Antibodies against measles and rubella virus among different age groups in Thailand: A population-based serological survey


Autoři: Nasamon Wanlapakorn aff001;  Rujipat Wasitthankasem aff001;  Preeyaporn Vichaiwattana aff001;  Chompoonut Auphimai aff001;  Pornsak Yoocharoen aff004;  Sompong Vongpunsawad aff001;  Yong Poovorawan aff001
Působiště autorů: Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand aff001;  Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand aff002;  National Biobank of Thailand, National Science and Technology Development Agency, Pathum Thani, Thailand aff003;  Department of Disease Control, Division of Vaccine Preventable Diseases, Ministry of Public Health, Nonthaburi, Thailand aff004
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225606

Souhrn

Measles and rubella are highly contagious viral diseases transmitted via respiratory secretions and aerosolized droplets. Thailand has implemented universal vaccination against measles using the monovalent measles (M) or the trivalent measles-mumps-rubella (MMR) vaccine for the past 30 years. Nevertheless, incidence of measles and rubella remains in some parts of the country. We conducted a seroprevalence study to evaluate the antibodies to measles and rubella virus among Thais of all ages and to determine pre-existing immunity resulting from either vaccination and/or natural exposure. A total of 1,781 serum samples collected in 2014 was tested for IgG to measles and rubella virus by commercial enzyme-linked immunosorbent assays (ELISA). Percentages of individuals with protective antibody levels and the geometric mean concentrations (GMC) of IgG in each age group were analysed. The GMC of anti-measles IgG and anti-rubella IgG were 653.7 IU/L (95% confidence interval (CI); 555.9–751.4) and 39.5 IU/mL (95% CI;35.0–43.9), respectively. Thais between the ages of six months and 25 years did not demonstrate sufficient protective herd immunity for measles. This observation is consistent with the recent measles outbreaks in this age group. Lower prevalence of immunity against rubella was found among children ages 5–6 years who may not have completed vaccination as infants. Our findings identify gaps in rubella and measles immunity in specific age groups and support recommendations for catch-up MMR vaccination in individuals 30 years of age or younger.

Klíčová slova:

Age groups – Immunity – Measles – MMR vaccine – Rubella – Thailand – Vaccination and immunization – Vaccines


Zdroje

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Článek vyšel v časopise

PLOS One


2019 Číslo 11