Association of uric acid in serum and urine with subclinical renal damage: Hanzhong Adolescent Hypertension Study


Autoři: Yang Wang aff001;  Chen Chen aff001;  Yu Yan aff001;  Yue Yuan aff001;  Ke-Ke Wang aff001;  Chao Chu aff001;  Jia-Wen Hu aff001;  Qiong Ma aff001;  Yue-Yuan Liao aff001;  Bo-Wen Fu aff001;  Ke Gao aff001;  Yue Sun aff001;  Yong-Bo Lv aff003;  Wen-Jing Zhu aff001;  Lei Yang aff001;  Jie Zhang aff004;  Rui-Hai Yang aff005;  Jun Yang aff005;  Jian-Jun Mu aff001
Působiště autorů: Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China aff001;  Key Laboratory of Molecular Cardiology of Shaanxi Province, Xi’an, China aff002;  Department of Cardiology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China aff003;  Department of Cardiology, Xi’an Fourth People’s Hospital, Xi’an, China aff004;  Institute of Cardiovascular Sciences, Hanzhong People’s Hospital, Hanzhong, China aff005
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0224680

Souhrn

Background and objectives

The aim of the study was to examine the associations of uric acid (UA) in blood and urine with subclinical renal damage (SRD) and its progression in a Chinese cohort.

Methods

1) 2342 participants from our previously established cohort who were followed up in 2017 were included. Cross-sectional analysis was used to examine the relationships between serum and urinary UA and the risk of SRD. 2) A total of 266 participants were recruited from the same cohort in 2013, and followed up in 2017. Longitudinal analysis was used to determine the relationships of serum and urinary UA with progression of SRD, which was defined as urinary albumin-to-creatinine ratio (uACR) progression or estimated glomerular filtration rate (eGFR) decline.

Results

In cross-sectional analysis, higher levels of uACR were associated with higher levels of serum uric acid (SUA) and urinary uric acid/creatinine ratio (uUA/Cre). Lower eGFR was associated with higher levels of SUA and fractional excretion of uric acid (FEUA) but lower uUA/Cre levels in all subjects. In addition, the multivariate-adjusted odds ratios for SRD compared with non-SRD were 3.574 (2.255–5.664) for uUA/Cre. Increasing uUA/Cre levels were associated with higher risk of SRD. In longitudinal analysis, 4-year changes of uUA/Cre and SUA were significantly associated with eGFR decline.

Conclusions

This study suggested that urinary UA excretion was significantly associated with the risk of SRD in Chinese adults. Furthermore, 4-year changes of serum and urinary UA were associated with SRD progression. These findings suggest that UA, especially urinary UA, may be used as a simple, noninvasive marker for early detection of decreased renal function in otherwise healthy subjects.

Klíčová slova:

Creatinine – Excretion – Glomerular filtration rate – Hypertension – Cholesterol – Urine – Uric acid


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