Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011–2012

Autoři: Qi Yao aff001;  Ge Zhou aff002;  Meilin Xu aff003;  Jianguo Dai aff001;  Ziwei Qian aff001;  Zijing Cai aff001;  Luyao Zhang aff001;  Yong Tan aff002;  Rongkui Hu aff002
Působiště autorů: Department of Pathology and Pathophysiology, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China aff001;  Department of Reproductive Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu Province, China aff002;  Medical department life science China, GE healthcare China, Beijing, China aff003
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
doi: 10.1371/journal.pone.0224892


Environmental exposure to metals is ubiquitous, but its relation to androgen hormone levels is not well understood, especially in children and adolescents. This study aimed to explore the relationship between blood metal concentrations (lead, cadmium, total mercury, selenium, and manganese) and serum total testosterone (TT) levels in 6–19-year-old children and adolescents in the National Health and Nutrition Examination Survey (NHANES) 2011–2012. Weighted multivariable linear regression models using NHANES sampling weights were employed to evaluate the association between log-transformed serum TT and each metal categories in male and female children (age 6-11years) and adolescents (age 12–19 years). We established that blood cadmium and manganese levels were associated with significantly higher serum TT levels in the female adolescents. Additionally, the blood selenium levels in male adolescents were related to significantly higher serum TT. No significant associations between blood lead or total mercury levels and TT were observed in children or adolescents of either sex. These findings suggest that environmental exposure to certain metals could affect serum TT levels in adolescents, which might have important implications for the health of adolescents. Further research is required to confirm and extend our present findings.

Klíčová slova:

Adolescents – Blood – Cadmium – Manganese – Metallic lead – Selenium – Testosterone – Metallic mercury


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