Overactive bladder and bladder pain syndrome/interstitial cystitis in primary Sjögren’s syndrome patients: A nationwide population-based study

Autoři: Chun-Kang Lee aff001;  Ching-Pei Tsai aff002;  Tsai-Ling Liao aff003;  Wen-Nan Huang aff005;  Yi-Hsing Chen aff001;  Ching-Heng Lin aff003;  Yi-Ming Chen aff003
Působiště autorů: Department of Medical Education, Taichung Veterans General Hospital, Taichung, Taiwan aff001;  Department of Obstetrics, Gynecology & Women's Health, Taichung Veterans General Hospital, Taichung, Taiwan aff002;  Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan aff003;  Institute of Biomedical Science and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan aff004;  Division of Allergy, Immunology and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan aff005;  Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan aff006;  Department of Public Health, Fu-Jen Catholic University, New Taipei City, Taiwan aff007;  Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan aff008;  Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, Taiwan aff009
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225455


To investigate the risks of overactive bladder (OAB) and bladder pain syndrome/interstitial cystitis (BPS/IC) in primary Sjögren’s syndrome (pSS) patients. A nationwide, population-based cohort study was conducted using data from Taiwan’s National Health Insurance Research Database. From 2001 to 2010, participants with newly diagnosed pSS were recognized as the study group. In addition, a comparison cohort of non-pSS participants was matched for age, gender, and initial diagnosis date. Risks of developing OAB and BPS/IC in pSS patients of different age, sex, and various therapeutic strategies were calculated. Hazard ratios (HR) and a 95% confidence interval (CI) were analyzed by Cox proportional hazard model. In total, 11,526 pSS patients were recognized. The HRs of OAB and BPS/IC in pSS patients were 1.68 (95% C.I.: 1.48–1.91, p<0.01) and 2.34 (95% C.I.: 1.59–3.44, p<0.01), respectively. The risks of OAB and BPS/IC were significantly increased for pSS patients aged < 65 years (HR: 1.73 and 2.67), female patients (HR: 1.74 and 2.34), and patients requiring treatment for dry eyes and dry mouth (HR: 2.06 and 2.93). pSS patients exhibited an increased risk of OAB and BPS/IC. Female gender, younger age, and severe glandular dysfunction requiring treatments were potential risk factors.

Klíčová slova:

Bladder – Coronary heart disease – Eyes – Outpatients – Bladder and ureteric disorders – Irritable bowel syndrome – Cystitis – Chronic fatigue syndrome


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Článek vyšel v časopise


2019 Číslo 11