Friends with malefit. The effects of keeping dogs and cats, sustaining animal-related injuries and Toxoplasma infection on health and quality of life


Autoři: Jaroslav Flegr aff001;  Marek Preiss aff002
Působiště autorů: Division of Biology, Faculty of Science, Charles University in Prague, Prague, Czech Republic aff001;  National Institute of Mental Health, Klecany, Czech Republic aff002
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0221988

Souhrn

Many studies show that keeping cats and dogs has a positive impact on humans’ physical and mental health and quality of life. The existence of this “pet phenomenon” is now widely discussed because other studies performed recently have demonstrated a negative impact of owning pets or no impact at all. The main problem of many studies was the autoselection–participants were informed about the aims of the study during recruitment and later likely described their health and wellbeing according to their personal beliefs and wishes, not according to their real status. To avoid this source of bias, we did not mention pets during participant recruitment and hid the pet-related questions among many hundreds of questions in an 80-minute Internet questionnaire. Results of our explorative study performed on a sample of 10,858 subjects showed that liking dogs has a weak positive association with quality of life. However, keeping pets, especially cats, and even more being injured by pets, were strongly negatively associated with many facets of quality of life. Our data also confirmed that infection by the cat parasite Toxoplasma had a very strong negative effect on quality of life, especially on mental health. However, the infection was not responsible for the observed negative effects of keeping pets, as these effects were much stronger in 1,527 Toxoplasma-free subjects than in the whole population. Any cross-sectional study cannot discriminate between a cause and an effect. However, because of the large and still growing popularity of keeping pets, the existence and nature of the reverse pet phenomenon deserve the outmost attention.

Klíčová slova:

Cats – Dogs – Health economics – Mental health and psychiatry – Pets and companion animals – Quality of life – Toxoplasma – Toxoplasmosis


Zdroje

1. Sterneberg-van der Maaten T, Turner D, Van Tilburg J, Vaarten J. Benefits and risks for people and livestock of keeping companion animals: Searching for a healthy balance. J Comp Pathol. 2016;155(1 Suppl 1):S8–S17. Epub 2015/08/22. doi: 10.1016/j.jcpa.2015.06.007 26292769.

2. Nimer J, Lundahl B. Animal-assisted therapy: A meta-analysis. Anthrozoos. 2007;20(3):225–38. doi: 10.2752/089279307X224773

3. Allen K, Shykoff B. E., Izzo J. L. Jr. Pet ownership but not ACE inhibitor therapy blunts home blood pressure responses to mental stress. Hypertension. 2001;38:815–20. 11641292

4. Black K. The relationship between companion animals and loneliness among rural adolescents. J Pediatr Nurs. 2012;27(2):103–12. doi: 10.1016/j.pedn.2010.11.009 22341188

5. Westgarth C, Pinchbeck GL, Bradshaw JW, Dawson S, Gaskell RM, Christley RM. Factors associated with dog ownership and contact with dogs in a UK community. BMC Vet Res. 2007;3:5. Epub 2007/04/05. doi: 10.1186/1746-6148-3-5 17407583.

6. Wood L, Giles-Corti B, Bulsara M. The pet connection: Pets as a conduit for social capital? Soc Sci Med. 2005;61(6):1159–73. doi: 10.1016/j.socscimed.2005.01.017 15970228

7. Souter MA, Miller M. D. Do animal-assisted activities effectively treat depression: A meta-analysis. Anthrozoos 2007;20:167–80.

8. Barker SB, Wolen AR. The benefits of human-companion animal interaction: A review. J Vet Med Educ. 2008;35(4):487–95. doi: 10.3138/jvme.35.4.487 19228898

9. Bennett PC, Trigg JL, Godber T, Brown C. An experience sampling approach to investigating associations between pet presence and indicators of psychological wellbeing and mood in older Australians. Anthrozoos. 2015;28(3):403–20. doi: 10.1080/08927936.2015.1052266

10. McConnell AR, Brown CM, Shoda TM, Stayton LE, Martin CE. Friends with benefits: On the positive consequences of pet ownership. JPSP. 2011;101(6):1239–52. doi: 10.1037/a0024506 21728449

11. Friedmann E, Thomas SA. Pet ownership, social support, and one-year survival after acute myocardial-infarction in the cardiac-arrhythmia suppression trial (cast). Am J Cardiol. 1995;76(17):1213–7. doi: 10.1016/s0002-9149(99)80343-9 7502998

12. Chowdhury EK, Nelson MR, Jennings GL, Wing LM, Reid CM. Pet ownership and survival in the elderly hypertensive population. J Hypertens. 2017;35(4):769–75. Epub 2016/12/24. doi: 10.1097/HJH.0000000000001214 28009706.

13. Mubanga M, Byberg L, Nowak C, Egenvall A, Magnusson PK, Ingelsson E, et al. Dog ownership and the risk of cardiovascular disease and death—a nationwide cohort study. Sci Rep. 2017;7(1):15821. Epub 2017/11/19. doi: 10.1038/s41598-017-16118-6 29150678.

14. Parslow RA, Jorm AF. Pet ownership and risk factors for cardiovascular disease: another look. Med J Aust. 2003;179(9):466–8. Epub 2003/10/30. 14583076.

15. Qureshi AI, Memon MZ, Vazquez G, Suri MF. Cat ownership and the risk of fatal cardiovascular diseases. Results from the Second National Health and Nutrition Examination Study Mortality Follow-up Study. J Vasc Interv Neurol. 2009;2(1):132–5. Epub 2009/01/01. 22518240.

16. Walster D. How pets can be good for your health J Dementia Care. 1997;5(2):20–1.

17. Brown CM, Hengy SM, McConnell AR. Thinking about cats or dogs provides relief from social rejection. Anthrozoos. 2016;29(1):47–58. doi: 10.1080/20414005.2015.1067958

18. Herzog H. The impact of pets on human health and psychological well-being: Fact, fiction, or hypothesis? Curr Dir Psychol Sci. 2011;20(4):236–9. doi: 10.1177/0963721411415220

19. Antonacopoulos NMD. A longitudinal study of the relation between acquiring a dog and loneliness. Soc Anim. 2017;25(4):319–40. doi: 10.1163/15685306-12341449

20. Enmarker I, Hellzen O, Ekker K, Berg AG. Depression in older cat and dog owners: the Nord-Trondelag Health Study (HUNT)-3. Aging Ment Health. 2015;19(4):347–52. Epub 2014/07/06. doi: 10.1080/13607863.2014.933310 24990174.

21. Toohey AM, Hewson JA, Adams CL, Rock MJ. Pets, social participation, and aging-in-place: Findings from the Canadian longitudinal study on aging. Can J Aging. 2018;37(2):200–17. doi: 10.1017/S0714980818000107 29631643

22. Wells Y, Rodi H. Effects of pet ownership on the health and well-being of older people. Australas J Ageing. 2000;19(3):143–8.

23. Koivusilta LK, Ojanlatva A. To have or not to have a pet for better health? PLoS ONE. 2006;1(2):ARTN e109. doi: 10.1371/journal.pone.0000109 17205113

24. Gillum RF, Obisesan TO. Living with companion animals, physical activity and mortality in a US national cohort. Int J Env Res Public Health. 2010;7(6):2452–9. doi: 10.3390/ijerph7062452 20644682

25. Pikhartova J, Bowling A, Victor C. Does owning a pet protect older people against loneliness? BMC Geriatr. 2014;14:ARTN 106. doi: 10.1186/1471-2318-14-106 25240250

26. Rijken M, Van Beek S. About cats and dogs a Euro broken vertical bar reconsidering the relationship between pet ownership and health related outcomes in community-dwelling elderly. Soc Indic Res. 2011;102(3):373–88. doi: 10.1007/s11205-010-9690-8

27. Hinkert C. The influence of dogs and cats on the mental health and emotional wellbeing of their owners in the Netherlands.: Utrecht University; 2013.

28. Miltiades H, Shearer J. Attachment to pet dogs and depression in rural older adults. Anthrozoos. 2011;24(2):147–54. doi: 10.2752/175303711X12998632257585

29. Parslow RA, Jorm AF, Christensen H, Rodgers B, Jacomb P. Pet ownership and health in older adults: Findings from a survey of 2,551 community-based Australians aged 60–64. Gerontology. 2005;51(1):40–7. doi: 10.1159/000081433 15591755

30. Parker GB, Gayed A, Owen CA, Hyett MP, Hilton TM, Heruc GA. Survival following an acute coronary syndrome: a pet theory put to the test. Acta Psychiatr Scand. 2010;121(1):65–70. doi: 10.1111/j.1600-0447.2009.01410.x 19522884

31. Wells DL. Associations between pet ownership and self-reported health status in people suffering from chronic fatigue syndrome. J Altern Complement Med. 2009;15(4):407–13. doi: 10.1089/acm.2008.0496 19388863

32. Bao KJ, Schreer G. Pets and happiness: Examining the association between pet ownership and wellbeing. Anthrozoos. 2016;29(2):283–96. doi: 10.1080/08927936.2016.1152721

33. Straede CM, Gates GR. Psychological health in a population of Australian cat owners. Anthrozoos. 1993;6(1):30–42. doi: 10.2752/089279393787002385

34. McNicholas J, Gilbey A, Rennie A, Ahmedzai S, Dono JA, Ormerod E. Pet ownership and human health: a brief review of evidence and issues. Br Med J. 2005;331(7527):1252–4. doi: 10.1136/bmj.331.7527.1252 16308387

35. Mullersdorf M, Granstrom F, Sahlqvist L, Tillgren P. Aspects of health, physical/leisure activities, work and socio-demographics associated with pet ownership in Sweden. Scand J Public Health. 2010;38(1):53–63. doi: 10.1177/1403494809344358 19717574

36. Lindsay DS, Dubey JP, Butler JM, Blagburn BL. Mechanical transmission of Toxoplasma gondii oocysts by dogs. Vet Parasitol. 1997;73(1–2):27–33. Epub 1998/02/27. doi: 10.1016/s0304-4017(97)00048-4 9477489.

37. Sutterland AL, Fond G, Kuin A, Koeter MW, Lutter R, van Gool T, et al. Beyond the association. Toxoplasma gondii in schizophrenia, bipolar disorder, and addiction: systematic review and meta-analysis. Acta Psychiatr Scand. 2015;132(3):161–79. Epub 2015/04/17. doi: 10.1111/acps.12423 25877655.

38. Torrey EF, Bartko JJ, Yolken RH. Toxoplasma gondii and other risk factors for schizophrenia: An update. Schizophr Bull. 2012;38(3):642–7. doi: 10.1093/schbul/sbs043 22446566

39. Flegr J. Neurological and neuropsychiatric consequences of chronic Toxoplasma infection Clin Microbiol Rep. 2015;2(4):doi: 10.1007/s40588-015-0024-0

40. Kankova S, Flegr J, Calda P. The influence of latent toxoplasmosis on women’s reproductive function: four cross-sectional studies. Folia Parasitol. 2015;62. Epub 2015/08/19. doi: 10.14411/fp.2015.041 26278510.

41. Flegr J. Predictors of Toxoplasma gondii infection in Czech and Slovak populations: the possible role of cat-related injuries and risky sexual behavior in the parasite transmission. Epidemiol Infect. 2017;145(7):1351–62. doi: 10.1017/S095026881700019X 28183362

42. Orley J, Harper A, Power M, Billington R. Development of the WHOQOL-BREF quality of life assessment. Qual Life Res. 1997;6(7–8):273-.

43. Dragomirecka E. Czech version of the World Health Organization Quality of Life (WHOQOL)—translation and designing the response scales. Psychiatrie. 2006;10(2):68–73.

44. R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing. Vienna. Austria2018. https://www.R-project.org/.

45. Kim S. ppcor: An R package for a fast calculation to semi-partial correlation coefficients. Commun Stat Appl Methods. 2015;22(6):665–74. doi: 10.5351/CSAM.2015.22.6.665 26688802

46. Benjamini Y, Hochberg Y. Controlling the false discovery rate: A practical and powerful approach to multiple testing. J Roy Stat Soc B Met. 1995;57(1):289–300.

47. Šebánková B, Flegr J. Physical and mental health status in Toxoplasma-infected women before and three years after they learn about their infection: Manipulation or side-effects of impaired health? Front Ecol Evol. 2017;5:144. doi: 10.3389/fevo.2017.00144

48. Kolbeková P, Kourbatova E, Novotná M, Kodym P, Flegr J. New and old risk-factors for Toxoplasma gondii infection: prospective cross-sectional study among military personnel in the Czech Republic. Clin Microbiol Infec. 2007;13:1012–7.

49. Lindová J, Novotná M, Havlíček J, Jozífková E, Skallová A, Kolbeková P, et al. Gender differences in behavioural changes induced by latent toxoplasmosis. Int J Parasitol. 2006;36:1485–92. doi: 10.1016/j.ijpara.2006.07.008 16978630

50. Lindová J, Kuběna AA, Šturcová A, Křivohlavá R, Novotná M, Rubešová A, et al. Pattern of money allocation in experimental games supports the stress hypothesis of gender differences in Toxoplasma gondii-induced behavioural changes. Folia Parasitol. 2010;57:136–42. 20608476

51. Flegr J, Zitkova S, Kodym P, Frynta D. Induction of changes in human behaviour by the parasitic protozoan Toxoplasma gondii. Parasitology. 1996;113:49–54. doi: 10.1017/s0031182000066269 8710414

52. Flegr J, Prandota J, Sovickova M, Israili ZH. Toxoplasmosis—A global threat. Correlation of latent toxoplasmosis with specific disease burden in a set of 88 countries. PLoS ONE. 2014;9(3). doi: 10.1371/journal.pone.0090203 24662942

53. Flegr J, Escudero DQ. Impaired health status and increased incidence of diseases in Toxoplasma-seropositive subjects—an explorative cross-sectional study. Parasitology. 2016;143(14):1974–89. doi: 10.1017/S0031182016001785 27719690

54. Flegr J, Horáček J. Toxoplasmosis, but not borreliosis, is associated with psychiatric disorders and symptoms. Schizophr Res. 2018;197:603–4. doi: 10.1016/j.schres.2018.02.008 29459052

55. Flegr J, Preiss M., Balatova P. Depressiveness and neuroticism in Bartonella seropositive and seronegative subjects-Preregistered case-controls study. Front Psychiatry. 2018;9. doi: 10.3389/fpsyt.2018.00314 30061846

56. Flegr J, Hodny Z. Cat scratches, not bites, are associated with unipolar depression—cross-sectional study. Parasit Vectors. 2016;9. doi: 10.1186/s13071-015-1290-7 26728406

57. Niebuhr DW, Cowan DN, Millikan AM, Yolken R, Li Y, Weber N. Risk of schizophrenia and antibodies to Toxoplasma gondii among U.S. military personnel. Schizophr Bull. 2007;33:243–4.

58. Flegr J. Schizophrenia and Toxoplasma gondii: an undervalued association? Expert Rev Anti-Infect Ther. 2015;13(7):817–20. doi: 10.1586/14787210.2015.1051033 26027807

59. Hill AB. The environment and disease: association or causation? (Reprinted from JRSM, vol 58, 1965). J R Soc Med. 2015;108(1):32–7. doi: 10.1177/0141076814562718 25572993

60. Flegr J, Vedralova M. Specificity and nature of the associations of twenty-four neuropsychiatric disorders with contacts with cats and dogs. Schizophr Res. 2017;189:219–20. Epub 2017/02/17. doi: 10.1016/j.schres.2017.02.007 28202292.

61. Torrey EF, Yolken RH. Schizophrenia and infections: The eyes have it. Schizophr Bull. 2017;43(2):247–52. doi: 10.1093/schbul/sbw113 27507268

62. Chang CC, Lee CJ, Ou LS, Wang CJ, Huang YC. Disseminated cat-scratch disease: case report and review of the literature. Paediatrics and International Child Health. 2016;36(3):232–4. doi: 10.1179/2046905515Y.0000000005 25940800

63. Mazur-Melewska K, Mania A, Kemnitz P, Figlerowicz M, Sluzewski W. Cat-scratch disease: a wide spectrum of clinical pictures. Postep Derm Alergol. 2015;32(3):216–20. doi: 10.5114/pdia.2014.44014 26161064

64. Rondet B, Sarret C, Lacombe P, Rouveyrol F, Chenel C, Romaszko JP, et al. Neurological symptoms with Bartonella henselae infection: Report on 2 pediatric cases. Arch Pediatr. 2012;19(8):823–6. doi: 10.1016/j.arcped.2012.05.011 22749487

65. Breitschwerdt EB, Maggi RG, Nicholson WL, Cherry NA, Woods CW. Bartonella sp bacteremia in patients with neurological and neurocognitive dysfunction. J Clin Microbiol. 2008;46(9):2856–61. doi: 10.1128/JCM.00832-08 18632903

66. Hanauer DA, Ramakrishnan N, Seyfried LS. Describing the relationship between cat bites and human depression using data from an electronic health record. PLoS ONE. 2013;8(8):e70585. Epub 2013/08/13. doi: 10.1371/journal.pone.0070585 23936453.

67. Kolpakova J, Bedwell JS. Childhood cat bites and disorganized symptoms of schizotypy in adulthood. Schizophr Res. 2013;146(1–3):370–1. Epub 2013/03/23. doi: 10.1016/j.schres.2013.02.039 23517663.

68. Wells DL. The effects of animals on human health and well-being. J Soc Iss. 2009;65(3):523–43. doi: 10.1111/j.1540-4560.2009.01612.x


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2019 Číslo 11