Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC)

Autoři: Pei Yuan Fong aff001;  Sze Huey Tan aff002;  Darren Wan Teck Lim aff001;  Eng Huat Tan aff001;  Quan Sing Ng aff001;  Kiattisa Sommat aff003;  Daniel Shao Weng Tan aff001;  Mei Kim Ang aff001
Působiště autorů: Division of Medical Oncology, National Cancer Centre, Singapore aff001;  Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore aff002;  Division of Radiation Oncology, National Cancer Centre, Singapore aff003
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0224665



Treatment strategies in laryngeal squamous cell cancer (LSCC) straddle the need for long term survival and tumor control as well as preservation of laryngeal function as far as possible. We sought to identify prognostic factors affecting LSCC outcomes in our population.


Clinical characteristics, treatments and survival outcomes of patients with LSCC were analysed. Baseline comorbidity data was collected and age-adjusted Charlson Comorbidity Index (aCCI) was calculated. Outcomes of overall survival (OS), progression-free survival (PFS) and laryngectomy-free survival (LFS) were evaluated.


Two hundred and fifteen patients were included, 170 (79%) underwent primary radiation/ chemoradiation and the remainder upfront surgery with adjuvant therapy where indicated. The majority of patients were male, Chinese and current/ex-smokers. Presence of comorbidity was common with median aCCI of 3. Median OS was 5.8 years. On multivariable analyses, high aCCI and advanced nodal status were associated with inferior OS (HR 1.24 per one point increase in aCCI, P<0.001 and HR 3.52; p<0.001 respectively), inferior PFS (HR 1.14; p = 0.007 and HR 3.23; p<0.001 respectively) and poorer LFS (HR 1.19; p = 0.001 and HR 2.95; p<0.001 respectively). Higher tumor (T) stage was associated with inferior OS and LFS (HR 1.61; p = 0.02 and HR 1.91; p = 0.01 respectively).


In our Asian population, the presence of comorbidities and high nodal status were associated with inferior OS, PFS and LFS whilst high T stage was associated with inferior LFS and OS.

Klíčová slova:

Cancer detection and diagnosis – Cancer chemotherapy – Cancer treatment – Oncology – Radiation therapy – Surgical and invasive medical procedures – Surgical oncology – Laryngectomy


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