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Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease


Autoři: Min Seok Kim aff001;  Han Yeong Jeong aff002;  Kwan Hyuk Cho aff003;  Seung Won Oh aff004;  Seong Jun Byun aff001;  Se Joon Woo aff001;  Hee Kyung Yang aff001;  Jeong Min Hwang aff001;  Kyu Hyung Park aff001;  Chi Kyung Kim aff006;  Sang Jun Park aff001
Působiště autorů: Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea aff001;  Department of Neurology, Seoul National University Hospital, Seoul, South Korea aff002;  Retina Center, Moon's Eye Clinic, Suwon, South Korea aff003;  Department of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea aff004;  School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea aff005;  Department of Neurology, Korea University Guro Hospital and College of Medicine, Korea University, Seoul, South Korea aff006
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0225322

Souhrn

We investigated the presence of cerebral small vessel disease (SVD) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) compared to control subjects without NAION to identify the association between NAION and cerebral SVD. We retrospectively reviewed the cases of 63 patients with NAION and 2749 control subjects without any neurologic and ocular diseases including NAION who underwent careful medical interviews, ophthalmic examinations, and magnetic resonance imaging (MRI) studies of the brain. We assessed and compared the degree of cerebral SVD on the MRIs. The patients with NAION presented with cerebral SVD more frequently than controls (68% versus 37%, respectively, p<0.001), which was also observed after adjusting for age, sex, comorbid conditions including hypertension, diabetes, and dyslipidemia, and smoking using the standardized mortality ratio (68% vs. 37%, p<0.001). A multivariate logistic regression analysis showed that the odds of cerebral SVD were 4.86 (95% CI, 2.10 to 11.24, p<0.001) times higher in patients with NAION than in the controls. We found that there was an association between cerebral SVD and NAION even after adjusting for age, sex, and medical histories. Clinicians should consider brain MRI scans in patients with NAION to prevent neurological impairment after cerebral SVD.

Klíčová slova:

Brain diseases – Cerebral ischemia – Hypertension – Magnetic resonance imaging – Neuroimaging – Optic neuropathy


Zdroje

1. Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. The Lancet Neurology. 2010;9(7):689–701. Epub 2010/07/09. doi: 10.1016/S1474-4422(10)70104-6 20610345.

2. Wardlaw JM, Smith C, Dichgans M. Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. The Lancet Neurology. 2013;12(5):483–97. Epub 2013/04/23. doi: 10.1016/S1474-4422(13)70060-7 23602162; PubMed Central PMCID: PMC3836247.

3. van Norden AG, de Laat KF, Gons RA, van Uden IW, van Dijk EJ, van Oudheusden LJ, et al. Causes and consequences of cerebral small vessel disease. The RUN DMC study: a prospective cohort study. Study rationale and protocol. BMC Neurol. 2011;11:29. Epub 2011/03/02. doi: 10.1186/1471-2377-11-29 21356112; PubMed Central PMCID: PMC3053228.

4. Shi Y, Wardlaw JM. Update on cerebral small vessel disease: a dynamic whole-brain disease. Stroke Vasc Neurol. 2016;1(3):83–92. Epub 2017/09/30. doi: 10.1136/svn-2016-000035 28959468; PubMed Central PMCID: PMC5435198.

5. Hayreh SS, Joos KM, Podhajsky PA, Long CR. Systemic diseases associated with nonarteritic anterior ischemic optic neuropathy. American journal of ophthalmology. 1994;118(6):766–80. Epub 1994/12/15. doi: 10.1016/s0002-9394(14)72557-7 7977604.

6. Kerr NM, Chew SS, Danesh-Meyer HV. Non-arteritic anterior ischaemic optic neuropathy: a review and update. J Clin Neurosci. 2009;16(8):994–1000. Epub 2009/07/15. doi: 10.1016/j.jocn.2009.04.002 19596112.

7. Arnold AC. Pathogenesis of nonarteritic anterior ischemic optic neuropathy. J Neuroophthalmol. 2003;23(2):157–63. Epub 2003/06/05. 12782932.

8. Kaup M, Plange N, Arend KO, Remky A. Retrobulbar haemodynamics in non-arteritic anterior ischaemic optic neuropathy. Br J Ophthalmol. 2006;90(11):1350–3. Epub 2006/07/11. doi: 10.1136/bjo.2006.093559 16825277; PubMed Central PMCID: PMC1857495.

9. Arnold AC, Hepler RS. Fluorescein angiography in acute nonarteritic anterior ischemic optic neuropathy. American journal of ophthalmology. 1994;117(2):222–30. Epub 1994/02/15. doi: 10.1016/s0002-9394(14)73080-6 8116751.

10. Kim CK, Lee SH, Kim BJ, Ryu WS, Choi SH, Oh BH, et al. Elevated leukocyte count in asymptomatic subjects is associated with a higher risk for cerebral white matter lesions. Clinical neurology and neurosurgery. 2011;113(3):177–80. Epub 2010/11/26. doi: 10.1016/j.clineuro.2010.10.013 21094582.

11. Cho KH, Kim CK, Oh K, Oh SW, Park KH, Park SJ. Retinal Vein Occlusion as the Surrogate Marker for Premature Brain Aging in Young Patients. Investigative ophthalmology & visual science. 2017;58(6):Bio82–bio7. Epub 2017/05/20. doi: 10.1167/iovs.17-21413 28525562.

12. Cho KH, Kim CK, Woo SJ, Park KH, Park SJ. Cerebral Small Vessel Disease in Branch Retinal Artery Occlusion. Investigative ophthalmology & visual science. 2016;57(13):5818–24. Epub 2016/11/02. doi: 10.1167/iovs.16-20106 27802487.

13. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR American journal of roentgenology. 1987;149(2):351–6. Epub 1987/08/01. doi: 10.2214/ajr.149.2.351 3496763.

14. Braun H, Schreiber S. Microbleeds in cerebral small vessel disease. The Lancet Neurology. 2013;12(8):735–6. Epub 2013/07/23. doi: 10.1016/S1474-4422(13)70148-0 23867194.

15. Cordonnier C, Al-Shahi Salman R, Wardlaw J. Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain: a journal of neurology. 2007;130(Pt 8):1988–2003. Epub 2007/02/27. doi: 10.1093/brain/awl387 17322562.

16. Sacco S, Marini C, Totaro R, Russo T, Cerone D, Carolei A. A population-based study of the incidence and prognosis of lacunar stroke. Neurology. 2006;66(9):1335–8. Epub 2006/05/10. doi: 10.1212/01.wnl.0000210457.89798.0e 16682663.

17. Chen PH, Gao S, Wang YJ, Xu AD, Li YS, Wang D. Classifying Ischemic Stroke, from TOAST to CISS. CNS Neurosci Ther. 2012;18(6):452–6. Epub 2012/01/25. doi: 10.1111/j.1755-5949.2011.00292.x 22268862.

18. Lee YC, Wang JH, Huang TL, Tsai RK. Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective Cohort Study. American journal of ophthalmology. 2016;170:183–9. Epub 2016/08/16. doi: 10.1016/j.ajo.2016.08.006 27521605.

19. Hayreh SS. Increased Risk of Stroke in Patients With Nonarteritic Anterior Ischemic Optic Neuropathy: A Nationwide Retrospective Cohort Study. American journal of ophthalmology. 2017;175:213–4. Epub 2017/01/18. doi: 10.1016/j.ajo.2016.12.010 28093100.

20. Miller NR, Arnold AC. Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy. Eye (London, England). 2015;29(1):65–79. Epub 2014/07/06. doi: 10.1038/eye.2014.144 24993324; PubMed Central PMCID: PMC4289822.

21. Hasanreisoglu M, Robenshtok E, Ezrahi D, Stiebel-Kalish H. Do patients with non-arteritic ischemic optic neuritis have increased risk for cardiovascular and cerebrovascular events? Neuroepidemiology. 2013;40(3):220–4. Epub 2013/02/01. doi: 10.1159/000342155 23364133.

22. Argyropoulou MI, Zikou AK, Tzovara I, Nikas A, Blekas K, Margariti P, et al. Non-arteritic anterior ischaemic optic neuropathy: evaluation of the brain and optic pathway by conventional MRI and magnetisation transfer imaging. Eur Radiol. 2007;17(7):1669–74. Epub 2006/11/30. doi: 10.1007/s00330-006-0506-9 17131125.

23. Arnold AC, Hepler RS, Hamilton DR, Lufkin RB. Magnetic resonance imaging of the brain in nonarteritic ischemic optic neuropathy. J Neuroophthalmol. 1995;15(3):158–60. Epub 1995/09/01. 8574360.

24. Fanning JP, Wesley AJ, Wong AA, Fraser JF. Emerging spectra of silent brain infarction. Stroke. 2014;45(11):3461–71. Epub 2014/10/09. doi: 10.1161/STROKEAHA.114.005919 25293663.

25. Greenberg SM, Vernooij MW, Cordonnier C, Viswanathan A, Al-Shahi Salman R, Warach S, et al. Cerebral microbleeds: a guide to detection and interpretation. The Lancet Neurology. 2009;8(2):165–74. Epub 2009/01/24. doi: 10.1016/S1474-4422(09)70013-4 19161908; PubMed Central PMCID: PMC3414436.


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