Imported severe malaria and risk factors for intensive care: A single-centre retrospective analysis

Autoři: Alessandra D’Abramo aff001;  Luciana Lepore aff001;  Marco Iannetta aff001;  Saba Gebremeskel Tekle aff001;  Angela Corpolongo aff001;  Laura Scorzolini aff001;  Nazario Bevilacqua aff001;  Andrea Mariano aff001;  Maria Letizia Giancola aff001;  Antonella Vulcano aff001;  Micaela Maritti aff001;  Alessandro Agresta aff001;  Mario Antonini aff001;  Umberto D’Alessandro aff002;  Emanuele Nicastri aff001
Působiště autorů: National Institute for Infectious Diseases, IRCCS, Lazzaro Spallanzani, Rome, Italy aff001;  MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, Fajara, The Gambia aff002
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225135



This study aims to identify the risk factors for intensive care (IC) in severe malaria patients admitted to the “Lazzaro Spallanzani” National Institute for Infectious Diseases, Rome, Italy.


All patients with confirmed severe malaria and hospitalized between 2007 and 2015 were included in the analysis and stratified into two groups: those requiring IC and those who did not. Five prognostic malaria scores were estimated; clinical severity at IC unit admission was assessed using the Sequential Organ Failure Assessment and the quick-Sequential Organ Failure Assessment scores. Univariate and multivariate analysis were performed to assess factors independently associated to IC.


A total of 98 severe malaria patients were included; 10 of them required IC. There were no deaths or sequelae. Patients requiring IC had higher severity scores. At the multivariate analysis, only the number of World Health Organization criteria and the aspartate aminotransferase value were independently associated with the need of IC.


An early and accurate assessment of the severity score is essential for the management of severe malaria patients.

Klíčová slova:

Aminotransferases – Coma – Intensive care units – Malaria – Malarial parasites – Parasitic diseases – Plasmodium


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Článek vyšel v časopise


2019 Číslo 11