Parasitic infections and medical expenses according to Health Insurance Review Assessment claims data in South Korea, 2011–2018

Autoři: Ju Yeong Kim aff001;  Myung-hee Yi aff001;  Tai-Soon Yong aff001
Působiště autorů: Department of Environmental Medical Biology, Institute of Tropical Medicine, Arthropods of Medical Importance Resource Bank, Yonsei University College of Medicine, Seoul, Korea aff001;  Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea aff002
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225508



In South Korea, Health Insurance Review and Assessment claims data contain comprehensive information on healthcare services for almost the entire population. The present study used claims data on parasitic diseases from 2011 to 2018, and associated medical expenses to investigate infection trends associated with endemic parasitic diseases in South Korea, including those not monitored by Korea Centers for Disease Control and Prevention.


Basic data regarding each parasitic disease were curated from the Healthcare Bigdata Hub ( Ten endemic parasitic diseases, three pandemic protozoan diseases, and three ectoparasitic diseases were evaluated between 2011 and 2018. Data on each parasitic disease included the number of patients of each sex, age range within 5 years, province, and total medical expenses. Heatmap and principal component analysis were performed to visualize the incidence pattern of parasitic diseases by provinces.


Clonorchiasis and pinworm infections decreased remarkably from 6,097 and 4,018 infections in 2011 to 3,008 and 1,988 infections in 2018, respectively. Other endemic parasitic diseases mostly declined or remained steady over the 8-year period, except for anisakiasis, which doubled from 409 in 2011 to 818 in 2018. Provinces close to North Korea had a higher frequency of claims for Plasmodium vivax infection. The highest rate of clonorchiasis was in Gyeongsangnam-do, while that of anisakiasis was in southern Korea. Jeju province had the highest number of claims for cysticercosis, anisakiasis, pinworm infection, and soil-transmitted helminth infections. The total medical expense for anisakiasis was 65 million Korean won (57,000 US$) in 2011, rising to 237 million Korean won (206,000 US$) in 2018. The medical expense for trichomoniasis was 6,063 million won and for scabies was 1,669 million won in 2018. Since the claims data include only data reported by healthcare providers, some discrepancies might have occurred.


Our findings provide the basis for a health policy to reduce further infections and medical expense.

Klíčová slova:

Parasitic diseases – principal component analysis – Protozoan infections – South Korea – Enterobiasis – Cysticercosis – Ectoparasitic infections – Clonorchiasis


1. Hong ST, Chai JY, Choi MH, Huh S, Rim HJ, Lee SH. A successful experience of soil-transmitted helminth control on the Republic of Korea. Korean J Parasitol. 2006;44(3):177–85. doi: 10.3347/kjp.2006.44.3.177 16969055

2. Shin EN, Guk SM, Kim HJ, Lee SM, Chai JY. Trends in parasitic diseases in the Republic of Korea. Trends Parasitol. 2008;24(3):143–50. doi: 10.1016/ 18255338

3. Chai JY, Murrell KD, Lymbery AJ. Fish-borne parasitic zoonoses: Status and issues. Int J Parasitol. 2005;35(11–12):1233–54. doi: 10.1016/j.ijpara.2005.07.013 16143336

4. Song HO, Ahn MH, Choi HK, Ryu JS, Min DY, Ree HI. Analysis of 205 cases of Parasite infection confirmed in clinical specimens. Korean J Clin Microbiol. 2004;7(1):66–71.

5. Park JW, Jun G, Yeom JS. Plasmodium vivax malaria: Status in the Republic of Korea following reemergence. Korean J Parasitol. 2009;47(suppl):S39–50.

6. Kim JA, Yoon S, Kim LY, Kim DS. Towards Actualizing the Value Potential of Korea Health Insurance Review and Assessment (HIRA) Data as a Resource for Health Research: Strengths, Limitations, Applications, and Strategies for Optimal Use of HIRA Data. J Korean Med Sci. 2017;32(5):718–28. doi: 10.3346/jkms.2017.32.5.718 28378543

7. Cho SK, Kim D, Won S, Han M, Lee J, Jang EJ, et al. Safety of resuming biologic DMARDs in patients who develop tuberculosis after anti-TNF treatment. Semin Arthritis Rheum. 2017;47(1):102–7. doi: 10.1016/j.semarthrit.2017.01.004 28216194

8. Kim YJ, Kwon A, Jung MK, Kim KE, Suh J, Chae HW, et al. Incidence and Prevalence of Central Precocious Puberty in Korea: An Epidemiologic Study Based on a National Database. J Pediatr. 2019;208:221–8. doi: 10.1016/j.jpeds.2018.12.022 30857777

9. Han M, Jung YS, Cheon JH, Park S. Regional variations in the use of biologics and immunomodulators among Korean patients with inflammatory bowel diseases. J Gastroenterol Hepatol. 2019.

10. Jung YS, Han M, Kim DY, Cheon JH, Park S. Cancer risk in Korean patients with Behcet's disease: A nationwide population-based study. PLoS One 2017;12(12):e0190182 doi: 10.1371/journal.pone.0190182 29287101

11. Kim L, Kim JA, Kim S. A guide for the utilization of Health Insurance Review and Assessment Service National Patient Samples. Epidemiol Health. 2014;36:e2014008. doi: 10.4178/epih/e2014008 25078381

12. Korea Centers for Disease Control and Prevention; Korea National Institute of Health. National survey of the prevalence of intestinal parasitic infections in Korea, 2012. The 8th Report. Osong. Chungcheongbuk-do, Korea. 2013.

13. Do KR, Cho YS, Kim HK, Hwang BH, Shin EJ, Jeong HB, et al. Intestinal helminthic infections diagnosed by colonoscopy in a regional hospital during 2001–2008. Korean J Parasitol. 2010;48(1):75–8. doi: 10.3347/kjp.2010.48.1.75 20333290

14. Lee SH, Chai JY. A review of Gymnophalloides seoi (Digenea: Gymnophallidae) and human infections in the Republic of Korea. Korean J Parasitol. 2001;39(2):85–118. doi: 10.3347/kjp.2001.39.2.85 11441510

15. Chai JY, Lee SH. Food-borne intestinal trematode infections in the Republic of Korea. Parasitol International. 2002;51(2):129–154.

16. Soh CT, Lee KT, Shin EW, Kang TC. Incidence of Parasites in Seoul area based on an examination of the Severance Hospital out-patients. Yonsei Med J. 1961;2(1):31–41.

17. Choi WH, Chu JP, Jiang M, Lee YS, Kim BS, Kim DG, et al. Analysis of Parasitic diseases diagnosed by tissue biopsy specimens at KyungHee Medical Center (1984–2005) in Seoul, Korea. Korean J Parasitol. 2010;48(1):85–8. doi: 10.3347/kjp.2010.48.1.85 20333293

18. Son HJ, Kim MJ, Jung KH, Choi S, Jung J, Chong YP, et al. Neurocysticercosis: Clinical Characteristics and Changes from 26 Years of Experience in an University Hospital in Korea. Korean J Parasitol. 2019;57(3):265–71. doi: 10.3347/kjp.2019.57.3.265 31284349

19. Ahn MH, Shin HJ, Im KI, Soh CT. Imported malaria cases in Korea. Yonsei Rep Trop Med. 1982;13:23–9.

20. Soh CT, Lee KT, Im KI, Min DY, Ahn MH, Kim JJ, et al. Current status of malaria in Korea. Yonsei Rep Trop Med. 1985;16:11–8.

21. Chai IH, Lim GI, Yoon SN, Oh WI, Kim SJ, Chai JY. Occurrence of tertian malaria in a Male Patient who has never been abroad. Korean J Parasitol. 1994;32(3):195–200. doi: 10.3347/kjp.1994.32.3.195 7953245

22. Han ET, Lee DH, Park KD, Seok WS, Kim YS, Tsuboi T, et al. Reemerging vivax malaria: changing patterns of annual incidence and control programs in the Republic of Korea. Korean J Parasitol. 2006;44(4):285–94. doi: 10.3347/kjp.2006.44.4.285 17170570

23. Kim CH, Chung BS. A case report on human infection with Anisakis sp. in Korea. Korean J Parasitol. 1971;9(1):39–43.

24. Im KI, Shin HJ, Kim BH, Moon SI, Lee OJ. Gastric anisakiasis cases in Cheju-do, Korea. Korean J Parasitol. 1995;33(3):179–86. doi: 10.3347/kjp.1995.33.3.179 8528624

25. Lee EJ, Kim YC, Jeong HG, Lee OJ. The Mucosal changes and influencing factors in upper astrointestinal anisakiasis: analysis of 141 cases. Korean J Gastroenterol. 2009;53(2):90–7. 19237834

26. Sohn WM, Na BK, Kim TH, Park TJ. Anisakiasis: report of 15 gastric cases caused by Anisakis type I larvae and a brief review of Korean Anisakiasis cases. Korean J Parasitol. 2015;53(4):465–70. doi: 10.3347/kjp.2015.53.4.465 26323845

27. Song H, Jung BK, Cho J, Chang T, Huh S, Chai JY. Molecular Identification of Anisakis Larvae Extracted by Gastrointestinal Endoscopy from Health Check-up Patients in Korea. Korean J Parasitol. 2019;57(2):207–11. doi: 10.3347/kjp.2019.57.2.207 31104416

28. Joo CY, Choi DW. Prevalence of Trichomonas vaginalis in Korean military personnel. Korean J Parasitol. 1980;18(2):247–52.

29. Soh CT. Overview of Entamoeba histolytica and amebiasis in Korea with special reference to research notes. Korean J Parasitol. 1990;28 (suppl):13–27.

30. Soh CT, Lee SJ, Ahn YG. Latent Infection by Toxoplasma gondii in Korea. Yonsei Med J. 1960;1(1):52–4.

31. Choi WY. Diagnosis and epidemiology of Toxoplasmosis in Korea. Korean J Parasitol. 1990;28 (suppl):41–4.

32. Ryu JS, Min DY, Ahn MH, Choi HG, Rho SC, Shin YJ, et al. Toxoplasma antibody titers by ELISA and indirect latex agglutination test in pregnant women. Korean J Parasitol. 1996; 34(4):233–8. doi: 10.3347/kjp.1996.34.4.233 9017908

33. Chung KS, Kung RN, Chung KS, Kim PK, Yun DJ, Soh CT. Congenital Toxoplasmosis. Yonsei Med J. 1980;21(1):62–74. doi: 10.3349/ymj.1980.21.1.62 7269638

34. Choi JS, Choi CS, Soh CT. Isolation of Toxoplasma gondii from congenital and acquired chorioretinitis cases. Yonsei Rep Trop Med. 1980;11:39–42.

35. Kim SE, Kim YK, Shin WS, Kang MW, Kim BK, Nam HW, et al. A case of Toxoplasmosis infected in the laboratory. Korean J Inf Dis. 1993;25:63–9.

36. Choi WY, Nam HW, Kwak NH, Huh W, Kim YR, Kang MW, et al. Foodborne outbreaks of human Toxoplasmosis. J Inf Dis. 1997;175(5):1280–2.

37. Pai KS, Park MS, Lee YS, Kim DH, Chung KS, Lee KY, et al. The prevalence of head louse infestation among urban and rural children in Korea. Korean J Parasitol. 1989;27(4):271–5.

38. Sim SB, Lee IY, Lee KJ, Seo JH, Im KI, Shin MH, et al. A survey on head lice infestation in Korea (2001) and the therapeutic efficacy of oral trimethoprim/sulfamethoxazole adding to lindane shampoo. Korean J Parasitol. 2003;41(1):57–61. doi: 10.3347/kjp.2003.41.1.57 12666731

39. Cho BK. Reemerging skin disease caused by arthropods I: scabies. J Korean Med Assoc. 2011;54(5):511–20.

40. Park SY, Roh JY, Lee JY, Kim DW, Yoon TJ, Sim WY, et al. A clinical and epidemiological study of scabies in Korea: A multicenter prospective study. Korean J Dermatol. 2014;52(7):457–64.

Článek vyšel v časopise


2019 Číslo 11