Molecular epidemiological characteristics of dengue virus carried by 34 patients in Guangzhou in 2018


Autoři: Feng Liao aff001;  Huini Chen aff002;  Jieliang Xie aff003;  Shaofeng Zhan aff004;  Pan Pan aff005;  Zizhao Lao aff006;  Yaohua Fan aff004;  Lupin Lin aff007;  Yanni Lai aff004;  Shuangfeng Lin aff004;  Jianguo Wu aff002;  Xiaohong Liu aff001;  Geng Li aff001
Působiště autorů: Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou, China aff001;  Institute of Medical Microbiology, Jinan University, Guangzhou, China aff002;  School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China aff003;  The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China aff004;  College of Life Sciences, Wuhan University, Wuhan, China aff005;  Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China aff006;  Guangzhou eighth People's Hospital, Guangzhou Medical University, Guangzhou, China aff007
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0224676

Souhrn

Dengue fever is a major worldwide public health problem that, as estimated by the WHO, causes epidemics in over 100 countries, resulting in hundreds of millions of dengue virus (DENV) infections every year. In China, dengue fever mainly occurs in coastal areas. Recurring dengue outbreaks were reported by Guangdong Province almost every year since the first epidemic in 1978. DENV infections persisted in Guangzhou in consecutive years since 2000, with the dengue epidemic reaching a historical peak in 2014. Because Guangzhou is one of the largest cities for opening up in China, understanding the epidemiological characteristics of dengue fever in the city can hopefully provide a significant basis for developing effective dengue prevention strategies. In this study, a total of 34 DENV strains, including 29 DENV-1 strains and 5 DENV-2 strains, were isolated from a blood samples drawn from patients who were diagnosed with dengue fever by hospitals in Guangzhou during 2018. To explore the epidemiological characteristics of dengue fever, the envelope (E) gene obtained from the isolates was amplified for phylogenetic analysis. The results from the phylogenetic analysis showed that DENV in Guangzhou was mainly imported from Southeast Asian countries. Additionally, propagation paths based on phylogeographical analysis suggested potential local dengue transmission in Guangzhou.

Klíčová slova:

Dengue fever – Dengue virus – China – Mosquitoes – Phylogenetic analysis – Phylogenetics – Sequence analysis – Sequence databases


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2019 Číslo 11