Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia

Autoři: Heng Choon Cheong aff001;  Polly Soo Xi Yap aff001;  Chun Wie Chong aff002;  Yi Ying Cheok aff001;  Chalystha Yie Qin Lee aff001;  Grace Min Yi Tan aff001;  Sofiah Sulaiman aff003;  Jamiyah Hassan aff003;  Negar Shafiei Sabet aff004;  Chung Yeng Looi aff005;  Rishein Gupta aff006;  Bernard Arulanandam aff006;  Sazaly AbuBakar aff001;  Cindy Shuan Ju Teh aff001;  Li Yen Chang aff001;  Won Fen Wong aff001
Působiště autorů: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia aff001;  School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Selangor, Malaysia aff002;  Department of Obstetrics and Gynecology, Faculty of medicine, University of Malaya, Kuala Lumpur, Malaysia aff003;  Faculty of Medicine, SEGi University, Kota Damansara, Selangor, Malaysia aff004;  School of Bioscience, Taylor’s University, Subang Jaya, Selangor, Malaysia aff005;  Center of Excellence in Infection Genomics, South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, Texas, United States of America aff006;  Tropical Infectious Disease Research and Education Center, University of Malaya, Kuala Lumpur, Malaysia aff007
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0224658


The cervical microbiota constitutes an important protective barrier against the invasion of pathogenic microorganisms. A disruption of microbiota within the cervical milieu has been suggested to be a driving factor of sexually transmitted infections. These include Chlamydia trachomatis which frequently causes serious reproductive sequelae such as infertility in women. In this study, we profiled the cervical microbial composition of a population of 70 reproductive-age Malaysian women; among which 40 (57.1%) were diagnosed with genital C. trachomatis infection, and 30 (42.8%) without C. trachomatis infection. Our findings showed a distinct compositional difference between the cervical microbiota of C. trachomatis-infected subjects and subjects without C. trachomatis infection. Specifically, significant elevations of mostly strict and facultative anaerobes such as Streptococcus, Megasphaera, Prevotella, and Veillonella in the cervical microbiota of C. trachomatis-positive women were detected. The results from the current study highlights an interaction of C. trachomatis with the environmental microbiome in the endocervical region.

Klíčová slova:

Chlamydia infection – Lactobacillus – Microbiome – Pseudomonas infections – Ribosomal RNA – Streptococcal infections – Prevotella infection


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2019 Číslo 11