficus rubiginosa
- Unilateral versus bilateral pedicle screw fixation in lumbar fusion: A systematic review of overlapping meta-analyses
- Edible ectomycorrhizal fungi and Cistaceae. A study on compatibility and fungal ecological strategies
- Physical space interacts with clonal fragmentation and nutrient availability to affect the growth of Salvinia natans
- Odd haemoglobins in odd-toed ungulates: Impact of selected haemoglobin characteristics of the white rhinoceros (Ceratotherium simum) on the monitoring of the arterial oxygen saturation of haemoglobin
- Somatic mutations in intracranial arteriovenous malformations
- Clinical feasibility of NGS liquid biopsy analysis in NSCLC patients
- Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH)
- Chemical analysis of Hg0-containing Hindu religious objects
- Hipk is required for JAK/STAT activity during development and tumorigenesis
- Transfer of skin microbiota between two dissimilar autologous microenvironments: A pilot study
- Correction: MiR-4524b-5p/WTX/β-catenin axis functions as a regulator of metastasis in cervical cancer
- Complete chloroplast genomes of two Siraitia Merrill species: Comparative analysis, positive selection and novel molecular marker development
- Lower levels of proteinuria are associated with elevated mortality in incident dialysis patients
- Optimising medication data collection in a large-scale clinical trial
- Personal response to immune checkpoint inhibitors of patients with advanced melanoma explained by a computational model of cellular immunity, tumor growth, and drug
- Hypofibrinolysis induced by tranexamic acid does not influence inflammation and mortality in a polymicrobial sepsis model
- Correction: Dose-dependent adverse effects of salinomycin on male reproductive organs and fertility in mice
- Endocrine profile of the VCD-induced perimenopausal model rat
- Inhibition of complement activation, myeloperoxidase, NET formation and oxidant activity by PIC1 peptide variants
- Domestication may affect the maternal mRNA profile in unfertilized eggs, potentially impacting the embryonic development of Eurasian perch (Perca fluviatilis)
- Intrauterine growth patterns in rural Ethiopia compared with WHO and INTERGROWTH-21st growth standards: A community-based longitudinal study
- Remote ischaemic conditioning and early changes in plasma creatinine as markers of one year kidney graft function—A follow-up of the CONTEXT study
- Validation of Plasmodium vivax centromere and promoter activities using Plasmodium yoelii
- Variation in neophobia among cliff swallows at different colonies
- Soil C, N, and P distribution as affected by plant communities in the Yellow River Delta, China
- Community-based sero-prevalence of hepatitis B and C infections in South Omo Zone, Southern Ethiopia
- Birth asphyxia and its associated factors among newborns in public hospital, northeast Amhara, Ethiopia
- Enhancement in dopamine reduces generous behaviour in women
- Correction: Risk factors for postoperative meningitis after microsurgery for vestibular schwannoma
- Correction: Evolution of high tooth replacement rates in theropod dinosaurs
- Hepatic sinusoidal hemophagocytosis with and without hemophagocytic lymphohistiocytosis
- Efficient intra mode decision for low complexity HEVC screen content compression
- Feature selection for helpfulness prediction of online product reviews: An empirical study
- Structure and age-dependent growth of the chicken liver together with liver fat quantification: A comparison between a dual-purpose and a broiler chicken line
- Important features of retail shoes for women with rheumatoid arthritis: A Delphi consensus survey
- The impact of gut microbiota manipulation with antibiotics on colon tumorigenesis in a murine model
- The characteristic of patulous eustachian tube patients diagnosed by the JOS diagnostic criteria
- Nine years of in situ soil warming and topography impact the temperature sensitivity and basal respiration rate of the forest floor in a Canadian boreal forest
- A novel model for malaria prediction based on ensemble algorithms
- “Because at school, you can become somebody” – The perceived health and economic returns on secondary schooling in rural Burkina Faso
- Experiences of health services and unmet care needs of people with late-stage Parkinson’s in England: A qualitative study
- Electrochemical analysis of uric acid excretion to the intestinal lumen: Effect of serum uric acid-lowering drugs and 5/6 nephrectomy on intestinal uric acid levels
- Does completion of sputum smear monitoring have an effect on treatment success and cure rate among adult tuberculosis patients in rural Eastern Uganda? A propensity score-matched analysis
- Identifying fetal yawns based on temporal dynamics of mouth openings: A preterm neonate model using support vector machines (SVMs)
- Hepatitis B virus seromarkers among HIV infected adults on ART: An unmet need for HBV screening in eastern Ethiopia
- Assessment of knowledge and practice of breast self-examination among reproductive age women in Akatsi South district of Volta region of Ghana
- Evaluation of quantitative biosensor for glucose-6-phosphate dehydrogenase activity detection
- Antibiotic treatment adequacy and death among patients with Pseudomonas aeruginosa airway infection
- Effects of experimentally induced fatigue on healthy older adults’ gait: A systematic review
- Monounsaturated fatty acids protect against palmitate-induced lipoapoptosis in human umbilical vein endothelial cells
- An assessment of the utility and repeatability of the renal resistive index in horses
- Analysis of center of mass acceleration and muscle activation in hemiplegic paralysis during quiet standing
- The association between dengue incidences and provincial-level weather variables in Thailand from 2001 to 2014
- Asylum seekers’ perspectives on vaccination and screening policies after their arrival in Greece and The Netherlands
- A new, fast method to search for morphological convergence with shape data
- Zinc thiazole enhances defense enzyme activities and increases pathogen resistance to Ralstonia solanacearum in peanut (Arachis hypogaea) under salt stress
- Effect of thermal control of dry fomites on regulating the survival of human pathogenic bacteria responsible for nosocomial infections
- Spatial dynamics in the classroom: Does seating choice matter?
- Hematologic profile of Amazon river dolphins Inia geoffrensis and its variation during acute capture stress
- Association between body mass index and asthma severity in Arab pediatric population: A retrospective study
- Toxic trajectories under future climate conditions
- Bioassay- and metabolomics-guided screening of bioactive soil actinomycetes from the ancient city of Ihnasia, Egypt
- Awareness of treatment: A source of bias in subjective grading of ocular complications
- Genome-wide identification and expression analysis of the PHD-finger gene family in Solanum tuberosum
- Exploring functional core bacteria in fermentation of a traditional Chinese food, Aspergillus-type douchi
- Folk theories of gender and anti-transgender attitudes: Gender differences and policy preferences
- Lower S-adenosylmethionine levels and DNA hypomethylation of placental growth factor (PlGF) in placental tissue of early-onset preeclampsia-complicated pregnancies
- Simulating the route of the Tang-Tibet Ancient Road for one branch of the Silk Road across the Qinghai-Tibet Plateau
- Evaluation of the ecological niche model approach in spatial conservation prioritization
- Important gene–gene interaction of TNF-α and VDR on osteoporosis in community-dwelling elders
- Traffic light labelling could prevent mortality from noncommunicable diseases in Canada: A scenario modelling study
- Choice-induced inter-trial inhibition is modulated by idiosyncratic choice-consistency
- HomeSTEAD’s physical activity and screen media practices and beliefs survey: Instrument development and integrated conceptual model
- What nature separated, and human joined together: About a spontaneous hybridization between two allopatric dogwood species (Cornus controversa and C. alternifolia)
- Cell sources of inflammatory mediators present in bone marrow areas inside the meniscus
- The effects of exercise variation in muscle thickness, maximal strength and motivation in resistance trained men
- High prevalence of abnormal menstruation among women living with HIV in Canada
- A quantitative engineering study of ecosystem robustness using thermodynamic power cycles as case studies
- External morphology and developmental changes of tarsal tips and mouthparts of the invasive spotted lanternfly, Lycorma delicatula (Hemiptera: Fulgoridae)
- Small joint arthrodesis technique using a dowel bone graft in a rabbit model
- An investigation of far and near transfer in a gamified visual learning paradigm
- Isolation and characterization of fowl aviadenovirus serotype 11 from chickens with inclusion body hepatitis in Morocco
- Translocation of Mycobacterium tuberculosis after experimental ingestion
- Health literacy as a mediator of the relationship between socioeconomic status and health: A cross-sectional study in a population-based sample in Florence
- Genomic insights on heterogeneous resistance to vancomycin and teicoplanin in Methicillin-resistant Staphylococcus aureus: A first report from South India
- “I am alive; my baby is alive”: Understanding reasons for satisfaction and dissatisfaction with maternal health care services in the context of user fee removal policy in Nigeria
- A systems biology approach uncovers a gene co-expression network associated with cell wall degradability in maize
- Correction: DNA barcodes corroborating identification of mosquito species and multiplex real-time PCR differentiating Culex pipiens complex and Culex torrentium in Iran
- Heterogeneous root zone salinity mitigates salt injury to Sorghum bicolor (L.) Moench in a split-root system
- Effects and cost-effectiveness of postoperative oral analgesics for additional postoperative pain relief in children and adolescents undergoing dental treatment: Health technology assessment including a systematic review
- Spatial ecology of coyotes in the urbanizing landscape of the Cuyahoga Valley, Ohio
- The role of gadolinium in magnetic resonance imaging for early prostate cancer diagnosis: A diagnostic accuracy study
- Modeling succinate dehydrogenase loss disorders in C. elegans through effects on hypoxia-inducible factor
- The association of parents’ behaviors related to salt with 24 h urinary sodium excretion of their children: A Spanish cross-sectional study
- Transcriptional changes during hepatic ischemia-reperfusion in the rat
- NAT2 gene polymorphisms and endometriosis risk: A PRISMA-compliant meta-analysis
- Effects of lutein supplementation in age-related macular degeneration
- Correction: Genetic susceptibility to angiotensin-converting enzyme-inhibitor induced angioedema: A systematic review and evaluation of methodological approaches
- Recovery cycles of posterior root-muscle reflexes evoked by transcutaneous spinal cord stimulation and of the H reflex in individuals with intact and injured spinal cord
- Virulence beneath the fleece; a tale of foot-and-mouth disease virus pathogenesis in sheep
- The delay of motherhood: Reasons, determinants, time used to achieve pregnancy, and maternal anxiety level
- Glycated albumin as a diagnostic tool in diabetes: An alternative or an additional test?
- Quantification of circulating cell-free DNA (cfDNA) in urine using a newborn piglet model of asphyxia
- Correction: Elevated levels of eEF1A2 protein expression in triple negative breast cancer relate with poor prognosis
- Inhibiting the copper efflux system in microbes as a novel approach for developing antibiotics
- Rapid pathogen identification and antimicrobial susceptibility testing in in vitro endophthalmitis with matrix assisted laser desorption-ionization Time-of-Flight Mass Spectrometry and VITEK 2 without prior culture
- Identification of loci of functional relevance to Barrett’s esophagus and esophageal adenocarcinoma: Cross-referencing of expression quantitative trait loci data from disease-relevant tissues with genetic association data
- Inter- and intraspecific diversity of food legumes among households and communities in Ethiopia
- Walking-speed estimation using a single inertial measurement unit for the older adults
- The relationship between glutathione levels in leukocytes and ocular clinical parameters in glaucoma
- The home field advantage of modern plant breeding
- High concentrations of middle ear antimicrobial peptides and proteins and proinflammatory cytokines are associated with detection of middle ear pathogens in children with recurrent acute otitis media
- A modern approach to identifying and characterizing child asthma and wheeze phenotypes based on clinical data
- Validation of a novel time-to-event nest density estimator on passerines: An example using Brewer’s sparrows (Spizella breweri)
- Use of GeneXpert and the role of an expert panel in improving clinical diagnosis of smear-negative tuberculosis cases
- Heat-induced hyperthermia impacts the follicular fluid proteome of the periovulatory follicle in lactating dairy cows
- One-shot phase-recovery using a cellphone RGB camera on a Jamin-Lebedeff microscope
- Change of surfactant protein D and A after renal ischemia reperfusion injury
- Antibiotic saving effect of combination therapy through synergistic interactions between well-characterized chito-oligosaccharides and commercial antifungals against medically relevant yeasts
- Impact of the change in the antitubercular regimen from three to four drugs on cure and frequency of adverse reactions in tuberculosis patients from Brazil: A retrospective cohort study
- Ontogenic mRNA expression of RNA modification writers, erasers, and readers in mouse liver
- Intrinsic and extrinsic factors associated with sputum characteristics of presumed tuberculosis patients
- Vaccination with a live-attenuated small-colony variant improves the humoral and cell-mediated responses against Staphylococcus aureus
- A versatile modular vector set for optimizing protein expression among bacterial, yeast, insect and mammalian hosts
- Rapid evolution of prey maintains predator diversity
- Correction: Consumption of rice, acceptability and sensory qualities of fortified rice amongst consumers of social safety net rice in Nepal
- Indicators to distinguish symptom accentuators from symptom producers in individuals with a diagnosed adjustment disorder: A pilot study on inconsistency subtypes using SIMS and MMPI-2-RF
- Postural stability of 5-year-old girls and boys with different body heights
- The association between exposure to interferon-beta during pregnancy and birth measurements in offspring of women with multiple sclerosis
- Variations in neurotoxicity and proteome profile of Malayan krait (Bungarus candidus) venoms
- Altered functional connectivity density in the brains of hemodialysis end-stage renal disease patients: An in vivo resting-state functional MRI study
- Transboundary movements of foot-and-mouth disease from India to Sri Lanka: A common pattern is shared by serotypes O and C
- Medical and productivity costs after trauma
- Defining pharmacists' roles in disasters: A Delphi study
- Comprehensive assessment of tissue and serum parameters of bone metabolism in a series of orthopaedic patients
- Predictors of alcohol use transitions among drug-using youth presenting to an urban emergency department
- Longitudinal changes in structural lung abnormalities using MDCT in chronic obstructive pulmonary disease with asthma-like features
- Endocannabinoid 2-arachidonoylglycerol is elevated in the coronary circulation during acute coronary syndrome
- Contextual factors and sporting success: The relationship between birth date and place of early development on the progression of Jamaican track and field athletes from junior to senior level
- Potential application of Aloe Vera-derived plant-based cell in powering wireless device for remote sensor activation
- Retraction: Inhibition of reactive gliosis prevents neovascular growth in the mouse model of oxygen-induced retinopathy
- Measuring and addressing the childhood tuberculosis reporting gaps in Pakistan: The first ever national inventory study among children
- Arterial blood gas analysis in dogs with bronchomalacia
- Trends in the incidence of thymoma, thymic carcinoma, and thymic neuroendocrine tumor in the United States
- Optogenetic inhibition of ventral hippocampal neurons alleviates associative motor learning dysfunction in a rodent model of schizophrenia
- Safe and effective subcutaneous adipolysis in minipigs by a collagenase derivative
- The correlation between optical coherence tomography retinal shape irregularity and axial length
- Length of gestation and birth weight are associated with indices of combined kidney biomarkers in early childhood
- Essential oil-incorporated carbon nanotubes filters for bacterial removal and inactivation
- Domiciliary high-flow treatment in patients with COPD and chronic hypoxic failure: In whom can we reduce exacerbations and hospitalizations?
- Comprehensive analysis of putative dihydroflavonol 4-reductase gene family in tea plant
- Comparative proteomic analysis of mitochondria isolated from Euglena gracilis under aerobic and hypoxic conditions
- Secreted metabolite-mediated interactions between rhizosphere bacteria and Trichoderma biocontrol agents
- Experimental evidence of subtle victim blame in the absence of explicit blame
- Effects of different fatigue locations on upper body kinematics and inter-joint coordination in a repetitive pointing task
- Cannula and circuit management in peripheral extracorporeal membrane oxygenation: An international survey of 45 countries
- Economic evaluations of screening strategies for the early detection of colorectal cancer in the average-risk population: A systematic literature review
- Vitreous levels of Lipocalin-2 on patients with primary rhegmatogenous retinal detachment
- Light intensity and spectrum affect metabolism of glutathione and amino acids at transcriptional level
- The potential role of acrolein in plant ferroptosis-like cell death
- General practitioners’ consultation counts and associated factors in Swiss primary care – A retrospective observational study
- Potential of mesenchymal- and cardiac progenitor cells for therapeutic targeting of B-cells and antibody responses in end-stage heart failure
- Correction: Constitutive expression of an A-5 subgroup member in the DREB transcription factor subfamily from Ammopiptanthus mongolicus enhanced abiotic stress tolerance and anthocyanin accumulation in transgenic Arabidopsis
- A single institution experience of the treatment of pancreatic ductal carcinoma: The demand and the role of radiation therapy
- Correction: Intestinal mucosal injury induced by obstructive jaundice is associated with activation of TLR4/TRAF6/NF-κB pathways
- Relationship between scapular initial position and scapular movement during dynamic motions
- Correction: The circadian rhythm of bladder clock genes in the spontaneously hypersensitive rat
- Applications of machine learning in decision analysis for dose management for dofetilide
- Retraction: Nuclear factor kappa-B signaling is integral to ocular neovascularization in ischemia-independent microenvironment
- Using archaeological and geomorphological evidence for the establishment of a relative chronology and evolution pattern for Holocene landslides
- Who reported having a high-strain job, low-strain job, active job and passive job? The WIRUS Screening study
- Longitudinal monitoring of KRAS-mutated circulating tumor DNA enables the prediction of prognosis and therapeutic responses in patients with pancreatic cancer
- Retraction: Epigenetic Silencing of Peroxisome Proliferator-Activated Receptor γ Is a Biomarker for Colorectal Cancer Progression and Adverse Patients’ Outcome
- Correction: Severe cases of seasonal influenza in Russia in 2017-2018
- Differences between occupational and non-occupational-related motor vehicle collisions in West Virginia: A cross-sectional and spatial analysis
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