Liquid Chromatography/Mass Spectrometry based serum metabolomics study on recurrent abortion women with antiphospholipid syndrome

Autoři: Lili Zhang aff001;  Ying Li aff002;  Xiuying Lin aff003;  Chunshu Jia aff004;  Xiaowei Yu aff004
Působiště autorů: Department of Ultrasonography, First Hospital, Jilin University, Changchun, China aff001;  Department of Neonatology, First Hospital, Jilin University, Changchun, China aff002;  Center for Reproductive Medicine, Jilin Province People's Hospital, Changchun, China aff003;  Centre for Reproductive Medicine, Centre for Prenatal Diagnosis, First Hospital, Jilin University, Changchun, China aff004
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225463



The antiphospholipid syndrome (APS) is an important cause of acquired thromboembolic complications and pregnancy morbidity. The pathogenic mechanisms that damage the fetal–maternal unit and cause abnormal placental development are incompletely understood in APS patients. Liquid Chromatography/Mass Spectrometry (LC/MS) based metabolomics are applied for the mechanism of disease and further supporting the research of diagnosis and management in recent years. The aim of this research was to investigate the difference of serum metabolic profiles in recurrent abortion women with APS and healthy women to explore the mechanism of this disease.


Serum samples of 25 recurrent abortion women with APS and 25 healthy women were collected and analyzed by LC/MS in this study. Potential biomarkers were discovered by multivariate statistical analysis and then identified based on analysis results.


Totally, we identified five biomarkers that involved in different metabolic pathway such as purine metabolism, amino acid metabolism and tyrosine metabolism. These biomarkers showed different roles in disease development.


Metabolomics was proved as a powerful tool in understanding the mechanism of recurrent abortion caused by APS.

Klíčová slova:

Amino acid metabolism – Biomarkers – Metabolomics – Pregnancy – Termination of pregnancy – Thyroid – Uric acid – Purine metabolism


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2019 Číslo 11