Genetic susceptibility to angiotensin-converting enzyme-inhibitor induced angioedema: A systematic review and evaluation of methodological approaches


Autoři: Haivin Aziz Ali aff001;  Anne Fog Lomholt aff002;  Seyed Hamidreza Mahmoudpour aff003;  Thorbjørn Hermanrud aff002;  Anette Bygum aff004;  Christian von Buchwald aff002;  Marianne Antonius Jakobsen aff005;  Eva Rye Rasmussen aff002
Působiště autorů: Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark aff001;  Department of Oto-Rhino-Laryngology—Head and Neck Surgery and Audiology, Denmark aff002;  IMBEI—Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg, CTH -Center for Thrombosis and Hemostasis Mainz, Mainz, Germany aff003;  Department of Dermatology I and Allergy Center, Odense University Hospital, Indgang, Odense C, Denmark aff004;  Department of Clinical Immunology, Odense University Hospital, Denmark, Odense C, Denmark aff005
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0224858

Souhrn

Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II which causes vasoconstriction. ACE inhibitors reduce blood pressure by inhibiting ACE. A well-known adverse drug reaction to ACE inhibitors is ACE inhibitor-induced angioedema (ACEi-AE). Angioedema is a swelling of skin and mucosa, which can be fatal if the airway is compromised. We have performed a systematic review of the evidence suggesting that genetic polymorphisms are associated with ACEi-AE and evaluated the methodological approaches of the included studies. The Cochrane Database of Systematic Reviews, Google Scholar, and PubMed were searched. Studies investigating the association between genetic markers and ACEi-AE were included. The Q-genie tool was used to evaluate the quality of the study methodologies. Seven studies were included. With the exception of one whole genome study, all of the included studies were candidate gene association studies. Study quality assessment scores ranged from 36 to 55. One study was found to be of good quality, suggesting that the detected associations may be unreliable. The inferior quality of some studies was due to poor organization, lack of analyses and missing information. Polymorphisms within XPEPNP2, BDKRB2–9/+ 9 and neprilysin genes, were reported to be associated with increased risk of ACEi-AE. However, due to low quality, these associations need to be confirmed in larger studies.

Klíčová slova:

Adverse reactions – Case-control studies – Database searching – Genetic polymorphism – Genome-wide association studies – Haplotypes – Systematic reviews – ACE inhibitors


Zdroje

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