Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats

Autoři: Jordânia M. O. Freire aff001;  Hellíada V. Chaves aff001;  Alrieta H. Teixeira aff002;  Luzia Herminia T. de Sousa aff001;  Isabela Ribeiro Pinto aff001;  José Jackson do N. Costa aff003;  Nayara Alves de Sousa aff004;  Karuza Maria A. Pereira aff005;  Virgínia C. C. Girão aff005;  Vanessa C. S. Ferreira aff006;  João Evangelista de Ávila dos Santos aff007;  Mary Anne S. Lima aff007;  Antônia T. A. Pimenta aff007;  Raquel de C. Montenegro aff008;  Maria Elisabete A. de Moraes aff008;  Vicente de P. T. Pinto aff004;  Gerardo C. Filho aff004;  Mirna M. Bezerra aff004
Působiště autorů: Northeast Biotechnology Network–Ph.D. Program, Federal University of Ceará, Sobral, Ceará, Brazil aff001;  School of Dentistry, Federal University of Ceará, Sobral, Ceará, Brazil aff002;  School of Medicine, University CenterINTA–UNINTA, Sobral, Ceará, Brazil aff003;  School of Medicine, Federal University of Ceará, Sobral, Ceará, Brazil aff004;  Department of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil aff005;  Postgraduate Program in Morphofunctional Sciences, Department of Morphology, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil aff006;  Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil aff007;  Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil aff008
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0223800


Periodontitis is an immuno-inflammatory disease, which can lead to tooth loss. This study aimed to investigate the efficacy of Platymiscium floribundum Vog., a Brazilian tree which has been used in folk medicine as an anti-inflammatory agent, in a pre-clinical trial of periodontitis in rats. Periodontitis was induced by placing a sterilized nylon (3.0) thread ligature around the cervix of the second left upper molar of the rats, which received (per os) P. floribundum extract (0.1, 1 or 10 mg/kg) or vehicle 1h before periodontitis-challenge and once daily during 11 days. Treatment with P. floribundum (10mg/kg) decreased alveolar bone loss, MPO activity nitrite/nitrate levels, oxidative stress, TNF-α, IL1-β, IL-8/CINC-1, and PGE2 gingival levels, and transcription of TNF-α, IL1-β, COX-2, iNOS, RANK, and RANKL genes, while elevated both BALP serum levels and IL-10 gingival levels. The animals did not show signs of toxicity throughout the experimental course. These findings show that P. floribundum has anti-inflammatory and anti-resorptive properties in a pre-clinical trial of periodontitis, representing an interesting biotechnological tool.

Klíčová slova:

Alveolar bone – Cytokines – Inflammation – Nitric oxide – Oxidative stress – Periodontitis – Scanning electron microscopy – Toxicity


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