The association between cigarette smoking and serum thyroid stimulating hormone, thyroid peroxidase antibodies and thyroglobulin antibodies levels in Chinese residents: A cross-sectional study in 10 cities


Autoři: Yan Zhang aff001;  Lixin Shi aff001;  Qiao Zhang aff001;  Nianchun Peng aff001;  Lulu Chen aff002;  Xiaolan Lian aff003;  Chao Liu aff004;  Zhongyan Shan aff005;  Bingyin Shi aff006;  Nanwei Tong aff007;  Shu Wang aff008;  Jianping Weng aff009;  Jiajun Zhao aff010;  Weiping Teng aff005
Působiště autorů: Department of Endocrinology, Affiliated Hospital of Guizhou Medical University, Guiyang, China aff001;  Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China aff002;  Department of Endocrinology, Peking Union Medical College Hospital, Beijing, China aff003;  Department of Endocrinology, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China aff004;  Department of Endocrinology and Metabolism, Key Laboratory of Thyroid Diseases in Liaoning Province, The First Hospital of China Medical University, Shenyang, China aff005;  Department of Endocrinology, First Affiliated Hospital of Medical College of Xi’an Jiaotong University, Xi’an, China aff006;  Department of Endocrinology, West China Hospital, Sichuan University, Chengdu, China aff007;  Department of Endocrinology, The Ruijin Hospital of Shanghai Jiaotong University, Shanghai, China aff008;  Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China aff009;  Department of Endocrinology, The Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China aff010
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225435

Souhrn

Objectives

Although several studies have shown that cigarette smoking is associated with thyroid stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb), the exact relationship between smoking and thyroid function is controversial. As little is known about the effects of smoking on TSH, TPOAb and TgAb in Chinese residents. This study aimed to evaluate the association between cigarette smoking and TSH, TPOAb and TgAb in ten-city residents of China.

Study design

This was a population-based cross-sectional study.

Methods

In this cross-sectional study, 15,181 subjects from ten major cities of China were investigated. Data regarding demographic characteristics, smoking status and consumption of iodine status were collected using in-person interviews based on a self-designed structured questionnaire. Serum concentrations of TSH, TPOAb and TgAb were measured using electrochemiluminescence immunoassays. Univariate analysis and multivariate linear stepwise regression analyses were used to analyze the data.

Results

The regular smokers had lower concentrations of TSH, TPOAb and TgAb than occasional smokers, former smokers and never smokers. Multivariate analysis demonstrated that regular smoking was associated with the decreased concentrations of TSH (β = -0.178), TPOAb (β = -0.287) and TGAb (β = -0.453) after adjusting other factors. Furthermore, daily smoking number was significantly associated with the decreased level of TSH (β = -0.045) and TPOAb(β = -0.080), and smoking duration was associated with the decreased TSH level (β = -0.030).

Conclusions

Our findings suggest that cigarette smoking is related to a significant decline in the concentrations of TSH, TPOAb and TgAb. In addition, daily smoking number and long-term smoking decrease serum TSH and TPOAb levels. Cigarette smoking plays a significant role in the development of thyroid dysfunction.

Klíčová slova:

Cross-sectional studies – Iodine – Seaweed – Smoking habits – Smoking related disorders – Thyroid – Thyroid-stimulating hormone


Zdroje

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