Oxygen delivery, oxygen consumption and decreased kidney function after cardiopulmonary bypass

Autoři: Rik H. J. Hendrix aff001;  Yuri M. Ganushchak aff001;  Patrick W. Weerwind aff001
Působiště autorů: Department of Extra-Corporeal Circulation, Maastricht University Medical Centre+, Maastricht, the Netherlands aff001;  Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands aff002
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225541



Low oxygen delivery during cardiopulmonary bypass is related to a range of adverse outcomes. Previous research specified certain critical oxygen delivery levels associated with acute kidney injury. However, a single universal critical oxygen delivery value is not sensible, as oxygen consumption has to be considered when determining critical delivery values. This study examined the associations between oxygen delivery and oxygen consumption and between oxygen delivery and kidney function in patients undergoing cardiopulmonary bypass.


Oxygen delivery, oxygen consumption and kidney function decrease were retrospectively studied in 65 adult patients.


Mean oxygen consumption was 56 ± 8 ml/min/m2, mean oxygen delivery was 281 ± 39 ml/min/m2. Twenty-seven patients (42%) had an oxygen delivery lower than the previously mentioned critical value of 272 ml/min/m2. None of the patients developed acute kidney injury according to RIFLE criteria. However, in 10 patients (15%) a decrease in the estimated glomerular filtration rate of more than 10% was noted, which was not associated with oxygen delivery lower than 272 ml/min/m2. Eighteen patients had a strong correlation (r >0.500) between DO2 and VO2, but this was not related to low oxygen delivery. Central venous oxygen saturation (77 ± 3%), oxygen extraction ratio (21 ± 3%) and blood lactate levels at the end of surgery (1.2 ± 0.3 mmol/l) showed not to be indicative of insufficient oxygen delivery either.


This study could not confirm an evident correlation between O2 delivery and O2 consumption or kidney function decrease, even at values below previously specified critical levels. The variability in O2 consumption however, is an indication that every patient has individual O2 needs, advocating for an individualized O2 delivery goal.

Klíčová slova:

Blood flow – Blood pressure – Cardiopulmonary bypass – Glomerular filtration rate – Hemoglobin – Kidneys – Oxygen – Oxygen consumption


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Článek vyšel v časopise


2019 Číslo 11