Factors associated with medication adherence among people with diabetes mellitus in poor urban areas of Cambodia: A cross-sectional study

Autoři: Akiyo Nonogaki aff001;  Hen Heang aff002;  Siyan Yi aff003;  Maurits van Pelt aff002;  Hiroko Yamashina aff006;  Chie Taniguchi aff007;  Tomoko Nishida aff008;  Hisataka Sakakibara aff009
Působiště autorů: Department of Nursing, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan aff001;  MoPoTsyo Patient Information Centre, Phnom Penh, Cambodia aff002;  KHANA Center for Population Health Research, Phnom Penh, Cambodia aff003;  Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore aff004;  Center for Global Health Research, Touro University California, Vallejo, CA, United States of America aff005;  Faculty of Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan aff006;  College of Nursing, Aichi Medical University, Nagakute, Aichi, Japan aff007;  Department of Nursing, Sugiyama Jogakuen University, Nagoya, Aichi, Japan aff008;  School of Nursing, Ichinomiya Kenshin College, Ichinomiya, Aichi, Japan aff009;  Nagoya University, Nagoya, Aichi, Japan aff010
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225000



In Cambodia, the age-standardized prevalence of diabetes mellitus has increased in both men and women. The main objective of this study was to identify factors associated with diabetes medication adherence among people with diabetes mellitus in poor urban areas of Phnom Penh, Cambodia.


A cross-sectional study was conducted in 2017 using a structured questionnaire for face-to-face interviews by trained interviewers. The participants were people with diabetes mellitus who were the active members of a peer educator network, lived in poor urban areas of Phnom Penh, and attended weekly educational sessions during the survey period. Diabetes medication adherence was measured using four items of modified Morisky Medication Adherence Scale. Participants were classified into two groups based on their adherence score: 0 (high adherence) and from 1 to 4 (medium or low adherence). Sociodemographic characteristics; medical history; accessibility to health services; and knowledge, attitude, and practices related to diabetes mellitus were examined. A multiple logistic regression analysis was conducted adjusting for sex, age, marital status, and education levels.


Data from 773 people with diabetes were included in the analyses. Of the total, 49.3% had a high level of diabetes medication adherence. A high level of adherence was associated with higher family income (≥50 USD per month) (adjusted odds ratio [AOR] = 5.00, 95% confidence interval [CI] = 2.25–11.08), absence of diabetes mellitus-related complications (AOR = 1.66, 95% CI = 1.19–2.32), use of health services more than once per month (AOR = 2.87, 95% CI = 1.64–5.04), following special diet for diabetes mellitus (AOR = 1.81, 95% CI = 1.17–2.81), and absence of alcohol consumption (AOR = 13.67, 95% CI = 2.86–65.34).


High diabetes medication adherence was associated with better family economic conditions, absence of diabetes mellitus-related complications, and healthy behaviors. It would be crucial to improve affordable access to regular follow-ups including promotion of healthy behaviors through health education and control of diabetes mellitus-related complications.

Klíčová slova:

Alcohol consumption – Blood pressure – Blood sugar – Diet – Health education and awareness – Medical education – Socioeconomic aspects of health


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2019 Číslo 11