Chronic exercise modulates the cellular immunity and its cannabinoid receptors expression

Autoři: Salvador Valencia-Sánchez aff001;  Karen Elizabeth Nava-Castro aff002;  Margarita Isabel Palacios-Arreola aff002;  Oscar Prospéro-García aff003;  Jorge Morales-Montor aff004;  René Drucker-Colín aff001
Působiště autorů: Instituto de Fisiología Celular, Departamento de Neuropatología Molecular, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Ciudad Universitaria, Ciudad de México, México aff001;  Genotoxicología y Mutagénesis Ambientales, Ciencias Ambientales, Centro de Ciencias de la Atmósfera, Ciudad de México, México aff002;  Laboratorio de Cannabinoides, Departamento de Fisiología, Facultad De Medicina, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Ciudad Universitaria, Ciudad de México, México aff003;  Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP, Ciudad de México, México aff004
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0220542


The impact of performing exercise on the immune system presents contrasting effects on health when performed at different intensities. In addition, the consequences of performing chronic exercise have not been sufficiently studied in contrast to the effects of acute bouts of exercise. The porpoise of this work was to determine the effect that a popular exercise regimen (chronic/moderate/aerobic exercise) has on the proportion of different immune cell subsets, their function and if it affects the cannabinoid system with potentially functional implications on the immune system. A marked increase in several immune cell subsets and their expression of cannabinoid receptors was expected, as well as an enhanced proliferative and cytotoxic activity by total splenocytes in exercised animals. For this study male Wistar rats performed treadmill running 5 times a week for a period of 10 weeks, at moderate intensity. Our results showed a significant decrease in lymphocyte subpopulations (CD4+, Tγδ, and CD45 RA+ cells) and an increase in the cannabinoid receptors expression in those same cell. Although functional assays did not reveal any variation in total immunoglobulin production or NK cells cytotoxic activity, proliferative capability of total splenocytes increased in trained rats. Our results further support the notion that exercise affects the immunological system and extends the description of underlying mechanisms mediating such effects. Altogether, our results contribute to the understanding of the benefits of exercise on the practitioner´s general health.

Klíčová slova:

Analysis of variance – B cells – Exercise – Immune cells – Immune response – Lymphocytes – T cells – Cannabinoids


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