Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease


Autoři: Min Seok Kim aff001;  Han Yeong Jeong aff002;  Kwan Hyuk Cho aff003;  Seung Won Oh aff004;  Seong Jun Byun aff001;  Se Joon Woo aff001;  Hee Kyung Yang aff001;  Jeong Min Hwang aff001;  Kyu Hyung Park aff001;  Chi Kyung Kim aff006;  Sang Jun Park aff001
Působiště autorů: Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea aff001;  Department of Neurology, Seoul National University Hospital, Seoul, South Korea aff002;  Retina Center, Moon's Eye Clinic, Suwon, South Korea aff003;  Department of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea aff004;  School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea aff005;  Department of Neurology, Korea University Guro Hospital and College of Medicine, Korea University, Seoul, South Korea aff006
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0225322

Souhrn

We investigated the presence of cerebral small vessel disease (SVD) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) compared to control subjects without NAION to identify the association between NAION and cerebral SVD. We retrospectively reviewed the cases of 63 patients with NAION and 2749 control subjects without any neurologic and ocular diseases including NAION who underwent careful medical interviews, ophthalmic examinations, and magnetic resonance imaging (MRI) studies of the brain. We assessed and compared the degree of cerebral SVD on the MRIs. The patients with NAION presented with cerebral SVD more frequently than controls (68% versus 37%, respectively, p<0.001), which was also observed after adjusting for age, sex, comorbid conditions including hypertension, diabetes, and dyslipidemia, and smoking using the standardized mortality ratio (68% vs. 37%, p<0.001). A multivariate logistic regression analysis showed that the odds of cerebral SVD were 4.86 (95% CI, 2.10 to 11.24, p<0.001) times higher in patients with NAION than in the controls. We found that there was an association between cerebral SVD and NAION even after adjusting for age, sex, and medical histories. Clinicians should consider brain MRI scans in patients with NAION to prevent neurological impairment after cerebral SVD.

Klíčová slova:

Brain diseases – Cerebral ischemia – Hypertension – Magnetic resonance imaging – Neuroimaging – Optic neuropathy


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PLOS One


2019 Číslo 11