Mindfulness-Based Blood Pressure Reduction (MB-BP): Stage 1 single-arm clinical trial

Autoři: Eric B. Loucks aff001;  William R. Nardi aff001;  Roee Gutman aff004;  Ian M. Kronish aff005;  Frances B. Saadeh aff001;  Yu Li aff001;  Anna E. Wentz aff001;  Julie Webb aff002;  David R. Vago aff006;  Abigail Harrison aff002;  Willoughby B. Britton aff002
Působiště autorů: Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, United States of America aff001;  Department of Behavioral Sciences, Brown University School of Public Health, Providence, Rhode Island, United States of America aff002;  Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America aff003;  Department of Biostatistics, Brown University School of Public Health, Providence, Rhode Island, United States of America aff004;  Department of Medicine, Columbia University Medical Center Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America aff005;  Department of Psychiatry and Behavioral Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America aff006;  Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, United States of America aff007
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0223095


Background and objectives

Impacts of mindfulness-based programs on blood pressure remain equivocal, possibly because the programs are not adapted to engage with determinants of hypertension, or due to floor effects. Primary objectives were to create a customized Mindfulness-Based Blood Pressure Reduction (MB-BP) program, and to evaluate acceptability, feasibility, and effects on hypothesized proximal self-regulation mechanisms. Secondary outcomes included modifiable determinants of blood pressure (BP), and clinic-assessed systolic blood pressure (SBP).


This was a Stage 1 single-arm trial with one year follow-up. Focus groups and in-depth interviews were performed to evaluate acceptability and feasibility. Self-regulation outcomes, and determinants of BP, were assessed using validated questionnaires or objective assessments. The MB-BP curriculum was adapted from Mindfulness-Based Stress Reduction to direct participants’ mindfulness skills towards modifiable determinants of blood pressure.


Acceptability and feasibility findings showed that of 53 eligible participants, 48 enrolled (91%). Of these, 43 (90%) attended at least 7 of the 10 MB-BP classes; 43 were followed to one year (90%). Focus groups (n = 19) and semi-structured interviews (n = 10) showed all participants viewed the delivery modality favorably, and identified logistic considerations concerning program access as barriers. A priori selected primary self-regulation outcomes showed improvements at one-year follow-up vs. baseline, including attention control (Sustained Attention to Response Task correct no-go score, p<0.001), emotion regulation (Difficulties in Emotion Regulation Score, p = 0.02), and self-awareness (Multidimensional Assessment of Interoceptive Awareness, p<0.001). Several determinants of hypertension were improved in participants not adhering to American Heart Association guidelines at baseline, including physical activity (p = 0.02), Dietary Approaches to Stop Hypertension-consistent diet (p<0.001), and alcohol consumption (p<0.001). Findings demonstrated mean 6.1 mmHg reduction in SBP (p = 0.008) at one year follow-up; effects were most pronounced in Stage 2 uncontrolled hypertensives (SBP≥140 mmHg), showing 15.1 mmHg reduction (p<0.001).


MB-BP has good acceptability and feasibility, and may engage with self-regulation and behavioral determinants of hypertension.

Klíčová slova:

Alcohol consumption – Antihypertensives – Blood pressure – Diet – Emotions – Hypertension – Instructors – Physical activity


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