Vasopressin SNP pain factors and stress in sickle cell disease

Autoři: Keesha L. Powell-Roach aff001;  Yingwei Yao aff003;  Ellie H. Jhun aff005;  Ying He aff006;  Marie L. Suarez aff004;  Miriam O. Ezenwa aff003;  Robert E. Molokie aff006;  Zaijie Jim Wang aff006;  Diana J. Wilkie aff002
Působiště autorů: Department of Community Dentistry and Behavioral Science, College of Dentistry, University of Florida, Gainesville, Florida, United States of America aff001;  Center for Palliative Care Research and Education, University of Florida College of Nursing, Gainesville, Florida, United States of America aff002;  Department of Biobehavioral Nursing Science, University of Florida College of Nursing, Gainesville, Florida, United States of America aff003;  Department of Biobehavioral Health Sciences, University of Illinois at Chicago College of Nursing, Chicago, Illinois, United States of America aff004;  Committee on Clinical Pharmacology and Pharmacogenetics, University of Chicago, Chicago, Illinois, United States of America aff005;  Department of Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois, United States of America aff006;  Cancer Center, University of Illinois at Chicago, Chicago, Illinois, United States of America aff007;  Division of Hematology/Oncology, University of Illinois at Chicago College of Medicine, Chicago, Illinois, United States of America aff008;  Jessie Brown Veteran’s Administration Medical Center, Chicago, Illinois, United States of America aff009
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0224886



Frequencies of single nucleotide polymorphisms (SNPs) from pain related candidate genes are available for individuals with sickle cell disease (SCD). One of those genes, the arginine vasopressin receptor 1A gene (AVPR1A) and one of its SNPs, rs10877969, has been associated with pain and disability in other pain populations. In patients with SCD, clinical factors such as pain and stress have been associated with increased health care utilization, but it is not known if the presence of the AVPR1A SNP plays a role in this observation. The study purpose was to explore the relationships between rs10877969 and self-reported pain, stress, and acute care utilization events among individuals with SCD.


In a cross-sectional investigation of outpatients with SCD, participants completed PAINReportIt®, a computerized pain measure, to describe their pain experience and contributed blood or saliva samples for genetic analysis. We extracted emergency department and acute care utilization from medical records.


The SNP genotype frequencies (%) for this sample were CC 30 (28%), CT 44 (41%), TT 33 (31%). Acute care utilization and stress as an aggravator of pain were significantly associated with the rs10877969 genotype (p = .02 and p = .002, respectively). The CT genotype had the highest mean utilization and CC genotype was associated with not citing stress as a pain aggravator. Chronic pain was not associated with rs10877969 (p = .41).


This study shows that rs10877969 is related to indicators of stress and acute pain. Further research is recommended with other measures of stress and acute pain.

Klíčová slova:

African American people – Arginine – Critical care and emergency medicine – Molecular genetics – Outpatients – Psychological stress – Sickle cell disease – Vasopressin


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