Comparison of potential drug-drug interactions with metabolic syndrome medications detected by two databases

Autoři: Bovornpat Suriyapakorn aff001;  Pun Chairat aff002;  Suwanan Boonyoprakarn aff003;  Pimonwan Rojanarattanangkul aff003;  Wassana Pisetcheep aff003;  Natthaphon Hunsakunachai aff003;  Pornpun Vivithanaporn aff004;  Supakit Wongwiwatthananukit aff006;  Phisit Khemawoot aff007
Působiště autorů: Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand aff001;  Osotsala the Community Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand aff002;  Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand aff003;  Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand aff004;  Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodhi Hospital, Mahidol University, Samutprakarn, Thailand aff005;  Department of Pharmacy Practice, Daniel K. Inouye College of Pharmacy, University of Hawai’i, Hilo, Hawaii, United States of America aff006;  Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand aff007;  Preclinical Pharmacokinetics and Interspecies Scaling for Drug Development Research Unit, Chulalongkorn University, Bangkok, Thailand aff008
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225239



Drug-drug interactions (DDIs) are one of the most common drug-related problems. Recently, electronic databases have drug interaction tools to search for potential DDIs, for example, Micromedex and However, Micromedex and have different abilities in detecting potential DDIs, and this might cause misinformation to occur between patients and health care providers.

Methods and findings

The aim of this study was to compare the ability of Micromedex and to detect potential DDIs with metabolic syndrome medications using the drug list from the U-central database, King Chulalongkorn Memorial Hospital in April 2019. There were 90 available drugs for the treatment of the metabolic syndrome and its associated complications, but six were not found in the Micromedex and databases; therefore, only 84 items were used in the present study. There were 1,285 potential DDI pairs found by the two databases. Micromedex reported DDIs of 724 pairs, while, reported 1,122 pairs. For the severity of the potential DDI reports, the same severity occurred between the two databases of 481 pairs (37.43%) and a different severity for 804 pairs (62.57%).

Conclusion had a higher sensitivity to detect potential DDIs by approximately 1.5-fold, but Micromedex supplied more informative documentation for the severity classification. Therefore, pharmacists should use at least two databases to evaluate potential DDIs and determine the appropriate drug regimens for physician communications and patient consultations.

Klíčová slova:

Diuretics – Drug therapy – Drug-drug interactions – Drugs – Health care providers – Metabolic syndrome – Pharmacodynamics


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Článek vyšel v časopise


2019 Číslo 11