Flat electrode contacts for vagus nerve stimulation


Autoři: Jesse E. Bucksot aff001;  Andrew J. Wells aff001;  Kimiya C. Rahebi aff002;  Vishnoukumaar Sivaji aff001;  Mario Romero-Ortega aff001;  Michael P. Kilgard aff001;  Robert L. Rennaker, II aff001;  Seth A. Hays aff001
Působiště autorů: The University of Texas at Dallas, Erik Jonsson School of Engineering and Computer Science, Richardson, Texas, United States of America aff001;  Texas Biomedical Device Center, Richardson, Texas, United States of America aff002;  The University of Texas at Dallas, School of Behavioral Brain Sciences, Richardson, Texas, United States of America aff003
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0215191

Souhrn

The majority of available systems for vagus nerve stimulation use helical stimulation electrodes, which cover the majority of the circumference of the nerve and produce largely uniform current density within the nerve. Flat stimulation electrodes that contact only one side of the nerve may provide advantages, including ease of fabrication. However, it is possible that the flat configuration will yield inefficient fiber recruitment due to a less uniform current distribution within the nerve. Here we tested the hypothesis that flat electrodes will require higher current amplitude to activate all large-diameter fibers throughout the whole cross-section of a nerve than circumferential designs. Computational modeling and in vivo experiments were performed to evaluate fiber recruitment in different nerves and different species using a variety of electrode designs. Initial results demonstrated similar fiber recruitment in the rat vagus and sciatic nerves with a standard circumferential cuff electrode and a cuff electrode modified to approximate a flat configuration. Follow up experiments comparing true flat electrodes to circumferential electrodes on the rabbit sciatic nerve confirmed that fiber recruitment was equivalent between the two designs. These findings demonstrate that flat electrodes represent a viable design for nerve stimulation that may provide advantages over the current circumferential designs for applications in which the goal is uniform activation of all fascicles within the nerve.

Klíčová slova:

Axons – Curve fitting – Functional electrical stimulation – Medical implants – Nerve fibers – Nerves – Rabbits – Sciatic nerves


Zdroje

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Článek vyšel v časopise

PLOS One


2019 Číslo 11