Patients with limitation or withdrawal of life supporting care admitted in a medico-surgical intermediate care unit: Prevalence, description and outcome over a six-month period

Autoři: Perrine Molmy aff001;  Nicolas Vangrunderbeeck aff001;  Olivier Nigeon aff001;  Malcolm Lemyze aff002;  Didier Thevenin aff002;  Jihad Mallat aff001
Působiště autorů: Intermediate Care Unit, Centre Hospitalier de Lens, Lens, France aff001;  Intensive Care Unit, Centre Hospitalier de Lens, Lens, France aff002;  Respiratory & Infectious Diseases Unit, Centre Hospitalier de Lens, Lens, France aff003;  Department of Critical Care Medicine, Critical Care Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE aff004
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225303



There have been few studies on the limitation of Life Supporting Care (LSC) and Withdrawal of LSC in Intermediate Care Units (IMCUs). We report the prevalence of LSC limited patients in a medico-surgical IMCU over a six-month period, examining the description, outcomes, and patterns of LSC Limitations and Withdrawal of LSC.


Single center, retrospective observational study in an IMCU of a 500-bed general hospital.


Our study of 404 patients, reported 79 (19.5%, 95%CI: [16.0–23.7]%) being admitted with LSC limitations in the IMCU. This group of LSC limited patients presented with higher chronic and acute severity scores. The most common admission diagnosis of LSC limited patients was acute respiratory failure (51%). Non-invasive ventilation (NIV) was frequently used within this population (39%). Hospital mortality for LSC limited patients was high (53%) and associated with age (OR = 1.07, 95%CI: [1.01–1.13)]), SOFA score (OR 1.29, 95%CI: [1.01–1.64]), and hypoxemic respiratory failure (OR 7.2, 95%CI: [1.27–40.9]). Withdrawal of LSC occurred in 19.5% of cases, often accompanied with terminal sedation with or without NIV removal (43.8%).


Patients with limitation of LSC are frequently admitted into IMCU. Hospital mortality rate was high and associated with age, acute organ failures, and hypoxemic respiratory failure. Life support withdrawal includes palliative sedation with or without NIV discontinuation.

Klíčová slova:

Critical care and emergency medicine – Death rates – Diagnostic medicine – Hospitals – Intensive care units – Physicians – Respiratory failure – Surgical and invasive medical procedures


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2019 Číslo 11