Are viral-infections associated with Ménière’s Disease? A systematic review and meta-analysis of molecular-markers of viral-infection in case-controlled observational studies of MD


Autoři: Nicholas John Dean aff001;  Christopher Pastras aff002;  Daniel Brown aff003;  Aaron Camp aff002
Působiště autorů: The University of Sydney, Sydney, NSW, Australia aff001;  School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia aff002;  School of Pharmacy and Biomedical Sciences, Curtin University, Bentley, WA, Australia aff003
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225650

Souhrn

Despite considerable research, it remains controversial as to whether viral-infections are associated with Meniere’s Disease (MD), a clinically heterogeneous set of chronic inner-ear disorders strongly associated with endolymphatic hydrops. Here, we investigated whether viral-infections are associated with MD through a systematic review and meta-analysis of observational clinical studies using molecular-diagnostics. Eligible for inclusion were case-controlled studies which ascertained molecular-determinants of past or present viral-infection through either viral nucleic acids or host serological marker in MD cases and non-MD controls. Across online databases and grey literature, we identified 210 potentially relevant articles in the English language, from which a total of 14 articles fully satisfied our eligibility criteria such that meta-groups of 611 MD-cases and 373 controls resulted. The aggregate quality of the modest-sized (14 studies) body of evidence was limited and varied considerably with regards to participant selection, matching, and ascertainment(s) and determinant(s) of viral-infection. Most data identified concerned the human cytomegalovirus (CMV), and meta-analysis of eligible studies revealed that evidence of CMV-infection was associated approximately three-fold with MD compared to controls, however the timing of the infections was indeterminate as the pooled analyses combined antiviral serological markers with viral nucleic acid markers. No association was found for any of HSV-1, -2, VZV, or EBV. Associative analyses of any viral species not aforementioned were precluded by limited data, and thus potential associations between other viral species and MD, especially other than Herpesviridae, are yet to be characterised. Overall, we have found a small association between CMV-infection and MD, however it is to be determined for what sub-groups of MD this finding may be relevant, and ideally the reported association remains would be reproduced by a greater volume of higher quality evidence.

Klíčová slova:

Database searching – Enzyme-linked immunoassays – Herpes simplex virus-1 – Human cytomegalovirus – Meniere disease – Systematic reviews – Herpes simplex virus-2


Zdroje

1. Baloh RW. Prosper Ménière and his disease. Arch Neurol. 2001; 58(7): 1151–1156. doi: 10.1001/archneur.58.7.1151 11448308

2. Nakashima T, Pyykkö I, Arroll MA, Casselbrant ML, Foster CA, Manzoor NF, et al. Meniere’s disease. Nat Rev Dis Primers. 2016; 2. doi: 10.1038/nrdp.2016.28 27170253

3. Lopez-Escamez JA, Batuecas-Caltrio A, Bisdorff A. Towards personalized medicine in Ménière’s disease. F1000. 2018; 7: 1295. doi: 10.12688/f1000research.14417.1 30430003

4. Vassiliou A, Vlastarakos PV, Maragoudakis P, Candiloros D, Nikolopoulos TP. Meniere’s disease: still a mystery disease with a difficult differential diagnosis. Ann Indian Acad Neurol. 2011; 14(1): 12–18. doi: 10.4103/0972-2327.78043 21633608

5. Gazquez I, Requena T, Espinosa JM, Batuecas A, Lopez-Escamez JA. Genetic and clinical heterogeneity in Meniere’s disease. Autoimmun Rev. 2012; 11(12): 925–926. doi: 10.1016/j.autrev.2012.02.020 22415020

6. Frejo L, Soto-Varela A, Santos-Perez S, Aran I, Batuecas-Caletrio A, Perez-Guillen V, et al. Clinical Subgroups in Bilateral Meniere Disease. Front Neurol. 2016; 7. doi: 10.3389/fneur.2016.00182 27822199

7. Vrabec JT. Genetic Investigations of Meniere’s disease. Otolaryngol Clin North Am. 2010; 43(5): 1121–1132. doi: 10.1016/j.otc.2010.05.010 20713249

8. Derebery MJ, Berliner KI. Allergy and Its Relation to Meniere’s Disease. Otolaryngol Clin North Am. 2010; 43(5): 1047–1058. doi: 10.1016/j.otc.2010.05.004 20713244

9. Salt AN, Plontke SK. Endolymphatic Hydrops: Pathophysiology and Experimental Models. Otolaryngol Clin. 2010; 43(5): 971–983

10. Gurkov R. (2017). "Meniere and Friends: Imaging and Classification of Hydropic Ear Disease." Otol Neurotol 38(10): e539–e544. doi: 10.1097/MAO.0000000000001479 29135874

11. Gurkov R., Jerin C., Flatz W. and Maxwell R. (2019). "Clinical manifestations of hydropic ear disease (Meniere's)." Eur Arch Otorhinolaryngol 276(1): 27–40. doi: 10.1007/s00405-018-5157-3 30306317

12. Greco A, Gallo A, Fusconi M, Marinelli C, Macri GF, de Vincentiis M. Meniere’s disease might be an autoimmune condition? Autoimmun Rev. 2012; 11(10): 731–738. doi: 10.1016/j.autrev.2012.01.004 22306860

13. Flook M, Escamez JAL. Meniere’s Disease: Genetics and the Immune System. Current Otorhinolaryngology Reports. 2018; 6(1): 24–31.

14. Davis LE, Johnsson LG. Viral infections of the inner ear: clinical, virologic, and pathologic studies in humans and animals. Am J Otolaryngol. 1983; 4(5): 347–362. doi: 10.1016/s0196-0709(83)80022-2 6314834

15. Oliveira CA, Sampaio AL, Bahmad FM Jr., Araújo MFS. Viral Etiology for Inner Ear Diseases: Proven, Unproven, Unlikely. ORL. 2008; 70: 42–51. doi: 10.1159/000111047 18235205

16. Adour KK, Byl FM, Hilsinger RL Jr, Wilcox RD. Ménière’s disease as a form of cranial polyganglionitis. Laryngoscope. 1980; 90(3): 392–398. doi: 10.1002/lary.5540900304 7359961

17. Schuknecht HF, Benitez JT, Beekhuis J. LXXXIII Further Observations on the Pathology of Menière’s Disease. Ann Otol Rhinol. 1962; 71(4): 1039–1053.

18. Gacek RR. Ménière’s Disease Is a Viral Neuropathy. ORL. 2009; 71: 78–86. doi: 10.1159/000189783 19142031

19. Oliveira CA, Sampaio AL, Bahmad FM Jr., Araújo MFS. Viral Etiology for Inner Ear Diseases: Proven, Unproven, Unlikely. ORL. 2008; 70: 42–51. doi: 10.1159/000111047 18235205

20. Mirza S, Gokhale S. Pathophysiology of Meniere’s Disease. In: Bahmad F Jr. editor. Up to Date on Meniere’s Disease. IntechOpen; 2017. doi: 10.5772/66388 Available from: https://www.intechopen.com/books/up-to-date-on-meniere-s-disease/pathophysiology-of-meniere-s-disease.

21. Xu F, Schillinger JA, Sternberg MR, Johnson RE, Lee FK, Nahmias AJ, et al. Seroprevalence and coinfection with herpes simplex virus type 1 and type 2 in the United States, 1988–1994. J Infect Dis. 2002; 185(8): 1019–1024. doi: 10.1086/340041 11930310

22. Souf S. Recent advances in diagnostic testing for viral infections. Biosci Horizons. 2016; 9. doi: 10.1093/biohorizons/hzw010

23. Struelens MJ, Brisse S. From molecular to genomic epidemiology: transforming surveillance and control of infectious diseases. Euro Surveill. 2013; 18(4): 20386. doi: 10.2807/ese.18.04.20386-en 23369387

24. Gacek RR. The pathology of facial and vestibular neuronitis. Am J Otolaryngol. 1999; 20: 202–210. doi: 10.1016/s0196-0709(99)90001-7 10442771

25. Gacek RR. Evidence for viral neuropathy in recurrent vertigo. ORL. 2008; 70: 6–15. doi: 10.1159/000111042 18235200

26. Gacek RR, Gacek MR. Menière’s disease as a manifestation of vestibular ganglionitis. Am J Otolaryngol. 2001; 22(4): 241–250. doi: 10.1053/ajot.2001.24822 11464320

27. Palva T, Hortling L, Ylikoski J, Collan Y. Viral culture and electron microscopy of ganglion cells in Meniere’s disease and Bell’s palsy. Acta Otolaryngol. 1978; 86(3–4): 269–275. doi: 10.3109/00016487809124746 212928

28. Wackym PA, Storper IS, Fu YS, House WF, Ward PH. Differential diagnosis of virus-like particles in the human inner ear. Am J Otol. 1992; 13(5): 431–437. 1443078

29. Dimitriadis PA, Zis P. Nocebo Effect in Menière’s Disease: A Meta-analysis of Placebo-controlled Randomized Controlled Trials. Otol Neurotol. 2017; 38: 1370–1375. doi: 10.1097/MAO.0000000000001555 28832394

30. Guyot JP, Maire R, Delaspre O. Intratympanic application of an antiviral agent for the treatment of Ménière’s disease. ORL. 2008; 70(1): 21–26. doi: 10.1159/000111044 18235202

31. Derebery MJ, Fisher LM, Iqbal Z. Randomized double-blinded, placebo-controlled trial of famciclovir for reduction of Ménière’s disease symptoms. Otolaryngol Head Neck Surg. 2004; 131(6): 877–884. doi: 10.1016/j.otohns.2004.08.012 15577784

32. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015; 4(1). doi: 10.1186/2046-4053-4-1 25554246

33. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000; 283(15): 2008–2012. doi: 10.1001/jama.283.15.2008 10789670

34. Committee on Hearing and Equilibrium. Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Menière’s disease. American Academy of Otolaryngology-Head and Neck Foundation, Inc. Otolaryngol Head Neck Surg. 1995; 113(3): 181–185. doi: 10.1016/S0194-5998(95)70102-8 7675476

35. Goebel JA. 2015 Equilibrium Committee Amendment to the 1995 AAO-HNS Guidelines for the Definition of Ménière’s Disease. Otolaryngol Head Neck Surg. 2016; 154(3): 403–404.

36. Lopez-Escamez JA, Carey J, Chung WH, Goebel JA, Magnusson M, Mandalà M et al. Diagnostic criteria for Menière’s disease. J Vestib Res; 25(1): 1–7. doi: 10.3233/VES-150549 25882471

37. Brister JR, Ako-Adjei D, Bao Y, Blinkova O. NCBI viral genomes resource. Nucleic Acids Res. 2015; 43(Database issue): D571–577. doi: 10.1093/nar/gku1207 25428358

38. Dekkers OM, Vandenbroucke JP, Cevallos M, Renehan AG, Altman DG, Egger M. COSMOS-E: Guidance on conducting systematic reviews and meta-analyses of observational studies of etiology. PLOS Medicine. 2019. doi: 10.1371/journal.pmed.1002742 30789892

39. Bero L, Chartres N, Diong J, Fabbri A, Ghersi D, Lam J et al. The risk of bias in observational studies of exposures (ROBINS-E) tool: concerns arising from application to observational studies of exposures. Syst Rev. 2018; 7. doi: 10.1186/s13643-018-0915-2 30577874

40. Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.

41. NHMRC. NHMRC additional levels of evidence and grades for recommendations for developers of guidelines. Australian Government, 2009. Available from: https://www.mja.com.au/sites/default/files/NHMRC.levels.of.evidence.2008-09.pdf.

42. Viechtbauer W. Conducting Meta-Analyses in R with the metafor Package. J Stat Soft. 2010; 36(3). doi: 10.18637/jss.v036.i03

43. Schild AH, Voracek M. Finding your way out of the forest without a trail of breadcrumbs: development and evaluation of two novel displays of forest plots. Res Synth Methods. 2015; 6(1): 74–86. doi: 10.1002/jrsm.1125 26035471

44. Higgins JPT, Green S. Studies with zero-cell counts. In: The Cochrane Handbook for Systematic Reviews of Interventions [updated March 2011]. Available from: https://handbook-5-1.cochrane.org/chapter_16/16_9_2_studies_with_zero_cell_counts.htm

45. Ruxton GD, Neuhauser M. Review of alternative approaches for the odds ratio calculation of a 2x2 contingency table. Methods Ecol Evol. 2013; 4: 9–13.

46. Sterne JA, Egger M. Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol. 2001; 54(10): 1046–1055. doi: 10.1016/s0895-4356(01)00377-8 11576817

47. Duval S, Tweedie R. Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000; 56(2): 455–463. doi: 10.1111/j.0006-341x.2000.00455.x 10877304

48. Arenberg IK, Cabriac G, Marks S, Arenberg JG, Pfeiffer PR, Murray RS. Cytomegalovirus antibodies in endolymphatic sac biopsies of patients with endolymphatic hydrops and Ménière's disease. Ann N Y Acad Sci. 1997; 830: 314–318. doi: 10.1111/j.1749-6632.1997.tb51902.x 9616690

49. Arnold W, Niedermeyer HP. Herpes simplex virus in the perilymph of patients with Menière disease. Arch Otolaryngol Head Neck Surg. 1997; 123(1): 53–56. doi: 10.1001/archotol.1997.01900010061008 9006503

50. Bergstrom T, Edström S, Tjellström A, Vahlne A. Ménière's disease and antibody reactivity to herpes simplex virus type 1 polypeptides. Am J Otolaryngol. 1992; 13(5): 295–300. doi: 10.1016/0196-0709(92)90051-t 1337422

51. Calenoff E, Zhao JC, Derlacki EL, Harrison WH, Selmeczi K, Dutra K et al. Patients with Meniére's disease possess IgE reacting with herpes family viruses. Arch Otolaryngol Head Neck Surg. 1995; 121(8): 861–864. doi: 10.1001/archotol.1995.01890080029005 7619410

52. Gartner M, Bossart W, Linder T. Herpes virus and Ménière's disease. ORL. 2008; 70(1): 28–31. doi: 10.1159/000111045 18235203

53. Pyykkö I, Zou J. Do viruses cause inner ear disturbances? ORL. 2008; 70(1): 32–40. doi: 10.1159/000111046 18235204

54. Selmani Z, Ishizaki H, Seppälä I, Pyykkö I. IS MÉNIERE’S DISEASE A CONSEQUENCE OF A PATHOLOGICAL IMMUNE RESPONSE TRIGGERED BY VIRAL INFECTION? AJO. 2004; 7(2): 77–82.

55. Selmani Z, Marttila T, Pyykkö I. Incidence of virus infection as a cause of Meniere’s disease or endolymphatic hydrops assessed by electrocochleography. Eur Arch Otorhinolaryngol. 2005; 262: 331–334. doi: 10.1007/s00405-004-0816-y 15235799

56. Takahashi K, Aono T, Shichinohe M, Tamura M, Iwata Y, Yamanishi K et al. Herpesvirus DNA in Peripheral Blood Mononuclear Cells of Some Patients with Meniere’s Disease. Microbiol Immunol. 2001; 45(9): 635–638. doi: 10.1111/j.1348-0421.2001.tb01296.x 11694075

57. Vrabec JT. Herpes Simplex Virus and Meniere’s Disease. Laryngoscope. 2003; 113: 1431–1438. doi: 10.1097/00005537-200309000-00002 12972911

58. Welling DB, Daniels RL, Brainard J, Western LM, Prior TW. Detection of viral DNA in endolymphatic sac tissue from Menière’s disease patients. Am J Otol. 1994; 15(5): 639–643. 8572065

59. Welling DB, Miles BA, Western L, Prior TW. Detection of viral DNA in vestibular ganglia tissue from patients with Menière’s disease. Am J Otol. 1997; 18(6): 734–737. 9391669

60. Williams MD, Lowery HW, Shannon BT. Evidence of Persistent Viral Infection in Meniere’s Disease. Arch Otolaryngol Head Neck Surg. 1987; 113: 397–400. doi: 10.1001/archotol.1987.01860040059017 3814390

61. Yazawa Y, Suzuki M, Hanamitsu M, Kimura H, Tooyama I. Detection of Viral DNA in the Endolymphatic Sac in Ménière’s Disease by in situ hybridization. ORL. 2003; 65: 162–168. doi: 10.1159/000072254 12925817

62. Lau J, Ioannidis JPA, Terrin N, Schmid CH, Olkin I. The case of the misleading funnel plot. BMJ. 2006; 333(7568): 597–600. doi: 10.1136/bmj.333.7568.597 16974018

63. Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015; 349: g7647.

64. Goderis J, De LeenHeer E, Smets K, Van Hoecke H, Keymeulen A, Dhooge I. Hearing loss and congenital CMV infection: a systematic review. Pediatrics. 2014; 134(5): 972–982. doi: 10.1542/peds.2014-1173 25349318

65. Zagólski O. Vestibular-evoked myogenic potentials and caloric stimulation in infants with congenital cytomegalovirus infection. J Laryngol Otol. 2008; 122(6): 575–579.

66. Strauss M. Human cytomegalovirus labyrinthitis. Am J Otolaryngol. 1990; 11(5): 292–298. doi: 10.1016/0196-0709(90)90057-3 2176062

67. Kamei T. Delayed Endolymphatic Hydrops as a Clinical Entity. Int Tinnitus J. 2004; 10(2): 137–143. 15732511

68. Lobo D, Tuñon M, Villarreal I, Brea B, García-Berrocal JR. Intratympanic gadolinium magnetic resonance imaging supports the role of endolymphatic hydrops in the pathogenesis of immune-mediated inner-ear disease. J Laryngol Otol. 2018; 132(6): 554–559. doi: 10.1017/S0022215118000749 29888688

69. Himmelein S, Lindemann A, Sinicina I, Horn AKE, Brandt T, Strupp M et al. Differential Involvement during Latent Herpes Simplex Virus 1 Infection of the Superior and Inferior Divisions of the Vestibular Ganglia: Implications for Vestibular Neuritis. J Virol. 2017; 91(14): e003310–e003317.

70. Fukuda S, Keithley EM, Harris JP. The development of endolymphatic hydrops following CMV inoculation of the endolymphatic sac. Laryngoscope. 1988; 94(4): 439–443.

71. Fukuda S, Keithley EM, Harris JP. Experimental cytomegalovirus infection: Viremic spread to the inner ear. Am J Otolaryngol. 1988; 9(3): 135–141. doi: 10.1016/s0196-0709(88)80019-x 2845828

72. Keithley EM, Woolf NK, Harris JP. Development of morphological and physiological changes in the cochlea induced by cytomegalovirus. Laryngoscope. 1989; 99(4): 409–414. doi: 10.1288/00005537-198904000-00010 2538687

73. Wick CC, Semaan MT, Zheng QY, Megerian CA. A Genetic Murine Model of Endolymphatic Hydrops: The Phex Mouse. Curr Otorhinolaryngol Rep. 2014; 2(3): 144–151. doi: 10.1007/s40136-014-0048-7 25309828


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