Diagnostic ability of multifocal electroretinogram in early multiple sclerosis using a new signal analysis method

Autoři: L. Boquete aff001;  E. López-Guillén aff001;  E. Vilades aff002;  J. M. Miguel-Jiménez aff001;  L. E. Pablo aff003;  L. De Santiago aff001;  M. Ortiz del Castillo aff001;  M. C. Alonso-Rodríguez aff005;  E. M. Sánchez Morla aff006;  A. López-Dorado aff001;  E. Garcia-Martin aff002
Působiště autorů: Biomedical Engineering Group, Electronics Department, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain aff001;  RETICS: Thematic Networks for Co-operative Research in Health for Ocular Diseases, Madrid, Spain aff002;  Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain aff003;  Aragon Institute for Health Research (IIS Aragon), Innovative and Research Group Miguel Servet Ophthalmology (GIMSO), University of Zaragoza, Zaragoza, Spain aff004;  Physics and Mathematics Department, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain aff005;  Institute for Health Research 12 de Octubre Hospital (i+12), Madrid, Spain aff006
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0224500



To determine if a novel analysis method will increase the diagnostic value of the multifocal electroretinogram (mfERG) in diagnosing early-stage multiple sclerosis (MS).


We studied the mfERG signals of OD (Oculus Dexter) eyes of fifteen patients diagnosed with early-stage MS (in all cases < 12 months) and without a history of optic neuritis (ON) (F:M = 11:4), and those of six controls (F:M = 3:3). We obtained values of amplitude and latency of N1 and P1 waves, and a method to assess normalized root-mean-square error (FNRMSE) between model signals and mfERG recordings was used. Responses of each eye were analysed at a global level, and by rings, quadrants and hemispheres. AUC (area under the ROC curve) is used as discriminant factor.


The standard method of analysis obtains further discrimination between controls and MS in ring R3 (AUC = 0.82), analysing N1 waves amplitudes. In all of the retina analysis regions, FNRMSE value shows a greater discriminating power than the standard method. The highest AUC value (AUC = 0.91) was in the superior temporal quadrant.


By analysing mfERG recordings and contrasting them with those of healthy controls it is possible to detect early-stage MS in patients without a previous history of ON.

Klíčová slova:

Diagnostic medicine – Eyes – Magnetic resonance imaging – Multiple sclerosis – Ophthalmology – Retina – Vision – Visual acuity


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2019 Číslo 11