Acceleration of chemical shift encoding-based water fat MRI for liver proton density fat fraction and T2* mapping using compressed sensing

Autoři: Fabian K. Lohöfer aff001;  Georgios A. Kaissis aff001;  Christina Müller-Leisse aff001;  Daniela Franz aff001;  Christoph Katemann aff002;  Andreas Hock aff002;  Johannes M. Peeters aff003;  Ernst J. Rummeny aff001;  Dimitrios Karampinos aff001;  Rickmer F. Braren aff001
Působiště autorů: Institute for diagnostic and interventional Radiology, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Straße, München, Germany aff001;  Philips Healthcare, Hamburg, Germany aff002;  Philips Healthcare, Best, Netherlands aff003
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0224988



To evaluate proton density fat fraction (PDFF) and T2* measurements of the liver with combined parallel imaging (sensitivity encoding, SENSE) and compressed sensing (CS) accelerated chemical shift encoding-based water-fat separation.


Six-echo Dixon imaging was performed in the liver of 89 subjects. The first acquisition variant used acceleration based on SENSE with a total acceleration factor equal to 2.64 (acquisition labeled as SENSE). The second acquisition variant used acceleration based on a combination of CS with SENSE with a total acceleration factor equal to 4 (acquisition labeled as CS+SENSE). Acquisition times were compared between acquisitions and proton density fat fraction (PDFF) and T2*-values were measured and compared separately for each liver segment.


Total scan duration was 14.5 sec for the SENSE accelerated image acquisition and 9.3 sec for the CS+SENSE accelerated image acquisition. PDFF and T2* values did not differ significantly between the two acquisitions (paired Mann-Whitney and paired t-test P>0.05 in all cases). CS+SENSE accelerated acquisition showed reduced motion artifacts (1.1%) compared to SENSE acquisition (12.3%).


CS+SENSE accelerates liver PDFF and T2*mapping while retaining the same quantitative values as an acquisition using only SENSE and reduces motion artifacts.

Klíčová slova:

Fats – Fatty liver – Image processing – Imaging techniques – Liver and spleen scan – Magnetic resonance imaging – Steatosis – Compressed sensing


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Článek vyšel v časopise


2019 Číslo 11