The Shapley value for a fair division of group discounts for coordinating cooling loads
Authors:
Sasan Maleki aff001; Talal Rahwan aff002; Siddhartha Ghosh aff003; Areej Malibari aff004; Daniyal Alghazzawi aff005; Alex Rogers aff006; Hamid Beigy aff001; Nicholas R. Jennings aff007
Authors place of work:
Department of Computer Engineering, Sharif University of Technology, Tehran, Iran
aff001; Computer Science, New York University Abu Dhabi, Abu Dhabi, UAE
aff002; Electronics and Computer Science, University of Southampton, Southampton, United Kingdom
aff003; Computer Science Department, King Abdulaziz University, Jeddah, Saudi Arabia
aff004; Information Systems Department, King Abdulaziz University, Jeddah, Saudi Arabia
aff005; Department of Computer Science, Oxford University, Oxford, United Kingdom
aff006; Department of Computing, Imperial College London, Oxford, United Kingdom
aff007
Published in the journal:
PLoS ONE 15(1)
Category:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0227049
Summary
We consider a demand response program in which a block of apartments receive a discount from their electricity supplier if they ensure that their aggregate load from air conditioning does not exceed a predetermined threshold. The goal of the participants is to obtain the discount, while ensuring that their individual temperature preferences are also satisfied. As such, the apartments need to collectively optimise their use of air conditioning so as to satisfy these constraints and minimise their costs. Given an optimal cooling profile that secures the discount, the problem that the apartments face then is to divide the total discounted cost in a fair way. To achieve this, we take a coalitional game approach and propose the use of the Shapley value from cooperative game theory, which is the normative payoff division mechanism that offers a unique set of desirable fairness properties. However, applying the Shapley value in this setting presents a novel computational challenge. This is because its calculation requires, as input, the cost of every subset of apartments, which means solving an exponential number of collective optimisations, each of which is a computationally intensive problem. To address this, we propose solving the optimisation problem of each subset suboptimally, to allow for acceptable solutions that require less computation. We show that, due to the linearity property of the Shapley value, if suboptimal costs are used rather than optimal ones, the division of the discount will be fair in the following sense: each apartment is fairly “rewarded” for its contribution to the optimal cost and, at the same time, is fairly “penalised” for its contribution to the discrepancy between the suboptimal and the optimal costs. Importantly, this is achieved without requiring the optimal solutions.
Keywords:
Algorithms – Optimization – memory – Games – Electricity – Conditioned response – Payment – Game theory
Introduction
The transition to a smart electricity grid presents one of the greatest engineering challenges of this century, as countries face dwindling non-renewable energy sources and work to minimise the adverse effects of greenhouse gas emissions [1]. The Smart Grid represents a modern vision of a dynamic electricity grid, where the delivery, monitoring, and control of power are fully automated [2]. Currently, due to the high costs of upgrading equipment, it is often more economically viable for countries to create smart grids within the limits of the existing infrastructure, and pave way for the integration of renewable sources. However, this places a burden on conventional suppliers with ageing equipment to better manage supply and demand such that not only is the balance maintained at all times, but also peak demand is reduced.
Peaks in consumption are a consequence of unregulated demand. Meeting peaks needs large generation capacities which are only in use during peak periods. This is a significant inefficiency from a technical and financial point of view. This problem can be addressed through demand response programs by distributing peak loads throughout the day. To encourage consumers, financial incentives must be given, so that they shift their loads to off-peak periods. Policies that enforce such user behaviour are based on dynamic pricing which take into account changes in demand. This is in contrast to static pricing, such as flat tariffs, which offer electricity at fixed rates, regardless of the load.
Researchers divide electricity tariffs into the following categories: flat, block rate, seasonal, time of use, superpeak time of use, critical peak, variable peak, real-time, and peak-time rebates [3–5]. Under flat tariffs, prices remain fixed even with changes in demand. Block rate tariffs offer tier based pricing, where higher levels of consumption are charged at higher rates. Seasonal rates change from one season to another, to reflect increase or decrease in demand due to the time of year. Time of use, superpeak time of use, critical peak and variable peak charge users based on pre-declared rates that vary depending on the time of day. They are generally designed such that prices are high during peak hours and low during off-peak hours, with the difference being the duration and start of peak hours. Real-time tariffs offer prices that are adjusted every few minutes to the real cost of generation and delivery. Finally, peak time rebate schemes provide rebates for consuming below a predetermined threshold during peak hours.
Against this background, we design a demand response program whereby a block of apartments are rewarded for coordinating their cooling loads. More specifically, in order to encourage consumers to use less energy for air conditioning, which constitutes a significant amount of electricity consumption in warm-climate countries [6, 7], the electricity supplier offers a discount scheme similar to peak time rebate tariffs, but for a group of apartments. If the aggregate cooling load of all apartments in a block that sign up to the scheme does not exceed a certain threshold, they will be offered a discounted price for the entire day. To achieve the discount, the apartments coordinate and optimise their loads collectively, while also ensuring that their individual temperature preferences are met. Each householder specifies their preference in terms of deviations of the internal temperature from a setpoint temperature over a period of the day during which comfort is desired. Given a coalition of apartments, one can formulate a binary integer program so as to find the optimal cooling plan of each member, such that all temperature constraints as well as the load threshold are all satisfied. A cooling plan determines the periods of time when each apartment is allowed to turn on their air conditioning, which in turn, determines the cost of individual apartments.
Once the cooling plans that secure the discount are determined, the primary question that arises is how the apartments should divide the discount among themselves. Since the apartments need to cooperate together to get the discount, it is important that the way the discount is divided prevents abuse. For instance, it is possible that some apartments act as free-riders [8, 9]. That is, some apartments may not cooperate as much but reap the benefit of the joint effort at the cost of other apartments. Therefore, our aim is to put forward a division mechanism that is fair to all participants in the program. The most straightforward solutions that may come to mind are perhaps an equal division, or one proportional to consumptions. The former is obviously not necessarily fair, and the latter simply overlooks the complex interdependencies between apartments that actually result in the desirable coordination of loads. Moreover, as we discuss later, the thermal characteristics of apartments such as how well they are insulated, and how strict their preferences are, have a direct relationship with their ability to shift their loads. Therefore, the division must ensure that each apartment receives a share of the discount that corresponds to how much they have actually contributed to meeting the threshold and obtaining the discount.
Given this problem and its cooperative nature, we first propose that the apartments in the program are modelled as agents that form a coalition with the common goal of coordinating their cooling loads. This allows us to apply methods from cooperative game theory that will enable us to appropriately distribute the payoff of the game, which we define as the total cost of the grand coalition (i.e., the coalition that consists of all agents).
There are extensive studies in the smart grid domain on using cooperative game theory in this context [10–14]. The majority of payoff distribution concepts in the literature are concerned with some sort of stability of coalitions. A well known such concept is called the core, which is a set of distributions that satisfy an exponential number of certain constraints [15]. If a payoff distribution is a member of the core it guarantees that no subgroups of agents can be better off by breaking away and forming a different coalition. The drawback of the core is that, in the general case, it does not always exist and is difficult to compute. In fact, for several well studied problems it is co-NP-complete to even check whether a payoff distribution is a member of the core [16, 17]. Another stability concept, called the bargaining, deals with the dissatisfaction of agents with the share of payoff they receive. Suppose that an agent that is allocated a share of the payoff is unsatisfied with it. It can make an objection to it by requesting some part of the share of a particular agent. If that agent does not challenge this request, it is called a justified objection. The set of payoff distributions in which no agent has a justified objection against any other agent is the bargaining set and is always a superset of the core [18]. A somewhat similar concept is the kernel with weaker stability constraints than the core. The idea is that agents compare their strength with one another in terms of how much more they can gain by forming a new coalition. If their strengths differ, stronger agents can threaten to leave, unless they receive a higher payoff that balances the strengths [15].
In addition to the stability solution concepts, the Shapley value is a widely celebrated method in the literature that focuses on fairness of payoff distributions [19]. It satisfies a number of desirable fairness axioms (see Section cooperative game theory definitions), and is the only payoff division that does so. The Shapley value is based on the idea that the payoff of the game should be divided such that each agent’s share is proportional to its contribution to the payoff. This characteristic is particularly useful in our problem, given that we would like to divide the discount based on how much each apartment has contributed to it. Therefore, we use the Shapley value to divide the total cost of cooling all apartments. As we will explain later, this then results in a fair division of the discount.
However, the use of Shapley value in our problem poses two computational challenges: (i) the time complexity of the Shapley value itself, which is exponential in the number of agents, and (ii) solving an exponential number of binary integer programs, each being an NP-hard problem, in order to find the value (i.e., consumption cost) of every possible coalition. To address the former issue, several algorithms have been proposed to approximate, rather than calculate, the Shapley value [20–24]. Most of these approximations work by considering only a sample of coalition values, thus avoiding the need to consider an exponential number of such values. However, to obtain a reasonable bound on the approximation, the sample would often consist of tens of thousands (or more) of coalition values. In our setting, even a single coalition value can be hard to compute. In such a case, sampling techniques will fail, and a fundamentally different approach is needed in order to tackle the computational challenge. As such, we focus on mitigating the second issue, by assuming that coalitions are computationally bounded rational. That is, a coalition would internalise its limited computational resources when making decisions. This is opposite to most typical scenarios where agents are assumed to be perfectly rational (i.e., they are able to maximise their utility), which may not be always possible due to the limited computational resources of agents.
In the demand response problem stated above, we trade off optimality for the feasibility of dividing the total cost in a fair way, we model coalitions as computationally bounded rational. That is, due to limited computational resources, the rational value of each coalition (i.e., the optimal solution to the coalition’s load optimisation problem) cannot be computed in a reasonable time. More specifically, building upon the bounded rationality model proposed by Sandholm and Lesser [25] we argue that, given a suboptimal value for each coalition, it is still possible to divide the discount in a fair way. Our proposition leverages the additivity axiom [19], whereby the Shapley value of a game can be represented as the sum of the Shapley values of some alternative games (see section shapley value of bounded rational agents). Based on this, we represent the Shapley value of the game where every coalition is assigned its rational value as the sum of the Shapley values of two games:
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The game where the value of any coalition is its bounded rational value—the total consumption of the coalition given the best suboptimal solution found to the load optimisation problem.
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The game where the value of any coalition is its rationality discrepancy (i.e., the difference between its rational and bounded rational values).
Importantly, the bounded rational coalition values are possible to calculate, while using the limited computational resources available the rational values and the rationality discrepancy are not. As such, we can only compute the Shapley value of the game with bounded rational coalition values. We call this the bounded rational Shapley value. We argue that this payoff division scheme is fair in that it produces a payoff distribution that results from the following procedure (which is impossible to carry out given the available limited resources):
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Step 1: Divide the rational value of the grand coalition (despite the fact that we do not know it) “fairly” among the agents, i.e., in a way that meets Shapley’s axioms. Intuitively, the share of each agent can be thought of as a reward for its contribution to the rational value.
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Step 2: Divide the rationality discrepancy of the grand coalition (which again is unknown) fairly among the agents, in a way that meets Shapley’s axioms. Intuitively, each share can be thought of as a penalty for contributing to the failure of finding the rational value in reasonable time. For instance, if the presence of an agent in any coalition consistently increases the rational discrepancy (e.g., due to the agent’s strict constraints which increase the time required to compute the rational value), then this agent will be penalised. Note that the penalty may be negative if coalition values represent a cost.
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Step 3: Assign to each agent its fair reward minus its fair penalty.
Given this division mechanism, we introduce two greedy algorithms for optimising the cooling plan of apartments individually and collectively. These algorithms will help us find a reasonably good (but not necessarily optimal) solution in a timely manner, and as we explain later, these algorithms have useful features that we exploit to significantly expedite the optimisation of coalition loads. In more detail, the first algorithm incrementally finds intervals in a given day in which switching on the air conditioner results in the largest reduction of the discrepancy between householder’s preferences and the estimated temperature during the comfort period. The second algorithm optimises the load of a coalition of apartments (subject to the predetermined threshold and individual temperature preferences) by shifting the load of apartments that are more flexible in terms of their preferences. This algorithm exploits the fact that the more flexible an apartment is, the easier its preferences are satisfied. Using these two algorithms, we can identify a suboptimal coordination of loads (leading to a potentially lower saving from the discount compared to the optimal solution), while satisfying the householders’ temperature preferences. Then, our bounded rationality proposition establishes that, it is possible to obtain a fair division of the discount using the Shapley value.
As we mentioned earlier, the bounded rational Shapley value requires a suboptimal value for every coalition. To obtain this value, we use the above greedy algorithms to determine the minimum cost of the coalition when they coordinate their loads. However, instead of running the algorithms over and over for every coalition, we show that this process can be carried out much more efficiently using a dedicated dynamic programming algorithm. This is because the information accrued from the optimised load of a coalition can be re-used in optimising the load of some other coalitions.
Finally, our experimental results evaluate how the costs incurred by an apartment vary, as its cooling preferences are changed, on a single day. We compare the costs that an apartment would be charged for its consumption in four different cases: (i) when the apartment does not sign up to the discount scheme and optimises its load independently, (ii) when the apartment optimises its load as a member of the coalition and and benefits from the discount, but only its consumption in the grand coalition is considered (unlike the Shapley value which considers all subsets of the grand coalition), (iii) when the apartment optimises its load as a member of the coalition and each apartment receives an equal share of the total saving from the discount (the difference between the payment of the grand coalition at the discounted and normal rates is equally divided and deducted from the payment of each apartment), and (iv) when the apartment optimises its load as a member of the coalition and receives its bounded rational Shapley value. The results show that with higher setpoint temperatures the payments drop, with higher rates of thermal leakage (poorer insulation) they increase, and with higher tolerances of setpoint deviation the payments decrease.
In summary, our main technical contribution in this paper includes: (i) exploiting an often less noted property of the Shapley value to extend it to games with bounded rationality, (ii) designing a demand response program to help mitigate peaks caused by cooling loads, (iii) designing two greedy algorithms to coordinate the loads of individual and groups of apartments to cap aggregate loads and avoid peaks, and (iv) developing a dynamic program for the greedy algorithms to speed up calculation of the Shapley value even further.
The rest of this article is organised as follows. Section cooperative game theory definitions introduces cooperative game theory definitions and provides a background on the Shapley value. Section coordinating cooling loads discount scheme formalises the discount scheme as a cooperative game. Sections thermal dynamics of apartments and user comfort model present formal models of thermal dynamics of apartments and the cooling preferences of users. In sections independent optimisation of loads and collective optimisation of loads we formalise the problem of optimising cooling loads of apartments individually and as coalitions. Section an example with three apartments provides an example of optimising the load of a block consisting of three apartments. In section computationally efficient optimisation of loads, we provide two greedy algorithms for efficient optimisation of loads. In section calculating payments using the Shapley value, we present the bounded rationality model and provide a dynamic programming algorithm to calculate the Shapley value efficiently. Section evaluation of the payments of apartments presents an experimental evaluation of our model and algorithms. Finally, section conclusions and future work concludes the article and states potential directions for future work.
Cooperative game theory definitions
In this section, we introduce cooperative game theory notations and definitions, borrowed from [15], which we will refer to throughout the paper. Given a set of agents, N = {1, …, n}, a coalition C is a subset of N. The coalition N is referred to as the grand coalition. The value or worth of a coalition is expressed by a characteristic function, v, which maps each subset of N to a real number, i.e., v : 2 N ↦ R. A cooperative characteristic function game is specified using a pair, (N, v), consisting of the set of agents N and a characteristic function v. A payoff distribution is a vector x = [x1…xn], where xi represents how much of the value of the coalition should be allocated to agent i. A game is super-additive if the value of every coalition is at least equal to the sum of the values of any two disjoint subsets of that coalition, i.e., ∀C, D ⊆ N;C ∩ D = ∅ ⇒ v(C ∪ D) ≥ v(C) + v(D).
The Shapley value
In order for the agents to evaluate their prospects of playing a superadditive game, Shapley proposed a value [19], whereby agents receive a payoff equal to their value. More specifically, Shapley argued that a coalition of n agents can form in n! different ways (considering all the possible joining orders), and that in each order, as an agent steps in the coalition, it makes a marginal contribution to the agents who joined before it. The marginal contribution of agent i to coalition C is the difference in C’s value that is due to i joining C, i.e., it is equal to v(C ∪ {i}) − v(C). Shapley argued that the fair way to divide the payoff of the grand coalition is to allocate each agent its average marginal contribution in all joining orders. This solution concept is known as the Shapley value. More formally, the Shapley value of agent i in game (N, v) is calculated as:
The Shapley value satisfies the axioms of symmetry, efficiency, null-player, and additivity. Symmetry states that if two agents make the same marginal contributions to any coalition, their values are equal. Efficiency implies that the value of the grand coalition is fully divided. The null-player axiom states that any player whose marginal contribution to every coalition is zero, would have a value of zero. Finally, the additivity axiom states that if a new game is obtained by adding the characteristic function of two different games with the same set of agents, the value of an agent in the new game is equal to the sum of its values in the two games. More formally:
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Symmetry: ∀i, j ∈ N ∀C ⊆ N\{i, j} v(C ∪ {i}) = v(C ∪ {j}) ⇔ xi = xj;
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Efficiency: ∑i∈N xi = v(N);
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Null player: ∀i ∈ N∀C ⊆ Nv(C ∪ {i}) = v(C) ⇔ xi = 0;
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Additivity: Let the game (N, v) be the sum of two other games, namely (N, v1) and (N, v2), i.e., ∀C ⊆ N, v(C) = v1(C) + v2(C). Furthermore, let x, x1, x2 denote the payoff distributions of (N, v), (N, v1), and (N, v2), respectively. Then, the following holds: ∀ i ∈ N , x i = x i 1 + x i 2.
As is common in the literature, we say that a division of the grand coalition value is fair if it satisfies the above axioms. In fact, the Shapley value is the only value that satisfies them [19]. The Shapley value is also individual rationality in superadditive games (∀i ∈ N;ϕ[i, v] ≥ v({i})).
Coordinating cooling loads discount scheme
Consider a set of n apartments in a block, indexed by i ∈ N ≔ {1, 2, …, n}. Denote by l i t the cooling load of apartment i at time t (in kW), and denote by p the price at which every kWh is charged. In order to encourage consumers to use less energy for cooling, which constitutes a significant amount of the domestic load in warm-climate countries [6, 7], the electricity supplier offers a discount scheme. Specifically, each apartment in a block is offered a binary option of signing up to the scheme or not. Let K = {1, …, k} represent an entire day divided into k equal-length time slots, and l i = [ l i 1 l i 2 … l i k ] represent the vector of cooling loads of apartment i in all time slots in K. If at any point in time throughout the day, the cooling load of the block is not more than ψ kW, i.e., ∀ t ∈ K ; ∑ i ∈ N l i t ≤ ψ, then those apartment that have signed up are charged at f < p per kWh of usage, and the rest are charged at p per kWh. The cooling load of an apartment i at time t is:
Since the discount is offered only when the whole block’s load is below ψ, the price at which a coalition C ⊆ N is charged is also influenced by the behaviour of the apartments in the same block that have not subscribed to the scheme, i.e., N∖C. In cooperative game theory terms, the value of the coalition in this case is influenced by the agents outside it. If those apartments could form other coalitions, then we would have a game with externalities (also known as a partition function game), which is a game where the value of a coalition depends on how other agents are structured [26]. However, since the discount scheme does not cater for other arrangements, the apartments that do not sign up cannot form any other coalitions. Therefore, we have a special case of externalities where the agents outside the coalition can only be structured as singletons, and the game is reduced to a characteristic function game.
Naturally, each apartment, whether signed up to the scheme or not, would want to optimise its use of the AC such that its internal temperature preferences are satisfied with minimal electricity consumption. In order to secure the discount, those apartments that do sign up need to coordinate their loads so that the aggregate load will be kept below the threshold and their internal temperatures remain as they individually deem comfortable. Clearly, if an apartment decides not to sign up, it can only optimise its load independently, without any coordination with other apartments.
Assuming that some of the n apartments form a coalition, C, and sign up to the scheme, the aggregate cooling load of all n apartments (in kW) at time t is given by:
Observe that a coalition can meet the threshold mostly through running its members’ ACs for longer periods (e.g., during off-peak times). Therefore, meeting the threshold potentially requires extra consumption of electricity, which would incur a higher cost. In theory, it is possible that the extra consumption becomes so high that even at the discounted rate the cost becomes higher than the sum of independent costs. This outcome is clearly not desirable, Therefore, if the discounted cost turns out to be higher, or if a feasible solution to the collective optimisation cannot be found, then the apartments optimise their loads independently. Based on this, we can write the optimal consumption of a coalition (measured in kWh) as:
With respect to the above characteristic function, it is clear that the apartments will not be worse off by joining the grand coalition. Therefore, it would be in the interest of all apartments to sign up and benefit from the potential discount.
In the next section, we explain how the cooling load of each apartment can be optimised so as to minimise the electricity consumption and satisfy its temperature preferences. We first present the model of thermal dynamics of an apartment that governs the evolution of its internal temperature.
Thermal dynamics of apartments
We use a standard thermal model in which heat is assumed to enter an apartment (by thermal conduction) at a rate that is proportional to the temperature difference between the cold air inside and the hot air outside [27–29]. This model also incorporates the thermal capacity of the building structure, since through experimentation on real data collected from apartments in Jeddah, Saudi Arabia we found that this model best explains the observed data. This thermal model is represented as a set of coupled difference equations as per:
Eq (6) is the discrete equivalent to a set of coupled differential equations which has been used previously to model data collected from real buildings [30]. In this model, an envelope is introduced to act as an additional thermal mass to minimise internal temperature changes due to extremes of temperature outside. Given historical observations of T i n t t and T e x t t, and the times during which the AC was on (which we collected from a number of apartments in Jeddah, Saudi Arabia) we predicted the evolution of the internal temperature, T ¯ i n t t. The error in this prediction is given by ∑ t ∈ K ( T ¯ i n t t - T i n t t ) 2. Consequently, the best estimates of the parameters are those that minimise this error and can be learned through recursive least squares [31].
User comfort model
We outline a few assumptions that underpin the operation of the cooling system in an apartment. We assume that an apartment has a central air conditioning driven by a heat pump that transfers heat from a lower temperature heat source (the apartment) into a higher temperature heat sink (external ambient air). This system is connected to a thermostat within the apartment, where a user can set a desired temperature to be maintained, i.e., the setpoint temperature, denoted as Tset (°C).
The user in each apartment can specify the time interval during which “comfort” is desired. That is, the time slots when the user wants the internal temperature to be maintained at, or close to, Tset. We refer to this interval as the comfort period, and define it as: H = {t ∈ K|CST ≤ t ≤ CET}, where CST ∈ K and CET ∈ K are the comfort start time and comfort end time, respectively. A tolerance level is specified by the user to limit deviations of the internal temperature from the setpoint temperature, during the comfort period. We denote this tolerance by θ ∈ R + (°C). Note that lower values of Tset suggest that a user feels more comfortable at lower temperatures, and smaller values of θ indicate that a user is sensitive to deviations of the temperature from the setpoint.
Intrinsically, the above preferences have an impact on the cooling load (Eq (3)). Fig 1 shows the effect of varying Tset, θ and γ on the temperature and cooling profiles. The bottom of each subplot shows the cooling actions over the course of a day. As Tset is lowered, the amount of cooling required increases proportionately to achieve lower temperatures. As can be seen in the corresponding plots in Fig 1, more cooling is required when Tset = 21°C than internal temperature profile in an apartment when Tset equals 21°C Tset = 23°C. The total time when the AC is on is 52% less in the latter case. Similarly, when θ is small, a user is more sensitive to deviations of the internal temperature from Tset. Consequently, the AC is turned on for longer to ensure that the deviation of the internal temperature from Tset lies within the tolerance level, resulting in higher energy consumption. This is evident in Fig 1, where the θ is set to 0.6°C and 1.5°C. As can be seen, more cooling is required for a larger θ. The total time when the AC is on is 12% less in the former case. Furthermore, as per Eq (6), an apartment that is well-insulated will have a small γ value, whereas a leaky apartment will have a high value. This observation is of interest as more cooling is required to maintain a leaky apartment at a certain temperature. This effect is evident in Fig 1, where the value of γ used to generate the plots are 0.36 1/hr and 0.48 1/hr, respectively. The total amount of time when the AC is on is 24% more for γ = 0.48.
Independent optimisation of loads
Having introduced the comfort model, we describe how an apartment optimises its use of the AC so as to satisfy only its own comfort preferences. In summary, as we described in section user comfort model, the preferences of an apartment are: (i) the desired setpoint temperature, denoted by Tset, (ii) a tolerance level on the deviation of the internal temperature from the setpoint, denoted by θ ∈ R +, and (iii) the comfort start time (CST) and comfort end time (CET) which determine H—the set of time slots representing the comfort period. Based on these, we define an optimal cooling plan for apartment i to be a vector of cooling actions [η1 η2…ηk], that result in meeting the above preferences as well as the following requirements: (i) the overall energy consumption is minimised, i.e., all constraints are satisfied with the AC running in as few time slots as possible, (ii) the internal and envelope temperatures at the start and end of the day converge. Note that the latter requirement is to ensure that the cooling plan is optimised over an infinite horizon, which prevents erroneous solutions that minimise AC use in the short term, but require additional cooling later, as would be the case if a finite planning horizon were used. Given the above preferences and requirements, the optimal cooling load of an apartment throughout the day can be computed as per Eq (3) using η1, η2, …, ηk found by solving the following optimisation problem:
Observe that our formulation avoids the explicit trade-off between consumption and comfort within a single objective function, which is dependent on specifying appropriate weights for both objectives. This is because, in practice, there is no principled way to specify such weights [32].
Collective optimisation of loads
We now describe how a coalition of apartments, C, collectively optimise their cooling loads. Similar to the single apartment case, the user in each apartment in C specifies their individual cooling preferences. These include their desired setpoint temperature, Tset[i], their tolerance on the deviation of the internal temperature during the comfort period, θi, and their comfort start and end times which determine Hi. In finding an optimal cooling plan for the coalition, we introduce a key additional constraint, which ensures that at all times, the total load of all apartments in the coalition, plus the total load of the apartments who optimise their loads independently, is less than or equal to ψ. More formally, the vector of optimal cooling actions, [ η i 1 η i 2 … η i k ], for every apartment i ∈ C is given by the following optimisation problem:
If a feasible solution to the above optimisation did not exist, the apartments would optimise their loads individually as per Eq (7). Note that it is possible for an individual apartment in C to have a significant impact on the feasibility of C satisfying the threshold constraint. For instance, if Tset[i] is set to a particularly low temperature, or θi is particularly small, the corresponding energy consumption in that apartment will be greater, which in turn increases the likelihood of the aggregate load exceeding the threshold. As the individual apartments become more flexible and less stringent with their preferences, the aggregate cooling load, l N t, is more likely to satisfy the constraint on the threshold.
An example with three apartments
Having established the theoretical underpinnings of how cooling loads are independently and collectively optimised, we now illustrate how they work in practice through a simple example. Consider a 3-player game (N = {1, 2, 3}), where a block consists of three apartments. All three apartments agree to participate in the discount scheme. Apartment 1 desires that the temperature be maintained at 21°C (Tset[1] = 21°C) for 6 hours from CST = 10 : 00 to CET = 16 : 00, and is satisfied with wide swings of temperature (θ1 = 1.5°C). Apartment 2 desires the temperature to be at 22°C (Tset[1] = 22°C) for 8 hours from CST = 09 : 00 to CET = 17 : 00, and has very strict preferences over temperature (θ2 = 0.5°C). Apartment 3 too desires the temperature to be at 21°C (Tset [3] = 21°C) from CST = 10 : 00 to CET = 16 : 00, and is satisfied with wide swings of temperature (θ1 = 1.5°C).
We assume that the AC in each apartment operates on a 10-minute cycle, i.e., a cooling decision is made for each 10-minute interval in a day (Δt = 600s). As a result, K = [1, …, 144] and the decision variable is η i t, ∀t ∈ K. We also assume that the ACs in all three apartments are similar and consume at a rate of 3 kW when on, i.e. Pi = 3 kW. Hence, the total possible energy load of all three apartments if they optimise their loads independently is 9 kW. Now, when the apartments participate in the scheme, a threshold at 3 kW (i.e., a 2 3 reduction), is set on their total load.
We first consider the case where all 3 apartments optimise their cooling loads independently. The bottom of plots in Fig 2 show the individual cooling profiles of each apartment for a single day. Each profile is obtained by solving the optimisation problem in Eq (7) using CPLEX, to yield η i t (∀t ∈ K). Also shown in Fig 3 are the corresponding internal temperature profiles, which are estimated by iterating Eq (6) for each apartment, using the cooling actions, η i t as inputs. It is evident from the plot that the internal temperature is within the desired setpoint deviation tolerance at times when the users desire cooling. Also, this deviation is greater in Apartment 1 and 2, as they are less sensitive to large swings in temperature. Finally, the optimisation ensures that the temperature at the start and end of each day is the same, as required.
Next, we consider the case where all 3 apartments form a coalition and collectively optimise their loads to ensure that their aggregate load does not exceed the threshold. The bottom of plots in Fig 3 show the cooling profiles of each apartment for a single day. Each profile is obtained by solving the optimisation problem in Eq (8) using CPLEX, to yield η i t (∀t ∈ K), which in turn generate a temperature profile based on the thermal model as per Eq (6).
More importantly, as shown in Fig 4, the collective optimisation results in the aggregate never exceeding the threshold during the day, making the block eligible for the discount. This is not the case when optimised independently.
Since optimising the loads of the three apartments is tractable, we can readily divide the total cost of the apartments based on the Shapley value as per Eq (1b). We assume that the electricity cost is $0.15 per kWh when apartments optimise their cooling loads independently. As per the discount scheme, if they ensure that their aggregate load does not exceed 3 kW, then the electricity cost will be reduced to $0.08 per kWh.
When optimised collectively to keep the aggregate load below the threshold, Apartment 2’s preferences are so strict that a somewhat small change is only possible. However, Apartment 1 and Apartment 3 are able to shift their cooling loads to satisfy their preferences as well as the threshold constraint, but to do so, they have to run their AC earlier and longer. These are naturally reflected in the value of each coalition as shown in Table 1. As can be seen, all apartments would incur the same cost if they did not participate in the scheme. However, when they do participate, interestingly, Apartment 2’s share of the discount becomes slightly less than that of the other two. This is due to its stricter preferences that are harder to satisfy in the collective optimisation. Also note that the optimal loads of Apartment 1 and Apartment 3, who have identical preferences, are the same. Therefore, all of their marginal contributions (and their Shapley values, in turn) are equal. Based on the coalition values given in the table and the Shapley value formula (Eq 1b), the payments of apartments 1, 2 and 3, are $3.08, $3.20 and $3.08, respectively.
Computationally efficient optimisation of loads
In the simple example of three apartments, optimising the cooling loads did not require a considerable amount of computation, and calculating the Shapley value was easy. However, as more apartments are added to the game, satisfying the constraints takes considerably more time. Considering the fact that, in calculating the Shapley value, an exponential number of coalitions must be optimised, the time it takes to calculate the payoff of only a few agents can be very long. In order to overcome this, we next present two greedy algorithms, namely, iOPT and cOPT, for optimising the cooling load of the apartments independently and collectively. Due to the difficulty of finding the optimal solutions in reasonable time, we use these algorithms and trade off optimality for computation speed. Thus, we consider a feasible cooling plan given by these algorithms to be the best solution we can find given our limited computational resources, which may or may not coincide with the actual optimal solution. Given this, we call such a solution best-found.
Algorithm 1 Greedy Algorithm For Optimising Apartments Independently
function iOPT (Tset, θ, Text, Λ, maxIterations)
η ← []
for iteration = 1 to maxIterations do
bestTime ← −1
minDiscomfort ← ∞
maxDeviation ← 0
for t = 0 to k do
if t ∈ Λ then
continue
end if
ηtest ← η
η t e s t t ← 1
∀t ∈ K update T i n t t [ t e s t ] and T e n v t [ t e s t ] as per Eq (6)
Calculate ΔDtest
if ΔDtest < minDiscomfort then
bestTime ← t
minDiscomfort ← ΔDtest
end if
end for
if bestTime > −1 then
ηbestTime ← 1
∀t ∈ K update T i n t t and T e n v t
end if
end for
return maxDeviation ≤ θ
First, we explain the workings of iOPT, the pseudocode of which is presented in Algorithm 1. Using a heuristic, iOPT searches for a set of cooling actions that satisfy the constraints of an individual apartment as per Eq (7). This heuristic, which we call the discomfort of an apartment, represents the discrepancy between an apartment’s preferences (as outlined in section user comfort model) and the temperature profile resulting from a cooling plan found by the algorithm. More formally, the discomfort of apartment i, denoted by ΔDi, is the largest deviation of the internal temperature from the setpoint temperature during the comfort period. This is given as:
The algorithm incrementally finds the time slots where switching the AC on results in the largest discomfort reduction. Initially, the AC is off in all time slots (i.e., ∀ t ∈ K , η i t = 0), and is then switched on only if it results in a reduction of the discomfort. This way, in addition to searching for a feasible solution, the consumption is also minimised (as required in the optimisation problem in Eq (7)). However, as soon as the constraints of the apartment are satisfied, the algorithm will not seek to minimise the consumption further. Since this procedure is indepedent of the number of apartments, the time complexity of the algorithm is constant. To be more exact, it is a function of |K|2, which implies even with finer time resolutions the computation will increase very reasonably. Similarly, the space complexity of iOPT is independent of n, and is only a multiple of |K|, which is also constant.
Furthermore, recall that one of the constraints in Eq (7) is that the internal and envelope temperatures at the start and end of the day should converge (i.e., T i n t 1 = T i n t k and T e n v 1 = T e n v k). To ensure this, one can run Algorithm 1 repeatedly, and in each iteration calculate T i n t 1 based on T i n t k from the previous iteration. We have found through experiments that, this way, no more than 4 iterations are typically needed for the internal and envelope temperatures at the end of the day to be within 0.1°C of the start of the day. Moreover, if iOPT does not find a feasible solution, the algorithm will terminate after maxIterations iterations. Lastly, iOPT takes a set of time slots Λ as input, which, as we explain later, is used in cOPT to indicate the time slots in which the aggregate load is greater or equal to the threshold. When an apartment is optimised independently, this set is empty.
If iOPT finds a feasible solution for apartment i, it gives a vector of η i t values, based on which we calculate the best-found cooling load of the apartment when is independent of the coalition. This load is then used to calculate the consumption of apartment i as per Eq (4), based on which we obtain the bounded rational value of the singleton {i}, i.e., vBR({i}). Next, we describe the workings of cOPT, which optimises the cooling load of the members of a coalition. The pseudocode is given in Algorithm 2.
Algorithm 2 Algorithm For Optimising Apartments Collectively
function cOPT (C, N, ψ, Tset, θ, Text, maxIterations)
for all i ∈ N do
iOPT(Tset[i], θi, Text, ∅, maxIterations)
end for
if ∀ t ∈ K l N t ≤ ψ then
return true
end if
// C is sorted beforehand based on Eq (10)
for all i ∈ C do
Λ ← { t ∈ K | l N t ≥ ψ }
successfullyReOptimised← iOPT (Tset[i], θi, Text, Λ, maxIterations)
if successfullyReOptimised then
if ∀ t ∈ K l N t ≤ ψ then
return true
end if
else
Revert i to its individually optimised state
end if
end for
return false
Given a coalition, all member apartments are first independently optimised using iOPT. If by doing so the constraints of all apartments, as well as the threshold constraint are already satisfied, then the best-found cooling plan of the members of the coalition, in this case, is the same as when the apartments optimise their loads independently. However, if the threshold is not satisfied, it means that at least in one time slot there is congestion, i.e., the aggregate load is higher than the threshold. We denote the set of congested time slots by Λ, which is formally defined as: { t ∈ K | l N t ≥ ψ }. The objective of the algorithm is to decongest these time slots by re-optimising at least some of the apartments such that they do not run their ACs in these time slots. Re-optimising an apartment given a set of congested time slots means that after all apartments are initially independently optimised, the apartment in question is again optimised using iOPT, such that its AC is not turned on in any of the congested time slots. Obviously, those members of the coalition that are stringent with their temperature preferences may not be able to avoid the congested time slots. As such, the algorithm performs decongestion with respect to the flexibility of the load of the apartments. The idea is that the more flexible an apartment is, the more likely it can satisfy its constraints without having to run its AC in the congested time slots. Observe that the longer the comfort period is, the more cooling is needed. Furthermore, as we saw in Fig 1, the higher the tolerance on the setpoint temperature of an apartment is, the less cooling it requires, and thus, it can be considered more flexible than an apartment that has a lower tolerance. Based on these observations, we use the following ratio as a heuristic to determine the severity of the preferences of the apartments relative to one another:
Using the above heuristic, we initially sort the apartments in the coalition in ascending order, so that the least flexible apartment is dealt with first. Given a set of congested time slots, cOPT iteratively re-optimises the apartments using iOPT. In each iteration, the set of congested time slots, Λ, is computed anew. If Λ is not empty (i.e, the threshold constraint has not been satisfied yet), iOPT will be called again to optimise the apartment in the current iteration without being allowed to run its AC in the congested time slots. If the constraints of the apartment are successfully satisfied this way, the algorithm moves on to the next member, and repeats this procedure until the threshold is satisfied or all apartments have been re-optimised. In any iteration, if the constraints of the apartment are not successfully satisfied, its best-found cooling plan (as a member of the coalition) will be reverted to its independently optimised case. Similarly, if at the end of the process the threshold constraint is not satisfied, the best-found cooling plan of all apartments will be reverted to their independently optimised cases. Since cOPT deals with each member of C at most once, its time complexity is a linear function of |C|. With the average coalition size being (n + 1)/2, the time complexity complexity is O((n + 1)/2) in the average case. As for memory requirement, for each member of C, we do not need to store more than what iOPT requires. Therefore, the space complexity is again a linear function of |C|, which in the average case is O((n + 1)/2).
The effect of this collective coordination on individual apartments is that those that are more flexible turn out to lower their internal temperature ahead of their comfort period, so that they can avoid running their AC in the congested time slots. This process can potentially result in an incremental reduction of the congestions, until the threshold is eventually satisfied. While the end result may not be optimal, this ensures that joining the grand coalition will not make any member worse off in any case, making it rational for them to sign up to the discount scheme.
Calculating payments using the Shapley value
Recall from section coordinating cooling loads discount scheme that the value of a coalition is given by the sum of the consumption of its members, when they collectively optimise their loads. Furthermore, we explained how a coalition can optimise its cooling plan in a computationally efficient manner. Therefore, based on the best-found cooling plans, we can calculate the coalition values and in turn the Shapley value of apartments, which is what they must pay for their consumption. In the next subsection, we argue why using the Shapley value based on the best-found cooling plans still results in a fair division of the discounted total cost. We then explain how the Shapley value in this setting can be efficiently calculated.
Shapley value of bounded rational agents
A common assumption in cooperative game theory literature is that the characteristic function has a negligible computational cost, e.g., it can be done in constant time. However, in many real world problems, such as our discount scheme, and those considered in [33, 34], computing the value of a coalition C involves solving a hard optimisation problem. In our setting, v(C) is hard to compute optimally. As such, we will refer to v(C) as the rational value (rather than simply the value) of C. The corresponding bounded rational game of (N, v) is a new game, denoted by (N, vBR), where vBR(C) is the best-found solution to the cooling plan of C that is obtained given the available computational resources. We will refer to vBR(C) as the bounded rational value of coalition C.
Under the full rationality assumption, the rational value of every coalition is known, and thus, the value of the game can be fairly divided using the Shapley value. However, with bounded rational agents, the rational values of the coalitions are unknown, and it is not immediately clear how a fair division of the value of the game can be obtained. Next, we propose one way to deal with this issue.
We assume that it is possible to find a suboptimal solution to the cooling plan of every coalition in reasonable time (i.e., the bounded rational value). We also assume that an equal amount of computational resource is dedicated to calculating the value of each coalition. Note that this assumption does not imply that the cost of finding the bounded rational value of all coalitions is the same. Furthermore, in order to treat all agents without discrimination, we assume that the algorithm by which the coalition values are found is the same for all coalitions.
Proposition 1. Given a game, (N, v), by allocating to each agent its Shapley value of the corresponding bounded rational game, (N, vBR), a payoff division is obtained that is fair in the following sense: (i) it fairly allocates each agent a payoff for its contribution to the total value of the game, i.e., v(N), (ii) each agent is fairly penalised for contributing to v(N) not being equal to vBR(N).
Let us introduce some additional notation to better understand the intuition behind this proposition. For every C ⊆ N, let vRD(C) denote the rationality discrepancy of coalition C, defined as the difference between the rational and bounded rational values of C. This can be viewed as a penalty that C as a whole has to pay due to its members’ lack of full rationality. More formally,
From Eq (11) it is evident that the game (N, v) can be written as the sum of (N, vBR) and (N, vRD). Therefore, based on the additivity axiom of the Shapley value, the following holds:
The sign in the above equation is negative or positive depending on whether v represents profit or cost, respectively. While both ϕ[i, v] and ϕ[i, vRD] are unknown by assumption, it is possible to calculate ϕ[i, vBR]. Importantly, this is in fact agent i’s fair share of the total cost of the grand coalition (i.e., v(N)), which also factors in agent i’s fair share of the penalty due to its bounded rationality.
The implication of Proposition 1 is that when agents cannot find an optimal solution, they can still expect to receive a fair share of vBR(N). This is because ϕ[i, vBR] also satisfies the Shapley value axioms, and is the only value that does so.
Intuitively, the more rational a coalition’s members are (i.e., more computational resources are used to optimise their cooling loads), the smaller the rationality discrepancy of the coalition is. Therefore, if the agents in a game were fully rational, they would be able to diminish their penalty completely (i.e., vRD(C) would be zero), and thus, ϕ[i, vBR] would become exactly equal to ϕ[i, v] for all agents.
To illustrate Proposition 1 further, consider an example of a block consisting of three apartments that participate in the discount scheme. Through optimal coordination of their cooling loads, they are able to cap their aggregate load and achieve a discount of 50% per unit of electricity consumed. However, suppose that due to the thermal characteristics of the apartments and their temperature preferences, finding an optimal coordination in practice is so complex that they can manage to meet the threshold requirement, but can only approximately minimise their consumptions. As a result, the cost associated with coalitions is potentially higher than what would be possible if coordinating their loads were easier or more computational resources were available.
Now, to highlight the significance of Proposition 1, let us assume that Apartment 1 and 2 are identical in every respect, except that Apartment 1 is less flexible with its temperature preferences. Consequently, if computational resources were unlimited and its load were optimally coordinated with others, its cooling plan and temperature profile would be identical to those of Apartment 2. However, since in practice computational resources are limited, Apartment 1’s stricter preferences require more computation to satisfy compared to Apartment 2. A set of example values that describe this scenario, and the corresponding Shapley values are shown in Table 2.
It is immediately clear that for all three apartments, Eq (12) holds. Note that when agents are rational, Apartment 1 and 2 have identical values and marginal contributions, and therefore equal Shapley values. However, when they are bounded rational, the higher complexity of coordinating Apartment 1’s load with others means that Apartment 2 deserves a lower cost than Apartment 1, which is reflected by their bounded rational Shapley values. Proposition 1 establishes the fairness of this division. Apartment 1 and 2 are both fairly allocated a cost for contributing to the cost of any coalition in which they are involved. Simultaneously, they are individually penalised proportional to their contribution to the discrepancy between vBR and v in any coalition in which they are involved. Moreover, Apartment 3, which has a higher individual cost than the other two in the rational case, still receives a portion of the discount when is bounded rational because it is able to coordinate its load when it is in a coalition with others.
Efficient implementation of the Shapley value
Calculating the bounded rational Shapley value of all agents using the standard formula, i.e., Eq (1b), requires computing the value of each coalition multiple times. This is because in the standard formula, for each agent, one must iterate through all C ⊆ N, and in doing so v(C) is used multiple times. Therefore, the time complexity of computing the Shapley value for all agents using the standard implementation is O(n × 2n × O(v)). This is not an issue in games where the characteristic function does not have a considerable computational complexity. However, given the bounded rationality assumption, computing v(C) more than once is highly costly. One trivial way to overcome this is to store all coalition values in memory, but doing so requires exponential memory space. Alternatively, instead of iterating through agents, we can iterate through all subsets of N, and in each iteration, we calculate the value of the subset. Then, we use this to update all marginal contributions of all agents that require that value. This ensures that the value of any given coalition is computed exactly once. This results in a time complexity of O(2n × O(v)), at no additional memory space cost. Next, we explain this idea in more detail.
First, observe that calculating the marginal contribution of agent i to a coalition D requires the following two terms: v(D ∪ {i}) and v(D), which represent the value of the coalition with and without the agent, respectively. More formally:
For each C ⊆ N, we can use v(C) to calculate the “with agent” and “without agent” terms in marginal contributions of two groups of agents:
-
∀i ∈ C since ∃D ⊂ C s.t. D ∪ {i} = C; v(C) corresponds to the “with agent” term.
-
∀i ∈ N∖C; v(C) corresponds to the “without agent” term.
Furthermore, recall that in Eq (1b), each marginal contribution is multiplied by a weight given by Eq (2). If we multiply each of the two terms above by its corresponding weight, they become ω(n, |D|)v(D ∪ {i}) and −ω(n, |D|)v(D). Therefore, to calculate the Shapley value, we sum all coalition values multiplied by their corresponding weight just as in Eq (1b):
-
For every non-empty coalition C ⊂ N, v(C) is multiplied by ω(n, |C| − 1) for every i ∈ N∖C, and multiplied by −ω(n, |C|) for every i ∈ C, v(C).
-
For C = ∅, v(C), which only represents the value of a coalition without the agent, is multiplied by −ω(n, 0).
-
For C = N, v(C), which only represents the value of a coalition with the agent, is multiplied by ω(n, n − 1).
The pseudocode of this process is presented in Algorithm 3.
Algorithm 3 Efficient Implementation of the Shapley Value
function ShapleyValue(N, v)
ϕ ← [];
∀i ∈ N, ϕ[i, v] ← 0;
for all C ⊆ N do
weightWithAgent ← ω(|N|, max(|C| − 1, 0));
weightWithoutAgent ← −ω(|N|, min(|C|, |N| − 1));
for all i ∈ N do
if i ∈ C then
ϕ[i, v] ← ϕ[i, v] + (weightWithAgent × v(C));
else
ϕ[i, v] ← ϕ[i, v] + (weightWithoutAgent × v(C));
end if
end for
end for
return ϕ
Efficient calculation of the Shapley value using dynamic programing
In calculating the bounded rational Shapley value, when cOPT is sequentially applied to the subsets of the grand coalition, some steps of optimising one coalition are repeated in optimising subsequent coalitions. By taking advantage of this recurrence, we can create a dynamic programming (DP) algorithm to calculate the bounded rational Shapley value much more efficiently. Next, we explain this approach in more detail.
To calculate the Shapley value using Algorithm 3, we need to optimise all subsets C of the grand coalition one by one. Recall that based on the flexibility heuristic of Eq (10), we initially sort N such that Apartment 1 and Apartment n are the least and most flexible members, respectively. Then, cOPT independently optimises all apartments using iOPT, and the set of congested time slots given the independent optimisations are identified. If the result of the optimisations (and the congested time slots) up to this point were stored, we could avoid re-computing them 2n times. This is because these steps are repeated in each iteration of the collective optimisation.
The next step of cOPT is re-optimising the members of C given the congested time slots. This is always done starting from the least flexible member. Clearly, in any subset of N, one member is the least flexible, which is exactly the least flexible member in many other subsets as well. Therefore, that member is always re-optimised first in all those coalitions, which always results in exactly the same load profile for that apartment and the same set of congested time slots. For instance, when cOPT wants to optimise any coalition containing Apartment 1, it always performs decongestion starting from Apartment 1, since it is the least flexible member of the coalition. If the re-optimisation of Apartment 1 is successful (i.e., merely its own preferences are satisfied, not necessarily the threshold), the optimisation results and the newly computed congested time slots can be reused in any other coalition of which Apartment 1 is a member. If the re-optimisation is not successful, we revert back to the independently optimised load profile and the corresponding set of congested time slots which were previously stored in the memory. Likewise, when the next least flexible apartment in the coalition is re-optimised the results can be stored in the memory so that they are later used by cOPT in re-optimising other coalitions. Taking advantage of this recursion can greatly reduce the computation needed for optimising the 2n subsets of N. The following example further illustrates the recursion.
Suppose that in a game of 5 apartments, we want to optimise {1}. We must first optimise all apartments independently, which yields a load profile for all members as well as a set of congested time slots Λ∅. If Apartment 1 can be re-optimised such that its temperature preferences are satisfied, a new set of congested time slots, Λ{1}, will be yielded. Let us assume that re-optimising Apartments 1 indeed results in satisfying its preferences, but Λ{1} is not empty (i.e., there are some congested time slots). Here, although the best-found cooling plan of Apartment 1 will be reverted to its independently optimised cooling plan (since the threshold is not satisfied), we can store the result of re-optimising Apartment 1 as well as Λ{1} so that they can be reused in optimising any other coalition that contains Apartment 1. Now, suppose that we would like to optimise {1, 2}. After using the stored results from re-optimising {1}, since Λ{1} is not empty, we need to also re-optimise Apartment 2 which will yield Λ{1,2}. Regardless of whether Λ{1,2} is empty or not, every time a coalition that contains Apartment 1 and Apartment 2 (e.g., {1, 2, 4, 5}) is optimised, re-optimising Apartment 1 and Apartment 2 will result in the same cooling plans for these two, and the same Λ{1} and Λ{1,2}. Therefore, if after each re-optimisation we stored the cooling plans along with the resulting set of congested time slots, we would not need to compute them again in optimising the subsequent coalitions. This way, for each coalition we would need to re-optimise only one apartment, which is essentially the most flexible member. Furthermore, note that when Shapley values are calculated using Algorithm 3, it is important to iterate through the subsets of the grand coalition such that optimising any coalition would depend only on the previously visited ones. To ensure this, we use the natural order of subsets in binary representation. In this representation, a non-empty coalition C = {c1, c2, …, cm} is represented by the binary equivalent of 2 c 1 − 1 + 2 c 2 − 1 + … + 2 c m − 1, where each bit indicates whether or not the corresponding agent is a member of the coalition. For instance, {2, 3} comes immediately before {1, 2, 3} as their corresponding binary numbers are 110 and 111, respectively. Table 3 illustrates the recursion in the collective optimisation using the binary representation. For example, for optimising {1, 2, 4}, the right column shows that the result of optimising {1, 2} is re-used, which is itself optimised using the result of optimising {1}.
Based on the recursion described above, we can construct a DP algorithm to calculate the Shapley value of the apartments more efficiently. This will enable us to (re-)optimise only one apartment per coalition—the most flexible apartment—since the cooling plan of the rest of the members can be used from the previously optimised coalitions. In fact, the time complexity of calculating the Shapley value of all agents can be reduced to O(2n), down from O(n × 2n). However, this computational benefit comes at a memory space cost of O(|C|) for each C ⊆ N, which implies an exponential space complexity overall. We next formalise the recurrence relation.
Let a coalition sorted in the ascending order of its members’ flexibility (according to Eq 10) be C = {1, 2, …, m}, such that apartments 1 and m are the least and most flexible apartments, respectively. Furthermore, let ΛC denote the set of congested time slots obtained by re-optimising m, given the set of congested time slots, ΛC∖{m}, obtained by re-optimising the most flexible apartment in C∖{m} (i.e., m − 1). As such, Λ∅ is the set of congested time slots after optimising all apartments independently, and ΛN is the set of congested time slots obtained by re-optimising apartment n given ΛN∖{n}. Moreover, let a vector of re-optimised cooling actions of the most flexible apartment in coalition C over an entire day be denoted by η m Λ C \ { m }, which is obtained by re-optimising m given ΛC∖{m}. Note that if m cannot be re-optimised based on ΛC∖{m} such that its temperature preferences can be satisfied, then η m Λ C \ { m } will simply be the independently optimised plan that is found by iOPT. Denote by l m Λ C \ { m } the vector of best-found cooling load of apartment m that is given by Eq (3) using η m Λ C \ { m }. We can now compute the vector of best-found aggregate cooling load, l C ′ = [ l C ′ 1 l C ′ 2 … l C ′ k ], of a coalition, C ≠ ∅, using the following recursive formula:
Evaluation of the payments of apartments
We now undertake an evaluation of applying the bounded rational Shapley value to the discount scheme. To this end, we consider a block of 15 apartments participating in the scheme. However, since there are myriad ways in which 15 apartments can require cooling over the course of a day, it is impossible to systematically evaluate their payments with all possible combinations of setpoints, tolerances and comfort periods. Therefore, our experiments investigate how the payments incurred by one apartment change, as its preferences are varied, while other apartments’ preferences remain constant. This is to isolate the effect of each varying parameter on the payments. Our aim is to simulate the preferences and thermal characteristics of the apartments in a way that represents a severe case in terms of satisfying the optimisation constraints–most, if not all, other cases will be arguably easier to deal with. One such case is realised when a maximum peak occurs in all congested time slots. The following preferences and thermal characteristics ensure this.
We assume that the AC system in all apartments operate on a 10-minute cycle, i.e., a cooling decision is made for each 10-minute interval in a day (Δt = 1/6hr), and thus, K = [1, …, 144]. We also assume that the AC systems in all apartments are similar, with an r value of 1.0 °C/h and consume at a rate of 4.0 kW when on (i.e., Pi = 4.0 kW). Therefore, the maximum possible load of the entire block is 60 kW. When the apartments participate in the scheme, a threshold (ψ) at 32 kW (representing a 47% reduction), is set on the block’s load. If the aggregate load throughout the day is always below 32 kW, the price per kWh of energy consumed over the entire day is $0.08, otherwise it is $0.15. All apartments have the same setpoint of 22°C, tolerance level of 1°C, and require cooling from 15 : 00 to 21 : 30. As can be seen in Fig 5, these assumptions ensure that when all apartments optimise their load independently, their AC is run during exactly the same time slots, causing a maximum peak (i.e., 60 kW) in all congested time slots. Moreover, to exclude the impact of thermal characteristics of the other 14 apartments, we assume that all leakage rates are equal and as follows: α = 0.005, β = 0.005, and γ = 0.05. These numbers are based on realistic values learned from real data collected from a number of apartments in Jeddah, Saudi Arabia.
The total cooling load when the 15 apartments, with the above settings and parameters, optimise their load individually and collectively are shown in Fig 5. As is evident, using cOPT (Algorithm 2), the apartments are able to find an alternative cooling plan such that in addition to their individual temperature preferences, the threshold of 32 kW is also met.
Having established the satisfiability of the threshold constraint, we now vary the preferences of one of the 15 apartments, and keep the preferences and thermal properties of others constant. We compare the payments that the apartment can be charged for its consumption in four different cases: (i) when the apartment does not sign up to the discount scheme and optimises its load independently, (ii) when the apartment optimises its load as a member of the coalition and benefits from the discount, but only its consumption in the grand coalition is considered (unlike the Shapley value which considers all subsets of the grand coalition), (iii) when the apartment optimises its load as a member of the coalition and each apartment receives an equal share of the total saving from the discount (the difference between the payment of the grand coalition at the discounted and normal rates is equally divided and deducted from the payment of each apartment), and (iv) when the apartment optimises its load as a member of the coalition and receives its bounded rational Shapley value. We additionally show the bounded rational Shapley value of the rest of the apartments, which are essentially equal due to identical settings. The value of a coalition in this experiment is calculated as per Eq (5), which represents its bounded rationality value.
In our experiments, we investigate the relationship between payments and different values of setpoint temperature, setpoint deviation tolerance, and leakage rate, the results of which are depicted in Fig 6. These comparisons enable us to develop an in-depth understanding of how sensitive the bounded rational Shapley value and the other naive payment mechanisms are to the variations in the aforementioned parameters. As expected, all three experiments verify that the payments based on the bounded rationality Shapley value are consistently smaller than what the apartment would have to pay if it did not participate in the scheme.
To explore the relationship between the setpoint temperature settings and payments, we vary Tset from 22°C to 26°C, while leaving the other preferences unchanged. We calculate the four payment cases described above for each setpoint temperature setting, and calculate the corresponding payment that the apartment incurs for a single day of cooling. From Fig 6, it is evident that the relationship between the setpoint temperature and payments follows our intuition that when the setpoint is increased, less cooling is required and hence the payment reduces. This reduction occurs until the setpoint is set so high that very little cooling is needed, at which point the payments do not change. It is also evident that an apartment stands to benefit from its participation in the scheme by receiving its bounded rational Shapley value, since the payment it incurs for a setpoint setting is always lower than what it would incur if it chose to optimise its cooling load independently. Somewhat unsurprisingly, the bounded rationality Shapley value of other apartments across different setpoints of the apartment in question remains equal but consistently higher. This shows that the extra flexibility of this apartment (due to its higher setpoint) does not make other members better off or worse off. However, higher setpoint results in less cooling, hence the lower payment compared to others. Moreover, when the independently optimised and the bounded rationality Shapley value curves converge, it means that the energy consumption in and out of the coalition are very close, which occurs when the setpoint is set relatively high. Note that if the payment goes below zero–which could possibly occur due to the proportion of discount and consumption–the equivalent credit can be awarded to the apartments so that it can be used towards their bill. Furthermore, note that when the setpoint is 22.0°C, all payments (including those of other apartments) except the independently optimised one are equal. This indicates that when all apartments have identical settings, all methods result in the same payment. Therefore, in that case one can simply use the equally divided discount method whose computation is much simpler than the bounded rational Shapley value.
Previously, we described how θ is indicative of the sensitivity of an apartment to deviations of the internal temperature from the setpoint. We next explore how the payment incurred for a particular setting changes as θ is varied from 1.0°C to 4.0°C. Again, we calculate the corresponding payment cases for each setting, for a single day of cooling. From Fig 6, it is evident that the relationship between θ and payments is almost linear. As θ is increased, the payments decrease, which shows that the amount of energy required to satisfy the setpoint constraint becomes less and less. Therefore, an apartment with a high setpoint tolerance is easier to satisfy, which is one of the facts that we exploit in the collective optimisation to satisfy the load threshold. Observe that similar to the setpoint experiment, the payments of the other apartments are constant throughout.
In previous sections, we established how the leakage rate, γ is related to the level of insulation of an apartment. We also mentioned how an apartment with a high γ value will typically incur higher energy consumption. Following this trend, we now establish the relationship between γ and the payment that one apartment incurs for a single day of cooling. To do so, we vary γ from 0.05°C/hr, representing a relatively high level of insulation to to 0.096°C/hr, representing a relatively poorly insulated apartment. For each γ value, the payment that the apartment incurs for a single day of cooling is then calculated based on the four payment cases. Fig 6 depicts that the relationship between the leakage rates and the payments is monotonically increasing in all cases. The discounted payments are initially close, but as the apartment becomes leakier, the payments diverge, which makes it more justifiable to choose the method that is fair. Of the three parameters considered in these experiments, the payments seem to exhibit more sensitivity to leakage rate, as small changes in γ results in relatively higher changes in the payments. Also, the larger gap between the bounded rationality Shapley value and the independently optimised curves indicates a higher sensitivity of the payments to thermal leakage when the apartment is in the coalition than when it is not. This can further motivate a leaky apartment to sign up to the scheme and benefit from the better insulation of other apartments which require less cooling. Interestingly, the other apartments also stand to benefit from the existence of a leakier apartment in the coalition. As can be seen in the plot, the bounded rationality Shapley value of other apartments (whose leakage is less) slightly decreases with higher values of γ. This is in contrast to the two previous experiments.
The three experiments discussed above demonstrate the interesting properties of the bounded rationality Shapley value as a payment mechanism. We also note the computational advantage of using the bounded rational Shapley value particularly when it is calculated using the DP method described in subsection efficient calculation of the Shapley value using dynamic programing, which significantly reduces computation time. Fig 7 shows a comparison of the time it takes to calculate the bounded rational Shapley value of an entire block, when there are 3 to 15 apartments, using the DP method and without it. In both cases, the Shapley value is calculated using Algorithm 3, which is itself a significantly more efficient implementation of the standard Shapley value formula. It is evident that an exponential gain in computation time is achieved with the DP method.
Conclusions and future work
In this article, we considered a real-world problem where a block of apartments participate in a demand response program to ensure their aggregate cooling load does not exceed a certain threshold. In return, the apartments receive a discount for coordinating their loads. In this problem, a coalition of apartments needs to optimise its members’ use of air conditioning subject to the individual temperature preferences of each apartment and the given threshold. Due to the magnitude of the constraints involved, computing the optimal load of a coalition is computationally intensive. Instead of solving this problem optimally, we used a greedy algorithm which produced suboptimal solutions at a higher speed. Consequently, a suboptimal value for each coalition could be found, enabling us to calculate the cost of coalitions in a reasonable time. However, calculating the Shapley value in this setting still entails an extra computational challenge, namely solving an exponential number of optimisation problems. Since optimising the load of coalitions with respect to all constraints can take a considerable amount of time, and the agents do not have infinite computational resources, the agents are considered to be computationally bounded rational. While using the Shapley value as a fair division of the optimal value of the grand coalition may not be possible in practice, we proposed that based on the additivity axiom of the Shapley value it is still possible to obtain a fair division using the aforementioned greedy algorithm, which is fast but not necessarily optimal.
The Shapley value given the suboptimal coalition values (which we call the bounded rational Shapley value), is not only easier to calculate, but also provides a division of the grand coalition that is fair in the following sense: all agents are rewarded for their contribution to the total cost of the block (at the discounted rate), and simultaneously penalised for their contribution to the extra cost that is due to the discrepancy between the suboptimal and optimal solutions.
Since in many real world problems the number of agents is beyond what the Shapley value can be easily calculated for, one of our concerns is the scalability of the bounded rational Shapley value. Therefore, in future work, we would like to explore how our approach can be applied to similar demand response scenarios consisting of large number of agents. We would be interested in investigating how approximation techniques could be used to scale up the game, without losing the fairness properties of the bounded rational Shapley value.
Supporting information
S1 Dataset [zip]
The temperature data and thermal parameters of individual apartments.
Zdroje
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- Risk factors for third-generation cephalosporin resistant Enterobacteriaceae in gestational urine cultures: A retrospective cohort study based on centralized electronic health records
- Population-based estimates of humoral autoimmunity from the U.S. National Health and Nutrition Examination Surveys, 1960–2014
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- The treeness of the tree of historical trees of life
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- Measuring the diffusion of innovations with paragraph vector topic models
- Role of ecology in shaping external nasal morphology in bats and implications for olfactory tracking
- Neandertals on the beach: Use of marine resources at Grotta dei Moscerini (Latium, Italy)
- Allergic inflammation is initiated by IL-33–dependent crosstalk between mast cells and basophils
- High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer
- Wattpad as a resource for literary studies. Quantitative and qualitative examples of the importance of digital social reading and readers’ comments in the margins
- Constructing and influencing perceived authenticity in science communication: Experimenting with narrative
- Development and validation of a prognostic model predicting symptomatic hemorrhagic transformation in acute ischemic stroke at scale in the OHDSI network
- Immune recovery markers in a double blind clinical trial comparing dolutegravir and raltegravir based regimens as initial therapy (SPRING-2)
- A non-canonical role for p27Kip1 in restricting proliferation of corneal endothelial cells during development
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- Estimating the impact of drug use on US mortality, 1999-2016
- Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction
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- Digging the diversity of Iberian bait worms Marphysa (Annelida, Eunicidae)
- Influence of light on the infection of Aureococcus anophagefferens CCMP 1984 by a “giant virus”
- MESSAR: Automated recommendation of metabolite substructures from tandem mass spectra
- Temporal ordering of input modulates connectivity formation in a developmental neuronal network model of the cortex
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- Manual dexterity of mice during food-handling involves the thumb and a set of fast basic movements
- Research on an evolutionary game model and simulation of a cluster innovation network based on fairness preference
- Reconstructing Krassilovia mongolica supports recognition of a new and unusual group of Mesozoic conifers
- Selection of memory clinic patients for CSF biomarker assessment can be restricted to a quarter of cases by using computerized decision support, without compromising diagnostic accuracy
- From organ to cell: Multi-level telomere length assessment in patients with idiopathic pulmonary fibrosis
- Training interval in cardiopulmonary resuscitation
- Quantum isomer search
- Ultrastructure of light-activated axons following optogenetic stimulation to produce late-phase long-term potentiation
- Optimization of tissue sampling for Borrelia burgdorferi in white-footed mice (Peromyscus leucopus)
- How do critical care staff respond to organisational challenge? A qualitative exploration into personality types and cognitive processing in critical care
- Symmetric core-cohesive blockmodel in preschool children’s interaction networks
- Effects of supplemental creatine and guanidinoacetic acid on spatial memory and the brain of weaned Yucatan miniature pigs
- Predicting antibacterial activity from snake venom proteomes
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- An investigation of transportation practices in an Ontario swine system using descriptive network analysis
- Comparison of gridded precipitation datasets for rainfall-runoff and inundation modeling in the Mekong River Basin
- Functional interactions in patients with hemianopia: A graph theory-based connectivity study of resting fMRI signal
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- The effects of dual-task cognitive interference on gait and turning in Huntington’s disease
- Effects of Allium hookeri on gut microbiome related to growth performance in young broiler chickens
- Novel imaging biomarkers for mapping the impact of mild mitochondrial uncoupling in the outer retina in vivo
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- Age and altitude of residence determine anemia prevalence in Peruvian 6 to 35 months old children
- Web service QoS prediction using improved software source code metrics
- Long term impact of PositiveLinks: Clinic-deployed mobile technology to improve engagement with HIV care
- Comparison of post-transplantation diabetes mellitus incidence and risk factors between kidney and liver transplantation patients
- Mothers’ oral health literacy and children’s oral health status in Pikine, Senegal: A pilot study
- A definition-by-example approach and visual language for activity patterns in engineering disciplines
- A network analysis revealed the essential and common downstream proteins related to inguinal hernia
- Use of conventional cardiac troponin assay for diagnosis of non-ST-elevation myocardial infarction: ‘The Ottawa Troponin Pathway’
- Low risk pregnancies after a cesarean section: Determinants of trial of labor and its failure
- Exploratory analysis of the potential for advanced diagnostic testing to reduce healthcare expenditures of patients hospitalized with meningitis or encephalitis
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- Identification and characterization of miRNAs involved in cold acclimation of zebrafish ZF4 cells
- Research on motion planning for an indoor spray arm based on an improved potential field method
- Camera-traps are a cost-effective method for surveying terrestrial squamates: A comparison with artificial refuges and pitfall traps
- Detailed analysis of the transverse arch of hallux valgus feet with and without pain using weightbearing ultrasound imaging and precise force sensors
- The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC
- Filling the human resource gap through public-private partnership: Can private, community-based skilled birth attendants improve maternal health service utilization and health outcomes in a remote region of Bangladesh?
- HIV antiretroviral drugs, dolutegravir, maraviroc and ritonavir-boosted atazanavir use different pathways to affect inflammation, senescence and insulin sensitivity in human coronary endothelial cells
- Still standing: Recent patterns of post-fire conifer refugia in ponderosa pine-dominated forests of the Colorado Front Range
- Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling
- Biogeographic study of human gut-associated crAssphage suggests impacts from industrialization and recent expansion
- Apolipoprotein-AI mimetic peptides D-4F and L-5F decrease hepatic inflammation and increase insulin sensitivity in C57BL/6 mice
- Treating patients with driving phobia by virtual reality exposure therapy – a pilot study
- The impact of race relations on NFL attendance: An econometric analysis
- The potential impact of the Affordable Care Act and Medicaid expansion on reducing colorectal cancer screening disparities in African American males
- Efficient processing of raster and vector data
- Rewilding with large herbivores: Positive direct and delayed effects of carrion on plant and arthropod communities
- Early life experience and alterations of group composition shape the social grooming networks of former pet and entertainment chimpanzees (Pan troglodytes)
- Muscarinic modulation of M and h currents in gerbil spherical bushy cells
- Therapeutic hypothermia after out of hospital cardiac arrest improve 1-year survival rate for selective patients
- Carotid plaques and neurological impairment in patients with acute cerebral infarction
- Deep learning based image reconstruction algorithm for limited-angle translational computed tomography
- Subterranean Deuteraphorura Absolon, 1901, (Hexapoda, Collembola) of the Western Carpathians — Troglomorphy at the northern distributional limit in Europe
- Fragmentation and inefficiencies in US equity markets: Evidence from the Dow 30
- Association between coffee drinking and telomere length in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
- Hyperbaric oxygen preconditioning and the role of NADPH oxidase inhibition in postischemic acute kidney injury induced in spontaneously hypertensive rats
- Rad51 paralogs and the risk of unselected breast cancer: A case-control study
- Aqueous ethanol extract of Libidibia ferrea (Mart. Ex Tul) L.P. Queiroz (juca) exhibits antioxidant and migration-inhibiting activity in human gastric adenocarcinoma (ACP02) cells
- Diagnostic differences in respiratory breathing patterns and work of breathing indices in children with Duchenne muscular dystrophy
- The role of narrative in collaborative reasoning and intelligence analysis: A case study
- Proportions of CD4 test results indicating advanced HIV disease remain consistently high at primary health care facilities across four high HIV burden countries
- Modelling of amino acid turnover in the horse during training and racing: A basis for developing a novel supplementation strategy
- Single-modal and multi-modal false arrhythmia alarm reduction using attention-based convolutional and recurrent neural networks
- Eye-gaze information input based on pupillary response to visual stimulus with luminance modulation
- Predictive value of comb-push ultrasound shear elastography for the differentiation of reactive and metastatic axillary lymph nodes: A preliminary investigation
- Type 1 diabetes is associated with an increased risk of venous thromboembolism: A retrospective population-based cohort study
- Trends of litter decomposition and soil organic matter stocks across forested swamp environments of the southeastern US
- Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration
- Were ancient foxes far more carnivorous than recent ones?—Carnassial morphological evidence
- Disruption in daily eating-fasting and activity-rest cycles in Indian adolescents attending school
- Plasma proteome profiling of freshwater and seawater life stages of rainbow trout (Oncorhynchus mykiss)
- Association between baseline abundance of Peptoniphilus, a Gram-positive anaerobic coccus, and wound healing outcomes of DFUs
- The earliest farming communities north of the Carpathians: The settlement at Gwoździec site 2
- Trends of the prevalence and incidence of hypertrophic cardiomyopathy in Korea: A nationwide population-based cohort study
- Percent amplitude of fluctuation: A simple measure for resting-state fMRI signal at single voxel level
- Antimicrobial activity of Asteraceae species against bacterial pathogens isolated from postmenopausal women
- Designing information provision to serve as a reminder of altruistic benefits: A case study of the risks of air pollution caused by industrialization
- Are changes in depressive symptoms, general health and residential area socio-economic status associated with trajectories of waist circumference and body mass index?
- Extracellular vesicles of U937 macrophage cell line infected with DENV-2 induce activation in endothelial cells EA.hy926
- FlexGraph: Flexible partitioning and storage for scalable graph mining
- Post-weaning infant-to-mother bonding in nutritionally independent female mice
- A little good is good enough: Ethical consumption, cheap excuses, and moral self-licensing
- Link-centric analysis of variation by demographics in mobile phone communication patterns
- Multimodal hand gesture recognition using single IMU and acoustic measurements at wrist
- Variance based weighting of multisensory head rotation signals for verticality perception
- Eligibility for hepatitis B antiviral therapy among adults in the general population in Zambia
- Tobacco smoking and health-related quality of life among university students: Mediating effect of depression
- Drivers of the opioid crisis: An appraisal of financial conflicts of interest in clinical practice guideline panels at the peak of opioid prescribing
- Nutritional inadequacies in commercial vegan foods for dogs and cats
- LTA1 and dmLT enterotoxin-based proteins activate antigen-presenting cells independent of PKA and despite distinct cell entry mechanisms
- The Shapley value for a fair division of group discounts for coordinating cooling loads
- Comparison and evaluation of the morphology of crowns generated by biogeneric design technique with CEREC chairside system
- Assessing risk factors and impact of cyberbullying victimization among university students in Myanmar: A cross-sectional study
- Incidence of hospital-acquired pressure ulcers in patients with "minimal risk" according to the "Norton-MI" scale
- Intra-host symbiont diversity in eastern Pacific cold seep tubeworms identified by the 16S-V6 region, but undetected by the 16S-V4 region
- Lipoprotein(a) plasma levels are not associated with survival after acute coronary syndromes: An observational cohort study
- Use of Nanotrap particles for the capture and enrichment of Zika, chikungunya and dengue viruses in urine
- Pancreatic secretory trypsin inhibitor reduces multi-organ injury caused by gut ischemia/reperfusion in mice
- The effect of diet on the gastrointestinal microbiome of juvenile rehabilitating green turtles (Chelonia mydas)
- Biochemical characterization of Ty1 retrotransposon protease
- Lateral pressure equalisation as a principle for designing support surfaces to prevent deep tissue pressure ulcers
- Immunomodulatory function of the cystic fibrosis modifier gene BPIFA1
- The validation of the Beijing version of the Montreal Cognitive Assessment in Chinese patients undergoing hemodialysis
- All of gene expression (AOE): An integrated index for public gene expression databases
- Characterization of the visceral and neuronal phenotype of 4L/PS-NA mice modeling Gaucher disease
- Inflammasome expression is higher in ovarian tumors than in normal ovary
- HCV genotype profile in Brazil of mono-infected and HIV co-infected individuals: A survey representative of an entire country
- Engaging with change: Information and communication technology professionals’ perspectives on change at the mid-point in the UK/EU Brexit process
- Adherence to iron-folic acid supplement and associated factors among antenatal care attending pregnant mothers in governmental health institutions of Adwa town, Tigray, Ethiopia: Cross-sectional study
- Flower, seed, and fruit development in three Tunisian species of Polygonum: Implications for their taxonomy and evolution of distyly in Polygonaceae
- Development of a risk score for prediction of poor treatment outcomes among patients with multidrug-resistant tuberculosis
- Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus
- Aqueous extract from Mangifera indica Linn. (Anacardiaceae) leaves exerts long-term hypoglycemic effect, increases insulin sensitivity and plasma insulin levels on diabetic Wistar rats
- Marine seafood production via intense exploitation and cultivation in China: Costs, benefits, and risks
- Signatures of medical student applicants and academic success
- Discovery of Jogalong virus, a novel hepacivirus identified in a Culex annulirostris (Skuse) mosquito from the Kimberley region of Western Australia
- The effects of extended photoperiod and warmth on hair growth in ponies and horses at different times of year
- Modeling the effect of prolonged ethanol exposure on global gene expression and chromatin accessibility in normal 3D colon organoids
- Clinical, cytogenetic and molecular genetic characterization of a tandem fusion translocation in a male Holstein cattle with congenital hypospadias and a ventricular septal defect
- Severity of misophonia symptoms is associated with worse cognitive control when exposed to misophonia trigger sounds
- Detection of Torque Teno Virus (TTV) and TTV-Like Minivirus in patients with presumed infectious endophthalmitis in India
- CD4 rate of increase is preferred to CD4 threshold for predicting outcomes among virologically suppressed HIV-infected adults on antiretroviral therapy
- The evolution of secondary flow phenomena and their effect on primary shock conditions in shock tubes: Experimentation and numerical model
- Estimating the basic reproduction number of a pathogen in a single host when only a single founder successfully infects
- What drugs modify the risk of iatrogenic impulse-control disorders in Parkinson’s disease? A preliminary pharmacoepidemiologic study
- Evaluating emotional distress and health-related quality of life in patients with heart failure and their family caregivers: Testing dyadic dynamics using the Actor-Partner Interdependence Model
- Community- and trophic-level responses of soil nematodes to removal of a non-native tree at different stages of invasion
- Association of ECG parameters with late gadolinium enhancement and outcome in patients with clinical suspicion of acute or subacute myocarditis referred for CMR imaging
- Sonographic measurement of normal common bile duct diameter and associated factors at the University of Gondar comprehensive specialized hospital and selected private imaging center in Gondar town, North West Ethiopia
- Catchment-scale export of antibiotic resistance genes and bacteria from an agricultural watershed in central Iowa
- Impact of multi-drug resistant bacteria on economic and clinical outcomes of healthcare-associated infections in adults: Systematic review and meta-analysis
- Characterization of a universal screening approach for congenital CMV infection based on a highly-sensitive, quantitative, multiplex real-time PCR assay
- Proof-of-concept for a non-invasive, portable, and wireless device for cardiovascular monitoring in pediatric patients
- On PTV definition for glioblastoma based on fiber tracking of diffusion tensor imaging data
- Multiregional origins of the domesticated tetraploid wheats
- Racism against Totonaco women in Veracruz: Intercultural competences for health professionals are necessary
- Increased inflammation and endothelial markers in patients with late severe post-thrombotic syndrome
- Genes associated with body weight gain and feed intake identified by meta-analysis of the mesenteric fat from crossbred beef steers
- Intraoperative computed tomography imaging for dose calculation in intraoperative electron radiation therapy: Initial clinical observations
- Multiple paedomorphic lineages of soft-substrate burrowing invertebrates: parallels in the origin of Xenocratena and Xenoturbella
- Human lung epithelial BEAS-2B cells exhibit characteristics of mesenchymal stem cells
- Simple non-mydriatic retinal photography is feasible and demonstrates retinal microvascular dilation in Chronic Obstructive Pulmonary Disease (COPD)
- Evaluating poverty alleviation strategies in a developing country
- RNAmountAlign: Efficient software for local, global, semiglobal pairwise and multiple RNA sequence/structure alignment
- Maternal depressive symptoms and children’s cognitive development: Does early childcare and child’s sex matter?
- Pan-cancer analysis of somatic mutations and epigenetic alterations in insulated neighbourhood boundaries
- Evaluation of a bioengineered ACL matrix’s osteointegration with BMP-2 supplementation
- Psychosocial profiles of physical activity fluctuation in office employees: A latent profile analysis
- Prevalence and characteristics of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) isolated from chicken meat in the province of Quebec, Canada
- HIV treatment response among female sex workers participating in a treatment as prevention demonstration project in Cotonou, Benin
- Soluble AXL as a marker of disease progression and survival in melanoma
- Using machine learning methods to determine a typology of patients with HIV-HCV infection to be treated with antivirals
- Quantifying tourism booms and the increasing footprint in the Arctic with social media data
- Gender differences influence over insomnia in Korean population: A cross-sectional study
- Impact of scion/rootstock reciprocal effects on metabolomics of fruit juice and phloem sap in grafted Citrus reticulata
- Adapting cognitive diagnosis computerized adaptive testing item selection rules to traditional item response theory
- Usability assessment of seven HIV self-test devices conducted with lay-users in Johannesburg, South Africa
- Autumn shifts in cold tolerance metabolites in overwintering adult mountain pine beetles
- Management of veterinary anaesthesia in small animals: A survey of current practice in Quebec
- Genetic structure of the European hedgehog (Erinaceus europaeus) in Denmark
- Molecular karyotyping of Siberian wild rye (Elymus sibiricus L.) with oligonucleotide fluorescence in situ hybridization (FISH) probes
- Umbilical cord separation time, predictors and healing complications in newborns with dry care
- The strain distribution in the lumbar anterior longitudinal ligament is affected by the loading condition and bony features: An in vitro full-field analysis
- Marine resource congestion in China: Identifying, measuring, and assessing its impact on sustainable development of the marine economy
- Analysis of attitudinal components towards statistics among students from different academic degrees
- Effects of fatigue induced by repeated-sprint on kicking accuracy and velocity in female soccer players
- A pre-clinical validation plan to evaluate analytical sensitivities of molecular diagnostics such as BD MAX MDR-TB, Xpert MTB/Rif Ultra and FluoroType MTB
- Leadership for success in transforming medical abortion policy in Canada
- Clinical correlates associated with the long-term response of bipolar disorder patients to lithium, valproate or lamotrigine: A retrospective study
- Determinants of change in long-acting or permanent contraceptives use in Ethiopia; A multivariate decomposition analysis of data from the Ethiopian demographic and health survey
- Forecasting stock prices with long-short term memory neural network based on attention mechanism
- On the genus Crossaster (Echinodermata: Asteroidea) and its distribution
- Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds
- Serum amyloid P component promotes formation of distinct aggregated lysozyme morphologies and reduces toxicity in Drosophila flies expressing F57I lysozyme
- Optogenetically induced cellular habituation in non-neuronal cells
- An integrated vitamin E-coated polymer hybrid nanoplatform: A lucrative option for an enhanced in vitro macrophage retention for an anti-hepatitis B therapeutic prospect
- The effect of strontium and silicon substituted hydroxyapatite electrochemical coatings on bone ingrowth and osseointegration of selective laser sintered porous metal implants
- Modeling the Theory of Planned Behaviour to predict adherence to preventive dental visits in preschool children
- Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma species in dogs with hemangiosarcoma from across the United States
- Color discrimination and gas chromatography-mass spectrometry fingerprint based on chemometrics analysis for the quality evaluation of Schizonepetae Spica
- Comparisons of recurrence-free survival and overall survival between microwave versus radiofrequency ablation treatment for hepatocellular carcinoma: A multiple centers retrospective cohort study with propensity score matching
- Transcriptome-wide identification of novel circular RNAs in soybean in response to low-phosphorus stress
- Oral misoprostol, low dose vaginal misoprostol, and vaginal dinoprostone for labor induction: Randomized controlled trial
- The association between dietary patterns before and in early pregnancy and the risk of gestational diabetes mellitus (GDM): Data from the Malaysian SECOST cohort
- Gene expression noise in a complex artificial toxin expression system
- Dynamic Extreme Aneuploidy (DEA) in the vegetable pathogen Phytophthora capsici and the potential for rapid asexual evolution
- Assertive, trainable and older dogs are perceived as more dominant in multi-dog households
- Prediction of Uropathogens by Flow Cytometry and Dip-stick Test Results of Urine Through Multivariable Logistic Regression Analysis
- Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2
- Copper to Tuscany – Coals to Newcastle? The dynamics of metalwork exchange in early Italy
- The Brazilian TP53 mutation (R337H) and sarcomas
- Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance
- Detection of amitraz resistance and reduced treatment efficacy in the Varroa Mite, Varroa destructor, within commercial beekeeping operations
- Impact of viral disease hypophagia on pig jejunal function and integrity
- Enzyme response of activated sludge to a mixture of emerging contaminants in continuous exposure
- Molecular evidence for horizontal transmission of chelonid alphaherpesvirus 5 at green turtle (Chelonia mydas) foraging grounds in Queensland, Australia
- Technology anxiety and resistance to change behavioral study of a wearable cardiac warming system using an extended TAM for older adults
- Evaluation and validation of 2D biomechanical models of the knee for radiograph-based preoperative planning in total knee arthroplasty
- Soil-Transmitted Helminth infections reduction in Bhutan: A report of 29 years of deworming
- Age-related differences in the temporal dynamics of spectral power during memory encoding
- cagA gene EPIYA motif genetic characterization from Colombian Helicobacter pylori isolates: Standardization of a molecular test for rapid clinical laboratory detection
- Mugharat an-Nachcharini: A specialized sheep-hunting camp reveals high-altitude habitats in the earliest Neolithic of the Central Levant
- Spectral characteristics of urine from patients with end-stage kidney disease analyzed using Raman Chemometric Urinalysis (Rametrix)
- Clinicians’ communication with patients receiving a MCI diagnosis: The ABIDE project
- Quantitative PCR provides a simple and accessible method for quantitative microbiota profiling
- Fast quantitative time lapse displacement imaging of endothelial cell invasion
- Two novel mutations in MSX1 causing oligodontia
- 7,200 years old constructions and mudbrick technology: The evidence from Tel Tsaf, Jordan Valley, Israel
- Tuberculosis recurrences and predictive factors in a vulnerable population in Catalonia
- Dome-shaped macula in children and adolescents
- Barriers in the access, diagnosis and treatment completion for tuberculosis patients in central and western Nepal: A qualitative study among patients, community members and health care workers
- Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer
- Targeted transcriptomic study of the implication of central metabolic pathways in mannosylerythritol lipids biosynthesis in Pseudozyma antarctica T-34
- Preliminary evidences of the presence of extracellular DNA single stranded forms in soil
- A comparison of quality of life between patients treated with different dialysis modalities in Taiwan
- The effectiveness of substance use interventions for homeless and vulnerably housed persons: A systematic review of systematic reviews on supervised consumption facilities, managed alcohol programs, and pharmacological agents for opioid use disorder
- Spatiotemporal characteristics and driving forces of construction land expansion in Yangtze River economic belt, China
- Comparison of Monocyte Distribution Width (MDW) and Procalcitonin for early recognition of sepsis
- Morphological association between the muscles and bones in the craniofacial region
- Transcriptome analysis of Actinidia chinensis in response to Botryosphaeria dothidea infection
- Evaluating two decision aids for Australian men supporting informed decisions about prostate cancer screening: A randomised controlled trial
- Serum galectins as potential biomarkers of inflammatory bowel diseases
- Linguistic Z-number weighted averaging operators and their application to portfolio selection problem
- Comparative study on skin protection activity of polyphenol-rich extract and polysaccharide-rich extract from Sargassum vachellianum
- Real-world data about emotional stress, disability and need for social care in a German IBD patient cohort
- The regenerative compatibility: A synergy between healthy ecosystems, environmental attitudes, and restorative experiences
- Fusion of augmented reality imaging with the endoscopic view for endonasal skull base surgery; a novel application for surgical navigation based on intraoperative cone beam computed tomography and optical tracking
- Functional characterization of NK cells in Mexican pediatric patients with acute lymphoblastic leukemia: Report from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia
- Radiomics signature for prediction of lateral lymph node metastasis in conventional papillary thyroid carcinoma
- Antenatal depression and its association with adverse birth outcomes in low and middle-income countries: A systematic review and meta-analysis
- Perceptions of risk and influences of choice in pregnant women with obesity. An evidence synthesis of qualitative research
- The role of refugee and migrant migration status on medication adherence: Mediation through illness perceptions
- Job stress and emotional exhaustion at work in Spanish workers: Does unhealthy work affect the decision to drive?
- Correction: Amphibians on the hotspot: Molecular biology and conservation in the South American Atlantic Rainforest
- Sexual risk classes among youth experiencing homelessness: Relation to childhood adversities, current mental symptoms, substance use, and HIV testing
- Time for change is now: Experiences of participants in a community-based approach for iron and folic acid supplementation in a rural county in Kenya, a qualitative study
- Non-invasive genetic monitoring for the threatened valley elderberry longhorn beetle
- Statistical learning for turboshaft helicopter accidents using logistic regression
- Vegetation change over seven years in the largest protected Pacific Northwest Bunchgrass Prairie remnant
- The effect of various metal-salts on the sedimentation of soil in a water-based suspension
- Using electronic health record system triggers to target delivery of a patient-centered intervention to improve venous thromboembolism prevention for hospitalized patients: Is there a differential effect by race?
- Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells
- Novel broad-spectrum activity-based probes to profile malarial cysteine proteases
- Health-related quality of life in cancer patients treated with immune checkpoint inhibitors: A systematic review on reporting of methods in randomized controlled trials
- Environmental tobacco smoke (ETS) and hyperlipidemia modified by perceived work stress
- Association between opioid analgesic therapy and initiation of buprenorphine management: An analysis of prescription drug monitoring program data
- Effect of a community-based approach of iron and folic acid supplementation on compliance by pregnant women in Kiambu County, Kenya: A quasi-experimental study
- Radiocarbon dating of two old African baobabs from India
- Improvement project in higher education institutions: A BPEP-based model
- An updated evaluation of serum sHER2, CA15.3, and CEA levels as biomarkers for the response of patients with metastatic breast cancer to trastuzumab-based therapies
- Genome-wide association study of metabolic syndrome in Korean populations
- The diagnostic accuracy of liver fibrosis in non-viral liver diseases using acoustic radiation force impulse elastography: A systematic review and meta-analysis
- Drug therapy problems and treatment satisfaction among ambulatory patients with epilepsy in a specialized hospital in Ethiopia
- Short- & long-term effects of monetary and non-monetary incentives to cooperate in public good games: An experiment
- Niche modeling reveals life history shifts in birds at La Brea over the last twenty millennia
- Morphological consequences of artificial cranial deformation: Modularity and integration
- Distributed flux balance analysis simulations of serial biomass fermentation by two organisms
- Plasma kynurenines and prognosis in patients with heart failure
- Occurrence and distribution of anthropogenic persistent organic pollutants in coastal sediments and mud shrimps from the wetland of central Taiwan
- Intensified visual clutter induces increased sympathetic signalling, poorer postural control, and faster torsional eye movements during visual rotation
- Restoration of cortical symmetry and binaural function: Cortical auditory evoked responses in adult cochlear implant users with single sided deafness
- A smartphone-enabled wireless and batteryless implantable blood flow sensor for remote monitoring of prosthetic heart valve function
- Gut microbiota composition alterations are associated with the onset of diabetes in kidney transplant recipients
- Shock index and TIMI risk index as valuable prognostic tools in patients with acute coronary syndrome complicated by cardiogenic shock
- Merit overrules theory of mind when young children share resources with others
- Economic burden of maternal morbidity – A systematic review of cost-of-illness studies
- Comparison of balance changes after inspiratory muscle or Otago exercise training
- Correction: Escherichia coli and Salmonella spp. isolated from Australian meat chickens remain susceptible to critically important antimicrobial agents
- Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue
- Cell-free DNA donor fraction analysis in pediatric and adult heart transplant patients by multiplexed allele-specific quantitative PCR: Validation of a rapid and highly sensitive clinical test for stratification of rejection probability
- Immunopathogenesis of canine chronic ulcerative stomatitis
- Correction: Quantification of speech and synchrony in the conversation of adults with autism spectrum disorder
- Efficacy and safety of ultrasonic circular cyclocoagulation with second-generation probe in glaucoma: A retrospective study
- Generalizing findings from a randomized controlled trial to a real-world study of the iLookOut, an online education program to improve early childhood care and education providers’ knowledge and attitudes about reporting child maltreatment
- Self-selection of food ingredients and agricultural by-products by the house cricket, Acheta domesticus (Orthoptera: Gryllidae): A holistic approach to develop optimized diets
- Machine learning detection of Atrial Fibrillation using wearable technology
- Comparative proteomic analysis of different stages of breast cancer tissues using ultra high performance liquid chromatography tandem mass spectrometer
- A cross-sectional study of psychopathy and khat abuse among prisoners in the correctional institution in Jimma, Ethiopia
- Head impulse compensatory saccades: Visual dependence is most evident in bilateral vestibular loss
- Complementarity of empirical and process-based approaches to modelling mosquito population dynamics with Aedes albopictus as an example—Application to the development of an operational mapping tool of vector populations
- Pepsin promotes laryngopharyngeal neoplasia by modulating signaling pathways to induce cell proliferation
- When and what to test for: A cost-effectiveness analysis of febrile illness test-and-treat strategies in the era of responsible antibiotic use
- Comparison of effects and safety in providing controlled hypotension during surgery between dexmedetomidine and magnesium sulphate: A meta-analysis of randomized controlled trials
- The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice
- Seroepidemiological study of rubella in Vojvodina, Serbia: 24 years after the introduction of the MMR vaccine in the national immunization programme
- Efficacy of a mitochondrion-targeting agent for reducing the level of urinary protein in rats with puromycin aminonucleoside-induced minimal-change nephrotic syndrome
- Association of endothelial nitric oxide synthase (NOS3) gene polymorphisms with primary open-angle glaucoma in a Saudi cohort
- Antitrust analysis with upward pricing pressure and cost efficiencies
- Machine learning models for identifying preterm infants at risk of cerebral hemorrhage
- Natural selection contributes to food web stability
- Pyramiding QTLs controlling tolerance against drought, salinity, and submergence in rice through marker assisted breeding
- Diversity and plant growth-promoting functions of diazotrophic/N-scavenging bacteria isolated from the soils and rhizospheres of two species of Solanum
- Sustainability effects of motor control stabilisation exercises on pain and function in chronic nonspecific low back pain patients: A systematic review with meta-analysis and meta-regression
- Sofosbuvir-based regimen for genotype 2 HCV infected patients in Taiwan: A real world experience
- The virulence domain of Shigella IcsA contains a subregion with specific host cell adhesion function
- Sequencing artifacts derived from a library preparation method using enzymatic fragmentation
- Analysis of the Rdr1 gene family in different Rosaceae genomes reveals an origin of an R-gene cluster after the split of Rubeae within the Rosoideae subfamily
- Concomitant phytonutrient and transcriptome analysis of mature fruit and leaf tissues of tomato (Solanum lycopersicum L. cv. Oregon Spring) grown using organic and conventional fertilizer
- Quantitative analysis of adsorption and desorption of volatile organic compounds on reusable zeolite filters using gas chromatography
- Comparing bioinformatic pipelines for microbial 16S rRNA amplicon sequencing
- TMEM98 is a negative regulator of FRAT mediated Wnt/ß-catenin signalling
- Modeling migration patterns in the USA under sea level rise
- Quo vadis Pantanal? Expected precipitation extremes and drought dynamics from changing sea surface temperature
- Cloud-computing and machine learning in support of country-level land cover and ecosystem extent mapping in Liberia and Gabon
- An exploratory study on the quality of patient screening and counseling for hypertension management in Tanzania
- Relation of fibroblast growth factor receptor 2 expression to hepatocellular carcinoma recurrence after liver resection
- The Brief Measure of Emotional Preoperative Stress (B-MEPS) as a new predictive tool for postoperative pain: A prospective observational cohort study
- The impact of diabetes mellitus medication on the incidence of endogenous endophthalmitis
- Correction: Chl1 DNA helicase and Scc2 function in chromosome condensation through cohesin deposition
- Clinical and pathological features of thrombotic microangiopathy influencing long-term kidney transplant outcomes
- Multidisciplinary investigation of two Egyptian child mummies curated at the University of Tartu Art Museum, Estonia (Late/Graeco-Roman Periods)
- Occupational exposure to particulate matter from air pollution in the outdoor workplaces in Almaty during the cold season
- Morphological adjustment in free-living Steinernema feltiae infective juveniles to increasing concentration of Nemafric-BL phytonematicide
- Murine Surf4 is essential for early embryonic development
- Using mHealth to improve health care delivery in India: A qualitative examination of the perspectives of community health workers and beneficiaries
- Algorithmic handwriting analysis of the Samaria inscriptions illuminates bureaucratic apparatus in biblical Israel
- Key necroptotic proteins are required for Smac mimetic-mediated sensitization of cholangiocarcinoma cells to TNF-α and chemotherapeutic gemcitabine-induced necroptosis
- Concurrent lipidomics and proteomics on malignant plasma cells from multiple myeloma patients: Probing the lipid metabolome
- Short treatment with antalarmin alters adrenal gland receptors in the rat model of endometriosis
- Is it really always only the others who are to blame? GP’s view on medical overuse. A questionnaire study
- Serum visfatin and vaspin levels in hepatocellular carcinoma (HCC)
- Retraction: SDR9C7 Promotes Lymph Node Metastases in Patients with Esophageal Squamous Cell Carcinoma
- iTRAQ proteomics reveals the regulatory response to Magnaporthe oryzae in durable resistant vs. susceptible rice genotypes
- A smartphone-based test for the assessment of attention deficits in delirium: A case-control diagnostic test accuracy study in older hospitalised patients
- Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis
- Incidence and predictors of loss to follow up among adult HIV patients on antiretroviral therapy in University of Gondar Comprehensive Specialized Hospital: A competing risk regression modeling
- Point-of-care diagnostic (POCD) method for detecting Bursaphelenchus xylophilus in pinewood using recombinase polymerase amplification (RPA) with the portable optical isothermal device (POID)
- Bioluminescent imaging of Arabidopsis thaliana using an enhanced Nano-lantern luminescence reporter system
- Biosynthetic pathway of indole-3-acetic acid in ectomycorrhizal fungi collected from northern Thailand
- Clinical implications of elevated serum interleukin-6 in IgG4-related disease
- Downscaling NLDAS-2 daily maximum air temperatures using MODIS land surface temperatures
- Sex-specific and opposite modulatory aspects revealed by PPI network and pathway analysis of ischemic stroke in humans
- Plasma Trimethylamine-N-oxide and impaired glucose regulation: Results from The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS)
- Self-esteem and other risk factors for depressive symptoms among adolescents in United Arab Emirates
- Control of the microsporidian parasite Nosema ceranae in honey bees (Apis mellifera) using nutraceutical and immuno-stimulatory compounds
- The effect of storage conditions on microbial communities in stool
- Role of donor genotype in RT-QuIC seeding activity of chronic wasting disease prions using human and bank vole substrates
- Influence of flow on phosphorus-dynamics and particle size in agricultural drainage ditch sediments
- A prospective, randomized, double-blind trial to compare body weight-adjusted and fixed doses of palonosetron for preventing postoperative nausea and vomiting in obese female patients
- Application of computerized 3D-CT texture analysis of pancreas for the assessment of patients with diabetes
- Predictive validation and forecasts of short-term changes in healthcare expenditure associated with changes in smoking behavior in the United States
- An information-based approach to handle various types of uncertainty in fuzzy bodies of evidence
- Oral magnesium supplementation for leg cramps in pregnancy—An observational controlled trial
- Health care professionals’ knowledge of commonly used sedative, analgesic and neuromuscular drugs: A single center (Rambam Health Care Campus), prospective, observational survey
- Campylobacter portucalensis sp. nov., a new species of Campylobacter isolated from the preputial mucosa of bulls
- OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model
- Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice
- Novel method to measure temporal windows based on eye movements during viewing of the Necker cube
- Whole blood transcriptomic analysis of beef cattle at arrival identifies potential predictive molecules and mechanisms that indicate animals that naturally resist bovine respiratory disease
- Effects of smoke flavoring using different wood chips and barbecuing on the formation of polycyclic aromatic hydrocarbons and heterocyclic aromatic amines in salmon fillets
- Sleep quality and sex modify the relationships between trait energy and fatigue on state energy and fatigue
- The role of peer, parental, and school norms in predicting adolescents’ attitudes and behaviours of majority and different minority ethnic groups in Croatia
- Filtered beauty in Oslo and Tokyo: A spatial frequency analysis of facial attractiveness
- The impact of rehabilitation frequency on the risk of stroke in patients with rheumatoid arthritis
- Availability, prices and affordability of selected antibiotics and medicines against non-communicable diseases in western Cameroon and northeast DR Congo
- The effect of mutations derived from mouse-adapted H3N2 seasonal influenza A virus to pathogenicity and host adaptation
- Detection of posttraumatic pneumothorax using electrical impedance tomography—An observer-blinded study in pigs with blunt chest trauma
- Educators’ perceptions of organisational readiness for implementation of a pre-adolescent transdisciplinary school health intervention for inter-generational outcomes
- Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA
- The effects of sport expertise and shot results on basketball players’ action anticipation
- Framework and algorithms for identifying honest blocks in blockchain
- Efficacy and safety of anti-viral therapy for Hepatitis B virus-associated glomerulonephritis: A meta-analysis
- Selective transmission of some HIV-1 subtype C variants might depend on Envelope stimulating dendritic cells to secrete IL-10
- Noise reduction and quantification of fiber orientations in greyscale images
- Exploring the impact of terminology differences in blood and organ donor decision making
- Ontogenetic similarities between giraffe and sauropod neck osteological mobility
- Load transfer mechanism and critical length of anchorage zone for anchor bolt
- Income inequalities in stroke incidence and mortality: Trends in stroke-free and stroke-affected life years based on German health insurance data
- Community’s perception, experiences and health seeking behavior towards newborn illnesses in Debre Libanos District, North Shoa, Oromia, Ethiopia: Qualitative study
- Platelet indices significantly correlate with liver fibrosis in HCV-infected patients
- Reanalysis of the Bridge et al. study of suicide following release of 13 Reasons Why
- Validation of the easyscreen flavivirus dengue alphavirus detection kit based on 3base amplification technology and its application to the 2016/17 Vanuatu dengue outbreak
- The nitrate content of fresh and cooked vegetables and their health-related risks
- Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results
- Serotonin transporter dependent modulation of food-seeking behavior
- Implicit task switching in Parkinson’s disease is preserved when on medication
- Root treatment with oxathiapiprolin, benthiavalicarb or their mixture provides prolonged systemic protection against oomycete foliar pathogens
- Real-world effectiveness and safety of ranibizumab for the treatment of myopic choroidal neovascularization: Results from the LUMINOUS study
- Non-gradient and genotype-dependent patterns of RSV gene expression
- Multiplex real-time PCR for the detection of Clavibacter michiganensis subsp. michiganensis, Pseudomonas syringae pv. tomato and pathogenic Xanthomonas species on tomato plants
- The 24-hour urinary cortisol in post-traumatic stress disorder: A meta-analysis
- Parasites modulate the gut-microbiome in insects: A proof-of-concept study
- The dynamics of shapes of vesicle membranes with time dependent spontaneous curvature
- Vascularization and biocompatibility of poly(ε-caprolactone) fiber mats for rotator cuff tear repair
- The shield of self-compassion: A buffer against disordered eating risk from physical appearance perfectionism
- Disease-specific out-of-pocket healthcare expenditure in urban Bangladesh: A Bayesian analysis
- Advanced biofilm analysis in streams receiving organic deicer runoff
- Upregulation of long non-coding RNA ROR1-AS1 promotes cell growth and migration in bladder cancer by regulation of miR-504
- Method development and validation for rapid identification of epigallocatechin gallate using ultra-high performance liquid chromatography
- Neonatal sepsis in Iran: A systematic review and meta-analysis on national prevalence and causative pathogens
- Drug-eluting versus bare-metal stents for first myocardial infarction in patients with atrial fibrillation: A nationwide population-based cohort study
- Same-day antiretroviral therapy initiation for HIV-infected adults in South Africa: Analysis of routine data
- Health-related quality of life among patients with type 2 diabetes mellitus in Eastern Province, Saudi Arabia: A cross-sectional study
- Photocatalytic biocidal effect of copper doped TiO2 nanotube coated surfaces under laminar flow, illuminated with UVA light on Legionella pneumophila
- The interoceptive hippocampus: Mouse brain endocrine receptor expression highlights a dentate gyrus (DG)–cornu ammonis (CA) challenge–sufficiency axis
- Educational attainment and HIV testing and counselling service utilisation during antenatal care in Ghana: Analysis of Demographic and Health Surveys
- Dissection of flag leaf metabolic shifts and their relationship with those occurring simultaneously in developing seed by application of non-targeted metabolomics
- Centromeres of Cucumis melo L. comprise Cmcent and two novel repeats, CmSat162 and CmSat189
- Acute high-intensity and moderate-intensity interval exercise do not change corticospinal excitability in low fit, young adults
- “I like the way I am, but I feel like I could get a little bit bigger”: Perceptions of body image among adolescents and youth living with HIV in Durban, South Africa
- Nanoparticle-based ‘turn-on’ scattering and post-sample fluorescence for ultrasensitive detection of water pollution in wider window
- The relationship of moral sensitivity and patient safety attitudes with nursing students’ perceptions of disclosure of patient safety incidents: A cross-sectional study
- Insights into the strategy of micro-environmental adaptation: Transcriptomic analysis of two alvinocaridid shrimps at a hydrothermal vent
- Thirty-day readmission after medical-surgical hospitalization for people who experience imprisonment in Ontario, Canada: A retrospective cohort study
- The effect of long-term brine discharge from desalination plants on benthic foraminifera
- Hyper-spectral response and estimation model of soil degradation in Kenli County, the Yellow River Delta
- Prescribing trends of glaucoma drugs in six major cities of China from 2013 to 2017
- Significant changes in synovial fluid microRNAs after high tibial osteotomy in medial compartmental knee osteoarthritis: Identification of potential prognostic biomarkers
- Reassortment and adaptive mutations of an emerging avian influenza virus H7N4 subtype in China
- Ischemia and reperfusion injury in superficial inferior epigastric artery-based vascularized lymph node flaps
- High failure rates of protease inhibitor-based antiretroviral treatment in rural Tanzania – A prospective cohort study
- Switchable resolution in soft x-ray tomography of single cells
- Mitochondrial DNA variations and mitochondrial dysfunction in Fanconi anemia
- Extended-spectrum beta-lactamase (ESBL)-producing and non-ESBL-producing Escherichia coli isolates causing bacteremia in the Netherlands (2014 – 2016) differ in clonal distribution, antimicrobial resistance gene and virulence gene content
- Molecular characterization of blaKHM-1 encoding plasmid in an Enterobacter hormaechei subsp. hoffmannii isolate from blood culture
- PR3 levels are impaired in plasma and PBMCs from Arabs with cardiovascular diseases
- Sex differences in self-regulation in early, middle and late adolescence: A large-scale cross-sectional study
- Interaction between elevated temperature and different types of Na-salicylate treatment in Brachypodium dystachion
- A highway crash risk assessment method based on traffic safety state division
- A brain connectivity characterization of children with different levels of mathematical achievement based on graph metrics
- Quantifying the level of difficulty to treat major depressive disorder with antidepressants: Treatment Resistance to Antidepressants Evaluation Scale
- Occupational gender segregation and economic growth in U.S. local labor markets, 1980 through 2010
- The association of telomere length and telomerase activity with adverse outcomes in older patients with non-ST-elevation acute coronary syndrome
- Construction of a high-density genetic map and fine mapping of a candidate gene locus for a novel branched-spike mutant in barley
- Alterations of aqueous humor Aβ levels in Aβ-infused and transgenic mouse models of Alzheimer disease
- Parameters impacting the live birth rate per transfer after frozen single euploid blastocyst transfer
- Deep2Full: Evaluating strategies for selecting the minimal mutational experiments for optimal computational predictions of deep mutational scan outcomes
- Economic compensation interventions to increase uptake of voluntary medical male circumcision for HIV prevention: A systematic review and meta-analysis
- Distinctive effect of anesthetics on the effect of limb remote ischemic postconditioning following ischemic stroke
- Natural hybridization between Phyllagathis and Sporoxeia species produces a hybrid without reproductive organs
- Preliminary evaluation of a novel nine-biomarker profile for the prediction of autism spectrum disorder
- The impact of peer attachment on prosocial behavior, emotional difficulties and conduct problems in adolescence: The mediating role of empathy
- Spatial and climatic variables independently drive elevational gradients in ant species richness in the Eastern Himalaya
- What is the qualitative evidence concerning the risks, diagnosis, management and consequences of gastrointestinal infections in the community in the United Kingdom? A systematic review and meta-ethnography
- Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress
- Key barriers and enablers associated with uptake and continuation of oral pre-exposure prophylaxis (PrEP) in the public sector in Zimbabwe: Qualitative perspectives of general population clients at high risk for HIV
- Characterizing the University of California’s tenure-track teaching position from the faculty and administrator perspectives
- Restoration of Mal overcomes the defects of apoptosis in lung cancer cells
- Patient preferences for maintenance therapy in Crohn’s disease: A discrete-choice experiment
- Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia
- Hesperidin improves insulin resistance via down-regulation of inflammatory responses: Biochemical analysis and in silico validation
- Accuracy of intraocular lens power calculation formulas using a swept-source optical biometer
- Characterization of black patina from the Tiber River embankments using Next-Generation Sequencing
- Comparison of blood lactate and perceived exertion responses in two matched time-under-tension protocols
- Fibrin hydrogels are safe, degradable scaffolds for sub-retinal implantation
- Post-translational modifications of Drosophila melanogaster HOX protein, Sex combs reduced
- Problem gambling, associations with comorbid health conditions, substance use, and behavioural addictions: Opportunities for pathways to treatment
- Liganded T3 receptor β2 inhibits the positive feedback autoregulation of the gene for GATA2, a transcription factor critical for thyrotropin production
- Characterization of METTL16 as a cytoplasmic RNA binding protein
- Impact of long-term storage and freeze-thawing on eight circulating microRNAs in plasma samples
- Nanosheet wrapping-assisted coverslip-free imaging for looking deeper into a tissue at high resolution
- Assessment of dynamic cerebral autoregulation in humans: Is reproducibility dependent on blood pressure variability?
- Early diagnosis of sepsis in emergency departments, time to treatment, and association with mortality: An observational study
- Validity of cerebrovascular ICD-9-CM codes in healthcare administrative databases. The Umbria Data-Value Project
- Tuberculoid leprosy: An in vivo microvascular evaluation of cutaneous lesions
- Neuromuscular blockers in the acute respiratory distress syndrome: A meta-analysis
- Identification of putative Type-I sex pheromone biosynthesis-related genes expressed in the female pheromone gland of Streltzoviella insularis
- Redefining transcriptional regulation of the APOE gene and its association with Alzheimer’s disease
- Disease-relevant mutations alter amino acid co-evolution networks in the second nucleotide binding domain of CFTR
- A bushel of viruses: Identification of seventeen novel putative viruses by RNA-seq in six apple trees
- Torque teno virus viral load is related to age, CMV infection and HLA type but not to Alzheimer's disease
- The variability of bacterial communities in both the endosphere and ectosphere of different niches in Chinese chives (Allium tuberosum)
- Tripartite factors leading to molecular divergence between human and murine smooth muscle
- Characterization of dermal skin innervation in fibromyalgia syndrome
- A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy
- A scoping review of importation and predictive models related to vector-borne diseases, pathogens, reservoirs, or vectors (1999–2016)
- Assessment of climate change impact on the malaria vector Anopheles hyrcanus, West Nile disease, and incidence of melanoma in the Vojvodina Province (Serbia) using data from a regional climate model
- Associations of cigarette smoking and burden of thoracic aortic calcification in asymptomatic individuals: A dose-response relationship
- Healthcare utilization of Mexican-American Medicare beneficiaries with and without Alzheimer’s disease and related dementias
- Evaluation of questionnaire as an instrument to measure the level of nutritional and weight gain knowledge in pregnant women in Poland. A pilot study
- TranCEP: Predicting the substrate class of transmembrane transport proteins using compositional, evolutionary, and positional information
- Non-Invasive Functional-Brain-Imaging with an OPM-based Magnetoencephalography System
- Expression of acyl-CoA-binding protein 5 from Rhodnius prolixus and its inhibition by RNA interference
- Transforming assessment of speech in children with cleft palate via online crowdsourcing
- High prevalence of off-label and unlicensed paediatric prescribing in a hospital in Indonesia during the period Aug.—Oct. 2014
- General practice management of rotator cuff related shoulder pain: A reliance on ultrasound and injection guided care
- Estimating the population size of female sex workers and transgender women in Sri Lanka
- Can helmet decrease mortality of craniocerebral trauma patients in a motorcycle accident?: A propensity score matching
- Obesity, smoking habits, and serum phosphate levels predicts mortality after life-style intervention
- Treatment of children under 4 years of age with medulloblastoma and ependymoma in the HIT2000/HIT-REZ 2005 trials: Neuropsychological outcome 5 years after treatment
- Can a semi-quantitative method replace the current quantitative method for the annual screening of microalbuminuria in patients with diabetes? Diagnostic accuracy and cost-saving analysis considering the potential health burden
- A two-arm parallel double-blind randomised controlled pilot trial of the efficacy of Omega-3 polyunsaturated fatty acids for the treatment of women with endometriosis-associated pain (PurFECT1)
- Association of benzodiazepines, opioids and tricyclic antidepressants use and falls in trauma patients: Conditional effect of age
- Burden and risk factors of cutaneous leishmaniasis in a peri-urban settlement in Kenya, 2016
- Predicting strike susceptibility and collision patterns of the common buzzard at wind turbine structures in the federal state of Brandenburg, Germany
- Embryonic thermal manipulation has short and long-term effects on the development and the physiology of the Japanese quail
- High-order radiomics features based on T2 FLAIR MRI predict multiple glioma immunohistochemical features: A more precise and personalized gliomas management
- Human-raptor conflict in rural settlements of Colombia
- Regional adaptations and parallel mutations in Feline panleukopenia virus strains from China revealed by nearly-full length genome analysis
- Long-term ecological research in southern Brazil grasslands: Effects of grazing exclusion and deferred grazing on plant and arthropod communities
- Assessment of peritoneal microbial features and tumor marker levels as potential diagnostic tools for ovarian cancer
- Survival analysis of 230 patients with unresectable hepatocellular carcinoma treated with bland transarterial embolization
- Adverse drug reaction reporting practice and associated factors among medical doctors in government hospitals in Addis Ababa, Ethiopia
- TaWAK6 encoding wall-associated kinase is involved in wheat resistance to leaf rust similar to adult plant resistance
- Deficiency syndromes in top predators associated with large-scale changes in the Baltic Sea ecosystem
- The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice
- Allele specific expression of Dof genes responding to hormones and abiotic stresses in sugarcane
- Perceived relative social status and cognitive load influence acceptance of unfair offers in the Ultimatum Game
- Quantitative evaluation of choriocapillaris using optical coherence tomography and optical coherence tomography angiography in patients with central serous chorioretinopathy after half-dose photodynamic therapy
- Structure-function analyses of candidate small molecule RPN13 inhibitors with antitumor properties
- Extracting lung function measurements to enhance phenotyping of chronic obstructive pulmonary disease (COPD) in an electronic health record using automated tools
- Multiple fragmented habitat-patch use in an urban breeding passerine, the Short-toed Treecreeper
- Histological and immunohistochemical characterization of the porcine ocular surface
- Household environmental tobacco smoke exposure in healthy young children in Hong Kong: Prevalence and risk factors
- Wind energy development and wildlife conservation in Lithuania: A mapping tool for conflict assessment
- Characteristics and prognosis of primary treatment-naïve oral cavity squamous cell carcinoma in Norway, a descriptive retrospective study
- Effect of epoch length on intensity classification and on accuracy of measurement under controlled conditions on treadmill: Towards a better understanding of accelerometer measurement
- Peer distribution of HIV self-test kits to men who have sex with men to identify undiagnosed HIV infection in Uganda: A pilot study
- Error rates of human reviewers during abstract screening in systematic reviews
- Faecal analyses and alimentary tracers reveal the foraging ecology of two sympatric bats
- Urethral realignment with maximal urethral length and bladder neck preservation in robot-assisted radical prostatectomy: Urinary continence recovery
- Error metrics determination in functionally approximated circuits using SAT solvers
- Spatial movement pattern recognition in soccer based on relative player movements
- A novel visual ranking system based on arterial spin labeling perfusion imaging for evaluating perfusion disturbance in patients with ischemic stroke
- Prospective Validation of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) Score for Necrotizing Fasciitis of the Extremities
- The importance of transporters and cell polarization for the evaluation of human stem cell-derived hepatic cells
- Incidence, trends, and outcomes of infection sites among hospitalizations of sepsis: A nationwide study
- Morphological and functional characteristics of mitral annular calcification and their relationship to stroke
- And the nominees are: Using design-awards datasets to build computational aesthetic evaluation model
- Service delivery interventions to increase uptake of voluntary medical male circumcision for HIV prevention: A systematic review
- Multidimensional Scales of Perceived Self-Efficacy (MSPSE): Measurement invariance across Italian and Colombian adolescents
- Diversity of Mycobacteriaceae from aquatic environment at the São Paulo Zoological Park Foundation in Brazil
- A graph-based algorithm for RNA-seq data normalization
- Parents’ underestimation of their child’s weight status. Moderating factors and change over time: A cross-sectional study
- Pharmacokinetics, absolute bioavailability and tolerability of ketamine after intranasal administration to dexmedetomidine sedated dogs
- Spatial variation in fertilizer prices in Sub-Saharan Africa
- Knowledge, beliefs, and concerns about bone health from a systematic review and metasynthesis of qualitative studies
- Successful isolation of Treponema pallidum strains from patients’ cryopreserved ulcer exudate using the rabbit model
- Effects of size and elasticity on the relation between flow velocity and wall shear stress in side-wall aneurysms: A lattice Boltzmann-based computer simulation study
- Pupil response to noxious corneal stimulation
- Incidence, risk factors and healthcare costs of central line-associated nosocomial bloodstream infections in hematologic and oncologic patients
- The impact of computed radiography and teleradiology on patients’ diagnosis and treatment in Mweso, the Democratic Republic of Congo
- Differential effects of synthetic psychoactive cathinones and amphetamine stimulants on the gut microbiome in mice
- Hepatitis B and C virus infection among HIV patients within the public and private healthcare systems in Chile: A cross-sectional serosurvey
- Increased episodes of aspiration on videofluoroscopic swallow study in children with nasogastric tube placement
- Obstructive sleep apnea and hypopnea syndrome in patients admitted in a tertiary hospital in Cameroon: Prevalence and associated factors
- Association of single nucleotide polymorphisms with dyslipidemia in antiretroviral exposed HIV patients in a Ghanaian population: A case-control study
- Sonic Hedgehog upregulation does not enhance the survival and engraftment of stem cell-derived cardiomyocytes in infarcted hearts
- The pharmacokinetic parameters and the effect of a single and repeated doses of memantine on gastric myoelectric activity in experimental pigs
- Blind method for discovering number of clusters in multidimensional datasets by regression on linkage hierarchies generated from random data
- Predictive factors of first dosage intravenous immunoglobulin-related adverse effects in children
- Description and characterization of the artisanal elasmobranch fishery on Guatemala’s Caribbean coast
- Individual and community level determinants of short birth interval in Ethiopia: A multilevel analysis
- Effects of rejection intensity and rejection sensitivity on social approach behavior in women
- The impact of IoT security labelling on consumer product choice and willingness to pay
- The development and validation of a measurement instrument to investigate determinants of health care utilisation for low back pain in Ethiopia
- Validity of the French version of the Autonomy Preference Index and its adaptation for patients with advanced cancer
- The epidemiological characteristics and spatio-temporal analysis of childhood hand, foot and mouth disease in Korea, 2011-2017
- Exponential random graph model parameter estimation for very large directed networks
- The implementation of community-based diabetes and hypertension management care program in Indonesia
- Effect of temperature variation on hospital admissions and outcomes in dogs with myxomatous mitral valve disease and new onset pulmonary edema
- The development of the Police Practices Scale: Understanding policing approaches towards street-based female sex workers in a U.S. City
- A capability approach to assess aquaculture sustainability standard compliance
- Pre-collecting lymphatic vessels form detours following obstruction of lymphatic flow and function as collecting lymphatic vessels
- Construct validity and reliability of the Talent Development Environment Questionnaire in Caribbean youth track and field athletes
- Optimization of cytotoxic activity of Nocardia sp culture broths using a design of experiments
- Tissue-resident macrophages can be generated de novo in adult human skin from resident progenitor cells during substance P-mediated neurogenic inflammation ex vivo
- Microbiota in foods from Inuit traditional hunting
- Investigating Italian disinformation spreading on Twitter in the context of 2019 European elections
- In vivo expression of peptidylarginine deiminase in Drosophila melanogaster
- Modelling zero-truncated overdispersed antenatal health care count data of women in Bangladesh
- Detection and density of breeding marsh birds in Iowa wetlands
- A lineage-specific rapid diagnostic test (Chagas Sero K-SeT) identifies Brazilian Trypanosoma cruzi II/V/VI reservoir hosts among diverse mammalian orders
- Aromatase deficiency in hematopoietic cells improves glucose tolerance in male mice through skeletal muscle-specific effects
- If host is refractory, insistent parasite goes berserk: Trypanosomatid Blastocrithidia raabei in the dock bug Coreus marginatus
- Antimicrobial resistance patterns and molecular resistance markers of Campylobacter jejuni isolates from human diarrheal cases
- Protective role of brain derived neurotrophic factor (BDNF) in obstructive sleep apnea syndrome (OSAS) patients
- An IL-18-centered inflammatory network as a biomarker for cerebral white matter injury
- Prevalence of antiphospholipid antibodies in Behçet's disease: A systematic review and meta-analysis
- Chemical analysis of snus products from the United States and northern Europe
- Effect of prednisolone on glyoxalase 1 in an inbred mouse model of aristolochic acid nephropathy using a proteomics method with fluorogenic derivatization-liquid chromatography-tandem mass spectrometry
- Impact of early-onset persistent stunting on cognitive development at 5 years of age: Results from a multi-country cohort study
- Aggregation of CAT tails blocks their degradation and causes proteotoxicity in S. cerevisiae
- Expression of concern: Compensatory increase of transglutaminase 2 is responsible for resistance to mTOR inhibitor treatment
- Common mental illness among epilepsy patients in Bahir Dar city, Ethiopia: A cross-sectional study
- Staging dementia based on caregiver reported patient symptoms: Implications from a latent class analysis
- Health-related quality of life and its determinants among ambulatory patients with epilepsy at Ambo General Hospital, Ethiopia: Using WHOQOL-BREF
- In silico analysis and high-risk pathogenic phenotype predictions of non-synonymous single nucleotide polymorphisms in human Crystallin beta A4 gene associated with congenital cataract
- Fungal diversity in canopy soil of silver beech, Nothofagus menziesii (Nothofagaceae)
- Referral decisions and its predictors related to orthopaedic care. A retrospective study in a novel primary care setting
- Readiness to prescribe: Using educational design to untie the Gordian Knot
- Influence of gelation on the retention of purple cactus pear extract in microencapsulated double emulsions
- Factors related to met needs for rehabilitation 6 years after stroke
- Association of cataract and sun exposure in geographically diverse populations of India: The CASE study. First Report of the ICMR-EYE SEE Study Group
- Investigation of injury severity in urban expressway crashes: A case study from Beijing
- Clinical outcomes of incident peritoneal dialysis patients coming from kidney transplantation program: A case-control study
- Evaluation of the factors influencing the housing safety awareness of residents in Shanghai
- Morphometric study of the diaphragmatic surface of the liver in the human fetus
- Food insecurity and dietary diversity among lactating mothers in the urban municipality in the mountains of Nepal
- Genetic characterization of Bacillus anthracis strains circulating in Italy from 1972 to 2018
- Promising antifungal activity of new oxadiazole against Candida krusei
- An atlas of personality, emotion and behaviour
- Long-term effects of intracranial islet grafting on cognitive functioning in a rat metabolic model of sporadic Alzheimer's disease-like dementia
- Compartmentalized profiling of amniotic fluid cytokines in women with preterm labor
- Comparison of the myometrial transcriptome from singleton and twin pregnancies by RNA-Seq
- Adverse reproductive effects of S100A9 on bovine sperm and early embryonic development in vitro
- Functional dynamics of bacterial species in the mouse gut microbiome revealed by metagenomic and metatranscriptomic analyses
- Astrocyte senescence promotes glutamate toxicity in cortical neurons
- Primary ciliary dyskinesia and psychological well-being in adolescence
- Dipeptidyl peptidase-4 is increased in the abdominal aortic aneurysm vessel wall and is associated with aneurysm disease processes
- Primary care physician knowledge, attitudes, and diagnostic testing practices for norovirus and acute gastroenteritis
- Microfluidic-prepared DOTAP nanoparticles induce strong T-cell responses in mice
- Intraocular scattering as a predictor of driving performance in older adults with cataracts
- Reduced bone mineral density among HIV infected patients on anti-retroviral therapy in Blantyre, Malawi: Prevalence and associated factors
- Correction: Extraversion personality, perceived health and activity participation among community-dwelling aging adults in Hong Kong
- A rainwater control optimization design approach for airports based on a self-organizing feature map neural network model
- Influence of inflammasome NLRP3, and IL1B and IL2 gene polymorphisms in periodontitis susceptibility
- 18F-FDG-PET/MRI in the diagnostic work-up of limbic encephalitis
- The socioeconomic impact of orthopaedic trauma: A systematic review and meta-analysis
- Treatment patterns among patients with moderate-to-severe ulcerative colitis in the United States and Europe
- City to city learning and knowledge exchange for climate resilience in southern Africa
- Nuclear translocation of Atox1 potentiates activin A-induced cell migration and colony formation in colon cancer
- Activity-dependent switches between dynamic regimes of extracellular matrix expression
- Molecular sequencing and morphological identification reveal similar patterns in native bee communities across public and private grasslands of eastern North Dakota
- A mathematical model for assessing the effectiveness of controlling relapse in Plasmodium vivax malaria endemic in the Republic of Korea
- Cryo-focused ion beam preparation of perovskite based solar cells for atom probe tomography
- Physiological and transcriptomic responses of Lanzhou Lily (Lilium davidii, var. unicolor) to cold stress
- Unusual genome expansion and transcription suppression in ectomycorrhizal Tricholoma matsutake by insertions of transposable elements
- Estimating associations between antidepressant use and incident mild cognitive impairment in older adults with depression
- The use of telephone communication between nurse navigators and their patients
- CNP mediated selective toxicity on melanoma cells is accompanied by mitochondrial dysfunction
- HIV RNA measurement in dried blood spots of HIV-infected patients in Thailand using Abbott m2000 system
- Retraction: Oncogenic Fibulin-5 Promotes Nasopharyngeal Carcinoma Cell Metastasis through the FLJ10540/AKT Pathway and Correlates with Poor Prognosis
- Ultra-rapid cooling of ibex sperm by spheres method does not induce a vitreous extracellular state and increases the membrane damages
- Some animals are more equal than others: Validation of a new scale to measure how attitudes to animals depend on species and human purpose of use
- Observation and quantification of the morphological effect of trypan blue rupturing dead or dying cells
- The visual perception of emotion from masks
- Hexavalent chromium removal and total chromium biosorption from aqueous solution by Quercus crassipes acorn shell in a continuous up-flow fixed-bed column: Influencing parameters, kinetics, and mechanism
- The predictive value of anthropometric indices for cardiometabolic risk factors in Chinese children and adolescents: A national multicenter school-based study
- Lean back and wait for the alarm? Testing an automated alarm system for nosocomial outbreaks to provide support for infection control professionals
- Regional disparities in health care resources in traditional Chinese medicine county hospitals in China
- Analysis on hydraulic characteristics of improved sandy soil with soft rock
- Development and use of a scale to assess gender differences in appraisal of mistreatment during childbirth among Ethiopian midwifery students
- Factors for starting biosimilar TNF inhibitors in patients with rheumatic diseases in the real world
- Correction: Force field generalization and the internal representation of motor learning
- Prevalence and foetomaternal effects of iron deficiency anaemia among pregnant women in Lagos, Nigeria
- Socioeconomic risk factors for fatal opioid overdoses in the United States: Findings from the Mortality Disparities in American Communities Study (MDAC)
- Microbiome signatures in neonatal central line associated bloodstream infections
- Interventions for incarcerated adults with opioid use disorder in the United States: A systematic review with a focus on social determinants of health
- Opening gap width influences distal tibial rotation below the osteotomy site following open wedge high tibial osteotomy
- The impact of lowbush blueberry (Vaccinium angustifolium Ait.) and cranberry (Vaccinium macrocarpon Ait.) pollination on honey bee (Apis mellifera L.) colony health status
- Surveys of knowledge and awareness of antibiotic use and antimicrobial resistance in general population: A systematic review
- Managerial capacity among district health managers and its association with district performance: A comparative descriptive study of six districts in the Eastern Region of Ghana
- Knee joint distraction in regular care for treatment of knee osteoarthritis: A comparison with clinical trial data
- Reconstruction of a regulated two-cell metabolic model to study biohydrogen production in a diazotrophic cyanobacterium Anabaena variabilis ATCC 29413
- Cochlear dysfunction is associated with styrene exposure in humans
- Intra-individual variation of particles in exhaled air and of the contents of Surfactant protein A and albumin
- Revisits, readmissions, and outcomes for pediatric traumatic brain injury in California, 2005-2014
- Enhanced handover mechanism using mobility prediction in wireless networks
- Association between regular exercise and asthma control among adults: The population-based Northern Finnish Asthma Study
- Pharyngeal microbiome alterations during Neisseria gonorrhoeae infection
- Assessment of the clinical utility of four NGS panels in myeloid malignancies. Suggestions for NGS panel choice or design
- Assessment of time management practice and associated factors among primary hospitals employees in north Gondar, northwest Ethiopia
- Genetic diversity and population structure of feral rapeseed (Brassica napus L.) in Japan
- Are the current gRNA ranking prediction algorithms useful for genome editing in plants?
- Difference between physical therapist estimation and psychological patient-reported outcome measures in patients with low back pain
- Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness
- Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies
- Investigating cumulative effects of pre-performance routine interventions in beach volleyball serving
- Dispensing of antibiotics without prescription and associated factors in drug retail outlets of Eritrea: A simulated client method
- MicroRNA expression and DNA methylation profiles do not distinguish between primary and recurrent well-differentiated liposarcoma
- Assessment of acyl-CoA cholesterol acyltransferase (ACAT-1) role in ovarian cancer progression—An in vitro study
- Cytoplasmic factories, virus assembly, and DNA replication kinetics collectively constrain the formation of poxvirus recombinants
- The wavelet power spectrum of perfusion weighted MRI correlates with tumor vascularity in biopsy-proven glioblastoma samples
- Agreement between cardiovascular disease risk assessment tools: An application to the United Arab Emirates population
- Constructing HLM to examine multi-level poverty-contributing factors of farmer households: Why and how?
- Patterns of symptoms possibly indicative of cancer and associated help-seeking behaviour in a large sample of United Kingdom residents—The USEFUL study
- An automated alarm system for food safety by using electronic invoices
- Neural effects of acute stress on appetite: A magnetoencephalography study
- Use of magnetic resonance imaging to determine laterality of meniscal size in healthy volunteers
- Co-prevalence of extracranial carotid aneurysms differs between European intracranial aneurysm cohorts
- Thermal biology of two tropical lizards from the Ecuadorian Andes and their vulnerability to climate change
- When weight is an encumbrance; avoidance of stairs by different demographic groups
- Non-mycosis fungoides cutaneous lymphomas in a referral center in Taiwan: A retrospective case series and literature review
- From the host's point of view: Effects of variation in burying beetle brood care and brood size on the interaction with parasitic mites
- Kernel-based Gaussian process for anomaly detection in sparse gamma-ray data
- Unmet care needs of children with ADHD
- Accelerometer-assessed outdoor physical activity is associated with meteorological conditions among older adults: Cross-sectional results from the OUTDOOR ACTIVE study
- Identification of Korean cancer survivors’ unmet needs and desired psychosocial assistance: A focus group study
- Evaluation of inactivated Bordetella pertussis as a delivery system for the immunization of mice with Pneumococcal Surface Antigen A
- The role of moral reasoning & personality in explaining lyrical preferences
- Would you like to participate in this trial? The practice of informed consent in intrapartum research in the last 30 years
- Correction: Mutation spectrums of TSC1 and TSC2 in Chinese women with lymphangioleiomyomatosis (LAM)
- Forward lunge before and after anterior cruciate ligament reconstruction: Faster movement but unchanged knee joint biomechanics
- Challenges associated with homologous directed repair using CRISPR-Cas9 and TALEN to edit the DMD genetic mutation in canine Duchenne muscular dystrophy
- Integrated targeted serum metabolomic profile and its association with gender, age, disease severity, and pattern identification in acne
- A prospective case-control study on miRNA circulating levels in subjects born small for gestational age (SGA) evaluated from childhood into young adulthood
- Polymer-fiber-coupled field-effect sensors for label-free deep brain recordings
- Global depth perception alters local timing sensitivity
- How to detect a polytrauma patient at risk of complications: A validation and database analysis of four published scales
- Module for SWC neuron morphology file validation and correction enabled for high throughput batch processing
- Reduced gray matter volume and cortical thickness associated with traffic-related air pollution in a longitudinally studied pediatric cohort
- Recombinant human soluble thrombomodulin is associated with attenuation of sepsis-induced renal impairment by inhibition of extracellular histone release
- Human and climatic drivers affect spatial fishing patterns in a multiple-use marine protected area: The Galapagos Marine Reserve
- Correction: Leisure-time physical activity and sports in the Brazilian population: A social disparity analysis
- Application of the mixture item response theory model to the Self-Administered Food Security Survey Module for Children
- Numerical simulation of atmospheric CO2 concentration and flux over the Korean Peninsula using WRF-VPRM model during Korus-AQ 2016 campaign
- Feline irradiated diet-induced demyelination; a model of the neuropathology of sub-acute combined degeneration?
- Improved multi-parametric prediction of tissue outcome in acute ischemic stroke patients using spatial features
- Genome-wide association and epistatic interactions of flowering time in soybean cultivar
- Correction: Association between workplace bullying and burnout, professional quality of life, and turnover intention among clinical nurses
- Correction: Estimation of membrane bending modulus of stiffness tuned human red blood cells from micropore filtration studies
- Correction: Limited indirect effects of an infant pneumococcal vaccination program in an aging population
- Correction: Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats
- Fieldwork-based determination of design priorities for point-of-use drinking water quality sensors for use in resource-limited environments
- Young women’s reproductive health conversations: Roles of maternal figures and clinical practices
- Correction: Differential recordings of local field potential: A genuine tool to quantify functional connectivity
- Survival of medial versus lateral unicompartmental knee arthroplasty: A meta-analysis
- Novel MscL agonists that allow multiple antibiotics cytoplasmic access activate the channel through a common binding site
- Is it time to stop sweeping data cleaning under the carpet? A novel algorithm for outlier management in growth data
- Changes in oak (Quercus robur) photosynthesis after winter moth (Operophtera brumata) herbivory are not explained by changes in chemical or structural leaf traits
- Mutual interaction between motor cortex activation and pain in fibromyalgia: EEG-fNIRS study
- Evaluation of liposomal ciprofloxacin formulations in a murine model of anthrax
- Analysis of cholesterol in mouse brain by HPLC with UV detection
- Sugar, amino acid and inorganic ion profiling of the honeydew from different hemipteran species feeding on Abies alba and Picea abies
- Exploring prior diseases associated with incident late-onset Alzheimer’s disease dementia
- Hypertension prevalence in patients attending tertiary pain management services, a registry-based Australian cohort study
- SRL pathogenicity island contributes to the metabolism of D-aspartate via an aspartate racemase in Shigella flexneri YSH6000
- Correction: Comprehensive genome-wide analysis of the pear (Pyrus bretschneideri) laccase gene (PbLAC) family and functional identification of PbLAC1 involved in lignin biosynthesis
- Epilepsy in a melanocyte-lineage mTOR hyperactivation mouse model: A novel epilepsy model
- Water consumption and prevalence of irritable bowel syndrome among adults
- Mixed evidence for the relationship between periodontitis and Alzheimer’s disease: A bidirectional Mendelian randomization study
- Correction: Health conditions associated with overweight in climacteric women
- Correction: Determining Glomerular Filtration Rate in Homozygous Sickle Cell Disease: Utility of Serum Creatinine Based Estimating Equations
- Modelling the number of antenatal care visits in Bangladesh to determine the risk factors for reduced antenatal care attendance
- Correction: Cumulative viral load as a predictor of CD4+ T-cell response to antiretroviral therapy using Bayesian statistical models
- Dominant negative effects by inactive Spa47 mutants inhibit T3SS function and Shigella virulence
- ICOS-deficient and ICOS YF mutant mice fail to control Toxoplasma gondii infection of the brain
- Diel patterns in swimming behavior of a vertically migrating deepwater shark, the bluntnose sixgill (Hexanchus griseus)
- Life history of northern Gulf of Mexico Warsaw grouper Hyporthodus nigritus inferred from otolith radiocarbon analysis
- Physiology education for intensive care medicine residents: A 15-minute interactive peer-led flipped classroom session
- Strengthening capacity for natural sciences research: A qualitative assessment to identify good practices, capacity gaps and investment priorities in African research institutions
- Systematic scoping review of the concept of ‘genetic identity’ and its relevance for germline modification
- Height of overburden fracture based on key strata theory in longwall face
- Laboratory strains of Bacillus anthracis lose their ability to rapidly grow and sporulate compared to wildlife outbreak strains
- Improvement of classification performance of Parkinson’s disease using shape features for machine learning on dopamine transporter single photon emission computed tomography
- Comparative pharmacokinetics and pharmacodynamics of the advanced Retinol-Binding Protein 4 antagonist in dog and cynomolgus monkey
- Correction: A handy method to remove bacterial contamination from fungal cultures
- Correction: Effect of statin on life prognosis in Japanese patients undergoing hemodialysis
- Retraction: Outer Membrane Protein A (OmpA) of Shigella flexneri 2a Induces TLR2-Mediated Activation of B Cells: Involvement of Protein Tyrosine Kinase, ERK and NF-κB
- Retraction: Biofabrication of streptomycin-conjugated calcium phosphate nanoparticles using red ginseng extract and investigation of their antibacterial potential
- Receiver operating characteristic curve analysis of clinical signs for screening of convergence insufficiency in young adults
- Correction: Drivers of deforestation in the basin of the Usumacinta River: Inference on process from pattern analysis using generalised additive models
- Efficacy of fertilizing method for different potash sources in cotton (Gossypium hirsutum L.) nutrition under arid climatic conditions
- Podocyte autophagy is associated with foot process effacement and proteinuria in patients with minimal change nephrotic syndrome
- Effect of Lactobacillus acidophilus D2/CSL (CECT 4529) supplementation in drinking water on chicken crop and caeca microbiome
- Retraction: MiR-30a-5p Antisense Oligonucleotide Suppresses Glioma Cell Growth by Targeting SEPT7
- Correction: Dynamics of plasma micronutrient concentrations and their correlation with serum proteins and thyroid hormones in patients with paracoccidioidomycosis
- Impact of lower limb osteoarthritis on health-related quality of life: A cross-sectional study to estimate the expressed loss of utility in the Spanish population
- Correction: Prevalence of damaged and missing teeth among women in the southern plains of Nepal: Findings of a simplified assessment tool
- Correction: Tissue-Specific Expressed Antibody Variable Gene Repertoires
- Retraction: Immunoglobulin G Expression in Lung Cancer and Its Effects on Metastasis
- Correction: Causal knowledge promotes behavioral self-regulation: An example using climate change dynamics
- Retraction: Use of Granulocyte Colony-Stimulating Factor for the Treatment of Thin Endometrium in Experimental Rats
- Correction: Dynamic mechanical and nanofibrous topological combinatory cues designed for periodontal ligament engineering
- Correction: Evaluating the foundations that help avert antimicrobial resistance: Performance of essential water sanitation and hygiene functions in hospitals and requirements for action in Kenya
- From seed to flour: Sowing sustainability in the use of cantaloupe melon residue (Cucumis melo L. var. reticulatus)
- Core Scientific Dataset Model: A lightweight and portable model and file format for multi-dimensional scientific data
- Accounting for measurement error to assess the effect of air pollution on omic signals
- Leucine zipper transcription factor-like 1 binds adaptor protein complex-1 and 2 and participates in trafficking of transferrin receptor 1
- Barriers for tuberculosis case finding in Southwest Ethiopia: A qualitative study
- Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia
- A lower psoas muscle volume was associated with a higher rate of recurrence in male clear cell renal cell carcinoma
- Two angles of overqualification-the deviant behavior and creative performance: The role of career and survival job
- Cost-utility analysis of de-escalating biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis
- Efficient estimation of stereo thresholds: What slope should be assumed for the psychometric function?
- Learning efficient haptic shape exploration with a rigid tactile sensor array
- Effects of dietary supplementation with a microalga (Schizochytrium sp.) on the hemato-immunological, and intestinal histological parameters and gut microbiota of Nile tilapia in net cages
- Regional versus local wind speed and direction at a narrow beach with a high and steep foredune
- Fragmented QRS complex in patients with systemic lupus erythematosus at the time of diagnosis and its relationship with disease activity
- Severe thiamine deficiency in eastern Baltic cod (Gadus morhua)
- Transfer entropy as a variable selection methodology of cryptocurrencies in the framework of a high dimensional predictive model
- Psychometric validation of Czech version of the Sport Motivation Scale
- Correction: Multiple innate antibacterial immune defense elements are correlated in diverse ungulate species
- Recognition of personality disorder and anxiety disorder comorbidity in patients treated for depression in secondary psychiatric care
- Correction: Strategies for achieving high sequencing accuracy for low diversity samples and avoiding sample bleeding using illumina platform
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