#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Periodontal disease: Repercussions in pregnant woman and newborn health—A cohort study


Autoři: Marina Guim Otsuka Padovan Figueiredo aff001;  Stefanie Yaemi Takita aff001;  Bianca Maria Ramos Dourado aff001;  Helderjan de Souza Mendes aff002;  Erick Olsen Terakado aff003;  Hélio Rubens de Carvalho Nunes aff001;  Cátia Regina Branco da Fonseca aff001
Působiště autorů: Pediatrics Department, Botucatu Medical School, São Paulo State University (UNESP),Botucatu city, São Paulo State, Brazil aff001;  Botucatu Clinics Hospital, Botucatu city, São Paulo State, Brazil aff002;  Psychology Department, Paulista University (UNIP), São Paulo city, São Paulo State, Brazil aff003
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0225036

Souhrn

The periodontal disease during pregnancy triggers an exacerbated immune response with high local and systemic concentrations of inflammatory markers.

Objective

To investigate the repercussion of periodontal disease (PD) in the pregnant woman health and the complications during pregnancy and delivery, as well as negative outcomes for the newborn (as infections, prematurity, low birth weight and fetal growth restriction).

Method

Retrospective cohort study, based on medical records of 142 pregnant women assisted at a prenatal service of usual risk between 2012–2014, with a dental evaluation for PD. Maternal variables, along with labor and newborn variables, were analyzed. The newborns were stratified into two groups: offspring of mothers with PD (subdivided into Severe Periodontal Disease—SPD) and offspring of mothers without PD. Each outcome was adjusted by a multiple logistic regression model, with significance for p-value <0.05, considering all potential confounding factors.

Results

Among women diagnosed with SPD, the odds ratio for vulvovaginitis was 3.45 times greater (OR = 3.45, p-value = 0.050) and 5.59 times higher for premature rupture of membranes (OR = 5.59; p-value = 0.017). For neonates, the chance of fetal growth restriction was 11.53 times higher for pregnant women with SPD (OR = 11.53, p = 0.041).

Conclusion

The periodontal disease increased the chance of neonatal and maternal negative outcomes, being the fetal growth restriction, vulvovaginitis and premature rupture of the membrane (PROM) the main results driven by the presence of Severe Periodontal Disease.

Klíčová slova:

Birth weight – Hypertensive disorders in pregnancy – Inflammatory diseases – Neonates – Periodontal diseases – Pregnancy – Urinary tract infections – Growth restriction


Zdroje

1. George A, Johnson M, Blinkhorn A, Ajwani S, Ellis S, Bhole S. Views of pregnant women in South Western Sydney towards dental care and an oral-health program initiated by midwives. Health Promot J Austr. 2013;24(3): 178–184. doi: 10.1071/HE13040 24300386

2. Chapple IL, Matthews JB. The role of reactive oxygen and antioxidant species in periodontal tissue destruction. Periodontology 2000. 2007;43: 160–232. doi: 10.1111/j.1600-0757.2006.00178.x 17214840

3. Offenbacher S, Jared HL, O'Reilly PG, Wells SR, Salvi GE, Lawrence HP. Potential pathogenic mechanisms of periodontitis associated pregnancy complications. Ann Periodontol. 1998;3(1): 233–250. doi: 10.1902/annals.1998.3.1.233 9722707

4. Keirse MJ, Plutzer K. Women's attitudes to and perceptions of oral health and dental care during pregnancy. J Perinat Med. 2010;38(1): 3–8. doi: 10.1515/JPM.2010.007 20047523

5. Xiong X, Buekens P, Fraser WD, Beck J, Offenbacher S. Periodontal disease and adverse pregnancy outcomes: a systemic review. BJOG. 2006;113(2): 135–143. doi: 10.1111/j.1471-0528.2005.00827.x 16411989

6. Laine MA. Effect of pregnancy on periodontal and dental health. Acta Odontol Scand. 2002;60(5): 257–264. doi: 10.1080/00016350260248210 12418714

7. Mendes HS, Peraçoli JC. Condições de saúde bucal das gestantes atendidas na atenção primária do município de Botucatu—SP e seu conhecimento sobre a importância da saúde bucal na gestação. Dissertação (mestrado). Universidade Estadual Paulista Júlio de Mesquita Filho. 2014.

8. Brasil. Ministério da Saúde. National Council of Health. Resolution 466/2012. Brasilia: Minis´terio da Saúde;2012.

9. Fenton TR, Kim JH. A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants. BMC Pediatr. 2013;13: 59. doi: 10.1186/1471-2431-13-59 23601190

10. Beune IM, Bloomfield FH, Ganzevoort W, Embleton ND, Rozance PJ, van Wassenaer-Leemhuis AG, et al. Consensus based definition of growth restriction in the newborn. J Pediatr. 2018;196: 71–76.e1. doi: 10.1016/j.jpeds.2017.12.059 29499988

11. Fisher LD. Biostatistics: a methodology for the health sciences. New York: Wiley Interscience; 1993.

12. Tettamanti L, Lauritano D, Nardone M, Gargari M, Silvestre-Rangil J, et al. Pregnancy and periodontal disease: does exist a two way relationship. Oral Implantol (Rome). 2017;10(2): 112–118. Review.

13. González-Jaranay M, Téllez L. Roa-López A, Gómez-Moreno G, Moreu G. Periodontal status during pregnancy and postpartum. PLoS One. 2017;12(5): 1–9.

14. Schwendicke F, Karimbux N, Allareddy V, Gluud C. Periodontal treatment for preventing adverse pregnancy outcomes: a meta- and trial sequential analysis. PLoS One. 2015;10: e0129060. doi: 10.1371/journal.pone.0129060 26035835

15. Offenbacher S, Jared HL, O'Reilly PG, Wells SR, Salvi GE, Lawrence HP. Changes in gingival crevicular fluid inflammatory mediator levels during the induction and resolution of experimental gingivitis in humans. J Clin Periodontol. 2010;37(4): 324–333. doi: 10.1111/j.1600-051X.2010.01543.x 20447255

16. Louro PM, Fiori HH, Louro Filho P, Steibel J, Fiori RM. Doença periodontal na gravidez e baixo peso ao nascer. J Pediatr. 2001;77(1): 23–28.

17. Passini Júnior R, Nomura ML, Politano GT. Doença periodontal e complicações obstétricas: há relação de risco?. Rev Bras Ginecol Obstet. 2007;29(7): 370–375.

18. Teshome A, Yitayeh A. Relationship between periodontal disease and preterm low birth weight: systematic review. Pan Afr Med J. 2016;24: 215. doi: 10.11604/pamj.2016.24.215.8727 27800070

19. Khan NS, Ashraf RN, Noor S, Mahmood-ur-Rahman, Mashhadi SF, Rashid Z, et al. Association of maternal periodontitis with low birth weight in newborns in a tertiary care hospital. J Ayub Med Coll Abbottabad. 2016;28(1): 120–125. 27323576

20. Ananth CV, Andrews HF, Papapanou PN, Ward AM, Bruzelius E, Conicella ML, et al. History of periodontal treatment and risk for intrauterine growth restriction (IUGR). BMC Oral Health. 2018;18(1): 161. doi: 10.1186/s12903-018-0623-2 30268113

21. Soucy-Giguère L, Tétu A, Gauthier S, Morand M, Chandad F, Giguère Y, et al. Periodontal disease and adverse pregnancy outcomes: a prospective study in a low-risk population. J Obstet Gynaecol Can. 2016;38(4): 346–350. doi: 10.1016/j.jogc.2016.02.012 27208603

22. Chanomethaporn A, Chayasadom A, Wara-Aswapati N, Kongwattanakul K, Suwannarong W, Tangwanichgapong K, et al. Association between periodontitis and spontaneous abortion: a case control study. J Periodontol. 2019;90(4): 381–390. doi: 10.1002/JPER.18-0174 30367824

23. Sobel JD. Vulvovaginal candidosis. Lancet. 2007;369(9577): 1961–1971. doi: 10.1016/S0140-6736(07)60917-9 17560449

24. Nunes RD, França CO, Traebert JL. Prevalência de vulvovaginites na gestação e sua associação com complicações perinatais. Arq Catarin Med. 2018;47(1): 121–132

25. Nascimento LFC. Grau de instrução materna: um marcador obstétrico. In: Resumos do V Congresso Brasileiro de Saúde Coletiva; 1997; Águas de Lindóia, SP, Brasil. Rio de Janeiro: ABRASCO; 1997. p. 271.

26. Haidar FH, Oliveira UF, Nascimento LFC. Escolaridade materna: correlação com os indicadores obstétricos. Cad Saúde Pública, 2001;17(4): 1025–1029. doi: 10.1590/s0102-311x2001000400037 11514884

27. Baldani MH, Brito WF, Lawder JAC, Mendes YBE, Silva FFM, Antunes JLF. Determinantes individuais da utilização de serviços odontológicos por adultos e idosos de baixa renda. Rev Bras Epidemiol. 2010;13(1): 150–162. doi: 10.1590/s1415-790x2010000100014 20683563

28. Al Habashneh R, Guthmiller JM, Levy S, Johnson GK, Squier C, Dawson DV, et al. Factors related to utilization of dental services during pregnancy. J Clin Periodontol. 2005;32(7): 815–821. doi: 10.1111/j.1600-051X.2005.00739.x 15966891

29. Sousa LLA, Cagnani A, Barros AMS, Zanin L, Flório FM. Pregnant women's oral health: knowledge, practices and their relationship with periodontal disease. Rev Gaúcha Odontol. 2016;64(2): 154–163.

30. Boggess KA, Urlaub DM, Massey KE, Moos MK, Matheson MB, Lorenz C. Oral hygiene practices and dental services utilization by pregnant women J Am Dent Assoc. 201;141(5): 553–561. doi: 10.14219/jada.archive.2010.0228 20436103

31. Sharif S, Saddki N, Yusoff A. Knowledge and attitude of medical nurses toward oral health and oral health care of pregnant women. Malays J Med Sci. 2016;23(1): 63–71. 27540327

32. Gupta S, Shrestha B, Gupta N, Tuladhar A, Kc S, Dhami B. Periodontal health status and pregnancy outcomes: a survey in medical doctors. JNMA J Nepal Med Assoc. 2018;56(210): 565–571. 30375998

33. Brasil. Ministério da Saúde. Centro Brasileiro de Análise e Planejamento. Assistência à gestação, ao parto e ao puerpério: diferenciais regionais e desigualdades socioeconômicas. In: Pesquisa Nacional de Demografia e Saúde da criança e da mulher–PNDS 2006: dimensões do processo reprodutivo e da saúde da criança. Brasília: Ministério da Saúde; 2009. p. 151–170.

34. Brasil. Ministério da Saúde. Secretaria de Atenção à Saúde. Departamento de Atenção Básica. Atenção ao pré-natal de baixo risco. Brasília: Editora do Ministério da Saúde; 2012. (Série A. Normas e Manuais Técnicos) (Cadernos de Atenção Básica; n° 32).

35. Shimizu HE, Lima MG. As dimensões do cuidado pré-natal na consulta de enfermagem. Rev Bras Enferm. 2009;62(3): 387–392 doi: 10.1590/s0034-71672009000300009 19597661

36. Victora C, Aquino EML, Leal MC, Monteiro CA, Barros FC, Szwarcwald CL. Saúde de mães e crianças no Brasil: progressos e desafios. Lancet. 2011;377(9780): 1863–1876. doi: 10.1016/S0140-6736(11)60138-4 21561656


Článek vyšel v časopise

PLOS One


2019 Číslo 11
Nejčtenější tento týden
Nejčtenější v tomto čísle
Kurzy

Zvyšte si kvalifikaci online z pohodlí domova

KOST
Koncepce osteologické péče pro gynekology a praktické lékaře
nový kurz
Autoři: MUDr. František Šenk

Sekvenční léčba schizofrenie
Autoři: MUDr. Jana Hořínková

Hypertenze a hypercholesterolémie – synergický efekt léčby
Autoři: prof. MUDr. Hana Rosolová, DrSc.

Svět praktické medicíny 5/2023 (znalostní test z časopisu)

Imunopatologie? … a co my s tím???
Autoři: doc. MUDr. Helena Lahoda Brodská, Ph.D.

Všechny kurzy
Kurzy Podcasty Doporučená témata Časopisy
Přihlášení
Zapomenuté heslo

Zadejte e-mailovou adresu, se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.

Přihlášení

Nemáte účet?  Registrujte se

#ADS_BOTTOM_SCRIPTS#