Early economic evaluation of MRI-guided laser interstitial thermal therapy (MRgLITT) and epilepsy surgery for mesial temporal lobe epilepsy

Autoři: Elysa Widjaja aff001;  Tina Papastavros aff004;  Beate Sander aff001;  Carter Snead aff003;  Petros Pechlivanoglou aff001
Působiště autorů: Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada aff001;  Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada aff002;  Division of Neurology, Hospital for Sick Children, Toronto, Canada aff003;  Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada aff004;  Toronto Health Economics Technology Assessment, University Health Network, Toronto, Canada aff005;  Institute of Clinical Evaluative Sciences (ICES), Toronto, Canada aff006;  Public Health Ontario, Toronto, Canada aff007;  Child Health Evaluative Sciences, Hospital for Sick Children, Toronto, Canada aff008
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0224571



MRI-guided laser interstitial thermal therapy (MRgLITT) is a new minimally invasive treatment for temporal lobe epilepsy (TLE), with limited effectiveness data. It is unknown if the cost savings associated with shorter hospitalization could offset the high equipment cost of MRgLITT. We examined the cost-utility of MRgLITT versus surgery for TLE from healthcare payer perspective, and the value of additional research to inform policy decision on MRgLITT.


We developed a microsimulation model to evaluate quality adjusted life years (QALYs), costs, and incremental cost-effectiveness ratio (ICER) of MRgLITT versus surgery in TLE, assuming life-time horizon and 1.5% discount rate. Model inputs were derived from the literature. We conducted threshold and sensitivity analyses to examine parameter uncertainties, and expected value of partial perfect information analyses to evaluate the expected monetary benefit of eliminating uncertainty on probabilities associated with MRgLITT.


MRgLITT yielded 0.08 more QALYs and cost $7,821 higher than surgery, with ICER of $94,350/QALY. Influential parameters that could change model outcomes include probabilities of becoming seizure-free from disabling seizures state and returning to disabling seizures from seizure-free state 5 years after surgery and MRgLITT, cost of MRgLITT disposable equipment, and utilities of disabling seizures and seizure-free states of surgery and MRgLITT. The cost-effectiveness acceptability curve showed surgery was preferred in more than 50% of iterations. The expected monetary benefit of eliminating uncertainty for probabilities associated with MRgLITT was higher than for utilities associated with MRgLITT.


MRgLITT resulted in more QALYs gained and higher costs compared to surgery in the base-case. The model was sensitive to variations in the cost of MRgLITT disposable equipment. There is value in conducting more research to reduce uncertainty on the probabilities and utilities of MRgLITT, but priority should be given to research focusing on improving the precision of estimates on effectiveness of MRgLITT.

Klíčová slova:

Cost-effectiveness analysis – Epilepsy – Equipment – Hospitalizations – Lasers – Magnetic resonance imaging – Minimally invasive surgery – Surgical and invasive medical procedures


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