Risk factors for the carriage of Streptococcus infantarius subspecies infantarius isolated from African fermented dairy products


Autoři: Kossia D. T. Gboko aff001;  Sylvain G. Traoré aff001;  Aimé R. Sanhoun aff001;  Jérôme Kirioua aff002;  Nize Otaru aff004;  Fabienne Kurt aff004;  Fabienne N. Jaeger aff005;  Julia Isenring aff004;  Dasel W. M. Kaindi aff007;  Bernd Kreikemeyer aff008;  Pierre Renault aff009;  Jan Hattendorf aff005;  Leo Meile aff004;  Christoph Jans aff004;  Roland Nguetta aff010;  Bassirou Bonfoh aff001
Působiště autorů: Centre Suisse de Recherches Scientifiques en Côte d’Ivoire (CSRS), Adiopodoumé Yopougon, Abidjan, Côte d'Ivoire aff001;  University of Peleforo Gon Coulibaly, Korhogo, Côte d'Ivoire aff002;  University of Nangui Abrogoua, Abidjan, Côte d'Ivoire aff003;  Laboratory of Food Biotechnology, Institute of Food, Nutrition and Health, ETH Zurich, Schmelzbergstrasse 7, Zurich, Switzerland aff004;  Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland aff005;  University of Basel, Basel, Switzerland aff006;  Department of Food Science, Nutrition and Technology, University of Nairobi, Nairobi, Kenya aff007;  Institute of Medical Microbiology, Virology, and Hygiene, Rostock University Medical Centre Rostock, Germany aff008;  Institut National de la Recherche Agronomique, UMR 1319 MICALIS, Jouy-en-Josas, France aff009;  Institut de cardiologie d’Abidjan (ICA), Abidjan, Côte d’Ivoire aff010;  Université Felix Houphouët-Boigny, Abidjan, Côte d’Ivoire aff011
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225452

Souhrn

Streptococcus infantarius subsp. infantarius (Sii) has been identified as predominant lactic acid bacteria in spontaneously fermented dairy products (FDPs) in sub-Saharan Africa including Côte d'Ivoire. However, Sii belongs to the Streptococcus bovis/Streptococcus equinus complex (SBSEC). Most SBSEC members are assumed to be involved as opportunistic pathogens in serious diseases in both humans and animals. A population-based cross-sectional survey, including 385 participants was conducted in Korhogo, northern Côte d'Ivoire, to identify risk factors for Sii fecal carriage, including consumption of local FDPs. A structured questionnaire was used to gather participant's socio-demographic and economic characteristics, their relation to livestock and dietary habits. In addition, fresh stool and milk samples were collected. The identification of Sii was done using a SBSEC-specific PCR assay targeting 16S rRNA and groEL genes. The overall prevalence of SBSEC and Sii carriage was 23.2% (confidence interval CI 95% = 18.9–27.5) and 12.0% (CI 95% = 8.4–15.5) for stool, respectively. Prevalence of Sii was significantly higher in consumers of artisanal butter compared with non-consumers (57.1% vs 10.1%, odds ratio OR: 11.9, 95% CI: 3.9–36.6), as well as in persons handling livestock (OR = 3.9; 95% CI = 1.6–9.3) and livestock primary products (OR = 5.7; 95% CI = 2.3–14.3). The closer contact with livestock was a risk factor for Sii fecal carriage. Sii strains were isolated from fresh and fermented milk products with a prevalence of 30.4% and 45.4%, respectively. Analysis of Sii population structure through the SBSEC multi locus sequence typing assay revealed a close relationship across human and dairy isolates, possibly linked to a Kenyan human isolate. All these outcomes underline the interest of in-depth investigations on the ecology, potential reservoirs and pathways of contamination by Sii at the human-animal-environment interface in comparison to yet to be collected data from Europe, Asia and the Americas to further elucidate the various roles of Sii.

Klíčová slova:

Africa – Food consumption – Livestock – Meat – Medical risk factors – Milk – Streptococcus – Group D streptococci


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