Differences in clinical features of cluster headache between drinkers and nondrinkers in Japan

Autoři: Noboru Imai aff001;  Eiji Kitamura aff002
Působiště autorů: Department of Neurology, Japanese Red Cross Shizuoka Hospital, Shizuoka, Shizuoka, Japan aff001;  Department of Neurology, Kitasato University, Sagamihara, Kanagawa, Japan aff002
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0224407



Alcohol has been recognized as the main trigger for a cluster headache attack, but clinical features to distinguish between cluster headache in drinkers and nondrinkers are unclear. Thus, the present study aimed to investigate the differences in clinical features of cluster headache between drinkers and nondrinkers.


This retrospective, observational study compared the clinical features of cluster headache between drinkers and nondrinkers among patients who were diagnosed with cluster headache between November 2004 and April 2018 at the Japanese Red Cross Shizuoka Hospital. Demographic and clinical data were collected from medical records and/or by patient interview.


Of 131 patients, 98 (75%) were drinkers, and 33 (25%) were nondrinkers. Compared with nondrinkers, drinkers had significantly more frequent conjunctival injection (43% vs. 21%, p = 0.037) but significantly less frequent nasal congestion (31% vs. 52%, p = 0.0037), vomiting (11% vs. 30%, p = 0.014), and photophobia (29% vs. 45%, p = 0.008).


Among individuals with cluster headache, the frequencies of conjunctival injection, nasal congestion, vomiting, and photophobia were different between drinkers and nondrinkers. These results suggested that drinking might influence the responses of the cranial autonomic reflex with respect to conjunctival injection or nasal congestion.

Klíčová slova:

Alcohol consumption – Body Mass Index – Headaches – Migraine – Nausea – Reflexes – Vomiting – Cluster headache


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Článek vyšel v časopise


2019 Číslo 11