Prognostic significance of non-sustained ventricular tachycardia on stored electrograms in pacemaker recipients

Autoři: Gianluigi Bencardino aff001;  Francesco Raffaele Spera aff001;  Gaetano Pinnacchio aff001;  Francesco Perna aff001;  Maria Lucia Narducci aff001;  Gianluca Comerci aff001;  Gemma Pelargonio aff001;  Francesca Augusta Gabrielli aff001;  Giulio La Rosa aff001;  Gaetano Antonio Lanza aff001;  Filippo Crea aff001
Působiště autorů: Dipartimento di Scienze Cardiovascolari e Toraciche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy aff001;  Università Cattolica del Sacro Cuore, Roma, Italy aff002
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225059



Little is known about the prognostic significance of non-sustained ventricular tachycardia (NS-VT) in outpatients scheduled for routine pacemaker controls. We therefore sought to investigate the prognostic significance of non-sustained ventricular tachycardia on stored electrograms in pacemaker recipients.


We enrolled patients implanted with dual chamber pacemaker for atrioventricular block or sinus node dysfunction from 2010 to 2016, with LVEF> 45%, older than 18 years, with at least 3 device interrogations at follow-up. Data were collected about medical history, pharmacological therapy at implantation, pacemaker programming, NS-VT occurrence, long-term survival.


A total of 308 patients were included in the final analysis, with median follow-up time of 56 months. No ventricular arrhythmic episodes were documented in 221 patients (Group 1), whereas 87 had at least 1 episode of NS-VT during follow-up (Group 2). As a whole, 282 episodes of NS-VT were documented. There was a higher prevalence of previous myocardial infarction and slightly lower left ventricular ejection fraction (LVEF) in Group 2. The primary endpoint (all-cause mortality) occurred in 50 patients (22%) of Group 1 and 12 (14%) patients of Group 2 (p = 0.07). Clinical predictors of all-cause mortality at univariate analysis included age, LVEF and coronary artery disease (CAD). Only age and CAD, however, remained as predictors of mortality at multivariable analysis. A sizeable, but not statistically significant, portion of patients who died had a de novo occurrence of NS-VT at the last pacemaker check.


Our data do not support a prognostic role for the detection of NS-VT during pacemaker controls.

Klíčová slova:

Arrhythmia – Cardiac pacing – Coronary heart disease – Ejection fraction – Medical devices and equipment – Medical implants – Pacemakers – Tachycardia


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2019 Číslo 11